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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 118-119页

作者：付海霞 Peking Univ People's Hosp Peking Univ Insit HematolNatl Clin Hematol Dis Res CenterBeijing Hematopoiet Stem Cell Transplant Key LabBeijing 100044

Objective To analyze the clinical characteristics and outcomes of patientswith invasive fungal sinusitis(invasive fungal rhinosinusitis,IFR)after allogeneic hematopoietic stem cell transplantation(allo-HSCT)and explored the risk factors for IFR after *** Nineteen patients with IFR after allo-HSCT at Peking University People's Hospital from January 2012 to December 2021 were selected as the study group,and 95 patients without IFR after allo-HSCT during this period were randomly selected as the control group(1:5 ratio).Results Nineteen patients,including 10 males and 9 females,had IFR after *** median age was 36(10-59)*** median IFR onset time was 68(9-880)days after *** wereseven patients with acute myeloid leukemia,five with acute lymphoblastic leukemia,two with myelodysplastic syndrome,two with chronic myeloid leukemia,one with acute mixed-cell leukemia,one with multiple myeloma,and one with T-lymphoblastic lymph node *** were 13 confirmed cases and 6 clinically diagnosed *** responsible fungus was Mucor in two cases,Rhizopus in four,Aspergillus in four,and Candida in three.

关键词： IFR ratio invasive

指向立德树人的职教高考职业技能测试命题策略研究

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九江职业技术学院学报 2024年第1期 40-44页

作者：连彩元付海霞福建技术师范学院福建福清350300

职业教育培养的人首先应是“社会人”,其次才是“职业人”,所以职教高考职业技能测试命题应以立德树人为根本指向。职业技能测试命题不仅要考查学生认识、理解、分析和解决问题所必须具备的专业知识和基本专业素养能力,还要考查学生的... 详细信息

职业教育培养的人首先应是“社会人”,其次才是“职业人”,所以职教高考职业技能测试命题应以立德树人为根本指向。职业技能测试命题不仅要考查学生认识、理解、分析和解决问题所必须具备的专业知识和基本专业素养能力,还要考查学生的综合素养,引导考生树立正确的世界观、人生观和价值观.

关键词：职教高考立德树人职业技能测试命题

腺嘌呤磷酸核糖转移酶基因突变导致2,8-二羟基腺嘌呤结晶性肾病1例

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中华肾脏病杂志 2024年第7期40卷 561-564页

作者：张然姜维娜陈增生刘丰海邵乐平傅海霞青岛大学附属青岛市市立医院肾内科青岛266071 青岛大学附属青岛市市立医院病理科青岛266071 青岛大学附属青岛市市立医院检验科青岛266071

该文报道1例由腺嘌呤磷酸核糖转移酶(adenine phosphoribosyltransferase,APRT)基因突变导致的2,8-二羟基腺嘌呤(2,8-dihydroxyadenine,2,8-DHA)结晶性肾病病例。患者,女,60岁,因发现"尿泡沫增多半年"就诊。肾活检光镜下可见不规则的棕... 详细信息

该文报道1例由腺嘌呤磷酸核糖转移酶(adenine phosphoribosyltransferase,APRT)基因突变导致的2,8-二羟基腺嘌呤(2,8-dihydroxyadenine,2,8-DHA)结晶性肾病病例。患者,女,60岁,因发现"尿泡沫增多半年"就诊。肾活检光镜下可见不规则的棕黄色、偏振光下具有折光性的2,8-DHA结晶,尿沉渣检测发现2,8-DHA结晶,基因检测发现APRT基因5号外显子纯合缺失(c.521523delTCT),最终确诊为2,8-DHA结晶性肾病。经别嘌醇治疗后,患者肾功能好转。该病例报告旨在提高临床医师对2,8-DHA结晶性肾病的认识,早期识别、正确诊断及早期药物干预可延缓肾衰竭进展,改善预后。

关键词：肾疾病腺嘌呤磷酸核糖基转移酶腺嘌呤 2,8-二羟基腺嘌呤结晶结晶性肾病

基于CiteSpace可视化分析经方麻杏石甘汤的研究应用与发展

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医学综述 2024年第14期30卷 1772-1780页

作者：温清杰李彤付海霞王艺锦艾军符标芳闫国跃广西中医药大学瑶医药学院南宁530001 广西中医药大学广西壮瑶医药与医养结合人才小高地南宁530001 广西中医药大学基础医学院南宁530001

目的运用CiteSpace软件对经方麻杏石甘汤的研究现状及发展趋势进行可视化分析。方法在中国知网数据库中检索与麻杏石甘汤相关的文献,检索时间为1980年1月1日至2023年1月1日,运用CiteSpace软件绘制该领域相关文献关键词共现分析、关键词... 详细信息

目的运用CiteSpace软件对经方麻杏石甘汤的研究现状及发展趋势进行可视化分析。方法在中国知网数据库中检索与麻杏石甘汤相关的文献,检索时间为1980年1月1日至2023年1月1日,运用CiteSpace软件绘制该领域相关文献关键词共现分析、关键词聚类分析、关键词突现分析的科学知识图谱。

