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Non-coding RNAs in exercise immunology:A systematic review

Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： Mona Kotewitsch Melina Heimer Boris Schmitz frank c.mooren Department of Rehabilitation Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflammation,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regulation,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systematic review and qualitative analysis was used to identify and categorize ncRNAs participating in immune modulation by physical *** combined approaches were used:(a)a systematic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DIANA-Tarbase v8)aligned with known target genes in the immune system based on the Reactome database,combined with a systematic literature search for“ncRNA and exercise”.Literature searches were based on PubMed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets validated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qualitative *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise modality(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“validated”with 100%of≥3 independent studies showing identical direction of regulation,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregulation of miR-206 was validated while downregulation of miR-133a appeared *** endurance exer

关键词： Immune system Inflammation MicroRNA ncRNA Physical exercise

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Solving traffic data occlusion problems in computer vision algorithms using DeepSORT and quantum computing

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 1-15页

作者： frank Ngeni Judith Mwakalonge Saidi Siuhi Department of Engineering South Carolina State UniversityOrangeburgSC 29117USA

Inaccuracies of traffic sensors during traffic counting and vehicle classification have persisted as transportation agencies have been prompted to calibrate sensors *** of multiple objects,heavy occlusions,and similar appearances in congested places are some causes of computer vision model *** paper used the YOLOv5 model for detection and the DeepSORT model for tracking *** to the nature of the reported problem caused by many misses and mismatches,the power of quantum computing with the alternating direction method of multipliers(ADMM)optimizer was leveraged.A basic Kalman filter and the Hungarian algorithm features were used in combination with a quantum optimizer to present robust multiple object tracking(MOT)*** hybrid combination of the classical and quantum model has fastened learning the occludes during frame matching of tracks and detections by generating minimum quantum cost function *** with the existing models indicated a significant increase in the primary MOT metric multiple object tracking accuracy(MOTA)by 16%more than the regular YOLOv5-DeepSORT model when using a quantum ***,a 6%multiple object tracking precision(MOTP)increases and a 6%identification metrics(F_(1))score increase were observed using the quantum optimizer with identity switching reduced from 6 to *** model is expected to assist transportation officials in improving the accuracy of traffic counts and vehicle classification and reduce the need for regular computer vision software calibration.

关键词： Traffic classification Traffic counting DeepSORT YOLOv5 Quantum computing

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Handheld bedside ultrasound in the diagnosis of myocarditis

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World Journal of Emergency Medicine 2024年第1期15卷 73-74页

作者： frank Wheeler Robin Lahr James Espinosa Alan Lucerna Henry Schuitema Department of Emergency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emergency Medicine Residency Program Jeff erson HealthStratford 08084USA Department of Emergency Medicine and Associate chief Medical Offi cer Stratford 08084USA

Myocarditis is a disease process that every emergency physician fears *** severity can be mild to life-threatening,and many cases are likely undetected because they are subclinical with nonspecifi c signs.[1]Subtle cardiac signs may be overshadowed by systemic symptoms of the underlying infectious ***,myalgias,lethargy,symptoms commonly associated with viral syndrome,can mask the life-threatening myocarditis that may be *** fact,in the United States Myocarditis Treatment Trial,almost 90%of patients reported symptoms consistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myocarditis had either reduced left ventricular ejection fraction,ventricular arrhythmias,or low cardiac ***,we present a case report,in which handheld point-of-care ultrasound was utilized at the bedside to aid in the critical diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary care facility in an expeditious manner and receive possible defi nitive treatment.

关键词： diagnosis myocarditis Fever

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Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(EcM) interactions leading to assembly of integrin adhesion complexes(IAcs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

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嗜铬细胞瘤和副神经节瘤的系统性放射性药物治疗

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中华核医学与分子影像杂志 2024年第3期44卷 187-192页

