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Journal of Life Sciences 2012年第7期6卷 747-753页

作者： frederic Nogbou Ello Thomas Yapo Aba Ismael Ouattara didier Koumavi Ekouvi Offoue Kra Pierre Aime Assemian Amath Wade Serge-Paul Eholie Emmanuel Bissagnene department of lnfectious and Tropical diseases in Abidjan University Hospital of Treichville 01 BP V3 Abidjan 01 Cote d 'lvoire PAC-CI Program Abidjan University Hospital ofTreichville USAC Extension 18 BP 1954 Abidjan 18 Cote d'Ivoire Laboratoire Sanofi Aventis Sanofi-Aventis Dakar BP 3529 Senegal

Malaria is a major public health problem in the Cote d＇Ivoire where it is the leading cause of morbidity and mortality. The objective of this study was to assess the knowledge, attitudes and practices of health care providers on the diagnosis and therapeutic procedures used to ensure the management of uncomplicated malaria in the health district of Abidjan. A cross-sectional study was conducted from November 2008 to december 2008 among 169 caregivers who treated 1,691 cases of uncomplicated malaria. Results： The knowledge of the caregivers of the national guidelines regarding malaria was sufficient （89%）. A diagnosis of uncomplicated malaria was established only on clinical arguments （70%）. The percentage of patients who were prescribed artemisinin-based combination therapy （ACT） was 86%. However, 25% of the antimalarials drugs that were prescribed to patients （oral quinine, artemisinin derivatives monotherapy, and herbal medicine） did not meet the recommendations on first choice treatment as suggested by the national program against malaria. These results indicate sufficient knowledge of the national guidelines for the treatment of malaria by health care providers as evidenced by acceptable prescriptions for ACTs despite an incomplete knowledge of the guidelines.

关键词： Malaria supplier of service ACT knowledge Africa.

Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity

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World Journal of Gastroenterology 2016年第31期22卷 7111-7123页

作者： Mathieu Meleine Ludivine Boudieu Agathe Gelot Emilie Muller Amandine Lashermes Julien Matricon Celine Silberberg Vassilia Theodorou Alain Eschalier denis Ardid frederic A Carvalho Clermont Université Université d'Auvergne INSERM 1107 Neuro-Dol Université d’Auvergne INSERM 1107 Neuro-Dol INRA EI-Purpan UMR 1054 Neuro-Gastroenterology and Nutrition

AIM: To investigate anti-hypersensitive effects of α2δ-1 ligands in non-inflammatory and inflammationassociated colonic hypersensitivity(CHS) mouse ***: To induce an inflammation-associated CHS, 1% dextran sulfate sodium(dSS) was administered to C57Bl/6J male mice, in drinking water, for 14 d. Regarding the non-inflammatory neonatal maternal separation(NMS)-induced CHS model, wild-type C57BI/6J pups were isolated from their mother from day 2 to day 14(P2 to P14), three hours per day(from 9:00 a.m. to 12:00 p.m.). Colorectal distension was performed by inflating distension probe from 20 μL to 100 μL by 20 μL increment step every 10 s. After a first colorectal distension(CRd), drugs were administered subcutaneously, in a cumulative manner,(Gabapentin at 30 mg/kg and 100 mg/kg; Pregabalin at 10 mg/kg and 30 mg/kg; Carbamazepine at 10 mg/kg and 30 mg/kg) and a second CRd was performed one hour after each ***: The visceromotor response(VMR) to CRd was increased by our NMS paradigm protocol in comparison to non-handled(NH) mice, considering the highest distension volumes(80 μL: 0.783 ± 0.056 mV /s vs 0.531 ± 0.034 m V/s, P d 100 μL: 1.087 ± 0.056 m V/s vs 0.634 ± 0.038 m V/s, P d NH mice, respectively). In the inflammationassociated CHS, dSS-treated mice showed a dramatic and significant increase in VMR at 60 and 80 μL distension volumes when compared to control mice(60 μL: 0.920 ± 0.079 m V/s vs 0.426 ± 0.100 m V/s P d 80 μL: 1.193 ± 0.097 mV /s vs 0.681 ± 0.094 mV /s P dSS- and Water-treated mice, respectively). Carbamazepine failed to significantly reduce CHS in both models. Gabapentin significantly reduced CHS in the dSS-induced model for both subcutaneous injections at 30 or 100 mg/kg. Pregabalin s i g n i f i c a n t l y r e d u c e d V M R t o C R d i n t h e n o n-inflammatory NMS-induced CHS model for the acute subcutaneous administration of the highest cumulative dose(30 mg/kg) and significan

