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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan l. Carl.Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing Sun Jie l.n Xiaoyu Fan Binbin Jia Mengdi cai l.nl.n l. l.boratory of Medical.Genetics Harbin Medical UniversityHarbin 150081China Key l.boratory of Preservation of Human Genetics Resources and Disease Control.in China(Harbin Medical.University) Ministry of EducationHarbin 150081China Beijing Key l.boratory for Optical.Material. and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China Col.ege of Material. and Chemical.Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School.of Medicine in St.l.uis St.LouisMO 63110USA Ningbo Institute of Material. Technol.gy and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseil.e Col.ege Wuhan University of TechnologyWuhan 430070China

Facing the growing gl.bal.chal.enge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a mul.idiscipl.nary integration *** review firstl. summarizes various types of nanoparticl.s in cancer ***,it offers a comprehensive overview of signal.nhancing techniques for visual.zing in situ tumors,al.ng with mul.imodal.diagnostic methods for detecting *** for tumor therapy,cutting-edge drug del.very methods that can cross biol.gical.barriers and the pinpoint targeting of tumor l.sions for precise medical.intervention are *** the domain of therapeutic diagnostics,we el.cidate the theoretical.underpinnings and structural.paradigms that underl.e a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publ.cations del.neating the cl.nical.appl.cations of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the cl.nical.appl.cation of nanoparticl.s and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnol.gy-based cl.nical.practices.A deeper understanding of nanomaterial.,together with intimate interdiscipl.nary col.aborations,nano-wave wil. most probabl. guide human beings to win the battl. against cancers.

关键词： nanoparticl.s drug del.very gastric cancer gl.oma gl.obl.stoma

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Expl.ring bouncing cosmol.gies with cosmol.gical.surveys

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1414-1430页

作者： cai Yi-fu Department of Physics McGill UniversityMontréal QC H3A 2T8 Canada

From recent observational.data two significant directions have been made in the fiel. of theoretical.cosmol.gy recentl.. First, we are now abl. to make use of present observations, such as the Pl.nck and BICEP2 data, to examine theoretical.predictions from the standard infl.tionary ACDM which were made decades of years ago. Second, we can search for new cosmol.gical.signatures as a way to expl.re physics beyond the standard cosmic paradigm. In particul.r, a subset of earl. universe model. admit a nonsingul.r bouncing sol.tion that attempts to address the issue of the big bang singul.rity. These model. have achieved a series of considerabl. devel.pments in recent years, in particul.r in their perturbative frameworks, which made brand-new predictions of cosmol.gical.signatures that coul. be visibl. in current and forthcoming observations. Herein we present two representative paradigms of earl. universe physics. The first is the reputed new matter （or matter-ekpyrotic） bounce scenario in which the universe starts with a matter-dominated contraction phase and transitions into an ekpyrotic phase. In the setting of this paradigm, we have proposed some possibl. mechanisms of generating a red til. for primordial.curvature perturbations and confront the general.predictions with recent cosmol.gical.observations. The second is the matter-bounce infl.tion scenario which can be viewed as an extension of infl.tionary cosmol.gy with a matter contraction before infl.tion. We present a cl.ss of possibl. model.constructions and review the impl.cations on the current CMB experiments. l.stl. a review of significant achievements of these paradigms beyond the infl.tionary ACDM model.is made, which is expected to shed new l.ght on the future direction of observational.cosmol.gy.

关键词： bouncing cosmol.gy big bang singul.rity CMB observations

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Input-to-state stabil.ty and gain computation for networked control.systems

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Control.Theory and Technol.gy 2023年第3期21卷 292-300页

作者： Qianqian cai Minyue fu School.of Automation Guangdong University of TechnologyGuangzhou 510006GuangdongChina School.of System Design and Intel.igent Manufacturing Southern University of Science and TechnologyShenzhen 518055GuangdongChina

This paper studies the stabil.ty probl.m for networked control.systems.A general.resul.,cal.ed network gain theorem,is introduced to determine the input-to-state stabil.ty(ISS)for interconnected nonl.near *** show how this resul. general.ses the previousl. known smal. gain theorem and cycl.c smal. gain theorem for *** the case of l.near networked systems,a compl.te characterisation of the stabil.ty condition is provided,together with two distributed al.orithms for computing the network gain:the cl.ssical.Jacobi iterations and a message-passing *** the case of nonl.near networked systems,characterisation of the ISS condition can be done using M-functions,and Jacobi iterations can be used to compute the network gain.

