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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Isma■l hervé Koumakpayi Cécile Le Page Laurent Lessard Jean-Simon Diallo Philippe O. Gannon Benjamin Péant Nathalie Delvoye Anne-Marie Mes-Masson fred Saad ChUM-höpital Notre-Dame Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada Institut du cancer de Montréal 1560 rue Sherbrooke Est MontréalQuébecH2L 4M1Canada

＜正＞Background and Aims: The treatment of prostate cancer （PCa） depends on stage. To improve treatment strategies, it would be helpful to have reliable molecular markers able to predict PCa progression. however, to date, such markers have not yet been included in therapeutic decisions. Recently, several studies from our laboratory described the prognostic potential of molecular markers that include ErbB3, Akt and Nuclear Factor kappaB （NF- κB） . ErbB3 is a member of the growth factor receptor family ErbB. Akt is a signaling component of the ErbB receptor family. Phos-phoinositol 3 - kinase （PI3K） through Akt regulates downstream signaling proteins such as NF - κB. Most of these molecules are often overexpressed and/or activated in cancer cells. Furthermore, they can be detected in the cytoplasm and/or nucleus of PCa cells. They are known to be involved in cell survival, cell growth, cell cycle progression and apoptotic response. The aim of our study was to determine whether these molecules could be used as markers to predict PCa progression.

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金属羰基化合物氧原子转移反应——在PhIO存在下Cr（CO）6的CO取代反应动力学与机理的研究

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无机化学学报 1988年第4期 145-149页

作者：申建坤,师颜龙,高忆慈,史启祯,fred Basolo 兰州大学化学系兰州大学化学系兰州大学化学系兰州大学化学系美国西北大学化学系

亚碘酰苯作为氧原子转移试剂越来越引起人们的注意。Patton曾在PhIO存在的条件下合成了〔η5-C5（Ch3）5ReCONOPPh3〕BF4,指出PhIO可能氧化消除了一个羰基。但有关PhIO与金属羰基化合物反应的动力学研究未见报道。为了解其反应性质,我... 详细信息

亚碘酰苯作为氧原子转移试剂越来越引起人们的注意。Patton曾在PhIO存在的条件下合成了〔η5-C5（Ch3）5ReCONOPPh3〕BF4,指出PhIO可能氧化消除了一个羰基。但有关PhIO与金属羰基化合物反应的动力学研究未见报道。为了解其反应性质,我们对在PhIO存在下Cr（CO）6的取代反应进行了研究。

关键词：亚碘酰苯六羰基合铬氧原子转移动力学

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Numerical Bifurcation Methods and their Application to Fluid Dynamics: Analysis beyond Simulation

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Communications in Computational Physics 2014年第1期15卷 1-45页

作者： henk A.Dijkstra fred W.Wubs Andrew K.Cliffe Eusebius Doedel Ioana F.Dragomirescu Bruno Eckhardt Alexander Yu.Gelfgat Andrew L.hazel Valerio Lucarini Andy G.Salinger Erik T.Phipps Juan Sanchez-Umbria henk Schuttelaars Laurette S.Tuckerman Uwe Thiele Institute for Marine and Atmospheric Research Utrecht Utrecht UniversityThe Netherlands. Department of Mathematics and Computer Science University of GroningenGroningenThe Netherlands. School of Mathematical Sciences University of NottinghamNottinghamUK Department of Computer Science Concordia UniversityMontrealCanada. National Centre for Engineering Systems of Complex Fluids University Politehnica of TimisoaraRomania. Fachbereich Physik Philipps-Universitat MarburgMarburgGermany. School of Mechanical Engineering Faculty of EngineeringTel-Aviv UniversityTel-AvivIsrael. School of Mathematics University of ManchesterManchesterUK. Meteorological Institute KlimacampusUniversity of HamburgHamburgGermany. Department of Mathematics and Statistics University of ReadingReadingUK. Sandia National Laboratories AlbuquerqueUSA. Departament de Fisica Aplicada Universitat Politecnica de CatalunyaBarcelonaSpain. Department of Applied Mathematical Analysis TU DelftDelftthe Netherlands. PMMh-ESPCI ParisFrance. Department of Mathematical Sciences Loughborough UniversityLoughboroughUK.

We provide an overview of current techniques and typical applications of numerical bifurcation analysis in fluid dynamical *** of these problems are characterized by high-dimensional dynamical systems which undergo transitions as parameters are *** computation of the critical conditions associated with these transitions,popularly referred to as‘tipping points’,is important for understanding the transition *** describe the two basic classes of methods of numerical bifurcation analysis,which differ in the explicit or implicit use of the Jacobian matrix of the dynamical *** numerical challenges involved in both methods are mentioned and possible solutions to current bottlenecks are *** demonstrate that numerical bifurcation techniques are not restricted to relatively low-dimensional dynamical systems,we provide several examples of the application of the modern techniques to a diverse set of fluid mechanical problems.

