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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel silva Luz Gabriel Reis Rocha Gabriel Lima Correa santos Luís Guilherme de Oliveira silva Mariana santos Calmon Cláudio Lima souza Ana Carla Zarpelon-schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBAsE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUAdas-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted spearman correlation analysis,and we generated summary receiver operating characteristic(sROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Olympic Games and 24-hour movement behaviors:A match worth making

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Journal of sport and Health science 2024年第6期13卷 728-731页

作者： Mark s.Tremblay Nicholas Kuzik Markus J.Duncan Diego Augusto santos silva CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of santa Catarina FlorianopolisSanta Catarina 88040-900Brazil

*** The Olympic motto,"Faster,Higher,stronger-Together",represents the pursuit of athletic excellence,united as a global community."Excellence,respect and friendship"are the Olympic *** the motto and values are multifaceted and holistic in nature,and all-encompassing in their reach while recognizing no single entity rises above the ***,these foundational statements anchor the Olympic movement in its quest to build a better world through sport.

关键词： movement Together pursuit

spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features:Case studies on two Brazilian urban centers

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Infectious Disease Modelling 2024年第1期9卷 142-157页

作者： Ana T.C.silva Rejane C.Dorn Lívia R.Tomás Leonardo B.L.santos Lacita M.skalinski suani T.R.Pinho Departamento de Física Universidade Estadual de Feira de SantanaAv.Transnordestinas/n.Novo HorizonteFeira de Santana44036-900BABrazil Instituto de Física Universidade Federal da BahiaRua Barão de Jeremoabo s/nCampus Universitário de OndinaSalvador40170-115BABrazil Centro Nacional de Monitoramento e Alertas de Desastres Naturais(CEMADEN) Estrada Dr.Altino Bondensan500São Josédos Campos12247-016SPBrazil Univers.dade Estadual de santa Cruz Campus Soane Nazaréde AndradeRodovia Jorge AmadoKm 16SalobrinhoIlhéus45662-900BABrazil Instituto de saúde Coletiva Universidade Federal da BahiaR.Basílio da Gamas/n-CanelaSalvador40110-140BABrazil Instituto Nacional de Ciência e Tecnologia-sistemas Complexos Virtual InstitutionBrazil

The study of the propagation of infectious diseases in urban centers finds a close connection with their population's social characteristics and *** work performs a spatial analysis of dengue cases in urban centers based on the basic reproduction numbers,R0,and incidence by planning areas(PAs),as well as their correlations with the Human Development Index(HDI)and the number of *** analyzed dengue epidemics in 2002 at two Brazilian urban centers,Belo Horizonte(BH)and Rio de Janeiro(RJ),using PAs as spatial *** results reveal heterogeneous spatial scenarios for both cities,with very weak correlations between R0 and both the number of trips and the HDI;in BH,the values of R0 show a less spatial heterogeneous pattern than in *** BH,there are moderate correlations between incidence and both the number of trips and the HDI;meanwhile,they weakly correlate for ***,the absence of strong correlations between the considered measures indicates that the transmission process should be treated considering the city as a whole.

关键词： Dengue Mathematical mode lBasic reproduction number Urban mobility Urban indices

Towards precision 24-hour movement behavior recommendations—The next new paradigm?

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Journal of sport and Health science 2024年第6期13卷 743-748页

作者： Mark s.Tremblay Markus J.Duncan Nicholas Kuzik Diego Augusto santos silva Valerie Carson CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of santa Catarina Santa Catarina 88040900Brazil Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAB T6G 2H9Canada

*** The importance of physical activity(PA)for health is unequivocal.^(1)Accordingly,population-based recommendations for exercise,and more recently public health guidelines for PA,have been developed and released by authoritative groups for many decades.^(2)such guidelines emerged with leadership from the exercise physiology discipline and were rooted in,and loyal to,the importance of moderate-to-vigorous intensity PA(MVPA)or exercise.