关键词：麻杏石甘汤 CiteSpace 知识图谱可视化分析研究趋势

导管消融术治疗心房颤动性心肌病的效果及预后的影响因素

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中华实用诊断与治疗杂志 2024年第7期38卷 708-715页

作者：赵晨晨马继芳周游王凡付海霞河南大学人民医院河南省人民医院心内科河南郑州450003 阜外华中心血管病医院心内科河南郑州451460 河南省人民医院急诊科河南郑州450003

目的观察心房颤动性心肌病(AF-CM)患者的临床特点、行导管消融术治疗的效果及预后的影响因素,探讨早期诊断AF-CM的指标及诊断价值。方法 2018年3月—2023年2月阜外华中心血管病医院行导管消融术治疗的心房颤动(AF)合并心力衰竭(HF)患者... 详细信息

目的观察心房颤动性心肌病(AF-CM)患者的临床特点、行导管消融术治疗的效果及预后的影响因素,探讨早期诊断AF-CM的指标及诊断价值。方法 2018年3月—2023年2月阜外华中心血管病医院行导管消融术治疗的心房颤动(AF)合并心力衰竭(HF)患者210例,术后6个月内左室射血分数(LVEF)升高15%或恢复正常者158例为AF-CM组,LVEF升高0.05)。(2)AF-CM组术前NT-proBNP [976.500(564.175,1 799.250) ng/L]、血肌酐[(81.300±25.190)μmol/L]水平低于DCM-AF组[1 231.000(838.275, 2 093.250) ng/L、(91.710±27.186)μmol/L](P0.05)。术后1个月,AF-CM组NT-proBNP、血肌酐水平低于DCM-AF组,NYHA心功能Ⅰ~Ⅱ级比率高于DCM-AF组(P0.05)。术后6个月,AF-CM组LVEDD[(49.820±4.624)mm]、LAD[(37.910±4.568)mm]、二尖瓣反流面积[1.900(1.100, 3.100)cm^(2)]均小于术前(P<0.05),LVEF[(57.580±4.351)%]大于术前(P<0.05),二尖瓣重度反流比率(1.3%)低于术前(P<0.05);DCM-AF组LVEDD[(60.000±8.586)mm]、LAD[(41.940±5.903)mm]小于术前(P<0.05),LVEF[(40.790±6.690)%]大于术前(P<0.05)。术后6个月,AF-CM组LVEDD、LAD、二尖瓣反流面积均小于DCM-AF组,LVEF大于DCM-AF组,二尖瓣重度反流比率低于DCM-AF组(P<0.05)。(4)随访至2023年9月1日,2组均无死亡病例,AF-CM组AF复发率(8.2%)、心血管事件再住院率(16.5%)均低于DCM-AF组(25.0%、65

关键词：心房颤动心力衰竭导管消融心肌病扩张性心肌病

Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT

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Science China(Life Sciences) 2019年第7期62卷 921-929页

作者： haixia fu Jingzhong Zhao Lanping Xu Kaiyan Liu Yu Wang Huan Chen Wei Han Jingzhi Wang Fengrong Wang Xiaojun Huang Xiaohui Zhang Peking University People's Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation for the Treatment of Hematological Diseases Beijing 100044China Peking University People's Hospital Department of Clinical LaboratoryBeijing 100044China

We aimed to measure platelet function and its relationship with β2-GPI in prolonged isolated thrombocytopenia(PT) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Fifty-six patients with PT and 60 allo-HSCT recipients without PT(non-PT controls) were *** aggregation and activation,β2-GPI and anti-β2-GPI antibody levels,vWF antigen,and vWF activity were *** effect of β2-GPI on platelet aggregation was also measured ex *** showed that ADP-induced platelet aggregation significantly increased(39%±7.5% vs.23%±8.5%,P=0.032),and the platelet expression of both CD62 p(33.6%±11.6% vs.8.5%±3.5%,P<0.001) and PAC-1(42.4%±7.6% vs.6.8%±2.2%,P<0.001) was significantly higher in patients with PT than in those without *** lower β2-GPI levels(164.2±12 μg m L^-1 vs.234.2±16 μg mL^-1,P<0.001),higher anti-β2-GPI IgG levels(1.78±0.46 U mL^-1 vs.0.94±0.39 U mL^-1,P<0.001),and increased vWF activity(133.06%±30.50% vs.102.17%±25.90%,P<0.001) were observed in patients with PT than in those without *** ADPinduced platelet aggregation(n=116,r^2=-0.5042,P<0.001) and vWF activity(n=116,r^2=-0.2872,P<0.001) were negatively correlated with β2-GPI *** summary,our data suggested that platelet aggregation and activation were significantly higher in patients with PT than in those without PT,which might be associated with reduced β2-GPI *** reduced β2-GPI levels might be due to the existence of anti-β2-GPI IgG.

