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小主应力方向加载条件下的掺砾黏土真三轴试验

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岩土力学 2018年第9期39卷 3270-3276页

作者：张坤勇李威 Charkley Nai frederick 陈恕河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 河海大学江苏省岩土工程技术工程研究中心江苏南京210098 河海大学岩土工程科学研究所江苏南京210098

对土石坝心墙掺砾黏土开展模拟心墙单元小主应力方向加载的真三轴试验,首先对试样进行不同围压条件下等向固结,然后保持小主应力恒定,通过调整大主应力和中主应力,以模拟土石坝竣工后的初始三向应力状态。试验过程中保持大主应力和中主... 详细信息

对土石坝心墙掺砾黏土开展模拟心墙单元小主应力方向加载的真三轴试验,首先对试样进行不同围压条件下等向固结,然后保持小主应力恒定,通过调整大主应力和中主应力,以模拟土石坝竣工后的初始三向应力状态。试验过程中保持大主应力和中主应力恒定,从小主应力方向单向加载,以模拟土石坝蓄水过程中心墙单元所经历的应力路径。试验结果与常规三轴试验以及复杂应力条件下大主应力方向真三轴加载试验结果都有显著不同。不同初始应力条件下,不同主应力方向的初始切线模量和初始切线泊松比的变化规律非常复杂,应力–应变显现出明显的各向异性。在心墙堆石坝施工过程及蓄水过程中,心墙单元所经历的应力路径明显不同,合理的土体本构模型应该对这种由于加荷路径不同所引起的不同方向模量和泊松比进行合理描述。

关键词：真三轴试验小主应力各向异性掺砾黏土应力路径

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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world Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： frederick Chi-wai Lui Oswens Siu-Hung Lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

bACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IbD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IbD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IbD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

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world Journal of Gastroenterology 2017年第22期23卷 3999-4006页

作者： Robert G bennett Ronda L Simpson frederick G Hamel Research Service Nebraska-Western Iowa Health Care System Department of Internal Medicine University of Nebraska Medical Center

To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic *** fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone (nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type I collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smooth muscle actin (SMA) levels. liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha (PGC1α) was determined by western *** of mice with CClb>4b> resulted in hepatic fibrosis as evidenced by increased liver enzyme levels (ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels (P liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen (P were supported by immunohistochemistry for type I collagen, in which only combination treatment reduced fibrillar collagen levels (P was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein *** combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential

关键词： Relaxin Peroxisome proliferator-activated receptors liver cirrhosis liver diseases Fibrosis

Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis

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Frontiers of Medicine 2020年第5期14卷 601-612页

作者： Jiuyang Xu Chaolin Huang Guohui Fan Zhibo liu lianhan Shang Fei Zhou Yeming wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang lixue Huang Xiaoying Gu Hui li Yi Zhang Yimin wang frederick G.Hayden Peter w.Horby bin Cao Chen wang Department of basic Medical Sciences Tsinghua University School of MedicineBeijing 100084China Department of Infectious Diseases Jinyintan HospitalWuhan 430030China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China beijing University of Chinese Medicine Beijing 100029China Department of Respiratory Medicine Capital Medical UniversityBeijing 100029China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China Department of Medicine University of Virginia School of MedicineCharlottesvilleVA 22904USA Centre for Tropical Medicine and Global Health University of OxfordOxford OX12JDUK Tsinghua University-Peking University Joint Center for life Sciences Beijing 100084China Chinese Academy of Engineering Beijing 100088China

The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARbs)on COVID-19 disease severity have generated considerable *** performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,*** on anti-hypertensive treatment with or without ACEI/ARb were compared on their clinical characteristics and *** medical records from 702 patients were *** the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARb as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/*** observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARb *** multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARb treatment and severe COVID-19 *** findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of *** should continue previous antihypertensive therapy until further evidence is available.

关键词： COVED-19 SARS-CoV-2 hypertension angiotensin-converting enzyme inhibitor angiotensinⅡreceptor blocker

Fundamentals of anatomy and physiology / frederick H. Martini ; with william C. Ober, art coordinator and illustrator ; Claire w. Garrison, illustrator ; Kathleen welch, clinical consultant ; Ralph T. 4th ed.

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Fundamentals of anatomy and physiology / Frederick H. Martin...

Preferences for pre-exposure prophylaxis among U.S. military men who have sex with men:results of an adaptive choice based conjoint analysis study

1998年

作者： frederick H. Martini with william C. Ober art coordinator and illustrator Claire w. Garrison illustrator Kathleen welch clinical consultant Ralph T. Hutchings biomedical photographer.

来源：畅想之星图书光盘版（南... 评论

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Military Medical Research 2022年第2期9卷 141-151页

