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A final size relation for epidemic models of vectortransmitted diseases

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Infectious Disease Modelling 2017年第1期2卷 12-20页

作者： fred Brauer University of British Columbia VancouverBCCanada

We formulate and analyze an age of infection model for epidemics of diseases transmitted by a vector,including the possibility of direct transmission as *** show how to determine a basic reproduction *** there is no explicit final size relation as for diseases transmitted directly,we are able to obtain estimates for the final size of the epidemic.

关键词： number. relation size

Mathematical epidemiology:Past,present,and future

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Infectious Disease Modelling 2017年第2期2卷 113-127页

作者： fred Brauer University of British Columbia VancouverBCCanada

We give a brief outline of some of the important aspects of the development of mathematical epidemiology.

关键词： Mathematical epidemiology brief

A singular perturbation approach to epidemics of vectortransmitted diseases

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Infectious Disease Modelling 2019年第1期4卷 115-123页

作者： fred Brauer University of British Columbia Vancouver BCCanada

In vector-borne epidemic models there is often a substantial difference between the vector and host time *** makes it possible to use the quasi-steady-state to obtain final size relations.

关键词： perturbation singular quasi

Modeling neuropsychiatric disorders using human induced pluripotent stem cells

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Protein & Cell 2020年第1期11卷 45-59页

作者： Meiyan Wang Lei Zhang fred H.Gage Laboratory of Genetics The Salk Institute for Biological Studies10010 N.Torrey Pines RdLa JollaCA 92037USA Neurobiology Section Division of Biological SciencesUniversity of California San DiegoLa JollaCA 92093USA

Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and widespread changes in anatomical *** the context of neuropsychiatric disorders,limited access to relevant tissue types presents challenges for understanding disease etiology and developing effective *** pluripotent stem cells(iPSCs)reprogrammed from patient somatic cells offer an opportunity to recapitulate disease development in relevant cell types,and they provide novel approaches for understanding disease mechanisms and for development of effective *** we review recent progress and challenges in differentiation paradigms for generating disease-relevant cells and recent studies of neuropsychiatric disorders using human pluripotent stem cell(hPSC)models where cellular phenotypes linked to disease have been *** use of iPSC-based disease models holds great promise for understanding disease mechanisms and supporting discovery of effective treatments.

关键词： neuropsychiatric disorders iPSCs brain organoid schizophrenia autism spectrum disorder bipolar disorder

A multi-metric approach for research evaluation

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Chinese Science Bulletin 2013年第26期58卷 3288-3290页

作者： RONALD Rousseau fred Y Ye VIVES (Association KU Leuven) Faculty of Engineering TechnologyZeedijk 1018400 Oostende Belgium Universiteit Antwerpen (UA) IBWStadscampus Venusstraat 352000 Antwerpen Belgium KU Leuven 3000 Leuven Belgium School of Information Management Nanjing University

Background information is provided about the Web 2.0 related term altmetrics. This term is placed in the context of the broader field of informetrics. The term influmetrics is proposed as a better term for altmetrics. The importance of considering research products and not just scientific publications is highlighted. Issues related to peer review and making funding decisions within a multi-metric approach are discussed and brought in relation with the new metrics field.

关键词：评价方法度量方法背景资料 Web 上下文出版物信息

Inflammatory bowel disease and thromboembolism

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World Journal of Gastroenterology 2014年第38期20卷 13863-13878页

作者： Petros Zezos Georgios Kouklakis fred Saibil Gastrointestinal Endoscopy Unit University General Hospital of AlexandroupolisDemocritus University of Thrace Division of Gastroenterology Department of Medicine Sunnybrook Health Sciences CentreUniversity of Toronto

