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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第8期22卷 695-700页

作者： Yang GAO Fei GAO Jimin SHI huarui fu He HUANG Yanmin ZHAO Bone Marrow Transplantation Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Institute of Hematology Zhejiang UniversityHangzhou 310058China Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy Hangzhou 310058China

Pure red cell aplasia(PRCA) is a well-recognized complication of ABO major mismatched allogeneic hematopoietic stem cell transplantation(allo-HSCT), with a reported incidence of 10% – 20%(Zhidong et al., 2012;Busca et al., 2018). It is clinically characterized by anemia, reticulocytopenia,and the absence of erythroblasts in a normal-appearing bone marrow biopsy(Shahan and Hildebrandt, 2015).The mechanism for PRCA has been presumed to be persistence of recipient isoagglutinins, produced by residual host B lymphocytes or plasma cells。

关键词： ABO al. hematopoietic

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

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Signal Transduction and Targeted Therapy 2024年第11期9卷 5267-5285页

作者： Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han huarui fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu Pengxu Qian He Huang Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi RoadHangzhou 311121China Institute of Hematology Zhejiang UniversityHangzhou 310003China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy Hangzhou 310003China Center of Stem Cell and Regenerative Medicine Zhejiang University School of MedicineHangzhou 310058China Department of Hematology The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200China

Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)***1/2 inhibitors(MEKIs),widely used in cancer treatment due to their ability to inhibit aberrant MAPK signaling,have shown potential synergistic effects when combined with ***,the impact and mechanisms of MEKIs on CAR-T cells remain uncertain and *** address this,we conducted a comprehensive investigation to determine whether MEKIs enhance or impair the efficacy of CAR-T *** findings revealed that MEKIs attenuated CAR-T cell exhaustion and terminal differentiation induced by tonic signaling and antigen stimulation,thereby improving CAR-T cell efficacy against hematological and solid ***,these effects were independent of the specific scFvs and costimulatory domains utilized in ***,analysis of bulk and single-cell transcriptional profiles demonstrates that the effect of MEK inhibition was related to diminish anabolic metabolism and downregulation of c-Fos and ***,the overexpression of c-Fos or JunB in CAR-T cells counteracted the effects of MEK ***,our Cut-and-Tag assay revealed that MEK inhibition downregulated the JunB-driven gene profiles associated with exhaustion,differentiation,anergy,glycolysis,and *** summary,our research unveil the critical role of the MAPK-c-Fos-JunB axis in driving CAR-T cell exhaustion and terminal *** mechanistic insights significantly broaden the potential application of MEKIs to enhance the effectiveness of CAR-T therapy.

关键词： JunB metabolism stimulation

不同界面次序CoFeMnSi多层膜的磁各向异性

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材料导报 2024年第18期38卷 136-141页

作者：乔礼红游才印付花睿田娜白洋刘小鱼西安理工大学材料科学与工程学院西安710048 包头稀土新材料技术研发中心内蒙古包头014020

利用磁控溅射仪制备Ta作缓冲层、最上层Pd作保护层的Ta/Pd/CoFeMnSi/MgO(t_(MgO))/Pd多层膜以及仅界面次序不同的Ta/MgO(t_(MgO))/CoFeMnSi/Pd多层膜,其中,t MgO分别为1.0 nm、1.2 nm、1.4 nm、1.6 nm、1.8 nm、2.0 nm、2.2 nm和2.4 nm,在300℃真空条件下退火30 min,探究界面次序不同导致多层膜不同磁各向异性的物理机理。磁性测试结果表明,Ta/Pd/CoFeMnSi/MgO(t_(MgO))/Pd多层膜在t MgO为1.6~2.0 nm时显示较好的垂直磁各向异性(PMA),Ta/MgO(t_(MgO))/CoFeMnSi/Pd多层膜在MgO厚度测试范围内均显示面内磁各向异性(IMA)。分析界面处元素化学态得到Ta/MgO/CoFeMnSi/Pd结构多层膜不能实现PMA的原因包括:Ta层对O的抢夺导致Co、Fe与O的键合不足;CoFeMnSi中Si和Mn发生一定量的氧化,进一步使Co-O、Fe-O键合含量减少。

关键词：垂直磁各向异性 CoFeMnSi 磁控溅射

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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甜樱桃栽培种指纹图谱构建及遗传多样性分析