作者： JoséI.Gutierrez Alex Dubov frederick L.Altice David Vlahov Yale School of Nursing 400 West Campus DriveOrangeCT 06477USA Philip R.Lee Institute for Health Policy Studies University of CaliforniaSan Francisco3333 California StSan FranciscoCA 94118USA Loma linda University Griggs Hall 11065Loma LindaCA 92350USA Yale School of Medicine Section of Infectious Diseases135 College StreetSuite 323New HavenCT 06510USA Department of Epidemiology-Microbial Diseases Yale School of Public Health60 College StNew HavenCT 06510USA

background: Pre-exposure prophylaxis(PrEP) prevents human immunodeficiency virus(HIV) infection, but its use remains low among U.S. military men who have sex with men(MSM), likely due to mis-matching with personal preferences. we conducted a study to characterize preferences to PrEP measures within this ***: HIV-negative military MSM were recruited through a closed, Lesbian, Gay, bisexual, and Transgendered(LGbT) military social media group. The survey was anonymous, and consisted of five experimentally varied attributes in service delivery: dosing method, provider type, visit location, lab work evaluation location, and dispensing *** importance and part-worth utility scores were generated using hierarchical bayes(Hb) estimation, and the randomized first choice model was used to examine participation interest across eight possible PrEP program ***: A total of 429 participants completed the survey. Among the eight scenarios with varying attributes, the most preferred scenario featured a daily tablet, PrEP injection or implant, along with a military provider, smartphone/telehealth visit, and on-base locations for lab evaluation and medication pick-up. The results also emphasized the importance for providers to be familiar with PrEP prescription knowledge, and to provide interactions sensitive to sexual identity and mental ***: A PrEP program consisting of daily tablet is preferred in military healthcare settings is preferred. Longacting implants and injections are also desired.

关键词： Conjoint analysis Pre-exposure prophylaxis Preference Decision science Human immunodeficiency virus Military health Infectious disease

基于PFC2D的砂土原生各向异性微观机理数值试验

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岩土工程学报 2017年第3期39卷 518-524页

作者：张坤勇李威罗兴军 CHARKLEY Nai frederick 河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 江苏省岩土工程技术工程研究中心(河海大学) 江苏南京210098 中国建筑西南勘察设计研究院有限公司四川成都610084

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增... 详细信息

采用颗粒流PFC数值模拟方法,生成符合标准砂室内单元试验结果的离散元数值试验试样。运用重力沉积法建立不规则砂土颗粒单元的平面双轴试验模型,给定不同沉积步数对试样不同初始原生状态进行模拟,然后分别从水平和竖直方向上施加荷载增量,得到不同沉积条件下不同加载方向上砂土试样宏观应力应变曲线和力学参数。数值试验结果显示,重力沉积步数对颗粒微观长轴定向排列、平均配位数有显著影响;初步建立了砂土微观结构变化和宏观应力应变曲线及力学参数的联系;分析了砂土试样表现出的宏观原生各向异性力学特性与内部颗粒结构的关系。

关键词：离散元砂土原生各向异性微观结构

biomarkers of Human Exposure to Carcinogens: An Overview

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biomedical and Environmental Sciences 1991年第1期4卷 69-72页

作者： frederick A.bELAND MIRIAM C.POIRIER National Center for Toxicological Research JeffersonNational Cancer Institute Bethesda Arkansas 72079-9502 Maryland 20892

Environmental, occupational, or dietary exposure to certain chemicals has been shown to be associated with carcinogenesis in humans. In the 18th century, for example, Percival Pott (1775) noted a high incidence of scrotal cancer in chimney sweeps, which he attributed to their exposure to soot and a concomitant lack of bathing. Subsequent epidemiological studies have identified a number of additional carcinogenic agents, including aromatic amine-based dyes (Case et al., 1954), cigarette smoke (wynder and Graham, 1950), asbestos (Doll, 1955), vinyl chloride (Creech and

关键词： An Overview biomarkers of Human Exposure to Carcinogens

Foraging ecology and occurrence of 7 sympatric babbler species （Timaliidae） in the lowland rainforest of borneo and peninsular Malaysia

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Current Zoology 2016年第4期62卷 345-355页

作者： Alison R. STYRING Roslina RAGAI Mohamed ZAKARIA frederick H. SHELDON The Evergreen State College Olympia Washington 98505 USA Grand Perfect Sdn. bhd. ParkCity Commerce Square 97000 Bintulu Sarawak Malaysia Department of Forest Management Faculty of Forestry Universiti Putra Malaysia Serdang Selangor Malaysia Museum of Natural Science and Department of biological Sciences Louisiana State University Baton Rouge Louisiana USA 70803

Understanding foraging strategies of birds is essential to understanding mechanisms of their community assembly. To provide such information on a key Southeast Asian rainforest family, the babblers （Timaliidae）, we evaluated foraging behavior and abundance in 7 morphologically and behaviorally similar sympatric species （Cyanoderma erythropterum, C. rufifrons, Stachyris maculata, S. nigricollis, S. poliocephala, Macronus ptilosus, and Mixornis gularis） in 5 habitats defined by structural complexity：（1） continuous native rainforest, （2） logged native rainforest fragments, （3） mature industrial tree plantation, （4） young industrial plantation, and （5） oil palm plantation. Enough data were obtained to compare abundance in all 7 species and foraging behavior in 5. All species were common in forest fragments and mature industrial tree plantations and less so in continuous rainforest and young industrial plantations; only M. gularis occurred in oil palm. In terms of foraging, M. gularis was the greatest generalist; C. rufifrons foraged mainly on live leaves in the forest midstory; and S. maculata, C. eryth- ropterum, and M. ptilosus foraged mainly on dead leaves suspended in understory vegetation at sig- nificantly different heights. The dead-leaf substrate depends on a rich supply of falling leaves and ex- tensive understory structure, conditions most common in native forest and old industrial plantations, and less so in mature forest, young plantations, and oil palm. because of the importance of foraging data to understanding and managing biodiversity, we encourage the development of foraging fields in ebird （***）, so that birdwatchers may help collect these relatively rare data.

关键词： brunei dead leaves logged forest plantation Sabah Sarawak.