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World Journal of Nuclear Science and Tech.ology 2022年第2期12卷 69-87页

作者： frederick Agyemang Steph.n Yamoah.Seth.Kofi Debrah Graduate Sch.ol of Nuclear and Allied Science University of Ghana Accra Ghana Nuclear Power Institute Ghana Atomic Energy Commission Accra Ghana

Effect of pseudocritical rapid energy dissipation (PRED) from Pressurizer in nuclear steam supply system of Pressurized Water Reactor, wh.re a single event as common cause failure, of considerable reduction of base-load electricity demand causes th. temperature of th. reactor coolant system (RCS) to increase, and corresponding pressure increases in pressurizer and steam generators above set-points. Th. study employed th. uses of MATLAB/Simulink library tools, to experimentally modelled pressure control as PRED, wh.re th. momentum of transport of kinematic viscosity fraction above pseudocritical point dissipated as excess energy, to maintain th. safety of th. Pressurizer and RCS and keep th. water from boiling. Th. result demonstrated th. significance of pressure vector and Prandlt number as h.at transfer coefficients th.t provided detailed activities in 2-D contour and 3-D graph.cs of specific internal energy and oth.r parameterization of fluid in th. pressurizer.

关键词： Pseudocritical Rapid Energy Dissipation Pseudocritical Saturation Parameterization Internal Energy Pressure Vector h.at Transfer Coefficient

Utilizing zebrafish.and okadaic acid to study Alzh.imer's disease

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Neural Regeneration Research 2018年第9期13卷 1538-1541页

作者： Daniel Koeh.er frederick E.Williams Department of Ph.rmacology and Experimental Th.rapeutics University of Toledo

Despite th. many years of extensive research.using rodent models to study Alzh.imer＇s disease （AD）, no cure or disease h.lting drug exists. An increasing number of people are suffering from th. disease and a th.rapeutic intervention is needed. Th.refore, it is necessary to h.ve complementary models to aid in th. drug discovery. Th. zebrafish.animal model is emerging as a valuable model for th. investigation of AD and neurodegenerative drug discovery. Th. main genes involved in h.man AD h.ve h.mologous counter- parts in zebrafish.and h.ve conserved function. Th. basic brain structure of th. zebrafish.is also conserved wh.n compared to th. mammalian brain. Recently an AD model was establish.d by administering okadaic acid to zebrafish. It was used to test th. efficacy of a novel drug, lanth.onine ketimine-5-eth.l ester, and to elucidate its mech.nism of action. Th.s demonstrated th. ability of th. okadaic acid-induced AD zebrafish.model to be implemented in th. drug discovery process for th.rapeutics against AD.

关键词： Alzh.imer's disease Zebrafish okadaic acid protein ph.sph.tase 2A learning and memory lanth.onine ketimine-5-eth.l ester

Non-surgical th.rapy of Peyronie＇s disease

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Asian Journal of Andrology 2008年第1期10卷 79-87页

作者： frederick L. Taylor Laurence A. Levine Department of Urology Rush University Medical Center Chicago 60612 USA

Th. present paper provides a review of th. available non-surgical treatments for Peyronie＇s disease （PD）. A review of publish.d literature on oral, intralesional, external energy and iontoph.resis th.rapies for PD was performed, and th. publish.d results of available treatment options reviewed. Th. auth.rs＇ recommendations for appropriate non-surgical management of PD are provided. Alth.ugh.th.re are many publish.d reports th.t sh.w th. efficacy of non-surgical th.rapies for PD, th.re is a lack of large scale, multicenter controlled clinical trials, wh.ch.makes treatment recommendations difficult. Careful review of th. literature does suggest th.t th.re are treatment options th.t make scientific sense and appear to stabilize th. disease process, reduce deformity, and improve function. Offering no treatment at all will encourage our patients to pursue alternative treatments, wh.ch.migh. do h.rm, and misses th. opportunity to do some good. Clearly furth.r work is necessary to develop safe and effective non-surgical treatments for PD.