西北农业学报 2017年第12期26卷 1813-1820页

作者：王丹丹付化瑞张彦文辽东学院农学院辽宁丹东118003 北票市林业局辽宁北票122100

为了对甜樱桃品种进行分子鉴别及分析不同品种间的亲缘关系,以叶片直接进行PCR扩增,采用EST-SSR分子标记技术构建生产上常用的40个甜樱桃栽培品种的数字指纹图谱和模式指纹图谱数据库(Cluster Project)并进行遗传多样性分析。采用24对... 详细信息

为了对甜樱桃品种进行分子鉴别及分析不同品种间的亲缘关系,以叶片直接进行PCR扩增,采用EST-SSR分子标记技术构建生产上常用的40个甜樱桃栽培品种的数字指纹图谱和模式指纹图谱数据库(Cluster Project)并进行遗传多样性分析。采用24对甜樱桃核心引物对所有品种基因组进行扩增,共检测到129个等位位点,包括118个多态性位点,多态性比率为91.2%。每对引物扩增出的等位位点数3~10个,每对引物平均扩增5.38个基因型,扩增条带大小介于100~500bp,多态信息含量(PIC)为0.654,基因流(Nm)为1.402,平均杂合率为0.495。8对引物,即PA17、PA32、PA51、PA54、PA73、PA99、PA101和PA202可作为指纹图谱构建的首选引物,利用其中的PA17、PA51、PA99、PA101和PA202以引物组合方式构建指纹图谱可区分40个品种;聚类分析表明在遗传距离0.71处40个品种被分为5类,聚类结果与品种的特性及成熟期具有较高的一致性。

关键词：甜樱桃 EST-SSR标记指纹图谱遗传多样性聚类分析

条纹图形Heusler合金CoFeMnSi薄膜的制备及其磁特性研究

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功能材料 2020年第4期51卷 4170-4174页

作者：乔礼红游才印付花睿马丽田娜西安理工大学材料科学与工程学院西安710048

以CoFeMnSi作为研究对象,对其进行图形化设计,以研究图形化CoFeMnSi薄膜的磁学特性。利用感光溶胶-凝胶法和激光干涉法制得条纹图形ZrO2薄膜,之后利用磁控溅射法在其表面溅射沉积CoFeMnSi,以达到制得图形化CoFeMnSi磁性薄膜的目的,并对... 详细信息

以CoFeMnSi作为研究对象,对其进行图形化设计,以研究图形化CoFeMnSi薄膜的磁学特性。利用感光溶胶-凝胶法和激光干涉法制得条纹图形ZrO2薄膜,之后利用磁控溅射法在其表面溅射沉积CoFeMnSi,以达到制得图形化CoFeMnSi磁性薄膜的目的,并对其表面形貌和磁学特性进行了表征。采用金相显微镜分析验证CoFeMnSi薄膜继承了ZrO2的条纹图形结构,条纹图形周期约为2μm;面内磁性测量显示薄膜398 kA/m磁场下的磁化强度与外磁场和条纹夹角θ呈180°周期性变化关系,且磁化强度介于390~440 kA/m;利用CoFeMnSi平膜面内磁化强度及面外磁化强度与外加磁场方向的变化关系,解释了条形薄膜磁化强度的θ角度依赖关系;采用磁力显微镜观察到磁畴结构形态为蜂窝状,磁畴尺寸大约1~2μm。

关键词： Heusler合金 CoFeMnSi 图形化薄膜磁控溅射磁性

异基因造血干细胞移植治疗GATA2突变所致MonoMAC综合征伴病态造血1例并文献复习

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中华血液学杂志 2024年第4期45卷 401-405页

作者：赵亦菲施继敏傅华睿赵叶千周华赵妍敏浙江大学医学院附属第一医院骨髓移植中心杭州310000 盐城市第一人民医院血液内科盐城224000 浙江大学医学院附属第一医院呼吸内科杭州310000

回顾性分析浙江大学医学院附属第一医院2022年10月收治的1例MonoMAC综合征病例,女性,16岁,有多年外周血单核细胞数减少及轻度贫血病史,因"反复咳嗽咯痰伴发热"在浙江大学医学院附属第一医院多次就诊,最终结合血常规、病原学宏基因组测... 详细信息

回顾性分析浙江大学医学院附属第一医院2022年10月收治的1例MonoMAC综合征病例,女性,16岁,有多年外周血单核细胞数减少及轻度贫血病史,因"反复咳嗽咯痰伴发热"在浙江大学医学院附属第一医院多次就诊,最终结合血常规、病原学宏基因组测序、肺穿刺活检、骨髓穿刺活检及外周血二代测序等检查,诊断为MonoMAC综合征,并接受单倍体造血干细胞移植。患者移植过程较顺利,+16 d粒细胞植入,+17 d血小板植入,最终单核细胞数和NK细胞数恢复正常。MonoMAC综合征患者常因感染症状首次就诊,结合血常规中单核细胞明显减低,非结核分枝杆菌感染史、GATA2胚系突变等检查结果可确诊。部分患者需行异基因造血干细胞移植治疗以改善预后。

