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Advances in NF-κB Signaling Transduction and Transcription

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Cellular & Molecular Immunology 2004年第6期1卷 425-435页

作者： Weihua Xiao~1 1 University of Science and Technology of China,China.2 Laboratory of Molecular Immunoregulation,NCI-frederick,frederick.MD 21702.USA. Institute of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China

The molecular mechanisms for NF-κB signaling transduction and transcription have been the most attractive subjects for both basic research and pharmaceutical industries due to its important roles in both physiological and pathogenesis,particularly the close association of dysregulated NF-κB with tumorgenesis and *** novel intracellular molecular events that regulate NF-κB activity have been described recently,including the discovery of an alternative signaling pathway that appears inducing a specific subset genes involved in adoptive immune ***-level and multi-dimensional regulation of NF-κB activity by phosphorylation and acetylation modifications have unveiled and became the hottest targets for potentially tissue specific molecular *** emerging mechanism for NF-κB-responsive gene's regulation where NF-κB participates the transcriptional regulation independent of its cognate regulatory binding site within the target gene's promoter but facilitating the transaction activity of other involved transcription factors, that implicated an novel transcriptional activities for NF-κ***,the current review will focus on these recent progresses that have been made on NF-κB signaling transduction and *** & Molecular Immunology.2004;1(6):425-435.

关键词： transcription factor NF-κB signaling pathway immunologyvtranscriptional regulation

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： frederick Chi-Wai Lui Oswens Siu-Hung Lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3891-3904页

作者： Ping Bai Prasenjit Mondal frederick A.Bagdasarian Nisha Rani Yan Liu Ashley Gomm Darcy R.Tocci Se Hoon Choi Hsiao-Ying Wey Rudolph E.Tanzi Can Zhang Changning Wang Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Genetics and Aging Research Unit McCance Center for Brain HealthMassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA

Although the epigenetic regulatory protein histone deacetylase 6(HDAC6)has been recently implicated in the etiology of Alzheimer’s disease(AD),little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potential therapeutic target for ***,we performed positron emission tomography(PET)imaging in combination with histopathological analysis to better understand the underlying pathomechanisms of HDAC6 in *** first developed[^(18)F]PB118 which was demonstrated as a valid HDAC6 radioligand with excellent brain penetration and high specificity to *** studies of[^(18)F]PB118 in 5xFAD mice showed significantly increased radioactivity in the brain compared to WT animals,with more pronounced changes identified in the cortex and *** translatability of this radiotracer for AD in a potential human use was supported by additional studies,including similar uptake profiles in non-human primates,an increase of HDAC6 in ADrelated human postmortem hippocampal tissues by Western blotting protein analysis,and our ex vivo histopathological analysis of HDAC6 in postmortem brain tissues of our ***,our findings show that HDAC6 may lead to AD by mechanisms that tend to affect brain regions particularly susceptible to AD through an association with amyloid pathology.

关键词： HDAC6 Alzheimer’s disease Radiotracer PET imaging Epigenetic

The atmosphere : an introduction to meteorology 9th ed. 9th ed.

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A Study of Motion Perception in Primary Open Angle Glaucoma

2004年

作者： Lutgens frederick K.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Eye Science 1996年第1期16卷 46-50页

作者： frederick W.Fitake Institute of Ophthalmology University of LondonUK

Purpose: To study the features of the motion perception (MP) and explore the worth of the clinical application of MP test in primary open angle glaucoma (POAG).Methods: MPs were recorded from 41 patients (67 eyes) with POAG ang 56 normal subjects (112 eyes) by the MP software in PC compatible computer. Meanwhile , the MP ways and MP sites were analyzed and MP abnormal rate was compared to the clinical parameters and the visual function indices related to glaucoma. . Results: The results showed that the total abnormal rate of MP was 89. 5% in POAG, and the abnormal rate was 81. 6% in early stage of POAG, and MP abnormal degree had positive correlation with C/D, ocular tension and corrected loss variance (CLV), and negative correlation with visual acuity and mean sensitivity (MS), and no correlation with age and short-term fluctuation (SF) in the patients with ***: These results suggest that the MP test provides a newly effctive examination method in diagnosing the early POAG. Eye Science 1996;

关键词： motion perception primary open angle glaucoma (POAG)

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

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World Journal of Gastroenterology 2017年第22期23卷 3999-4006页

作者： Robert G Bennett Ronda L Simpson frederick G Hamel Research Service Nebraska-Western Iowa Health Care System Department of Internal Medicine University of Nebraska Medical Center

AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic *** Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western *** Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein *** The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatmen

关键词：松弛激素 Peroxisome 激活 proliferator 的受体肝肝硬化肝疾病纤维变性

An Effective Error Resilient Packetization Scheme for Progressive Mesh Transmission over Unreliable Networks

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Journal of Computer Science & Technology 2008年第6期23卷 1015-1025页

作者：杨柏林 frederick W. B. Li 潘志庚王勋 College of Computer Science and Information Engineering Zhejiang Gongshang University State Key Laboratory of CAD & CG Zhejiang University Department of Computer Science University of DurhamU.K.