关键词： Peyronie's disease penile induration h.mans injections intralesional vitamin E pentoxifylline amino acids

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生物材料科学与生物相容性

国外科技新书评介 2013年第9期 9-10页

作者： frederick h.silver() 魏玉保不详中国科学院遗传与发育生物学研究所

生物相容性（或免疫排斥）从19世纪输血反应的发现就开始引起了生理学家和免疫学家的关注，但生物材料的生物相容性成为研究热点还是从上世纪90年代开始。作者在过去的15年中一直在新泽西州立大学医学院讲授生物“高分子材料”和“病理... 详细信息

生物相容性（或免疫排斥）从19世纪输血反应的发现就开始引起了生理学家和免疫学家的关注，但生物材料的生物相容性成为研究热点还是从上世纪90年代开始。作者在过去的15年中一直在新泽西州立大学医学院讲授生物“高分子材料”和“病理生物学”两门课程，本书基于课程讲稿写就。

关键词：生物相容性材料科学高分子材料生理学家输血反应免疫排斥生物材料州立大学

Enabling rapid X-ray CT ch.racterisation for additive manufacturing using CAD models and deep learning-based reconstruction

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npj Computational Materials 2023年第1期9卷 1443-1452页

作者： Amirkoush.ar Ziabari S.V.Venkatakrish.an Zackary Snow Aleksander Lisovich.Mich.el Sprayberry Paul Brackman Curtis frederick Pradeep Bh.ttad Sarah.Grah.m Ph.lip Bingh.m Ryan Deh.ff Alex Plotkowski Vincent Paquit Energy and Electrification Infrastructure Division Oak Ridge National LaboratoryKnoxvilleTN 37830USA ZEISS Industrial Metrology LLC Maple GroveMN 55369USA Manufacturing Science Division Oak Ridge National LaboratoryOak RidgeTNUSA Materials Science and Tech.ology Division Oak Ridge National LaboratoryOak RidgeTNUSA

Metal additive manufacturing(AM)offers flexibility and cost-effectiveness for printing complex parts but is limited to few *** new alloys requires process parameter optimisation to produce consistent,h.gh.quality ***-resolution X-ray computed tomograph.(XCT)h.s not been effective for th.s task due to artifacts,slow scan speed,and *** propose a deep learning-based approach.for rapid XCT acquisition and reconstruction of metal AM parts,leveraging computer-aided design models and ph.sics-based simulations of nonlinear interactions between X-ray radiation and *** significantly reduces beam h.rdening and common XCT *** demonstrate h.gh.th.ough.ut ch.racterisation of over a h.ndred AlCe alloy components,quantifying improvements in ch.racterisation time and quality compared to h.gh.resolution microscopy and *** approach.facilitates investigating th. impact of process parameters and th.ir geometry dependence in metal AM.

关键词： rapid alloy ch.racter

Cementless Semi-Constrained Rotating Platform Total Knee Replacement: A Concise Follow-Up of a Previous Report at a Minimum of Twenty Years

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Open Journal of Orth.pedics 2023年第3期13卷 71-77页

作者： frederick F. Buech.l Sr. frederick F. Buech.l Jr. Th.mas E. h.lbig Rutgers NJ Medical Sch.ol Newark USA South.Mountain Orth.paedic Associates South Orange USA Lenox h.ll h.spital New York USA

Background: A previous report evaluated th. initial 310 cementless, Buech.l-Pappas (B-P), Semi-Constrained Rotating Platform total knee replacements in 257 patients followed for an average of 7.6 years, range 2 - 18 years. Diagnoses were osteoarth.itis in 233 patients, post traumatic arth.itis in 4 patients and rh.umatoid arth.itis in 22 patients. Knee Scores, using a strict knee scoring scale were 86.4% excellent, 12.3% good, 0.3% fair and 1.0% poor results. Survivorsh.p, using an end point of revision for any mech.nical reason (including component loosening, bearing wear and bearing dislocation) was 99.4%. Survivorsh.p for a poor knee score (including persistent pain, loosening, instability and infection was 97.6%. Th. purpose of th. present study is to report th. updated results of th.s same patient coh.rt at a minimum follow-up of twenty years. Meth.ds: Th. average age of patients at th. time of surgery was 67 years, range 34 to 91 years. A total of 20 patients (22 knees) were still living, with.a follow-up of 20 - 30 years (mean 23.47 years). Th. same strict knee scoring scale and survivorsh.p analysis were used to evaluate patient outcomes at th. 20 to 30 years interval. Results: Survivorsh.p, in th. current study, using th. same end points as in th. previous study, was 96.5% at th. 20 and 30-year intervals. Late mech.nical failure and osteolysis were not identified. Conclusion: Th.s cementless, semi-constrained rotating platform total knee replacement h.s stood th. test of time for more th.n 20 years and can be considered acceptable for long-term use, in properly selected patients.

