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Clinical high-risk criteria of psychosis in 8–17-year-old community subjects and inpatients not suspected of developing psychosis

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World Journal of Psychiatry 2022年第3期12卷 425-449页

作者： frauke Schultze-Lutter Petra Walger Maurizia Franscini Nina Traber-Walker Naweed Osman Helene Walger Benno G Schimmelmann Rahel Flückiger Chantal Michel Department of Psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40629North-Rhine WestphaliaGermany Department of Psychology Faculty of PsychologyAirlangga UniversitySurabaya 60286Indonesia University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of BernBern 3000Switzerland Department of Child and Adolescent Psychiatry and Psychotherapy University of ZürichZürich 8032Germany Department of Psychiatry and Psychotherapy Ludwig-Maximilian-UniversityMunich 80336BavariaGermany University Hospital of Child and Adolescent Psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND In children and adolescents compared to adults,clinical high-risk of psychosis(CHR)criteria and symptoms are more prevalent but less psychosis-predictive and less clinically *** on high rates of non-converters to psychosis,especially in children and adolescents,it was suggested that CHR criteria were:(1)Pluripotential;(2)A transdiagnostic risk factor;and(3)Simply a severity marker of mental disorders rather than specifically *** any of these three alternative explanatory models were true,their prevalence should differ between persons with and without mental disorders,and their severity should be associated with functional impairment as a measure of *** To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and *** In the mainly cross-sectional examinations,8–17-year-old community subjects(n=233)randomly chosen from the population register of the Swiss Canton Bern,and inpatients(n=306)with primary diagnosis of attention-deficit/hyperactivity disorder(n=86),eating disorder(n=97),anxiety including obsessive–compulsive disorder(n=94),or autism spectrum disorder(n=29),not clinically suspected to develop psychosis,were examined for CHR symptoms/*** items of the Structured Interview for Psychosis-Risk Syndromes(SIPS)were used to assess the symptomatic ultra-high-risk criteria,and the Schizophrenia Proneness Instrument,Child and Youth version(SPI-CY)was used to assess the 14 basic symptoms relevant to basic symptom *** examined group differences in frequency and severity of CHR symptoms/criteria usingχ^(2) tests and nonparametric tests with Cramer’s V and Rosenthal’s r as effect sizes,and their association with functioning using correlation *** The 7.3%prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%rate in *** and severity of CHR criteria never differed bet

关键词： Psychotic disorders Risk assessment Minors Community Inpatients Psychosocial functioning

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A novel calcium-binding site of von Willebrand factor A2 domain provides new insights into the regulatory mechanism of A2 cleavage by ADAMTS13

A novel calcium-binding site of von Willebrand factor A2 dom...

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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Carsten Baldauf Timothy A.Springer frauke Grater Graduate School of Chinese Academy of Sciences 320 Yue-Yang RoadShanghai 200031China Immune Disease Institute Children’s Hospital Boston and Department of PathologyHarvard Medical School Heidelberg Institute for Theoretical Studies HeidelbergGermany

von Willebrand Factor(VWF) plays an important role in primary hemostasis through mediating platelet *** proteolysis of VWF by ADAMTS13 is an essential step for regulation of its hemostatic and thrombogenic *** cleavage occurs at strand β4 in the structural core of the A2 domain of VWF,thus unfolding of the A2 domain is pre-requisite for the *** investigate the molecular mechanism

关键词： domain ADAMTS A novel calcium-binding site of von Willebrand factor A2 domain provides new insights into the regulatory mechanism of A2 cleavage by ADAMTS13

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Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages

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World Journal of Gastroenterology 2007年第7期13卷 1032-1041页

作者： Tanja Spoettl Martin Hausmann Katrin Menzel Heidi Piberger Hans Herfarth Juergen Schoelmerich frauke Bataille Gerhard Rogler Department of Internal Medicine I and Institute of Pathology University of Regensburg Regensburg 93042 Germany

