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International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 684-692页

作者： Ya-jun Su xin-hua Liu Yong-fu Wu Hai-you Huang Jian-xin xie Key Laboratory for Advanced Materials Processing (Ministry of Education) Institute of Advanced Materials and Technology Uni- versity of Science and Technology Beijing

The steady-state temperature field of horizontal core-filling continuous casting （HCFC） for producing copper cladding aluminum rods was simulated by finite element method to investigate the effects of key processing parameters on the positions of solid-liquid interfaces （SLIs） of copper and aluminum. It is found that mandrel tube length and mean withdrawing speed have significant effects on the SLI positions of both copper and aluminum. Aluminum casting temperature （TAI）（1003-1123 K） and secondary cooling water flux （600-900 L.h-1） have little effect on the SLI of copper but cause the SLI of aluminum to move 2-4 mm. When TA1 is in a range of 1043-1123 K, the liquid aluminum can fill continuously into the pre-solidified copper tube. Based on the numerical simulation, reasonable processing parameters were determined.

关键词： metal cladding copper aluminum continuous casting interfaces computer simulation

Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan

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Science China(Life Sciences) 2025年第2期68卷 416-430页

作者： Jia-Yu Liu Yao Wang Yue Guo Run-Qi Zheng Yun-Ying Wang Yan-Yan Shen Yan-Hong Liu Ai-Ping Cao Rui-Bo Wang Bo-Yang xie Shuai Jiang Qiu-Ying Han Jing Chen Fang-Ting Dong Kun He Na Wang xin Pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-Na Zhang Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100850China

As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly *** an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic acid(TUDCA),a natural bile acid,offers additional health benefits beyond liver ***,we show that TUDCA extends the lifespan and healthspan of ***,oral supplementation of TUDCA improves fitness in old mice,including clinically relevant phenotypes,exercise capacity and cognitive ***,TUDCA treatment drives broad transcriptional changes correlated with anti-aging ***,we discover that TUDCA targets the chaperone HSP90 to promote its protein refolding *** collaboration further alleviates aging-induced endoplasmic reticulum(ER)stress and facilitates protein homeostasis,thus offering resistance to *** summary,our findings uncover new molecular links between an endogenous metabolite and protein homeostasis,and propose a novel anti-aging strategy that could improve both lifespan and healthspan.

关键词： tauroursodeoxycholic acid lifespan healthspan protein homeostasis

液态金属堆蒸汽发生器螺旋管束流动传热特性研究

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热力发电 2025年第2期54卷 109-117页

作者：谢海燕聂鑫赖建永田雅婧中国核动力研究设计院核反应堆技术全国重点实验室四川成都610213

液态金属堆的螺旋管蒸汽发生器一次侧为液态金属工质、二次侧为水工质,其热工水力特性相比传统压水堆的自然循环饱和式蒸汽发生器有较大区别。提出将螺旋管蒸汽发生器等效为流动网络系统的方法,将螺旋管束分为流动回路、压力节点等元件... 详细信息

液态金属堆的螺旋管蒸汽发生器一次侧为液态金属工质、二次侧为水工质,其热工水力特性相比传统压水堆的自然循环饱和式蒸汽发生器有较大区别。提出将螺旋管蒸汽发生器等效为流动网络系统的方法,将螺旋管束分为流动回路、压力节点等元件;基于质量守恒、动量守恒、能量守恒等方程,建立了计算蒸汽发生器螺旋管回路的压降、流量和温度等热工水力参数的数学模型和管束金属壁温计算的数学模型;通过对流动回路未知流量、压力节点组成的非线性方程组进行直接求解,最终得到了螺旋管束内流量分配、压降、工质温度变化、出口汽温分布、壁温分布、干度及换热系数等变化情况,获得了蒸汽发生器螺旋管束流动传热特性,开发了除RELAP5外的一维系统分析计算程序,并完善了液态金属堆螺旋管束蒸汽发生器热工水力计算分析手段。

关键词：液态金属堆蒸汽发生器螺旋管束流动网络流动传热特性热工水力

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A novel restricted-flow etching method for glass