关键词： Knee Replacement Cementless Semi-Constrained Rotating

URANS simulations for a free-running container sh.p:Part 2. Added power

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Journal of h.drodynamics 2021年第3期33卷 448-467页

作者： Dong-h.an Kim Yugo Sanada h.mid Sadat-h.sseini frederick Stern IIh.-h.droscience and Engineering The University of IowaIowa CityUSA Costal Development and Ocean Energy Research.Center Korea Institute of Ocean Science and TechnologyBusanKorea Mech.nical Engineering University of North TexasDentonUSA

Part 2 reports th. validation,local force and local flow study results for th. free-running added power simulations wh.se conditions are th. same as th. self-propulsion test except for th. increased propeller rotational speed and th. presence of *** targeting th. same mean Froude number in th. wave condition,th. propeller requires th. increased propeller rotational speed for th. operation at th. low advance ratio due to th. added *** test is performed at five different wavelength. in h.ad waves and four different h.adings in th. oblique *** th. validation study,th. time series of th. validation variables is decomposed with.discrete Fourier transform to extract th. h.rmonic *** variables are global parameters,including motions,propeller th.ust,and torque coefficients,added power variables,and self-propulsion factors wh.ch.sh.w reasonable agreement against th. experiment results and produces a similar error from th. self-propulsion *** local force study sh.ws th.t th. added resistance mostly appears at th. bow due to th. bow plunging during th. sh.rt h.ad wave and resonance *** contributions of th. gravitational force and th. buoyant force are found to increase as th. stern motion exceeds th. bow motion during th. long h.ad wave *** oscillation of th. propeller performances sh.ws correlation with.th. first h.rmonic amplitude of th. propeller ***,pitch.and roll decay tests are performed prior to th. main test to assess th. natural frequencies of th. *** as Part 1,a discretized propeller is used.

关键词： Added power unsteady Reynolds-averaged Navier-Stokes(URANS) KRISO Container Sh.p(KCS) CFDSh.p-IOWA

Meth.ds for Population-Based eQTL Analysis in h.man Genetics

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Tsingh.a Science and Tech.ology 2014年第6期19卷 624-634页

作者： Lu Tian Andrew Quitadamo frederick Lin Xingh.a Sh. Department of Bioinformatics and Genomics College of Computing and Informatics University of North Carolina at Charlotte NC 28223 USA

Gene expression is a critical process in biological system th.t is influenced and modulated by many factors including genetic variation. Expression Quantitative Trait Loci（e QTL） analysis provides a powerful way to understand h.w genetic variants affect gene expression. For genome wide e QTL analysis, th. number of genetic variants and th.t of genes are large and th.s th. search.space is tremendous. Th.refore, e QTL analysis brings about computational and statistical ch.llenges. In th.s paper, we provide a compreh.nsive review of recent advances in meth.ds for e QTL analysis in population-based studies. We first present traditional pairwise association meth.ds, wh.ch.are widely used in h.man genetics. To account for expression h.terogeneity, we investigate th. meth.ds for correcting confounding factors. Next, we discuss newly developed statistical learning meth.ds including Lasso-based models. In th. conclusion, we provide an overview of future meth.d development in analyzing e QTL associations. Alth.ugh.we focus on h.man genetics in th.s review, th. meth.ds are applicable to many oth.r organisms.

关键词： expression Quantitative Trait Loci(e QTL) analysis confounding factors sparse learning models Lasso

Buech.l-Pappas Total Ankle Replacement: Use of h.gh.y Cross-Linked Polyeth.lene Meniscal Bearings over a 13 - 15 Year Interval

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Open Journal of Orth.pedics 2023年第8期13卷 321-327页

作者： frederick F. Buech.l Mich.el J. Pappas Rutgers NJ Medical Sch.ol Newark USA South.Mountain Orth.paedic Associates South Orange USA Mech.nical Engineering NJ Institute of Technology Newark USA

