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A Non-parametric Gradient-Based Shape Optimization Approach for Solving Inverse Problems in Directed Self-Assemblyof Block Copolymers

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作者： Martini frederic.

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1472-1489页

作者： Daniil Bochkov frederic.Gibou Department of Mechanical Engineering University of CaliforniaSanta BarbaraSanta BarbaraCA93106USA Department of Computer Science University of CaliforniaSanta BarbaraSanta BarbaraCA 93!06 USA

We consider the inverse problem of finding guiding pattern shapes that result in desired self-assembly morphologies of block copolymer ***,we model polymer selfassembly using the self-consistent field theory and derive,in a non-parametric setting,the sensitivity of the dissimilarity between the desired and the actual morphologies to arbitrary perturbations in the guiding pattern *** sensitivity is then used for the optimization of the confining pattern shapes such that the dissimilarity between the desired and the actual morphologies is *** efficiency and robustness of the proposed gradient-based algorithm are demonstrated in a number of examples related to templating vertical interconnect accesses(VIA).

关键词： Block copolymers Directed self-assembly Inverse design Shape optimization Vertical interconnect accesses(VIA)

Growth of RB Population in the Conversion Phase of Chlamydia Life Cycle

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Communications on Applied Mathematics and Computation 2024年第1期6卷 90-112页

作者： frederic.Y.M.Wan Department of Mathematics University of CaliforniaIrvineCA92697-3875USA

Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended *** data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development *** data collected every 4 hpi,conversion to the elementary body(EB)form begins abruptly at a rapid rate sometime around 24 *** modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)EB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion ***,the simple birth and death model for the RB proliferation and conversion to EB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-EB *** working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.

关键词： Chlamydia Life cycle Optimal control Maximal infectious spread Specie competitive survival

Education of Hospitalized Diabetic Patients: Analysis of Training Needs among Nurses in a Lebanese Hospital - A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第4期8卷 353-369页

作者： Nisrine Moubarak frederic.Douville Laval University Quebec CityQuebecCanada

The design of diabetes inpatient educational preparation should be based on the needs of the nurses involved in terms of skills in this area. The objective of this qualitative study is to identify the preparatory needs of nurses working in the medical and surgical units of a Lebanese hospital in terms of Survival Skills Education for Hospitalized Diabetic Patients (SSEHDP). Method: The focus group method is used for data collection using a semi-structured interview guide. The needs expressed by the thirty-two participating nurses were classified into categories of the competency framework for providing self-management education to diabetic patients proposed by the American Diabetes Association. Results: By focusing on the themes of an SSEHDP, a list of preparatory needs was drawn up. The needs identified and analyzed are then translated into general and specific learning objectives for educational preparation. Conclusion: The needs analysis is only the first step in a work that will ideally continue into the implementation and eventual evaluation of an educational program developed to help nurses acquire skills in the education of diabetic patients.

关键词： Diabetes inpatient education Nurse training needs Survival Skills Education for Hospitalized Diabetic Patients(SSEHDP) Qualitative study Competency framework

Simultaneous genetic transformation and genome editing of mixed lines in soybean(Glycine max)and maize(Zea mays)

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aBIOTECH 2024年第2期5卷 169-183页

作者： Michelle Valentine David Butruille frederic.Achard Steven Beach Brent Brower-Toland Edward Cargill Megan Hassebrock Jennifer Rinehart Thomas Ream Yurong Chen Bayer Crop Science 700 Chesterfield Parkway WChesterfieldMO 63017USA

