Mesenchymal stem cell-based therapy for ischemic stroke

作     者：Johnathon D.Anderson Missy T.Pham Zelenia Contreras Madeline Hoon Kyle D.Fink Henrik J.Johansson Julien Rossignol Anderson Johnathon D.;Pham Missy T.;Contreras Zelenia;Hoon Madeline;Fink Kyle D.;Johansson Henrik J.;Rossignol Julien;Dunbar Gary L.;Showalter Megan;Fiehn Oliver;Bramlett Charles S.;Bardini Renee L.;Bauer Gerhard;Fury Brian;Hendrix Kyle J.;Chedin Frederic;EL-Andaloussi Samir;Hwang Billianna;Mulligan Michael S.;Lehtiö Janne;Nolta Jan A.

作者机构：Department of Internal Medicine Stem Cell Program University of California Davis Davis USAInstitute for Regenerative Cures University of California Davis Medical Center 2921 Stockton Blvd Room 1300 Sacramento CA 95817 USA Department of Internal Medicine Stem Cell Program University of California Davis Davis USA Department of Oncology-Pathology Karolinska InstituteCancer Proteomics Davis USA College of Medicine Central Michigan University Mt PleasantUSA 

出 版 物：《Chinese Neurosurgical Journal》 (中华神经外科杂志（英文）)

年 卷 期：2016年第2卷第4期

页      面：233-238页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 1009[医学-特种医学] 

基　　金：NIH T32-GM008799, (NSF GROW 201111600, T32-GM008799) NIH T32-HL086350, (T32-HL086350) NIH Transformative R01GM099688, (R01GM099688) NIH U2DK097154, (U2DK097154) NSF GRFP 2011116000, (GRFP 2011116000) 

主　　题：Mesenchymal stem cells Exosomes Ischemic stroke 

摘      要：Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.