关键词： Neonatal maternal separation dextran sulfate sodium Colonic hypersensitivity mouse models Colorectal distension α2δ-1 ligands

Covid-19 in Pregnancy: Cases of Women Managed in the City of douala-Cameroon

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Open Journal of Obstetrics and Gynecology 2022年第10期12卷 1019-1030页

作者： Bilkissou Moustapha Alphonse Nyong Ngalame Charlotte Nguefack Tchente frederic Victor Okala Kingsley Ombaku Humphry Tatah Neng diane Kamdem Ngo Batta Julie Nkendo Sandrine darolles Mwadjie Emile Telesphore Mboudou douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Faculty of Health Sciences University of Buea Buea Cameroon douala General Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Introduction: The SARS-COV-2 virus has been responsible for a health crisis in pregnancy, causing severe acute respiratory distress syndrome. Materno-foetal complications can be observed. Taking into account the materno-foetal risks associated with COVId-19 infection in pregnant women and the low sample size of the first publication in Cameroon, we considered it necessary to conduct an in-depth study on the maternal and foetal prognosis of this condition in pregnant women in three hospitals in douala. Materials and Methods: We conducted a cross-sectional survey with retrospective data collection in the three state tertiary and reference hospitals in douala (dGOPH, dGH and dLH) from November 1, 2021 to April 30 2022 after obtaining ethical and administrative clearances. All records of COVId-19 pregnant women confirmed by reverse transcription polymerase chain reaction (RT PCR) or COVId-19 rapid diagnostic test (COVId RdT) were included. The survey form contained socio-demographic data, clinical and para-clinical characteristics, management and materno-foetal outcome. SPSS.26 and Microsoft Excel 2016 software were used to analyze the data, and a logistic regression model was used to look for associations between the variables. Results: We found in total 96 files that met our inclusion criteria. The most represented sector of activity was the unemployed (44.46%). Patients with a secondary level of education constituted the majority with 47% (45). The main comorbidity found was diabetes (27.2%). The most frequent symptom was fever, found in 87 patients (90.1%). In our series, a chest CT scan was performed in 50 patients. Caesarean section was the most common mode of delivery (58.3%). We recorded 15.6% of maternal deaths, mainly in patients admitted to intensive care. Factors associated with maternal death were: Maternal diabetes, high LdH and d-dimer levels, and 75% lung involvement on chest CT scan. Oxygen saturation > 94% on admission was a protective factor. Regardin

关键词： COVId-19 Clinical Para-Clinical Materno-Foetal Outcomes Pregnant Women

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论行走

1例迟发性淀粉样多发性神经病中国男性患者出现异常甲状腺素运载蛋白突变V32A

2019年

作者： (法)弗里德里克·格鲁(frederic Gros)

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 54-54页

作者： pica E.C. Pramono Z.A.d. Verma K.K. 周永 dr. Neuromuscular Research Laboratory National Neuroscience Institute 11 Jalan Tan Tock Seng 308433 Singapore Singapore

We report a Chinese patient with amyloidotic polyneuropathy associated with a novel transthyretin mutation (V32A). He presented with slowly progressive sensorimotor polyneuropathy accompanied by autonomic dysfunction and cardiomyopathy by echocardiography. This mutation is likely to be associated with late onset and low-penetrance phenotype.

关键词：多发性神经病 V32A 淀粉样中国男性外显率感觉运动心肌病表型相关

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CMV蚜传相关蛋白CP基因的克隆与变异分析

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CMV蚜传相关蛋白CP基因的克隆与变异分析

Mesenchymal stem cell-based therapy for ischemic stroke

植保科技创新与病虫防控专业化——中国植物保护学会2011年学术年会

作者：尹荣岭陈巨莲刘勇程登发孙京瑞 Claude Bragard frederic FRANCIS 中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室山东农业大学植物保护学院 University Catholique de Louvain B-1348 Louvain-La-Neuve Belgium Universite de Liege Gembloux Agro-Bio-Tech 5030 Gembloux Belgium

据统计约75%的蚜传植物病毒通过以非持久性的方式进行传播的。黄瓜花叶病毒(Cucumber mosaic virus,CMV)作为为害蔬菜的主要病毒病,其传播的方式主要以蚜虫的非持久性传播为主。其传播机制中植物病毒与蚜虫介体的分子机制方面的研究,主... 详细信息