作者：席闯(译) 罗全勇(审校) 上海交通大学医学院附属第六人民医院上海200233

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生... 详细信息

良性嗜铬细胞瘤和副神经节瘤通常可以通过手术切除治愈,但转移性疾病的治疗在疾病控制和症状控制方面都存在挑战。幸运的是,有几种治疗方式可用于转移性疾病的治疗,包括化疗、放射治疗和外科手术。放射性核素标记的间碘苄胍(MIBG)和生长抑素受体显像为将这些放射性药物用作诊疗剂奠定了基础。^(131)I-MIBG治疗神经内分泌肿瘤历史悠久,美国食品与药品监督管理局最近批准将高比活度^(131)I-MIBG用于治疗转移性或不可手术的嗜铬细胞瘤或副神经节瘤,使^(131)I-MIBG的治疗应用更加广泛,并重新引起人们的兴趣。尽管已有文献报道使用90Y-或177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)偶联的生长抑素类似物对嗜铬细胞瘤和副神经节瘤进行多肽受体放射性核素治疗,但随着177Lu-DOTA-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)在美国和欧洲获批,以及美国国家综合癌症网络指南建议将其用于转移性或不可手术的嗜铬细胞瘤和副神经节瘤患者,这些药物引起了人们新的兴趣。已有证据表明这些放射性药物是对转移性或无法手术的嗜铬细胞瘤或副神经节瘤患者有效的姑息治疗方法。在该篇继续医学教育文章中,作者讨论了使用^(131)I-MIBG和90Y-或177Lu-DOTA生长抑素类似物治疗嗜铬细胞瘤和副神经节瘤。

关键词：嗜铬细胞瘤副神经节瘤生长抑素 MIBG DOATATE 多肽受体放射性核素治疗

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Effects of Added Mass on Muscle Activity and Joint Movement During Walking

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Journal of Bionic Engineering 2023年第6期20卷 2703-2715页

作者： Yali Han frank c.Sup IV Ziyang Han Zhangzhang Mi Department of Mechanical Engineering Nanjing Institute of TechnologyNanjing211167China Department of Mechanical and Industrial Engineering University of MassachusettsAmherstMA01003USA

Added mass provided irregular interference towards human movement and shifted the force generated by lower limb ***,the association between mass and muscle activities is not well *** study aims at investigating the influence of added mass on lower *** our study,five young,healthy walkers performed walking trials under three load conditions(unload;c1:0.25 pounds on feet,1 pound on calves,and 2 pounds on thighs;c2:1 pound on feet,2 pounds on calves,and 4 pounds on thighs).During walking,three-dimensional kinematics,sEMG signals,and oxygen consumption were collected which allowed us to understand the effects of added mass on *** also generated OpenSim simulation,designed to comprehend the relationship between added mass and *** the increase of added mass,maximum sEMG signal and peak joint torque increased;whereas,the horizontal stride time reduced(unload:1.697±0.02 s,c1:1.651±0.02 s,c2:1.622±0.02 s).Energy expenditure raised correspondingly(c1:6.53%,c2:24.85%).Moreover,joint moment increased,while same change occurred in muscle ***,our results show that participants responded positively to additional mass by adjusting muscle activities,joint movement,and stride frequency,which demonstrates the relationship between energy consumption and added mass.

关键词： Biomechanics Load carriage Gait Muscle force

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Impact on Soil Organic c and Total Soil N from cool- and Warm-Season Legumes Used in a Green Manure-Forage cropping System

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Agricultural Sciences 2024年第3期15卷 333-357页

作者： clark B. Neely Francis M. Rouquette Jr. cristine L.S. Morgan frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA chief Scientific Officer Soil Health Institute Morrisville NC USA Department of Soil and crop Science Texas A&M University College Station TX USA

Annual forage legumes are important components of livestock production systems in East Texas and the southeastern US. Forage legumes contribute nitrogen (N) to cropping systems through biological N fixation, and their seasonal biomass production can be managed to complement forage grasses. Our research objectives were to evaluate both warm- and cool-season annual forage legumes as green manure for biomass, N content, ability to enhance soil organic carbon (SOc) and soil N, and impact on post season forage grass crops. Nine warm-season forage legumes (WSL) were spring planted and incorporated as green manure in the fall. Forage rye (Secale cereale L.) was planted following the incorporation of WSL treatments. Eight cool-season forage legumes (cSL) were fall planted in previously fallow plots and incorporated as green manure in late spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was planted over all treatments in early summer after forage rye harvest and incorporation of cSL treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N concentration. Soil cores were taken from each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm, and soil c and N were measured using combustion analysis. Nylon mesh bags containing plant samples were buried at 15 cm and used to evaluate decomposition rate of above ground legume biomass, including change in c and N concentrations. Mungbean (Vigna radiata L. [Wilczek]) had the highest shoot biomass yield (6.24 t DM ha-1) and contributed the most total N (167 kg∙ha-1) and total c (3043 kg∙ha-1) of the WSL tested. Decomposition rate of WSL biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum L. spp. sativum), arrow leaf clover (Trifolium vesiculosum Savi.), and crimson clover (Trifolium incarnatum L.) were the most productive cSL in this trial. Austrian winter pea