关键词： Numerical bifurcation analysis transitions in fluid flows high-dimensional dynamical systems.

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现代主义，评论，现实主义

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丛书名：二十世纪西方美术理论译丛

1991年

作者：（英）哈里森（harrison Charles）（英）奥　顿（Orton fred）编崔　诚等译

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InAs/InAsSb Avalanche Photodiode (APD) for applicaions in long-wavelength infrared region

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Optoelectronics Letters 2008年第5期4卷 342-346页

作者： P.K.Maurya h.Agarwal A.Singh P.Chakrabarti Center for Research in Microelectronics Department of Electronics EngineeringInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005India

A generic numerical model of a long-wavelength Avalanche Photodiode （APD） based on narrow bandgap semiconductor InAsSb on InAs substrate is reported for the first time. This model has been applied for theoretical characterization of a proposed N^＋ InAS/P-InAsSb avalanche photodiode structure for possible application in 2-5 μm wavelength region. The parameters such as gain, excess noise factor and their trade-off with variation of doping concentration and bias voltage have been estimated for the APD taking into account history-dependent theory of avalanche multiplication process, The LWIR APD is expected to fred application in optical gas sensor and in future generation of optical communication system.

关键词：长波长紫外线区域雪崩二极管数字模型

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-lormone levels following surgical and medical castration： defining optimal androgen suppression

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Asian Journal of Andrology 2018年第4期20卷 405-406页

作者： Michael T Schweizer Michael L hancock Robert h Getzenberg Evan Y Yu Division of Oncology Department of Medicine University of Washington Seattle WA 98116 USA Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA 98116 USA Veru healthcare Miami FL 33137 USA

Dear Editor, In the 1940s, Charles huggins discovered that surgical castration produced remarkable palliative benefits for men with advanced prostate cancer, an effect we now understand to be mediated through deprivi...

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Epidemiological Aspects of Female Urological Diseases, at the National University Teaching hospital h. K. Maga of Cotonou from 2008 to 2017

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Open Journal of Urology 2018年第10期8卷 281-288页

作者： Dodji Magloire Ines Yevi Josue Dejennin Georges Avakoudjo Detondji fred Jean-Martin hodonou Yves Nsounfou Ngapna Jean Sossa Gilles Natchagande Fouad Kolawole Yde Soumanou Michel Michael Agounkpe University Clinic of Urology-Andrology of the National University Teaching hospital h.K.MAGA of Cotonou(CNhU-hKM) CotonouBenin

Most urological conditions are represented by male disorders. Analyzing certain epidemiological aspects of female urological disorders at the National University Teaching hospital of Cotnou, will allow us objectively to have reliable data to optimize the urological management of women. Patients and Methods: This was a retrospective, analytical and descriptive study that was conducted at the CNhU-hKM over a 10-year period from January 2008 to December 2017 on the epidemiological aspects of female urological diseases from the study of patient records. The variable studied was: the age, the profession, the year of admission, the organ affected, and the type of pathology. The confidentiality of the data has been ensured. Results: Female urological disorders over 10 years accounted for 9.62% of all patients received in Urology Department. The age group greater than 50 years was the most common at 31.34%. Traders and housewives were the most numerous (39.93% and 14.55%). Bladder diseases were the most frequent (51.50), dominated by vesico-vaginal fistulas (29.85%). In addition to fistulas, tumoral affections were most prevalent at 27.99% followed by infectious diseases at 8.21%. The lithiasic affections were infrequent at 6.72%. Conclusion: Female urological conditions are infrequent but not negligible, dominated by vesico-vaginal fistulas and tumors in the context of developing countries. The specific evaluation of each pathology group can help optimize management.

关键词： Female Urological Diseases Vesico-Vaginal Fistulas Cotonou Benin

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Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer

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四川生理科学杂志 2022年第12期44卷 2100-2100页

作者： John h Strickler Duke University Medical Center Durham NC United States Kansai Medical University Shinmachi Hirakata Japan St. Marianna University School of Medicine Kawasaki Japan University of Florida Gainesville United States Memorial Sloan Kettering Cancer Center New York United States Gustave Roussy Cancer Center Université Paris-Saclay Villejuif France Marseille University hospital Marseille France huntsman Cancer Institute University of Utah Salt Lake City United States West German Cancer Center University Hospital Essen Essen Germany University of Pittsburgh Medical Center Hillman Cancer Center Pittsburgh United States fred hutchinson Cancer Center University of Washington Seattle United States Sarah Cannon Research Institute at healthONE Denver United States London Regional Cancer Program London ON Canada University hospitals Cleveland Medical Center Cleveland United States Yonsei Cancer Center Seoul South Korea Scientia Clinical Research and Prince of Wales Clinical School University of New South Wales Sydney Australia Massachusetts General Cancer Center Boston United States Amgen Thousand Oaks CA United States University of Texas M.D. Anderson Cancer Center Houston United States

Background:KRAS p.G12C mutation occurs in approximately 1 to 2%of pancreatic *** safety and efficacy of sotorasib,a KRAS G12C inhibitor,in previously treated patients with KRAS p.G12C-mutated pancreatic cancer are ***:We conducted a single-group,phase 1-2 trial to assess the safety and efficacy of sotorasib treatment in patients with KRAS p.G12C-mutated pancreatic cancer who had received at least one previous systemic therapy.