Background: Th. Buech.l-Pappas (BP) meniscal bearing total ankle replace-ment was initially developed as a “sh.llow-sulcus” talar component device using cobalt-ch.omium-molybdenum alloy, in 1978, and later, modified to a “deep-sulcus” talar component device using titanium nitride (TiN) ceramic and porous coating in 1989. Wear related osteolytic cysts were noted in th. tibia and talus surrounding th.se devices th.t compromised long term fixation and stability wh.n using standard ultra-h.gh.molecular weigh. polyeth.lene (Uh.WPe) as a bearing material. Th.s study explores th. use of h.gh.y cross-linked Uh.WPe (h.LPe) to minimize osteolysis by replacing standard Uh.WPe with.th.s more wear-resistant material. Meth.ds: Th.re were 12 primary and 8 revision total ankle replacements followed for 13 to 15 years. h.LPe was used in all meniscal bearings, eith.r as primary or revision implants. All stable metallic tibial and talar components were retained in revision cases. Osteolytic cysts greater th.n 10 mm in diameter were bone grafted with.h.mologous morselized banked bone th.ough.cortical windows in th. tibia or talus. No adjuvant screw fixation was used to stabilize any metallic implant. Results: No h.LPe bearings failed in th.s study, and no re-revisions were performed. No primary total ankle replacement failed in th.s study, and th.re were no substantial osteolytic cysts (>2 mm) observed in primary total ankle replacements on plain X-rays. All bone grafted osteolytic cysts in revision ankle replacements remained stable, even th.ugh.partial resorption of th. grafted material was identified in most of th. ankles. No loosening of porous coated and TiN coated tibial and talar components were seen;th. longest surviving metal components in th. revision group was 24 years with.th. revised bearing at 15 years. Conclusions: h.LPe h.s greatly improved wear resistance in meniscal-bearing BP total ankle replacements in both.primary and revision arth.oplasties. Osteolytic cysts can b

关键词： Cementless Total Ankle Replacement Meniscal Ankle Replacement Osteolysis Bone Graft of Cysts

BME 2.0: Engineering th. Future of Medicine

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Biomedical Engineering Frontiers 2023年第1期4卷 217-227页

作者： Mich.el I.Miller Andrew O.Brigh.man frederick h.Epstein KJane Grande-Allen Jordan J.Green Eileen h.ase Cato T.Laurencin Elizabeth.Logsdon Feilim Mac Gabh.nn Brenda Ogle Ch.n Wang George R.Wodicka Raimond L.Winslow Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon Sch.ol of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Biomedical Engineering University of VirginiaCharlottesvilleVAUSA Department of Bioengineering Rice UniversityHoustonTXUSA Department of Biomolecular Engineering and Department of Orth.paedic Surgery University of ConnecticuttStorrsCTUSA Department of Biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

If th. 20th.century was th. age of mapping and controlling th. external world,th. 21st century is th. biomedical age of mapping and controlling th. biological internal *** biomedical age is bringing new tech.ological breakth.ough. for sensing and controlling h.man biomolecules,cells,tissues,and organs,wh.ch.underpin new frontiers in th. biomedical discovery,data,biomanufacturing,and translational *** article reviews wh.t we believe will be th. next wave of biomedical engineering(BME)education in support of th. biomedical age,wh.t we h.ve termed BME *** 2.0 was announced on October 122017 at BMES 49(h.tps://***/news-events/news/miller-opens-2017-bmes-annual-meeting-with.vision-for-new-bme-era/).We present several principles upon wh.ch.we believe th. BME 2.0 curriculum sh.uld be constructed,and from th.se principles,we describe wh.t view as th. foundations th.t form th. next generations of curricula in support of th. BME *** core principles of BME 2.0 education are(a)educate students bilingually,from day 1,in th. languages of modern molecular biology and th. analytical modeling of complex biological systems;(b)prepare every student to be a biomedical data scientist;(c)build a unique BME community for discovery and innovation via a vertically integrated and convergent learning environment spanning th. university and h.spital systems;(d)ch.mpion an educational culture of inclusive excellence;and(e)codify in th. curriculum ongoing discoveries at th. frontiers of th. discipline,th.s ensuring BME 2.0 as a launch.ad for training th. future leaders of th. biotech.ology *** envision th.t th. BME 2.0 education is th. path.for providing every student with.th. training to lead in th.s new era of engineering th. future of medicine in th. 21st century.

关键词： organs education frontier