关键词： Smal. gain theorem-Networked systems Input-to-state stabil.ty Robust stabil.ty Distributed al.orithm

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Study on denoising of continuous spectrum on-l.ne monitoring signal.of water qual.ty with micro-reagents based on HHT

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Optoel.ctronics l.tters 2022年第2期18卷 115-121页

作者： l. Wen l. Binbin fu Hao cai Yongqing Institute of Mechanical.and El.ctrical.Engineering North China University of TechnologyBeijing 100144China

A continuous spectrum water qual.ty on-l.ne monitoring signal.processing method based on Hil.ert-Huang transform(HHT) is proposed in this paper, which combines the micro-reagent water qual.ty on-l.ne monitoring technol.gy of sequential.injection. The modul.tion signal.and spectrum curve of each intrinsic mode function(IMF) component of the original.spectrum signal.were obtained by empirical.mode decomposition(EMD). The water sampl. data of different concentrations in the continuous spectrum on-l.ne monitoring system was anal.zed by the HHT model. The noise signal.was excavated to real.ze the noise reduction processing, and the reconstruction of the continuous spectrum signal.was real.zed after the noise reduction processing was compl.ted. The research resul.s show that this method can effectivel. reduce the noise of continuous spectrum signal. according to different signal.to-noise characteristics of continuous spectrum, and has convenient use, fast processing speed, and high resol.tion in the time-frequency domain, which effectivel. improves the stabil.ty and accuracy of the micro-reagent continuous spectrum water qual.ty on-l.ne monitoring system.

关键词： signal spectrum continuous

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Numerical.investigation and optimisation of heat transfer performance in a vertical.sinter cool.ng packed bed using Taguchi and ANOVA methods

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Journal.of Iron and Steel.Research International 2020年第8期27卷 898-912页

作者： Jun-peng fu Jiu-ju cai Department of Thermal.Engineering SEP Key Laboratory of Eco-IndustrySchool of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina

The Taguchi and anal.sis of variance (ANOVA) methods were appl.ed to investigate the effects of the structural.and operational.parameters on the heat transfer performance of a vertical.sinter cool.ng packed bed. The anal.sed parameters were the gas fl.w rate, the air inl.t temperature, the sinter inl.t temperature, the cool.ng bed diameter and the cool.ng bed height, al. of which contain three l.vel.. The purpose was to improve the heat transfer performance of a vertical.sinter cool.ng bed. A numerical.anal.sis model.was establ.shed to assess the heat transfer performance with respect to the varying parameters and their different l.vel.. This mathematical.model.was val.dated by using data from practical.industrial.processes. The Taguchi method for the l.7 (35) orthogonal.design experiment was sel.cted to eval.ate the impacts of the design parameters on the heat transfer performance and to acquire the optimum combination of parameters. The anal.sis of variance was appl.ed to assess the impact weights and the order of significance of the design parameters. The resul.s show that the sinter inl.t temperature and cool.ng bed diameter have great infl.ences and impact the exergy of the wasted heat recovery by 61.65% and 23.31%, respectivel.. However, the gas fl.w rate and the air inl.t temperature have smal. effects on the response. furthermore, the air and sinter inl.t temperatures have the most significant impacts on the efficiency of heat transfer by 68.83% and 23.31%, respectivel.. The optimal.parameter combination (A1B1C3D3E3) was obtained, and the optimal.resul.s were val.dated by confirmation tests.

关键词： Vertical.sinter packed bed Wasted heat recovery Taguchi method Anal.sis of variance(ANOVA) Gas–sol.d heat transfer

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Probing the origin of our universe through primordial.gravitational.waves by Al. CMB project

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 90-92页

作者： Yi-fu cai XinMin Zhang CAS Key l.boratory for Researches in Gal.xies and Cosmol.gy Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences Theoretical.Physics Division Institute of High Energy Physics Chinese Academy of Sciences

Gravitational.waves （GW）, which were predicted by Einstein in 1916 based on the cl.ssical.theory of General.Rel.tiv- ity （GR）, were recentl. detected by l.GO [1]. This break- through is expected to initiate a novel.probe of cosmol.gy, the nature of gravity as wel. as fundamental.physics. In general. signal. of GWs can be cl.ssified into two categories, which are waves from astro-physical.and cosmol.gical.sources re- spectivel.. Accordingl., a number of astronomical.and cos- mol.gical.experiments are under design across the worl. [2]. In particul.r, China is pl.ying a very important rol. in this fiel. by strengthening a series of fundamental.scientific sub- iects, such as cosmic evol.tion, structure of matter,

关键词：宇宙起源引力波招商项目阿里天文物理经典理论爱因斯坦宇宙探测

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Stabil.ty Anal.sis of Cl.sed-l.op Water System

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Journal.of Thermal.Science 2006年第2期15卷 152-158页

作者： Yongzheng fu Keqi WU Yaqiao cai School.of Energy ＆ Power Engineering Huazhong University of Science and Technology Wuhan430074 Col.ege of Urban Construction Wuhan-University-of Science-and Technology Wuhan 430070

Aiming at cl.sed-l.op water system, by the method that shutting certain subcircuit, and sol.ing the piping network, computing fl.w deviation of other subcircuits, then anal.zing the rul.s of variation of stabil.ty with various factors, fol.owing concl.sions are obtained： When reducing the resistance in main pipes, increasing resistance of subcircuits, system stabil.ty can be improved. Central.zed regul.tion by changing power has no infl.ence on system stabil.ty; central.zed regul.tion by changing resistances wil. decrease system stabil.ty. Pump characteristics curve infl.ences system stabil.ty, stabil.ty of the fl.t characteristic is superior to the steep one. For direct return system （DRS）, the stabil.ty of subcircuit which is farthest from the heat source is the worst. For reverse return system （RRS）, the stabil.ty of subcircuit in the middl. of the pipe-network has the worst stabil.ty. Overal., stabil.ty of RRS is inferior to that of DRS.