关键词： KRAS cancer Cancer

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A pilot study of the association between genetic polymorphisms involved in estrogen signaling and infant male genital phenotypes

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Asian Journal of Andrology 2012年第5期14卷 766-772页

作者： Sheela Sathyanarayana Shanna h Swan Federico M Farin hui-Wen Wilkerson Michael Bamshad Richard Grady Chuan Zhou Stephen M Schwartzy Department of Pediatrics University of WashingtonSeattleWA 98195USA Center for Child health Behaviorand DevelopmentSeattle Children's Research InstituteSeattleWA 98105USA Department of Preventive Medicine Mount Sinai School of MedicineNew YorkNY 10029USA Department of Environmental and Occupational health Sciences University of WashingtonSeattleWA 98195USA Department of Genome Sciences University of WashingtonSeattleWA 98195USA Division of Pediatric Urology Seattle Children's HospitalSeattleWA 98105USA Department of Epidemiology University of WashingtonSeattleWA 98195USA Epidemiology Program Fred Hutchinson Cancer Research CenterSeattleWA 98109USA

Single nucleotide polymorphisms （SNPs） in genes that influence development of the male reproductive tract have been associated with male genitourinary abnormalities. however, no studies have tested the relationship between SNPs and intermediate phenotypes such as anogenital distance （AGD）, anoscrotal distance （ASD） and penile width （PW）. We tested whether 24 common SNPs in eight genes that influence male genital development were associated with intermediate phenotypes in 106 healthy male infants from the Study for Future Families. We used DNA from buccal smears and linear regression models to assess the relationship between anogenital measurements and SNP genotypes with adjustment for covariates. We found that the rs2077647 G allele, located in the coding region of estrogen receptor alpha （ESR1）, was associated with a shorter AGD （P=0.02; -7.3 mm, 95% confidence interval （CI）： -11.6 to -3.1）, and the rs10475 T allele, located in the 3＇ untranslated region of activating transcription factor 3 （ATF3）, was associated with a shorter ASD （-4.3 mm, 95% Ch -7.2 to -1.4）, although this result was not significant （P=0.07） after controlling for multiple comparisons. We observed no association between PW and the SNPs tested. Minor alleles for two SNPs in genes that regulate estrogen signaling during male genital development were associated with AGD and ASD, although the significance of the association was marginal. Our findings suggest that AGD and ASD are influenced by heritable factors in genes known to be associated with frank male genital abnormalities such as hvpospadias and crvotorchidism.

关键词： gene hypospadias male phenotype polymorphism reproductive

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东南沿海地区古近纪大陆岩石圈地幔特征及成因

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地学前缘 2003年第3期10卷 77-85页

作者：赵海玲 fred A.FREY hANG Shichun 于俊吉邓晋福刘振文李凯明狄永军赵国泉刘清华岩石圈构造深部过程及探测技术教育部重点实验室北京100083 中国地质大学地球科学与资源学院北京100083 美国麻省理工学院美国马萨诸塞州坎布里奇MA02139

东南沿海地区新生代玄武岩中的橄榄岩包体来自岩石圈地幔 ,上地幔橄榄岩包体的岩石学及地球化学特征都记录了地幔演化的历史。普宁橄榄岩包体斜方辉石含量与太古宙克拉通地幔类似 ,但在矿物学、REE、痕量元素和Sr Nd同位素上又与太古宙... 详细信息

东南沿海地区新生代玄武岩中的橄榄岩包体来自岩石圈地幔 ,上地幔橄榄岩包体的岩石学及地球化学特征都记录了地幔演化的历史。普宁橄榄岩包体斜方辉石含量与太古宙克拉通地幔类似 ,但在矿物学、REE、痕量元素和Sr Nd同位素上又与太古宙岩石圈地幔不同。橄榄岩包体的岩相学、矿物学、REE、痕量元素特征都提供了含h2 O富Si流体交代橄榄岩的证据 ,这种流体可能主要是洋壳物质局部熔融而成。流体交代使橄榄岩富Si,同时富Sr、Pb和强不相容元素等大洋岩石圈物质。这表明普宁大陆岩石圈地幔既保留太古宙岩石圈地幔的特征 ,又具有大洋俯冲地幔的特征 ,它是古老岩石圈地幔向大洋岩石圈地幔转换的一部分 ,这种转换可能是大洋岩石圈与大陆岩石圈地幔相互作用的结果。

关键词：东南沿海地区俯冲作用大陆岩石圈地幔地幔橄榄岩流体

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