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Review of health risks of low testosterone and testosterone administration

World Journal of Clinical Cases 2015年第4期3卷 338-344页

作者： Huanguang Jia Charles t Sullivan Sean C McCoy Joshua F Yarrow matthew Morrow Stephen E Borst Center of Innovation on Disability and Rehabilitation Research North Florida/South Georgia Veterans Health System (151b) Pharmacy Services Malcom Randall VA Medical Center Geriatric Research Education and Clinical Center Malcom Randall VA Medical Center

Hypogonadism is prevalent in older men and testosteronereplacement therapy(tRt) for older hypogonadal men is a promising therapy. However, a number of important clinical concerns over tRt safety remain unsolved due to a lack of large-scale randomized clinical trials directly comparing the health risks of untreated hypogonadism vs long-term use of tRt. Meta-analyses of clinical trials of tRt as of 2010 have identified three major adverse events resulting from tRt: polycythemia, an increase in prostate-related events, and a slight reduction in serum high-density lipoprotein cholesterol. there are other purported health risks but their incidence can be neither confirmed nor denied based on the small number of subjects that have been studied to date. Furthermore, subsequent literature is equivocal with regard to the safety and utility of tRt and this topic has been subject to contentious debate. Since January 2014, the United States Food and Drug Administration has released two official announcements regarding the safety of tRt and clinical monitoring the risks in tRt users. Additionally, the health risks related to the clinical presentation of low or declining testosterone levels not been resolved in the current literature. Because tRt is prescribed in the context of putative risks resulting from reduced testosterone levels, we reviewed the epidemiology and reported risks of low testosterone levels. We also highlight the current information about tRt utilization, the risks most often claimed to be associated with tRt, and current or emerging alternatives to tRt.

关键词： Hypogonadism Epidemiology Aging Low testosterone testosterone replacement therapy

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High-throughput discovery of fluoride-ion conductors via a decoupled,dynamic,and iterative(DDI)framework

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npj Computational Materials 2022年第1期8卷 983-991页

作者： Jack D.Sundberg Daniel L.Druffel Lauren M.McRae matthew G.Lanetti Jacob t.Pawlik Scott C.Warren Department of Chemistry The University of North Carolina at Chapel HillChapel HillNC27599United States

Fluoride–ion batteries are a promising alternative to lithium–ion batteries with higher theoretical capacities and working voltages,but they have experienced limited success due to the poor ionic conductivities of known electrolytes and ***,we report a high-throughput computational screening of 9747 fluoride-containing materials in search of fluoride-ion *** a combination of empirical,lightweight DFt,and nudged elastic band(NEB)calculations,we identified>10 crystal systems with high fluoride *** applied a search strategy where calculations are performed in any order(decoupled),computational resources are reassigned based on need(dynamic),and predictive models are repeatedly updated(iterative).Unlike hierarchical searches,our decoupled,dynamic,and iterative framework(DDI)began by calculating high-quality barrier heights for fluoride-ion mobility in a large and diverse group of *** high-quality dataset provided a benchmark against which a rapid calculation method could be *** accurate method was then used to measure the barrier heights for 6797 fluoride–ion *** final dataset has allowed us to discover many fascinating,high-performance conductors and to derive the design rules that govern their *** materials will accelerate experimental research into fluoride–ion batteries,while the design rules will provide an improved foundation for understanding ionic conduction.

关键词： fluoride dynamic repeatedly

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tandem cervical carotid stenting for stenosis with flow diversion embolisation for the treatment of intracranial aneurysms

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Stroke & Vascular Neurology 2019年第1期4卷 43-47页

作者： Jessica K Campos Li-Mei Lin Narlin B Beaty matthew t Bender Bowen Jiang David A Zarrin Alexander L Coon Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMarylandUSA Department of Neurosurgery University of CaliforniaIrvineOrangeCaliforniaUSA