据统计约75%的蚜传植物病毒通过以非持久性的方式进行传播的。黄瓜花叶病毒(Cucumber mosaic virus,CMV)作为为害蔬菜的主要病毒病,其传播的方式主要以蚜虫的非持久性传播为主。其传播机制中植物病毒与蚜虫介体的分子机制方面的研究,主要集中在明确病毒参与传播的基因及产物和传播介体的病毒特异性受体结合蛋白的分析,并明确了外壳蛋白(Coat Protein,CP)与蚜虫非循环性传播有关。通过对北京、山东采集的病叶样品进行检测和克隆,并应用MEGA v4.1基于CMVCP基因核苷酸水平将测序所得CP基因的核苷酸序列(657bp)与在NCBI上检索国内外临近的标准CMV亚组序列进行系统分析,用Neighbor-Jioning法(1 000次随机抽样,计算自引导值)构建系统发育树,结果显示5个分离物均属于IB亚组。应用dNAstar对核苷酸序列和氨基酸序列与引用标准序列进行一致性比对。结果显示已得5序列与IB亚组标注株系Y16926(Tfn)在核苷酸具有最大97%的一致性,氨基酸水平上同样具有高度一致性(最大为99.5%);与IA亚组代表性株系d10538(Fny)在核苷酸水平上具有最大95%一致性,同时氨基酸水平上表现很高的一致性(大于96%)。其中与Ⅱ亚组序列AB006813(m2)、M21464(Q)、L15336(Trk7)相对比显示一致性均较低,说明已得5序列并非属于II亚组。通过对CMV病毒的CP基因序列的克隆,经同源性比对,其中5序列与II亚组分离物比对,无论是在核苷酸水平还是氨基酸水平均表现较低一致性;与IB亚组分离物的一致性较高,在核苷酸和氨基酸水平都表现出高度一致性,说明5序列不属于II亚组,而是属于IB亚组,并与系统发育树相一致。在氨基酸序列比对中,25位点发生突变,与报道相一致,会影响蚜虫的传毒。因此通过建立CMV分子变异与株系分化的快速检测方法,对北京与山东地区蔬菜作物上CMV病毒遗传结构与多样性进行了监测。研究结果对于了解植物病毒种群多样性及其进化机制,以及对CMV病毒病早期为害的监测防控提供了理论指导。

关键词：黄瓜花叶病毒序列比对亚组一致性

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Chinese Neurosurgical Journal 2016年第4期2卷 233-238页

作者： Johnathon d.Anderson Missy T.Pham Zelenia Contreras Madeline Hoon Kyle d.Fink Henrik J.Johansson Julien Rossignol department of Internal Medicine Stem Cell Program University of California Davis Davis USAInstitute for Regenerative Cures University of California Davis Medical Center 2921 Stockton Blvd Room 1300 Sacramento CA 95817 USA department of Internal Medicine Stem Cell Program University of California Davis Davis USA department of Oncology-Pathology Karolinska InstituteCancer Proteomics Davis USA College of Medicine Central Michigan University Mt PleasantUSA

Ischemic stroke represents a major,worldwide health burden with increasing *** affected by ischemic strokes currently have few clinically approved treatment options *** currently approved treatments for ischemic stroke have narrow therapeutic windows,severely limiting the number of patients able to be *** stem cells represent a promising novel treatment for ischemic *** studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic *** studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this *** the present review,we summarize the current literature on the use of mesenchymal stem cells to treat ischemic *** studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

关键词： Mesenchymal stem cells Exosomes Ischemic stroke

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通过柔性微针阵列集成的叉指电极装置产生电刺激用于癌症免疫治疗（英文）

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Science Bulletin 2023年第22期 2779-2792+2669-2670页

作者：潘奕璇张扬熙史雪莹李冬冬徐晓丹肖冰朴莹相佳佳邵世群 frederic Chun-Yip Ho 申有青张阿平唐建斌 Key Laboratory of Smart Biomaterials of Zhejiang Province College of Chemical and Biological Engineering Zhejiang University Photonics Research Institute Department of Electrical and Electronic Engineering The Hong Kong Polytechnic University ZJU-Hangzhou Global Scientific and Technological Innovation Center Institute of Pharmaceutics Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical Sciences Zhejiang University

免疫疗法通过化学或生物制剂来激活免疫系统,改变了癌症治疗的传统方式.但大多数免疫类药物在肿瘤组织内的渗透性差,容易产生副作用而使疗效不尽人意.电刺激疗法是一种新颖的癌症疗法,其可以不利用化学、生物制剂产生抑癌效果,但存在操...

