Advances in NF-κB Signaling Transduction and Transcription

作     者：Weihua Xiao~1 1 University of Science and Technology of China,China.2 Laboratory of Molecular Immunoregulation,NCI-Frederick,Frederick.MD 21702.USA. 

作者机构：Institute of Immunology School of Life Sciences University of Science and Technology of China Hefei Anhui China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2004年第1卷第6期

页      面：425-435页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：transcription factor NF-κB signaling pathway immunologyvtranscriptional regulation 

摘      要：The molecular mechanisms for NF-κB signaling transduction and transcription have been the most attractive subjects for both basic research and pharmaceutical industries due to its important roles in both physiological and pathogenesis,particularly the close association of dysregulated NF-κB with tumorgenesis and *** novel intracellular molecular events that regulate NF-κB activity have been described recently,including the discovery of an alternative signaling pathway that appears inducing a specific subset genes involved in adoptive immune ***-level and multi-dimensional regulation of NF-κB activity by phosphorylation and acetylation modifications have unveiled and became the hottest targets for potentially tissue specific molecular *** emerging mechanism for NF-κB-responsive gene s regulation where NF-κB participates the transcriptional regulation independent of its cognate regulatory binding site within the target gene s promoter but facilitating the transaction activity of other involved transcription factors, that implicated an novel transcriptional activities for NF-κ***,the current review will focus on these recent progresses that have been made on NF-κB signaling transduction and *** & Molecular Immunology.2004;1(6):425-435.