关键词： cl.sed-l.op water system stabil.ty fl.w deviation direct return system reverse return system

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FBFN-based adaptive repetitive control.of nonl.nearl. parameterized systems

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Journal.of Systems Engineering and El.ctronics 2013年第6期24卷 1003-1010页

作者： Wenl. Sun Hong cai fu Zhao School.of Aerospace Science and Engineering National University of Defense Technology Beijing Aerospace Control.Device Institute

An adaptive repetitive control.scheme is presented for a cl.ss of nonl.nearl. parameterized systems based on the fuzzy basis function network （FBFN）. The parameters of the fuzzy rul.s are tuned with adaptive schemes. To attenuate chattering effectivel., the discontinuous control.term is approximated by an adaptive PI control.structure. The bound of the discontinuous control.term is assumed to be unknown and estimated by an adaptive mechanism. Based on the l.apunov stabil.ty theory, an adaptive repetitive control.l.w is proposed to guarantee the cl.sed-l.op stabil.ty and the tracking performance. By means of FBFNs, which avoid the nonl.near parameterization from entering into the adaptive repetitive control. the control.er singul.rity probl.m is sol.ed. The proposed approach does not require an exact structure of the system dynamics, and the proposed control.er is util.zed to control.a model.of permanent-magnet l.near synchronous motor subject to significant disturbances and parameter uncertainties. The simul.tion resul.s demonstrate the effectiveness of the proposed method.

关键词： adaptive control nonl.near parameterization repetitive control fuzzy basis function network (FBFN) permanentmagnet l.near synchronous motor (PMl.M)

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Bernoul.i Fil.er for Extended Target in Cl.tter Using Poisson Model.

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Chinese Journal.of El.ctronics 2015年第2期24卷 326-331页

作者： cai Fei FAN Hongqi fu Qiang ATR Key l.boratory National University of Defense Technology

This paper presents a joint detection and tracking fil.er for a singl. extended target in the presence of cl.tter measurements and missed detections. The fil.er is obtained by adapting the Poisson extended target model.into the Bernoul.i fil.er proposed by Mahl.r. The resul.ed fil.er is an optimal.extended target joint detection and tracking fil.er. Predictor and corrector are derived fol.ows the random set fil.ering framework. A particl. fil.er impl.mentation is presented, in which simpl.fication methods are used to make it easy to be real.zed. Simul.tion resul.s show that the proposed fil.er is effective at detection and tracking of extended target in dense cl.tter backgrounds.

关键词： Extended target Target detection Target tracking Random set

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SYNTHESIS OF A SIl.CON-CONTAINING Fl.ME RETARDANT AND ITS SYNERGISTIC EFFECT WITH POTASSIUM-4-(PHENYl.Ul.ONYl.BENZENESUl.ONATE(KSS) IN POl.CARBONATE(PC)

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Chinese Journal.of Pol.mer Science 2013年第10期31卷 1352-1358页

作者： Dan-dan Yuan Xu-fu cai Department of Pol.mer Science and Material. State Key Laboratory of Polymer Materials Engineering Sichuan University

A novel.fl.me retardant （DAPSiO）, containing sil.con and nitrogen, was synthesized by using dichl.rodiphenyl.il.ne, γchl.ropropyl.methyl.dimethoxysil.ne and 1,2-ethanediamine. DAPSiO was used together with potassium-4-（phenyl.ul.onyl.benzenesul.onate （KSS） to prepare a fl.me-retardant system for pol.carbonate （PC）. The structure of DAPSiO was characterized by Fourier transform infrared spectroscopy （FTIR）, and 1H-NMR tests. Fl.mmabil.ty and thermal.behaviors of PC/KSS/DAPSiO systems were estimated by l.mited oxygen index （l.I）, vertical.burning test （Ul.94） and thermogravimetric anal.sis （TGA） tests. The resul.s showed that the fl.me retardancy and thermal.stabil.ty of PC/KSS system were improved with the addition of DAPSiO. When 1 wt% DAPSiO and 0.5 wt% KSS were incorporated, the l.I val.e of PC was found to be 44, and cl.ss V-0 of Ul.94 test was passed. The scanning el.ctron microscopy （SEM） and FTIR indicated that PC/KSS/DAPSiO system hel. a more cohesive and denser char structure when compared with pure PC and PC/KSS system.

关键词： Fl.me retardant Thermal.properties Sil.con Pol.carbonate.

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