关键词： movement behavior exercise

Enhancement of the Antigenotoxic and Antioxidant Actions of Eugenol from spice Clove and the stabilizer Gum Arabic on Colorectal Carcinogenesis

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Food and Nutrition sciences 2024年第1期15卷 71-100页

作者： Nayanna de Oliveira Ramos Melo Lucas Gabriel da Costa Marques Humberto Maia Costa Neto Matheus De sousa silva Francisco Vagnaldo Fechine Jamacaru Bruno Coêlho Cavalcanti Antônio Adailson De sousa silva Conceição Aparecida Dornelas Postgraduate Program in Medical-surgical sciences School of Medicine Federal University of Ceará Fortaleza Brazil school of Medicine Federal University of Ceará Fortaleza Brazil Nucleus of Research and Development of Medicines (NPDM) Laboratory of Pharmacology and Preclinical Research School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus for Research and Development of Medicines (NPDM) National Laboratory of Experimental Oncology Federal University of Ceará Fortaleza Brazil Postgraduate Program in Pathology and Medical-surgical sciences School of Medicine Federal University of Ceará Fortaleza Brazil

spices are defined as any aromatic condiment of plant origin used to alter the flavor and aroma of foods. Besides flavor and aroma, many spices have antioxidant activity, mainly related to the presence in cloves of phenolic compounds, such as flavonoids, terpenoids and eugenol. In turn, the most common uses of gum arabic are in the form of powder for addition to soft drink syrups, cuisine and baked goods, specifically to stabilize the texture of products, increase the viscosity of liquids and promote the leavening of baked products (e.g., cakes). Both eugenol, extracted from cloves, and gum arabic, extracted from the hardened sap of two species of the Acacia tree, are dietary constituents routinely consumed virtually throughout the world. Both of them are also widely used medicinally to inhibit oxidative stress and genotoxicity. The prevention arm of the study included groups: Ia, IIa, IIIa, Iva, V, VI, VII, VIII. Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the same period and for an additional 9 weeks, the animals received either water, 10% GA, EUG, or 10% GA + EUG by gavage. The treatment arm of the study included groups Ib, IIb, IIIb e IVb, IX, X, XI, XII). Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the subsequent 9 weeks, the animals received either water, 10% GA, EUG or 10% GA + EUG by gavage. The novelty of this study is the investigation of their use alone and together for the prevention and treatment of experimental colorectal carcinogenesis induced by dimethylhydrazine. Our results show that the combined use of 10% gum arabic and eugenol was effective, with antioxidant action in the colon, as well as reducing oxidative stress in all colon segments and preventing and treating genotoxicity in all colon segments. Furthermore, their joint administration reduced the number of aberrant crypts and th

关键词： Eugenol Gum Arabic Carcinogenesis Oxidative stress Genotoxicity

Effect of biochar on the metabolome of soybean seedlings

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Oil Crop science 2024年第1期9卷 60-68页

作者： Nathalia E.silva Mariana G.Aguilar Osania E.Ferreira Gleicia M.Paulino Jaqueline C.L.Carvalho Lúcia P.s.Pimenta Alan R.T.Machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de Engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias Exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(sCB300),400℃(sCB400)and 600℃(sCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative Germination,Relative Average Radicle Growth and Germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for sCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： Germination Metabolomics 1H NMR Pyrolysis sugarcane bagasse

Reckoning with COVID-19 denial: Brazil's exemplary model for global response

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World Journal of Methodology 2024年第3期14卷 163-166页

作者： Heslley Machado silva Department of science and Education University Center of Formiga and State University of Minas GeraisMinas Gerais 35570000Brazil

In the aftermath of the coronavirus disease 2019(COVID-19)pandemic in Brazil,accountability is crucial for those who denied the severity of the virus,spreading false information and causing *** individuals have already faced legal proceedings against them,revealing economic motivations behind their *** is equally important to hold doctors accountable for prescribing ineffective treatments,putting the population at *** leaders of the denial movement and the federal government,who mishandled the pandemic,should be held accountable for the high death *** justice from the legislative and executive branches is necessary,along with exemplary measures for those who spread misinformation about COVID-19.