Robust genome editing technologies are becoming part of the crop breeding ***,genome editing is usually conducted either at a single locus,or multiple loci,in a variety at one *** parallel genomics platforms,multifaceted genome editing capabilities,and flexible transformation systems enable targeted variation at nearly any locus,across the spectrum of genotypes within a *** demonstrate here the simultaneous transformation and editing of many genotypes,by targeting mixed seed embryo explants with genome editing machinery,followed by re-identification through genotyping after plant *** and Editing of Mixed Lines(TREDMIL)produced transformed individuals representing 101 of 104(97%)mixed elite genotypes in soybean;and 22 of 40(55%)and 9 of 36(25%)mixed maize female and male elite inbred genotypes,*** of edited genotypes for the regenerated individuals identified over 800 distinct edits at the Determinate1(Dt1)locus in samples from 101 soybean genotypes and 95 distinct Brown midrib3(Bm3)edits in samples from 17 maize *** results illustrate how TREDMIL can help accelerate the development and deployment of customized crop varieties for future precision breeding.

关键词： Maize Soybean Seed embryo explants TREDMIL Genetic transformation Genome editing

Cost-Effective Monitoring of the Fuel Air Equivalence-Ratio with a Lambda Sensor and a Microcontroller in a Downdraft Biomass Gasifier

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Open Journal of Applied Sciences 2024年第2期14卷 545-560页

作者： Jean Fidele Nzihou Salou Hamidou Ousmane Zoundi frederic.Ouattara Bila Gerard Segda Formation and Research Unit in Sciences and Technologies University Norbert ZONGO Koudougou Burkina-Faso

The operation of biomass treatment devices such as gasifiers is based on the control of key parameters that play an important role in product formation. These include: temperature, excess oxygen, relative humidity and biomass composition. This work focuses on excess oxygen and temperature. Unfortunately, flue gas oxygen analyzers are expensive and not accessible to small industries. However, the equivalence ratio is linked to excess oxygen and has the advantage of not depending on biomass composition. This study therefore focuses on the design and development of a device for controlling this equivalence ratio by measuring oxygen concentration using a self-propelled Lambda probe, and a system for monitoring this equivalence ratio using an Arduino Uno 3 microcontroller. The temperature is recorded with an accuracy of ±1.5°C. For a heating time of 10 minutes, the response time to temperature change is around 3 seconds, which is sufficient for the device to function properly. This simple device is an efficient and cost-effective means of checking the equivalence ratio.

关键词： Equivalence Ratio Biomass Gasification Lambda Sensor Microcontroller C++

A novel homozygous missense variant in ARSK causes MPS X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： Miao Sun Cornelia K.Kaminsky Philip Deppe Mai-Brittllse frederic.M.Vaz Barbara Plecko Torben Lubke Linda M.Randolph Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UMC Location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility Metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of Medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Mucopolysaccharidoses(MPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys

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绿色金融为中国经济的可持续发展注入动力

新金融 2024年第1期 10-14页

作者：范力民汇丰银行

目前,中国经济的发展面临着一系列挑战,需要妥善处理经济结构转型的问题,其中向绿色转型发展的需求日益迫切,因此建立合适的转型机制,为中国经济的绿色转型与可持续发展注入动力是当前中国经济的重要任务。本文梳理了中国近年来绿色转... 详细信息

目前,中国经济的发展面临着一系列挑战,需要妥善处理经济结构转型的问题,其中向绿色转型发展的需求日益迫切,因此建立合适的转型机制,为中国经济的绿色转型与可持续发展注入动力是当前中国经济的重要任务。本文梳理了中国近年来绿色转型方面的进展,从绿色贷款、绿色债券和绿色股权投资等方面分析了中国为建立多层次绿色金融体系而做出的努力,指出绿色转型需要更多社会资本参与,并根据《G20转型金融框架》中的“五个支柱”进一步明确提出了中国经济绿色转型分类、实施碳税以激励转型、提高气候信息披露要求、通过VC/PE/PPP等融资方式拓宽民间投资渠道、增加针对性货币和财政工具等建议,以期为中国的绿色转型发展提供参考。

关键词：绿色金融绿色转型可持续发展社会资本

工程尺度缓冲材料热-水-力多场耦合数值模拟研究

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岩土工程学报 2024年第8期46卷 1712-1722页