关键词： Annual Legumes Soil N Soil Organic c Green Manure Deer Browse Forage cropping Systems

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Legume Green Manure and Intercropping for High Biomass Sorghum Production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： clark B. Neely Francis M. Rouquette Jr. cristine L. S. Morgan frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [cynodon dactylon (L.) Pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, c concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOc). Main plots were split into crimson clover green manure (cLGM) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (cPGM), cowpea-sorghum intercrop (cPSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The cLGM increased (P sorghum biomass yield (16.5 t DM∙ha−1) 28% in year three but had no effect in the first two years. The cPSR treatment reduced sorghum yield up to 62% compared to SORG;whereas cPGM increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOc and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum Legumes Green Manure Intercrop cowpea crimson clover Soil Organic carbon Soil Nitrogen

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Dissecting symbiosis cell by cell

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Molecular Plant 2023年第2期16卷 308-309页

作者： Manuel frank Dugald Reid Department of Molecular Biology and Genetics Aarhus UniversityUniversitetsbyen 818000Aarhus CDenmark Department of Animal Plant and Soil SciencesSchool of AgricultureBiomedicine and EnvironmentLa Trobe UniversityMelbourneVIC 3086Australia

Symbiotic nitrogen fixation in legumes occurs in specialized root organs called *** development requires coordination across tissues as infection progresses from the epidermis to growing nodules derived from the cortex or ***,functional nodules include a variety of specialized cells,including those that house the nitrogen-fixing *** combination of developmental changes across tissues and specialized functions acquired by nodule cells makes dissecting the process difficult using bulk analysis of gene expression,proteins,and metabolites.

关键词： organs cortex specialized

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Using bioacoustic tools to clarify species delimitation within the Blakiston's Fish Owl(Bubo blakistoni)complex

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Avian Research 2022年第1期13卷 17-24页

作者： Nyanasengeran Movin Tatjana Gamova Sergei G.Surmach Jonathan c.Slaght A.A.Kisleiko James A.Eaton frank E.Rheindt Department of Biological Sciences National University of Singapore16 Science Drive 4Singapore117558Singapore Federal Scientific center for Biodiversity of Terrestrial Biota of East Asia FEB RAS.Vladivostok Russia Wildlife conservation Society 2300 Southern BlvdBronxNYUSA10460 Kurilskii State Nature Reserve Yuzhno-KurilskRussia A-3A-5 Casa Indah ⅠPersiaran Surian47810Petaling JayaMalaysia

Although Blakiston’s Fish Owl(Bubo blakistoni) is widely treated as a single species,marked differences in the structure of pair duets between continental and insular populations have been ***,no study has quantitatively assessed these vocal *** obtained 192 duets from 22 pairs of Blakiston’s Fish Owl:15 pairs of *** from the Japanese island of Hokkaido and the Russian Kuril island of Kunashir,and seven pairs of *** from Primorye on the Russian *** is a sizeable dataset for such a large,retiring,and rare *** conducted bioacoustic examinations of 14 vocal parameters using principal component analysis and the Isler criterion to quantitatively test species boundaries within the *** *** found that the insular populations on Hokkaido and Kunashir emerged as vocally similar to each other but markedly different from the continental populations of ***,corresponding closely with presently accepted subspecies *** differences in the duets of the insular and continental groups are greater than the pairwise comparisons of territorial vocalisations between other sympatric owl *** on the reproductive importance of vocal duets in owl biology,we propose the taxonomic elevation of the continental subspecies to species level as Northern Fish Owl *** study corroborates the importance of bioacoustics in ascertaining species boundaries in owls and has important implications for the management of the two newly delimited species,each likely to be assessed as *** species should be managed independently to optimise conservation outcomes.

关键词： Eagle Owl Japan Russian Far East Taxonomy Biogeography

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