关键词： Denialism Responsibility Mortality COVID-19 Brazil

The Use of secondary Grape Biomass in Beef Cattle Nutrition on Carcass Characteristics, Quality and shelf Life of Meat

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Food and Nutrition sciences 2024年第6期15卷 447-469页

作者： Vitor L. Molosse Guilherme L. Deolindo Rafael V. P. Lago Bruna Klein Claiton A. Zotti Marcelo Vedovato Marcylene V. da silveira Priscila M. Copetti Maria R. C. schetinger Juscivete F. Favero Eliana L. Fiorentin Aleksandro s. da silva Univers.dade do Estado de santa Catarina (UDEsC) Chapec Brazil Department of Animal science UDESC Chapec Brazil Department of Animal science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of Medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of 100 g/kg dry matter of grape pomace silage (GPs) and grape pomace bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf life. Twenty-four animals (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed for fatty acid (FA) profile and composition. The meat was sliced and stored in air-permeable packages for 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets influenced the pH of cold carcasses only. The GPs group had a higher pH than the control. The GPs and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control). On the first day of storage, the antioxidant enzyme glutathione s-transferase activity was more significant in the meat of the GPs and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPs inclusion;there were lower total coliform counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the FA profile of the meat;i.e., the GPB diet allowed for a more significant amount of the n-6 omegas in the meat, while the GPs diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPs and GPB) increased the amounts of long-chain FAs. The GPs diet decreased saturated FA levels. We conclude that the dietary treatments GPs and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of the meat due to the more significant amounts of FAs that im

关键词： Animal Nutrition Antioxidant Biomass Grape Meat Quality Microbiology Residue

screening of Environmental Bacterial strains for Wild Aedes Mosquito Larval Biocontrol

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Open Journal of Applied sciences 2024年第9期14卷 2431-2442页

作者： Alexandre Paulo Machado Liliana Alves Correa Gabriel de Paula Albuquerque Ana Lúcia Maria Ribeiro Rosina Djunko Miyazaki Jéssica da silva Gava Dyego Bichofre Cruz Laboratory of Microbiology Medical Faculty Federal University of Mato Grosso Mato Grosso Brazil Laboratory of Entomology Institute of Biosciences Federal University of Mato Grosso Mato Grosso Brazil

The effectiveness of current control measures against Aedes mosquitoes remains low, resulting in persistent epidemics in urban areas. The emergence of resistant mosquito populations to chemical insecticides highlights the need for novel, environmentally friendly, cost-effective control strategies. This study explored the potential of environmental bacterial isolates to biocontrol wild Aedes larvae. Initially, we collected bacterial samples from infectious masses of Aedes fluviatilis larvae. The isolated bacteria were identified using biochemical, enzymatic, and molecular methods, including 16s rRNA sequencing and MALDI-TOF. Previously, Aeromonas hydrophila and Bacillus thuringiensis isolated from these infectious masses showed limited Aedes larval inhibition. Consequently, we screened additional environmental isolates from the bacteriotheque. six isolates previously identified were tested: Chromobacterium violaceum, Enterobacter cloacae, Bacillus cereus, Bacillus sphaericus, and two strains of Bacillus thuringiensis israelensis. Among these strains, B. thuringiensis and C. violaceum exhibited significant inhibitory activities against wild Aedes larvae. Bacillus thuringiensis cultures grown under daylight conditions showed a slight ability to inhibit Aedes larvae. The potential of B. thuringiensis and C. violaceum strains studied, along with optimized culture growth conditions, will be further investigated to develop bioinsecticide products to provide safer and more sustainable alternatives for controlling larvae of Aedes mosquitoes.

关键词： Bacillus thuringiensis Chromobacterium violaceum Aedes Biocontrol Larval Inhibition