免疫疗法通过化学或生物制剂来激活免疫系统,改变了癌症治疗的传统方式.但大多数免疫类药物在肿瘤组织内的渗透性差,容易产生副作用而使疗效不尽人意.电刺激疗法是一种新颖的癌症疗法,其可以不利用化学、生物制剂产生抑癌效果,但存在操作复杂和难以制备微米级小型电刺激装置的问题.本文通过将光学3d微打印技术与化学镀工艺结合,成功制备了柔性微针阵列集成的叉指电极装置.其能够生成交变电场触发肿瘤细胞内线粒体的钙离子过载和细胞内活性氧的产生,导致损伤相关分子模式释放,从而激活免疫应答并引起肿瘤免疫原性细胞死亡.实验结果显示,本文的通电微针装置具有良好的生物安全性和全身抑瘤作用,抑制了原发肿瘤和远处肿瘤的生长以及黑色素瘤肺转移.因此,本文将电刺激与免疫疗法相结合,为无药物癌症治疗提供了新方向并为癌症治疗领域提供了创新思路.

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HACd1,a regulator of membrane composition and fluidity,promotes myoblast fusion and skeletal muscle growth

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分子细胞生物学报:英文版 2015年第5期7卷 429-440页

作者： Jordan Blondelle Yusuke Ohno Vincent Gache Stephane Guyot Sebastien Storck Nicolas Blanchard-Gutton Ines Barthelemy Gemma Walmsley Anaelle Rahier Stephanie Gadin Marie Maurer Laurent Guillaud Alexandre Prola Arnaud Ferry Genevieve Aubin-Houzelstein Jean demarquoy frederic Relaix Richard JPiercy Stephane Blot Akio Kihara Laurent Tiret Fanny Pilot-Storck Inserm IMRB U955-E1094000 CreteilFrance Universite Paris-Est Ecole nationale veterinaire d’Alfort(EnvA)94700 Maisons-AlfortFrance Universite Paris-Est Creteil Faculte de medecine94000 CreteilFrance Laboratory of Biochemistry Faculty of Pharmaceutical SciencesHokkaido UniversitySapporo 060-0812Japan Universite de Bourgogne UMR A 02.102 PAM-EPMBAgroSup Dijon21000 DijonFrance Institut Necker-Enfants Malades INSERM U1151-CNRS UMR 8253Sorbonne Paris CiteUniversite Paris DescartesFaculte de Medecine-Site Broussais75015 ParisFrance Comparative Neuromuscular disease Laboratory Department of Clinical Sciences and ServicesRoyal Veterinary CollegeLondon NW10TUUK Therapie des maladies du muscle strie INSERM U974-CNRS UMR7215-UPMC UM76-Institut de Myologie Universite Pierre et Marie Curie-Universite Paris Descartes75000 ParisFrance Universite de Bourgogne Faculte des Sciences GabrielBio-PeroxIL21000 DijonFrance

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies,yet the underlying cellular and molecular mechanisms remain *** this study,we investigate the role of HACd1/PTPLA,which is involved in the elongation of the very long chain fatty acids,in muscle fibre *** humans and dogs,HACd1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized *** of HACd1-deficient Labradors,Hacd1-knockout mice,and Hacd1-deficient myoblasts,we provide evidence that HACd1 promotes myoblast fusion during muscle development and *** further demonstrate that in normal differentiating myoblasts,expression of the catalytically active HACd1 isoform,which is encoded by a muscle-enriched splice variant,yields decreased lysophosphatidylcholine content,a potent inhibitor of myoblast fusion,and increased concentrations of≥C18 and monounsaturated fatty acids of *** lipid modifications correlate with a reduction in plasma membrane *** conclusion,we propose that fusion impairment constitutes a novel,non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACd1 is a key regulator of a lipid-dependent muscle fibre growth mechanism.

关键词： centronuclear myopathy LPC MUFA PTPLA VLCFA

装修设计网站Houzz获得红杉资本领投的d轮资金

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投资与合作 2014年第21期 99-99页

作者： frederic Lardinois

快速成长的室内外装修设计网站Houzz于10月1日宣布获得1.65亿美元d轮融资,领头方是其早期投资人红杉资本,其它的现有投资人,包括Oren Zeev、恩颐投资(New Enterprise Associates)、纪源资本(GGV)、凯鹏华盈(KPCB),以及本轮新加入的投资...

快速成长的室内外装修设计网站Houzz于10月1日宣布获得1.65亿美元d轮融资,领头方是其早期投资人红杉资本,其它的现有投资人,包括Oren Zeev、恩颐投资(New Enterprise Associates)、纪源资本(GGV)、凯鹏华盈(KPCB),以及本轮新加入的投资者dST GIobal、*** Price参与了跟投。Houzz并未透露自身的估值水平,但今年早些时候有消息披露称,当时的公司估值为23亿美元。

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