When a 3D model is transmitted over a lossy network, some model information may inevitably be missing. Under such situation, one may not be able to visualize the receiving model unless the lost model information has been retransmitted. Progressive model transmission offers an alternative to avoid the ＂all or nothing situation＂ by allowing a model to be visualized with a degraded quality when only part of the model data has been received. Unfortunately, in case some model refinement information is missing, one may still need to wait for such information to be retransmitted before the model can be rendered with a desired visual quality. To address this problem, we have developed a novel error resilient packetization scheme. We first construct a Non-Redundant Directed Acyclic Graph to encode the dependencies among the vertex splits of a progressive mesh. A special Global Graph Equipartition Packing Algorithm is then applied to partitioning this graph into several equal size sub-graphs, which is packed as packets. The packing algorithm comprises two main phases： initial partition phase and global refinement phase. Experimental results demonstrate that the proposed scheme can minimize the dependencies between packets. Hence, it reduces the delay in rendering 3D models with proper quality at the clients.

关键词： computer graphics packetization graph partition progressive transmission unreliable network

Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair Lydia M.Hite Jennifer Cloward Robert E.Ward Carter Kruse Herman A.van Wietmarchsen Nick van Eekeren Scott L.Kronberg frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,P<0.05).Relative to pasture-finished animals,the muscle of pen-finished animals displayed elevated glucose metabolites(~1.6-fold),triglycerides(~2-fold),markers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished animals displayed improved mitochondrial(~1.3-fold higher levels of various Krebs cycle metabolites)and carnitine metabolism(~3-fold higher levels of long-chain acyl carnitines)(all P<0.05).Pasture-finishing also concentrated higher levels of phenolics(~2.3-fold),alpha-tocopherol(~5.8-fold),carotene(~2.0-fold),and very long-chain fatty acids(~1.3-fold)in their meat,while having lower levels of a common advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all P<0.05).In contrast,vitamins B5,B6,and C,gamma/beta-tocopherol,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all P<0.05);suggesting some concentrate feeding,or grazing plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed Meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

Overprescription of opioid analgesia is common following ambulatory Otolaryngology—Head and Neck surgery procedures: A multicenter study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 145-151页

作者： Amr F.Hamour frederick Laliberte Jordan Levy Jason Xu Edward Park Vincent Lin John de Almeida Julie Strychowsky Antoine Eskander Eric Monteiro Department of Otolaryngology-Head and Neck Surgery University of TorontoTorontoOntarioCanada Department of Otolaryngology-Head and Neck Surgery London Health Sciences CentreLondonOntarioCanada Department of Otolaryngology-Head and Neck Surgery Mount Sinai HospitalTorontoOntarioCanada

Background: The rise in the use of prescription opioids for postoperative analgesia within surgery has mirrored an increased trend of opioid-related morbidity within Canada and the United States. This study prospectively studied daily pain levels and medication requirements postoperatively in patients undergoing elective Otolaryngology—Head and Neck surgery ***: Patients were asked to prospectively document their pain level and medication use daily for 7 days postoperatively. A final survey was used to quantify unused medication left at home and clarify each patient's disposal plan. We included patients undergoing elective outpatient or short stay surgeries from three tertiary care centers in Toronto, Ontario from September 2016 to September 2017. Previous opioids users or patients suffering from chronic pain were ***: A final cohort of 56 eligible adult patients were included in the study. The most common procedures were thyroidectomy (n = 19), endoscopic sinus surgery (n= 10), tympanoplasty/ossiculoplasty (n= 7), and cochlear implant (n = 5). Most patients received a prescription for acetaminophen/codeine (n = 29, 51.8%) or acetaminophen/oxycodone (n = 22, 39.3%) and used on average 29% of their initial prescription. Patients most commonly opted to keep their unused narcotics at home (n = 23, 41%). A total of 710 tablets of narcotics were overprescribed in our study population, 351 of which were kept in patients'' home for future ***: There is a clear tendency to overestimate postoperative pain resulting in significant overprescription of opioids among Otolaryngologists.

关键词： analgesia health policy opioid quality improvement quality of life