The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy

作     者：Victoria Jaeger Sharon DeMorrow Matthew McMillin 

作者机构：Baylor Scott&White HealthDepartment of Internal MedicineTempleTXUSA Texas A&M University Health Science CenterDepartment of Medical PhysiologyTempleTXUSA Central Texas Veterans Health Care SystemTempleTXUSA University of Texas at AustinDell Medical SchoolDepartment of Internal MedicineAustinTXUSA University of Texas at AustinCollege of PharmacyAustinTXUSA 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2019年第7卷第4期

页      面：352-361页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was funded by a VA Career Development award(BX003486)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Matthew McMillin.This study was also funded by NIH R01 awards(DK082435 and DK112803) a VA Merit award(BX002638)from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service to Dr.Sharon DeMorrow.This work was also supported by the resources of the Central Texas Veterans Health Care System Research Service,Temple,Texas.The content is t 

主　　题：Acute liver failure Microglia Neuroinflammation Ammonia Astroglia 

摘      要：Hepatic encephalopathy is a neurological complication result-ing from loss of hepatic function and is associated with poor clinical *** acute liver failure over 20%of mortality can be associated with the development of hepatic *** patients with liver cirrhosis,1-year sur-vival for those that develop overt hepatic encephalopathy is under 50%.The pathogenesis of hepatic encephalopathy is complicated due to the multiple disruptions in homeostasis that occur following a reduction in liver *** these,elevations of ammonia and neuroinflammation have been shown to play a significant contributing role to the develop-ment of hepatic *** of the urea cycle following liver dysfunction leads to elevations of circulating ammonia,which enter the brain and disrupt the functioning of *** results in dysregulation of metabolic path-ways in astrocytes,oxidative stress and cerebral *** ammonia,circulating chemokines and cytokines are increased following liver injury,leading to activation of micro-glia and a subsequent neuroinflammatory *** combination of astrocyte dysfunction and microglia activation are significant contributing factors to the pathogenesis of hepatic encephalopathy.