Background An estimated 2%-3%of the population harbour an intracranial *** atherosclerotic cervical carotid disease is not *** management of these two entities remains a challenge within the *** presentation We report a single case of concomitant carotid stenosis and two ipsilateral unruptured intracranial aneurysms treated with a single-staged cervical carotid stenting and cerebral aneurysm embolisation with the Pipeline embolisation *** No consensus currently exists to guide endovascular treatment of intracranial aneurysms associated with asymptomatic ipsilateral ***,we present a case of asymptomatic moderate carotid stenosis with two ipsilateral intracranial aneurysms and suggest carotid artery stenting takes procedural priority over aneurysm embolisation in single-stage *** rationale for the sequence of neurointerventions is based on the tracking a robust distal access system beyond a stenotic proximal carotid lesion and stabilisation of the ulcerated plaque to avoid thromboembolic complications associated with plaque irritation during aneurysm *** cases and longer follow-up will be needed to further assess the efficacy of this technique.

关键词： aneurysm carotid stenosis

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Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy

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Stroke & Vascular Neurology 2022年第3期7卷 209-214页

作者： matthew t Bender thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy t Cushman Webster H Pilcher Curtis G Benesch Adam G Kelly tarun Bhalla Department of Neurosurgery University of Rochester Medical CenterRochesterNew YorkUSA Department of Emergency Medicine University of Rochester Medical CenterRochesterNew YorkUSA Department of Neurology University of Rochester Medical CenterRochesterNew YorkUSA

Background the number of mobile stroke programmes has increased with evidence,showing they expedite intravenous *** questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical *** Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October *** reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical *** Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(ptients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS *** thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(Et)at 133.0 min(±37.0)(p=0.0002).there was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal *** Mobile stroke care expedited both intravenous thrombolysis and endovascular *** is an ongoing need to show improved functional outcomes with MSU care.

关键词： intravenous throm endovascular

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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav t Handge Vandana Sandeep Shah Yasser Eid Al-thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma tumor staging Immunohistochemistry Invasion Lymph node metastasis tNM stage

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Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo

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the Journal of Biomedical Research 2016年第4期30卷 272-284页

作者： matthew G.K. Benesch Xiaoyun tang Ganesh Venkatraman Raie t. Bekele David N. Brindley Signal transduction Research Group Department of Biochemistry University of Alberta T6G 2S2 Canada.

Extracellular lysophosphatidate （LPA） is a potent bioactive lipid that signals through six G-protein-coupled receptors. this signaling is required for embryogenesis, tissue repair and remodeling processes. LPA is produced from circulating lysophosphatidylcholine by autotaxin （AtX）, and is degraded outside cells by a family of three enzymes called the lipid phosphate phosphatases （LPPs）. In many pathological conditions, particularly in cancers, LPA concentrations are increased due to high AtX expression and low LPP activity. In cancers, LPA signaling drives tumor growth, angiogenesis, metastasis, resistance to chemotherapy and decreased efficacy of radiotherapy. Hence, targeting the AtX-LPA-LPP axis is an attractive strategy for introducing novel adjuvant therapeutic options. In this review, we will summarize current progress in targeting the AtX-LPA-LPP axis with inhibitors of autotaxin activity, LPA receptor antagonists, LPA monoclonal antibodies, and increasing low LPP expression. Some of these agents are already in clinical trials and have applications beyond cancer, including chronic inflammatory diseases.

关键词： cancer chronic inflammation cytokines monoclonal antibodies wound repair

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Money Won’t Buy You Happiness

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大学英语 2004年第11期 10-11页

作者： matthew Herper 刘嘉

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the Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy

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Journal of Clinical and translational Hepatology 2019年第4期7卷 352-361页

作者： Victoria Jaeger Sharon DeMorrow matthew McMillin Baylor Scott&White Health Department of Internal MedicineTempleTXUSA texas A&M University Health Science Center Department of Medical PhysiologyTempleTXUSA Central texas Veterans Health Care System TempleTXUSA University of texas at Austin Dell Medical SchoolDepartment of Internal MedicineAustinTXUSA University of texas at Austin College of PharmacyAustinTXUSA