Patients with inflammatory bowel disease (IBD) have an increased risk of vascular complications. Thromboembolic complications, both venous and arterial, are serious extraintestinal manifestations complicating the course of IBD and can lead to significant morbidity and mortality. Patients with IBD are more prone to thromboembolic complications and IBD per se is a risk factor for thromboembolic disease. Data suggest that thrombosis is a specific feature of IBD that can be involved in both the occurrence of thromboembolic events and the pathogenesis of the disease. The exact etiology for this special association between IBD and thromboembolism is as yet unknown, but it is thought that multiple acquired and inherited factors are interacting and producing the increased tendency for thrombosis in the local intestinal microvasculature, as well as in the systemic circulation. Clinicians’ awareness of the risks, and their ability to promptly diagnose and manage tromboembolic complications are of vital importance. In this review we discuss how thromboembolic disease is related to IBD, specifically focusing on: (1) the epidemiology and clinical features of thromboembolic complications in IBD; (2) the pathophysiology of thrombosis in IBD; and (3) strategies for the prevention and management of thromboembolic complications in IBD patients.

关键词： Inflammatory bowel disease Crohn’ s disease Ulcerative colitis Thrombosis Thromboembolism Hypercoagulability Epidemiology Endothelial dysfunction Treatment

Precision in harsh environments

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Microsystems & Nanoengineering 2016年第1期2卷 61-72页

作者： Paddy French Gijs Krijnen fred Roozeboom Faculty of Electrical Engineering Mathematics and Computer ScienceTU DelftDelftThe Netherlands Faculty of Electrical Engineering Mathematics and Computer ScienceTwente UniversityEnschedeThe Netherlands Eindhoven University of Technology Department of Applied PhysicsPO Box 5135600 MBEindhovenThe Netherlands TNO Holst Centre High Tech Campus 215656 AEEindhovenThe Netherlands

Microsystems are increasingly being applied in harsh and/or inaccessible environments,but many markets expect the same level of functionality for long periods of *** environments cover areas that can be subjected to high temperature,(bio)-chemical and mechanical disturbances,electromagnetic noise,radiation,or high *** the field of actuators,the devices must maintain stringent accuracy specifications for displacement,force,and response times,among *** new requirements present additional challenges in the compensation for or elimination of *** state-of-the-art precision devices lose their precision and reliability when exposed to harsh *** is also important that advanced sensor and actuator systems maintain maximum autonomy such that the devices can operate independently with low *** next-generation microsystems will be deployed in remote and/or inaccessible and harsh environments that present many challenges to sensor design,materials,device functionality,and *** of these aspects of integrated sensors and actuator microsystems require a multidisciplinary approach to overcome these *** main areas of importance are in the fields of materials science,micro/nano-fabrication technology,device design,circuitry and systems,(first-level)packaging,and measurement *** study examines the challenges presented by harsh environments and investigates the required *** of successful devices are also given.

关键词： atomic layer deposition harsh environments micro/nano-fabrication technology packaging sensors

Neural stem cells:mechanisms and modeling

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Protein & Cell 2012年第7期3卷 251-261页

作者： Jun Yao Yangling Mu fred H.Gage Laboratory of Genetics The Salk Institute for Biological StudiesLa JollaCA 92037USA

In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory *** derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological ***,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal *** addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal *** this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.

关键词： neural stem cell hippocampus olfactory bulb induced pluripotent stem cell neurodegenerative dis-ease neurodevelopmental disorder

On the Fourier Spectra of Distributions in Clifford Analysis

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Chinese Annals of Mathematics,Series B 2006年第5期27卷 495-506页

作者： fred BRACKX Bram De KNOCK Hennie De SCHEPPER Clifford Research Group Department of Mathematical Analysis Faculty of EngineeringGhent UniversityGalglaan 29000 GentBelgium

In recent papers by Brackx, Delanghe and Sommen, some fundamental higher dimensional distributions have been reconsidered in the framework of Clifford analysis, eventually leading to the introduction of four broad classes of new distributions in Euclidean space. In the current paper we continue the in-depth study of these distributions, more specifically the study of their behaviour in frequency space, thus extending classical results of harmonic analysis.

关键词： Fourier spectra Distributions Clifford analysis