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1601-1608页

作者： Hai-bo xie Yi ZHENG Yu-run FAN xin fu Hua-yong YANG State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

This paper presents a novel micro fabrication method based on the laminar characteristics of micro-scale flows. Therein the separator and etchant are alternatively arranged in micro channels to form multiple laminar streams, and the etchant is located at the site where the reaction is supposed to occur. This new micro fabrication process can be used for the high aspect ratio etching inside a microchannel on glass substrates. furthermore, the topography of microstructure patterned by this method can be controlled by changing the flow parameters of the separator and etchant. Experiments on the effects of flow parameters on the aspect ratio, side wall profile and etching rate were carried out on a glass substrate. The effect of flow rates on the etching rate and the micro topography was analyzed. In addition, experiments with dynamical changes of the flow rate ratio of the separator and etchant showed that the verticality of the side walls of microstructures can be significantly improved. The restricted flowing etching technique not only abates the isotropic effect in the traditional wet etching but also significantly reduces the dependence on expensive photolithographic equipment.

关键词： Microfluidics Micro fabrication Etching Laminar flow

Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 485-492页

作者： Jianyang fu Nicole A McGrath Jihye Lee xin Wang Gagandeep Brar Changqing xie Thoracic and Gastrointestinal Malignancies Branch Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Sandra and Edward Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA

Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival *** immunotherapy with the blockade of immune checkpoints has no clear benefit in *** inhibition of YAP1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing *** study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1(PD-1)in CCA mouse ***:We assessed the cytotoxicity of verteporfin in human CCA cell lines in vitro,including both intrahepatic CCA and extrahepatic CCA *** examined the in vitro effect of verteporfin on cell proliferation,apoptosis,and *** evaluated the in vivo efflcacy of verteporfin,anti-PD-1,and a combination of both in subcutaneous CCA mouse ***:Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human CCA tumor cells in vitro in a dose-dependent ***,verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation,decreased numbers of cells with aldehyde dehydrogenase activity and positive cancer stem cell markers(all P<0.05).The combination of verteporfin and anti-PD-1 reduced tumor burden in CCA subcutaneous SB1 tumor model compared to either agent ***:Verteporfin exhibits antitumor effects in both intrahepatic and extrahepatic CCA cell lines and the combination with anti-PD-1 inhibited tumor growth.

关键词： Verteporfin YAP1 Anti-programmed cell death-1 Immunotherapy Cholangiocarcinoma

绿光到深红光的有效调控:二苯并吡啶并喹喔啉类热激活延迟荧光材料

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材料导报 2025年第1期39卷 286-292页

作者：章博黄飞翔谢凤鸣杨耀祖胡英元赵鑫苏州科技大学化学与生命科学学院江苏苏州215009 苏州大学功能纳米与软物质研究院江苏省碳基功能材料与器件重点实验室江苏苏州215123

高效热激活延迟荧光(Thermally activated delayed fluorescence,TADF)材料在有机发光二极管(Organic light-emitting diodes,OLED)中有着重要的应用。然而,由于能隙定律的限制,开发波长超过600 nm的高效红色TADF材料充满了挑战。本工... 详细信息

高效热激活延迟荧光(Thermally activated delayed fluorescence,TADF)材料在有机发光二极管(Organic light-emitting diodes,OLED)中有着重要的应用。然而,由于能隙定律的限制,开发波长超过600 nm的高效红色TADF材料充满了挑战。本工作在设计合成刚性大共轭平面受体二苯并[f,h]吡啶[3,4-b]喹喔啉(DBPQ)的基础上,将不同给电子能力的供体(tCz、DMAC和PXZ)与受体DBPQ大扭角连接,合成了DBPQtCz、DBPQDMAC和DBPQPXZ三种新颖的TADF材料。随着相应供体给电子能力的增强,DBPQtCz、DBPQDMAC和DBPQPXZ的发射波长可有效调控,实现由绿光、红光到深红光的转变。基于DBPQDMAC器件的最大外量子效率(EQE_(max))最高可达16.0%,电致发光(Electroluminescent,EL)波长为612 nm;基于DBPQPXZ器件的EQE_(max)为3.2%,电致发光波长达到658 nm。同时,基于DBPQtCz、DBPQDMAC和DBPQPXZ的OLED均具有较低的开启电压,分别为2.4、2.5和2.8 V。