作者：赵敬波曹胜飞李杰彪陈亮 COLLIN frederic.刘月妙张奇核工业北京地质研究院国家原子能机构高放废物地质处置创新中心北京100029 哈尔滨工业大学环境学院黑龙江哈尔滨150090 南方科技大学环境科学与工程学院广东深圳518055 Departement GeomaC University of LiegeSartTilman B52/3Chevreuils Road1B-4000 Liege

缓冲材料作为填充在废物罐与地质体之间重要的人工屏障,对高放废物处置库的长期安全至关重要。以工程尺度缓冲材料热-水-力多场耦合大型模型试验系统(China-Mock-up)为研究对象,采用有限元数值模拟软件LAGAMINE,考虑试验过程中复杂的边... 详细信息

缓冲材料作为填充在废物罐与地质体之间重要的人工屏障,对高放废物处置库的长期安全至关重要。以工程尺度缓冲材料热-水-力多场耦合大型模型试验系统(China-Mock-up)为研究对象,采用有限元数值模拟软件LAGAMINE,考虑试验过程中复杂的边界条件与材料属性,实现了近5 a试验数据的定量模拟。模拟结果可准确预测试验系统内部不同特征点温度随室温周期性波动及线性增长这一动态变化规律;能够较好反映不同特征点相对湿度随时间的行为演化趋势,在加热器附近区域呈现出先干燥后饱和的现象,远离加热器区域则逐渐增大;模拟的总应力与实测试验数据间表现较好地一致性,能够反映试验台架内部不同特征点的总应力随时间逐渐增大这一演化过程。揭示了多场耦合条件下缓冲材料(膨润土)温度、湿度及应力的相互作用关系,为深入认识处置库环境下缓冲材料行为演化特征提供了重要的参考依据。

关键词：缓冲材料 China-Mock-up试验热-水-力多场耦合模拟高庙子膨润土

Influence of Solvent onto Chemical Extraction of America-Type Coconut (Coco nucifera L.) Fbers: Analysis of Physicochemical, Mechanical and Morphological Properties

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Journal of Textile Science and Technology 2024年第3期10卷 64-81页

作者： Delphine Korgai Gandai Zara Haman Djoda Pagore frederic.Memtine Ndong Augustin Abdourhamane Nsangou Niraka Blaise Hambate Gomdje Valery National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon School of Chemical Engineering and Mineral Industries University of Ngaoundere Ngaoundere Cameroon Department of Mechanical Engineering ENSET University of Douala Douala Cameroon

In this study, the natural fibers from Coconuts of the species Coco nucifera L. were Chemically extracted in different solvents such as sodium hydroxide (SH), acetone (AC) and sodium hydroxide-acetone (SHA) for their applications in the textile industries. Structural, morphological and physico-mechanical characterizations such as X-ray diffraction (XRD), Fourier transform infrared spectrometry (FTIR), scanned electron microscopy (SEM), measurements of density, Young’s modulus, water absorption rate and humidity were evaluated. The XRD and FTIR results show that Coco nucifera L. fibers contains type I cellulose. Mechanical characterizations were also carried out. These results show that by varying the different solvents used, the physico-chemical, mechanical and morphological properties of the fibers change, which implies that the solvent has an influence on the properties of these fibers. The fibers extracted by the sodium hydroxide-acetone mixture have a linear density of 1.636, the percentage of water absorption is 62.428%, the percentage of moisture absorption 9.605% compared to other values in the literature shows that this solvent mixture improves the properties of coconut fibers which contain type I cellulose. The tensile stress is 0.013 GPa, the percentage strain is 49.836% and the Young’s modulus is 0.114 GPa as well as the percentage elongation show that these fibers are elasto-plastic. The values obtained mean that these fibers are suitable for use in textiles.

关键词： Chemical Extraction Cellulose Coco nucifera L. Fibers Elasto-Plastic Textiles