关键词：浙江大学医学院首次就诊病态造血肺穿刺活检 MAC 外周血单核细胞粒细胞移植过程

Loss Aware Feature Attention Mechanism for Class and Feature Imbalance Issue

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Computers, Materials & Continua 2025年第1期82卷 751-775页

作者： Yuewei Wu Ruiling fu Tongtong Xing fulian Yin College of Information and Communication Engineering Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

In the Internet era,recommendation systems play a crucial role in helping users find relevant information from large *** imbalance is known to severely affect data quality,and therefore reduce the performance of recommendation *** to the imbalance,machine learning algorithms tend to classify inputs into the positive(majority)class every time to achieve high prediction *** can be categorized such as by features and classes,but most studies consider only class *** this paper,we propose a recommendation system that can integrate multiple networks to adapt to a large number of imbalanced features and can deal with highly skewed and imbalanced datasets through a loss *** propose a loss aware feature attention mechanism(LAFAM)to solve the issue of feature *** network incorporates an attention mechanism and uses multiple sub-networks to classify and learn *** better results,the network can learn the weights of sub-networks and assign higher weights to important *** propose suppression loss to address class imbalance,which favors negative loss by penalizing positive loss,and pays more attention to sample points near the decision *** on two large-scale datasets verify that the performance of the proposed system is greatly improved compared to baseline methods.

关键词： Imbalanced data deep learning e-commerce recommendation loss function big data analysis

Enhancing weather predictions:Initial condition sensitivity and error dynamics in data assimilation

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Science China Earth Sciences 2025年

作者： Weiwei fu Department of Atmospheric and Oceanic Sciences Fudan University Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate Ministry of Education Fudan University IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather Fudan University

Data Assimilation (DA) plays a crucial role in modern numerical forecasting (Kalnay, 2002). It has been demonstrated that incorporating real-time observational data into forecast models significantly enhances the accuracy of both shortterm weather forecasts (Bauer et al., 2015; Bannister, 2017)and long-term climate predictions (Karspeck et al., 2013;Mochizuki et al., 2016).

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异基因造血干细胞移植治疗Shwachman-Diamond综合征:3例报告及文献复习

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中华血液学杂志 2024年第7期45卷 689-693页

作者：冯安华施继敏傅华睿余建郑伟燕朱园园黄河赵妍敏浙江大学医学院附属第一医院骨髓移植中心杭州310003 山东第二医科大学附属医院血液病科潍坊261035

研究报告了在浙江大学医学院附属第一医院接受异基因造血干细胞移植(allo-HSCT)的3例Shwachman-Diamond综合征(SDS)患者,并结合相关文献资料总结SDS的临床表现和基因突变特征,探讨allo-HSCT对此类患者的疗效及移植时机。3例SDS患者均为... 详细信息

研究报告了在浙江大学医学院附属第一医院接受异基因造血干细胞移植(allo-HSCT)的3例Shwachman-Diamond综合征(SDS)患者,并结合相关文献资料总结SDS的临床表现和基因突变特征,探讨allo-HSCT对此类患者的疗效及移植时机。3例SDS患者均为男性,移植年龄分别为32、33、32岁。3例患者均为幼年发病,例1以贫血为首发临床表现,后逐渐进展为全血细胞减少;例2、3均以全血细胞减少为首发临床表现。例1、3有智力障碍,例3有胰腺脂肪化及慢性胰腺炎表现。3例患者均身材矮小。3例患者均检出SBDS:c.258+2T>C剪切位点杂合突变。3例患者的家系成员均无SDS临床表现。3例患者均采用减低剂量预处理方案(氟达拉滨+白消安+司莫司汀+兔抗人胸腺细胞免疫球蛋白)。例1、例2行单倍体造血干细胞移植,例3行无关供者造血干细胞移植。例1移植前诊断骨髓增生异常综合征转化急性髓系白血病,移植后早期复发并死亡;例2为继发性植入不良,血小板输注依赖;例3移植后脱离药物维持治疗,血常规正常。

关键词：全血细胞减少骨髓增生异常综合征急性髓系白血病慢性胰腺炎药物维持治疗身材矮小血小板输注造血干细胞移植