关键词：热激活延迟荧光二苯并[f h]吡啶[3 4-b]喹喔啉开启电压红光发射

Crystal Structure and Third order Nonlinear Optical Properties of cis-Configuration Biferrocene Trinuclear Complexes

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Chemical Research in Chinese Universities 1999年第3期15卷 218-225页

作者： WU Jie-ying TIAN Yu-peng xie fu-xin NI Shi-sheng Department of Chemistry Anhui UniversityHefei 230039P.R.China

The syntheses and characterization of novel biferrocene trinuclear complexes of Schiff base ligand, S methyl N (ferrocenyl 1 methyl methylidene)dithiocarbazate [hereafter abbreviated as HL (1)], are described. The X ray diffraction studies have established the structures of PdL 2 (3) and CuL 2 (4). The geometry of Pd(Ⅱ) in (3) is close to a square plane and in the novel cis configuration the two ferrocene moieties are in cis configuration, while that of Cu(Ⅱ) in (4) is close to a tetrahedral configuration. The electrochemical measurements suggested that the square planar configuration of Ni(Ⅱ) and Pd(Ⅱ) moieties can effectively transmit the redox effects of the ferrocene moieties, while the tetrahedral configuration of the Cu(Ⅱ) complex can not transmit the redox effects. The degenerate four wave mixing (DFWM) measurements showed that the complexes exhibit obviously nonlinear optical (NLO) response. The magnitude of their third order NLO susceptibility can be explained by their structure and electrochemical properties.

关键词： Electrochemistry cis Configuration biferrocene Third order nonlinear optical property

压水堆燃料棒径向热膨胀建模方法及其影响分析研究

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核动力工程 2025年第1期46卷 30-35页

作者：周雨锋谢伟戎万承辉曹新白家赫郭林西安交通大学核科学与技术学院西安710049 台山核电合营有限公司广东江门529228

在压水堆功率运行过程中,燃料芯块和燃料棒包壳由于温度变化会出现不同程度的热膨胀现象,对堆芯物理计算具有重要影响。为了在两步法计算流程中精确考虑燃料棒径向热膨胀对堆芯物理分析结果的影响,本文基于堆芯物理分析软件Bamboo-C提... 详细信息

在压水堆功率运行过程中,燃料芯块和燃料棒包壳由于温度变化会出现不同程度的热膨胀现象,对堆芯物理计算具有重要影响。为了在两步法计算流程中精确考虑燃料棒径向热膨胀对堆芯物理分析结果的影响,本文基于堆芯物理分析软件Bamboo-C提出了燃料棒径向热膨胀精确建模方法,分别在组件计算和堆芯计算层面对燃料棒径向热膨胀导致的几何变化予以考虑,且在堆芯计算层面通过温度场的迭代收敛最终确定精确的几何膨胀尺寸。本文以EPR1750机组为研究对象,对各燃料循环启动物理试验和功率运行过程进行计算,结果表明,与等温温度系数实测值的误差平均值由-3.065 pcm/K(1pcm=10^(–5))降低至-1.870 pcm/K,与临界硼浓度实测值的误差平均值由-5.9ppm(1ppm=10^(–6))、-5.7ppm降低至-2.5ppm、-2.7ppm。因此,本文提出的压水堆燃料棒径向热膨胀建模方法能够在一定程度上提高EPR1750机组关键安全参数的计算精度,具有一定的工程应用价值。

关键词：燃料棒径向热膨胀温度系数临界硼浓度 Bamboo-C软件

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低强度脉冲超声联合制霉菌素可协同抑制兔阴道白色念珠菌生物被膜感染

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南方医科大学学报 2025年第2期45卷 296-303页