AIM: To examine the factor(s) involved in differentiation of intestinal macrophages (IMACs) using a recently established in vitro model. METHODS: To test whether soluble or membrane bound factors induce IMAC-differentiation, freshly elutriated monocytes (MO) were incubated with conditioned media or cell membranes of intestinal epithelial cells (IEC) or cultured with IEC in transwell systems. To determine the importance of an active migration of MO, three- dimensional aggregates from a 1:1-mixture of MO and IEC were examined by immunohistochemistry and flow cytometry. Apoptosis was examined by caspase-3 Western blots. Extracellular matrix production in differentiation models was compared by immunohistochemistry. RESULTS: IMAC differentiation was observed in a complex three-dimensional co-culture model (multicellular spheroid, MCS) with IEC after migration of MO into the spheroids. By co-culture of MO with conditioned media or membrane preparations of IEC no IMAC differentiation was induced. Co-culture of MO with IEC in transwell- cultures, with the two cell populations separated by a membrane also did not result in intestinal-like differentiation of MO. In contrast to IEC-spheroids with immigrating MO in mixed MCS of IEC and MO only a small subpopulation of MO was able to survive the seven day culture period. CONCLUSION: Intestinal-like differentiation of MO in vitro is only induced in the complex three-dimensional MCS model after immigration of MO indicating a roleof cell-matrix and/or cell-cell interactions during the differentiation of IMACs.

关键词： Intestinal macrophages Intestinal epithelialcells Multicellular spheroids Inflammatory boweldisease Tolerance differentiation

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Living Matter in Crash Test:How Biomolecules Respond to Mecha nical Forces

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Bulletin of the Chinese Academy of Sciences 2014年第2期28卷 195-197页

作者： Max Planck-CAS Research Group on Protein Mechanics Evolution frauke Grater Max Planck-CAS Research Group on Protein Mechanics Evolution

The Group on Protein Mechanics and Evolution at the CAS-MPG Partner Institute for Computational Biology,Shanghai,was established in January 2007 and headed by *** Gr?*** Klaus Tschira Lab has continued the eff orts of this former Independent Junior Research Group,since ***?ter took up a position at the Heidelberg Institute of Theoretical Studies(HITS)in Heidelberg,Germany。

关键词： Living Matter Test:Biomolecules

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Qualitative and Quantitative Perfusion Parameters Determined by 3D Single-Shot GRASE ASL MR Imaging

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Open Journal of Medical Imaging 2012年第1期2卷 1-9页

作者： Claus Kiefer frauke Kellner-Weldon Marwan El-Koussy Martinus Hauf Gerhard Schroth Support Center for Advanced Neuroimaging Institute of Diagnostic and Interventional Neuroradiology University of Bern (Inselspital) Bern Switzerland

Rationale and Objectives: A particular arterial spin (ASL) labeling technique, called 3D-single-shot GRASE ASL is discussed with respect to the ability and limits of quantifying perfusion parameters. Materials and Methods: The technique enables the acquisition of perfusion weighted signal at multiple delay times (TI) in one scan. The readout part is a gradient and spin-echo combination (GRASE) that uses switched gradient rephrasing of signals to produce several times as many signals as turbo-spin-echo, which translates into faster imaging time and higher signal-to-noise ratio (SNR) per imaging time. The technique provides the possibility for model based quantification of cerebral blood flow and the determination of the bolus arrival information without use of contrast agent and thus the characterization and determina-tion of regions that are supported by collaterals. Results: Whereas for a quantification of the permeability using ASL the SNR is not high enough, at least qualitative permeability maps can be determined, if an optimal homogenous SNR was guaranteed. This was accomplished in brain regions with a high blood supply, typically given in tumors, and by using a correction for coil sensitivity at the highest possible additional scaling. Conclusion: The single-shot 3D GRASE ASL can provide information about the principal blood supply, the transit delay of the blood flow due to a stenosis or collaterals and a qualitative measure of the permeability.

关键词： ASL Perfusion GRASE Model Permeability

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标准组件：小批量组件冲压工具

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现代制造 2016年第36期 66-67页

作者： frauke Finus

众所周知，德国有两个地区以冲压工艺闻名，分别是Sauerland地区与Pforzheim附近地区。KarlFriedrich于1767年创立了珠宝与制表业，自此Pforzheim这座城市便名满天下，直至如今仍有约75％的德国珠宝产品在此生产制造。

关键词：冲压工艺标准组件小批量工具生产制造德国珠宝

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Body Pushers: Low-Dose CT, Always the Best Choice? A Study of the Diagnostic Performance of CT Scout View

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Open Journal of Radiology 2017年第2期7卷 112-120页