Hepatic encephalopathy is a neurological complication result-ing from loss of hepatic function and is associated with poor clinical *** acute liver failure over 20%of mortality can be associated with the development of hepatic *** patients with liver cirrhosis,1-year sur-vival for those that develop overt hepatic encephalopathy is under 50%.the pathogenesis of hepatic encephalopathy is complicated due to the multiple disruptions in homeostasis that occur following a reduction in liver *** these,elevations of ammonia and neuroinflammation have been shown to play a significant contributing role to the develop-ment of hepatic *** of the urea cycle following liver dysfunction leads to elevations of circulating ammonia,which enter the brain and disrupt the functioning of *** results in dysregulation of metabolic path-ways in astrocytes,oxidative stress and cerebral *** ammonia,circulating chemokines and cytokines are increased following liver injury,leading to activation of micro-glia and a subsequent neuroinflammatory *** combination of astrocyte dysfunction and microglia activation are significant contributing factors to the pathogenesis of hepatic encephalopathy.

关键词： Acute liver failure Microglia Neuroinflammation Ammonia Astroglia

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Delay-dependent Robust Stabilization and H_∞ Control for Uncertain Stochastic t-S Fuzzy Systems with Discrete Interval and Distributed time-varying Delays

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International Journal of Automation and computing 2013年第1期10卷 18-31页

作者： P.Balasubramaniam t.Senthilkumar Department of Mathematics Gandhigram Rural University

In this paper, delay-dependent robust stabilization and H∞ control for uncertain stochastic takagi-Sugeno （t-S） fuzzy systems with discrete interval and distributed time-varying delays are discussed. the purpose of the robust stochastic stabilization problem is to design a memoryless state feedback controller such that the closed-loop system is mean-square asymptotically stable for all admissible uncertainties. In the robust H∞ control problem, in addition to the mean-square asymptotic stability requirement, a prescribed H∞ performance is required to be achieved. Sufficient conditions for the solvability of these problems are proposed in terms of a set of linear matrix inequalities （LMIs） and solving these LMIs, a desired controller can be obtained. Finally, two numerical examples are given to illustrate the effectiveness and less conservativeness of our results over the existing ones.

关键词： Robust stability robust H∞ control stochastic fuzzy systems distributed delay linear matrix inequality (LMI)

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the effects of sun exposure on carotenoid accumulation and oxidative stress in the retina of the House Finch(Haemorhous mexicanus)

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Chinese Birds 2016年第1期7卷 56-67页

作者： matthew B.toomey Kevin J.McGraw School of Life Sciences Arizona State University Department of Pathology and Immunology Washington University Medical School

Background: Diet-derived carotenoid pigments are concentrated in the retinas of birds and serve a variety of functions, including photoprotection. In domesticated bird species(e.g., chickens and quail), retinal carotenoid pigmentation has been shown to respond to large manipulations in light exposure and provide protection against photodamage. However, it is not known if or how wild birds respond to ecologically relevant variation in sun ***: We manipulated the duration of natural sunlight exposure and dietary carotenoid levels in wild-caught captive House Finches(Haemorhous mexicanus), then measured carotenoid accumulation and oxidative stress in the ***: We found no significant effects of sun exposure on retinal levels of carotenoids or lipid peroxidation, in replicate experiments, in winter(Jan–Mar) and spring/summer(May–June). Dietary carotenoid supplementation in the spring/summer experiment led to significantly higher retinal carotenoid levels, but did not affect lipid peroxidation. Carotenoid levels differed significantly between the winter and spring/summer experiments, with higher retinal and lower plasma carotenoid levels in birds from the later ***: Our results suggest that variation in the duration of exposure to direct sunlight have limited influence on intraspecific variation in retinal carotenoid accumulation, but that accumulation may track other seasonal–environmental cues and physiological processes.

关键词： Carotenoids Haemorhous mexicanus House Finch Photostress Vision

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