关键词： β2-GPI hematopoietic stem cell transplantation prolonged isolated thrombocytopenia platelet aggregation platelet activation

Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization

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Science China(Life Sciences) 2020年第11期63卷 1744-1754页

作者： Xiao Liu Yan Su Xueyan Sun haixia fu Qiusha Huang Qi Chen Xiaodong Mo Meng Lv Yuan Kong Lanping Xu Xiaojun Huang Xiaohui Zhang Peking University People’s Hospital Beijing 100044China Peking University Institute of Hematology Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China

This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype.

关键词： ATO macrophage polarization acute graft-versus-host disease

Effects of aerosolized ketamine on the level of nitric oxide and nitric oxide synthetase in the lung tissue of rat with asthma

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Journal of Nanjing Medical University 2006年第2期20卷 94-96页

作者： Weiqian Tian Chengzhang fu Minmin Zhu haixia Li Department of Anesthesiology the First Affiliated Hospital of Nanjing Mcdical University Nanjing 210029 China

Objective： To explore the effects of aerosolized ketamine on the level of nitric oxide and nitric oxide synthetase in the lung tissue in rat asthma model. Methods： Forty SD rats were randomly assigned to five groups： control group （group N）, asthma model group （group A）, two pretreated groups of different concentrations of ketamine （group K1, K2） and dexamethasone group（group D） with eight rats in each group. The rats in group A were sensitized by injection of ovalbumin （OA） together with aluminum hydroxide and bordetella pertussis as adjuvants. Two weeks after the sensitization, aerosolized OA was used to cause asthma. The rats in group K1 and K2 were sensitized with OA as group A , and then exposed to aerosol of ketamine , with the concentration of 25 g/L and 50 g/L respectively. Before using aerosolized OA,the rats in group D were exposed to aerosol of 0.01% dexamethasone .The level of NO2^-/NO3^- in lung tissues, inducible nitric oxide synthetase（iNOS） and constitute nitric oxide synthetase（cNOS） was measured in all groups. Results： The level of NO2^-/NO3^- and the activity of iNOS in lung tissues in group A were signiticantly higher than those in the other groups. The iNOS activity and the level of NO2^-/NO3 ^- in lung tissues were highly positively correlated. Conclusion： NO can induce airway hyperreactivity that may worsen asthma. Aerosolized ketamine can decrease the iNOS expression and reduce the level of NO in the lung tissue in rat asthma model.

关键词： kemmine nitric oxide nitric oxide synthase asthma

Combined prednisone and levothyroxine improve treatment of severe thrombocytopenia in hepatitis B with compensatory cirrhosis accompanied by subclinical and overt hypothyroidism

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Science China(Life Sciences) 2018年第8期61卷 924-933页

作者： Jing Xue Ru Feng haixia fu Qian Jiang Hao Jiang Jing Lu Hui Liu Jingwen Wang Ting Niu Xin Wang YANDi Xie Hao Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Collaborative Innovation Center of Hematology Peking University Departments of Hematology Beijing HospitalNational Center of Gerontology Department of Hematology Beijing Tongren Hospital Department of Hematology Sichuan University West China Medical Center Department of Hematology Shandong Provincial Hospital Peking University People's Hospital Institute of Hepatic Diseases

The aim of the present study was to investigate the relationship between hypothyroidism and thrombocytopenia in hepatitis Brelated compensatory liver cirrhosis and to determine whether treatment with levothyroxine and prednisone is superior in a multicenter, open-label, observational study in China. In total, 125 consecutive hepatitis B-related compensated liver cirrhosis patients with severe thrombocytopenia accompanied by hypothyroidism were included. The patients were divided into four groups according to treatment strategy: a control group(n=29), a prednisone group(n=25), a levothyroxine group(n=32) and a prednisone plus levothyroxine group(n=39). Severe thrombocytopenia was more prevalent in hepatitis B-associated compensatory liver cirrhosis patients with hypothyroidism than in euthyroid patients(29.6% vs. 14.7%, P<0.05). Combination treatment with prednisone and levothyroxine decreased the risk of bleeding and improved platelet recovery compared to control treatment and treatment with either prednisone or levothyroxine alone. The platelet count before therapy, serum thyroid stimulating hormone and combination treatment with prednisone and levothyroxine were associated with bleeding events. Therefore, the present study suggests that hypothyroidism is associated with severe thrombocytopenia in hepatitis B-associated compensatory liver cirrhosis. Treatment with prednisone plus levothyroxine may present a novel approach in these patients.

关键词： hepatitis B cirrhosis thrombocytopenia hypothyroidism treatment

Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia

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Science China(Life Sciences) 2021年第5期64卷 766-783页

作者： Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang haixia fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang Peking University People's Hospital Peking University Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China National Center for Bioinformation Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Quantitative metagenomic studies have linked the gut microbiota to autoimmune ***,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy *** in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy *** particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical ***,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune ***,we found that corticosteroid treatment affected the gut microbiome of *** with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP ***,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP.

关键词： immune thrombocytopenia metagenomics gut microbiome corticosteroid resistance