作者： Robin Fabian Gohmann frauke Heckner Diane Uschner Christiane Katharina Kuhl Sebastian Daniel Reinartz Department of Diagnostic and Interventional Radiology University Hospital RWTH Aachen University Aachen Germany University Hospital RWTH Aachen University Aachen Germany Department of Medical Statistics University Hospital RWTH Aachen University Aachen Germany

Purpose: The purpose of this study has been to evaluate the diagnostic information contained in the CT scout view in the detection of body packing. Materials and methods: Retrospect analysis of 43 CT scans between July 2011 and June 2013 in asymptomatic suspects of body packing (29 men, 14 females, mean age 38 ± 9 years). Results: A total of 11 positive cases of body packing were identified. In 10 (91%) of the cases packets were relatively large and spares in number (3 or less);in 7 (64%) a single packet has been identified. 6 (55%) of the packets were located rectally, 4 (36%) vaginally and in 1 (9%) case multiple small packets of approximately 1 cm in size were found to have been ingested orally. Maximum and minimum diameters were 5.9 ± 3 cm and 2.9 ± 1.4 cm, respectively. The mean weight of packets was 7.5 ± 4.2 g (range 2 - 54 g). In 73% (n = 8) heroin had been detected;other drugs such as cocaine (n = 1) and cannabis (n = 1) were encountered once, respectively. One packet was identified retrospectively and its content could therefore not be identified. The average effective dose was 3.8 ± 2.1 mSv for CT, of that 0.12 ± 0.01 mSv was required for the CT scout view. Conclusion: If CT scout view were treated as a diagnostic image, some CT scans may be omitted, thereby maintaining streamlined operations and achieving further dose reduction jointly in the workup of body packing.

关键词： Body Packing CT Scout View CT Dose Reduction X-Ray

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Euroblech的夜晚——在博览周期间出去走走

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现代制造 2014年第34期 108-109页

作者： frauke FINUS

品酒并欣赏钢琴曲，南美的气息，半夜的比萨，一个男人要抛弃他的妻子，而另一个男人想要他的妻子回来，Frank Schatzing和Roman Lob——汉诺威提供的不仅仅是博览会场地。尽情享受Euroblech后的休闲时光吧！

关键词：周期夜晚钢琴曲博览会汉诺威 Lob 男人

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精密冲裁节约时间和成本

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现代制造 2022年第1期 20-21页

作者： frauke Finus 不详

众所周知,灯具中的所有连接件和变型连接件都固定在灯具中,以确保光源的电气接触。过去,这些传统的冲压件和弯曲件一直都是典型的钣金加工件。当前,它们都在伺服冲压机中进行生产。标准件生产厂商提供的这种专业化的伺服冲压-折弯机可... 详细信息

众所周知,灯具中的所有连接件和变型连接件都固定在灯具中,以确保光源的电气接触。过去,这些传统的冲压件和弯曲件一直都是典型的钣金加工件。当前,它们都在伺服冲压机中进行生产。标准件生产厂商提供的这种专业化的伺服冲压-折弯机可以节约时间和生产成本。照明技术专业厂BJB公司利用Bihler公司生产制造的标准数控冲压设备生产制造符合Meusburger公司标准的钣金件,因此节约了大笔的资金和大量的时间。

关键词：精密冲裁钣金加工数控冲压弯曲件折弯机冲压件钣金件冲压机

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激光应完美地整合为工艺的一部分

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现代制造 2014年第34期 92-95页

作者： frauke FINUS

激光切割与焊接设备提供了高度的灵活性，可获得高质量的加工效果。重要的是，我们不能只看到这些设备本身，而是要看到设备以外的东西，以便于将激光加工以最优的方式集成到生产工艺中去。目前，激光加工已经在微观与宏观领域站稳了... 详细信息

激光切割与焊接设备提供了高度的灵活性，可获得高质量的加工效果。重要的是，我们不能只看到这些设备本身，而是要看到设备以外的东西，以便于将激光加工以最优的方式集成到生产工艺中去。目前，激光加工已经在微观与宏观领域站稳了脚跟。无论是作为热分离工艺或是焊接工艺，激光束的加工处理提供了众多优势。相比其他分离与连接工艺，激光技术都表现得非常出色。

关键词：激光切割生产工艺整合焊接设备激光加工分离工艺加工效果焊接工艺

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