作者：谢梦瑶杨敏李欣杜永洪重庆医科大学超声医学工程国家重点实验室//生物医学工程学院重庆400016

目的探索低强度脉冲超声(LIPUS)联合制霉菌素(NYS)对阴道白色念珠菌生物被膜感染的治疗效果。方法建立体外白色念珠菌生物被膜模型,同时将体外培养成熟的生物被膜用自动微移液管接种至20只雌性新西兰大白兔阴道内,以建立兔阴道白色念珠... 详细信息

目的探索低强度脉冲超声(LIPUS)联合制霉菌素(NYS)对阴道白色念珠菌生物被膜感染的治疗效果。方法建立体外白色念珠菌生物被膜模型,同时将体外培养成熟的生物被膜用自动微移液管接种至20只雌性新西兰大白兔阴道内,以建立兔阴道白色念珠菌生物被膜感染模型,实验分为Control组、NYS组、US组和联合治疗组。体外实验采用XTT法检测生物被膜最低抑菌浓度(MIC),结晶紫染色定量生物被膜,激光共聚焦显微镜(CLSM)观察生物被膜活性,扫描电镜(SEM)观察形态学变化,DCFH-DA检测活性氧(ROS)。体内实验通过观察兔外阴症状,HE染色和透射电镜(TEM)观察治疗前后阴道组织病理结构变化。结果体外实验显示,联合治疗组MIC_(50)和MIC_(80)相比NYS组均降低2倍(P<0.05),此外,联合治疗组生物被膜清除率分别比NYS组和US组增加约26%和68%(P<0.001),同时联合治疗组生物被膜活性更低、结构破坏更严重,ROS产量更多。体内实验表明,与NYS组和US组比较,联合治疗组兔外阴症状与炎症浸润显著改善(P<0.05),阴道残留菌丝/菌株减少,上皮超微结构明显改善。结论LIPUS联合NYS对体内外白色念珠菌生物被膜有显著的协同抗真菌作用。

关键词：低强度脉冲超声白色念珠菌生物被膜制霉菌素阴道炎

分离乙酸乙酯+乙醇+水体系:离子液体筛选、汽液相平衡和过程模拟

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化工进展 2025年第1期44卷 75-85页

作者：李鑫王维张羽谢湫钰袁昊大连理工大学化工学院辽宁大连116024

乙酸乙酯、乙醇和水体系能够形成三个二元和一个三元的共沸体系。本文旨在以离子液体(IL)为萃取剂打破这些共沸,实现该三元体系的有效分离。基于COSMO-RS模型和黏度预测模型,计算了65种ILs的选择性、溶解度和黏度,发现1-丁基-3-甲基咪... 详细信息

乙酸乙酯、乙醇和水体系能够形成三个二元和一个三元的共沸体系。本文旨在以离子液体(IL)为萃取剂打破这些共沸,实现该三元体系的有效分离。基于COSMO-RS模型和黏度预测模型,计算了65种ILs的选择性、溶解度和黏度,发现1-丁基-3-甲基咪唑醋酸盐([BMIM][Ac])是65种ILs中最符合要求的萃取剂。进行了乙酸乙酯(1)+乙醇(2)+水(3)+IL(4)的四元汽液相平衡(VLE)实验,证实[BMIM][Ac]能够打破所有共沸体系,验证了筛选结果。NRTL和UNIQUAC方程关联四元VLE数据的均方根误差分别为1.69%和2.20%,关联结果可靠。通过量化计算定性和定量分析了IL分离该三元体系的机理,表明[BMIM][Ac]与乙酸乙酯发生弱氢键作用(-8.22kcal/mol,1kcal≈4.186kJ),与乙醇和水分别发生强氢键作用(-15.83kcal/mol和-16.14kcal/mol)。基于方程关联所得参数,模拟并优化了以IL为萃取剂分离乙酸乙酯+乙醇+水体系的萃取精馏过程,显示乙酸乙酯、乙醇和水的产品纯度均可达到0.999。研究结果验证了[BMIM][Ac]作为萃取剂分离该三元共沸体系工业化可行性。

关键词：离子液体共沸(混合)物萃取精馏汽液平衡机理分析模拟