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Dietary bile acid supplementation in weaned piglets with intrauterine growth retardation improves colonic microbiota,metabolic activity,and epithelial function

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2578-2595页

作者： Yang Liu MdAbul Kalam Azad Sujuan Ding Qian Zhu francois Blachier Zugong Yu Haijun Gao Xiangfeng Kong Key Laboratory of Agro‑Ecological Process in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina. College of Veterinary Medicine Nanjing Agricultural UniversityNanjingJiangsu 210095China. Universite Paris-SaclayAgroParisTech INRAEUMR PNCA75005ParisFrance. College of Medicine Howard UniversityWashingtonDC 20059USA.

Background Intrauterine growth retardation(IUGR)is one of the major constraints in animal *** previ-ous study showed that piglets with IUGR are associated with abnormal bile acid(BA)*** study explored whether dietary BA supplementation could improve growth performance and colonic development,function,micro-biota,and metabolites in the normal birth weight(NBW)and IUGR piglets.A total of 48 weaned piglets(24 IUGR and 24 NBW)were allocated to four groups(12 piglets per group):(i)NBW group,(ii)NBW+BA group,(iii)IUGR group,and(iv)IUGR+BA *** were collected after 28 days of *** The results showed that dietary BA supplementation increased the length and weight of the colon and colon weight to body weight ratio,while decreased the plasma diamine oxidase(DAO)concentration in the NBW pig-lets(P<0.05).Dietary BA supplementation to IUGR piglets decreased(P<0.05)the plasma concentrations of D-lactate and endotoxin and colonic DAO and endotoxin,suggesting a beneficial effect on epithelial ***,dietary BA supplementation to NBW and IUGR piglets increased Firmicutes abundance and decreased Bacteroidetes abundance(P<0.05),whereas Lactobacillus was the dominant genus in the *** analysis revealed 65 and 51 differential metabolites in the colon of piglets fed a diet with/without BA,respectively,which was associated with the colonic function of IUGR ***,dietary BA supplementation to IUGR piglets upregulated the expressions of CAT,GPX,SOD,Nrf1,IL-2,and IFN-γin colonic mucosa(P<0.05).Conclusions Collectively,dietary BA supplementation could improve the colonic function of IUGR piglets,which was associated with increasing proportions of potentially beneficial bacteria and ***,BA shows a promising application prospect in improving the intestinal ecosystem and health of animals.

关键词： Bile acid Intrauterine growth retardation Metabolite Microbiota Piglet

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Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal cancer,liver metastasis of colorectal cancer and hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第23期12卷 3782-3783页

作者： Muriel Mathonnet Bernard Descottes Denis Valleix francois Labrousse Véronique Truffinet Yves Denizot Service de Chirurgie Digestive Endocrinienne et GénéraleCHU Dupuytren2 avenue Luther KingLimoges 87045France Service de Chirurgie Viscérale et Transplantation CHU Dupuytren2 avenue Luther King87045 LimogesFrance Service d'Anatomo-Pathologie CHU Dupuytren2 avenue Luther King87045 LimogesFrance UMR CNRS 6101 Faculté de Médecine2 rue Docteur Marcland87025 LimogesFrance

Angiogenesis consists of the sprouting of capillaries from pre-existing vessels. It is well-known that tumor growth is angiogenesis-dependent. Vascular endothelial growth factor （VEGF） and basic fibroblast growth factor （bFGF） stimulated vascular endothelial cell proliferation and are involved in the neoplastic angiogenesis of several types of tumors including those of the intestinal tract. Authors usually investigated VEGF and using immunohistochemistry bFGF protein expressions or Western blotting and VEGF and bFGF transcripts using reverse transcriptase Dolymerase chain reaction （RT-PCR）.

关键词： Vascular endothelial growth factor Basicfibroblast growth factor Colorectal cancer Hepatocellularcarcinomas

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Fluorination of suspended graphene

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Nano Research 2017年第9期10卷 3151-3163页

作者： Claudia Struzzi Mattia Scardamaglia Nicolas Reckinger Jean-francois Colomer Hikmet Sezen Matteo Amati Luca Gregoratti Rony Snyders Carla Bittencourt Chimie des Interactions Plasma-Surface CIRMAP University of Mons 7000 Mons Belgium Research Group on Carbon Nanostructures (CARBONNAGe) University of Namur 5000 Namur Belgium Elettra - Sincrotrone Trieste S.C.p.A. di interesse nazionale Strada Statale 14 km 163.5 34149 Trieste Italy Materia Nova Research Center B-7000 Mons Belgium

Suspended graphene is exposed to different fluorine-containing species produced by a plasma source fed with CF4 precursor gas. We investigate the fluorination process by selecting two different kinetic energies for the ions striking the graphene surface. The chemical-bonding environment is discussed, and the control of the graphene-fluorination homogeneity is investigated at the individual graphene sheets. The modifications of the electronic and structural properties are examined by scanning photoelectron microscopy, micro-Raman analysis, and scanning electron microscopy. The results are compared with those obtained for supported graphene on copper. Suspended graphene provides a quasi-ideal model for investigating the intrinsic properties of irradiated carbon nano-systems while avoiding damage due to backscattered atoms and recoil due to a supporting substrate.

关键词： graphene fluorination spectromicroscopy X-ray photoelectron spectroscopy (XPS) Raman scanning electron microscopy (SEM)

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Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

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Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： Elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor francois Brisset Marie-francoise Bernet-Camard Didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization

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Post Blast Tympanic Perforations, Clinical and Paraclinical Study at Six Yaounde Hospitals

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International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2024年第2期 126页

作者： Andjock Nkouo Yves Christian Lekassa Pierrette Meva’a Biouele Roger Christian Moboung Prudence Mindja Eko David Djomou francois Njock Richard Ndjolo Alexis

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Electronic properties of 2H-stacking bilayer MoS_(2)measured by terahertz time-domain spectroscopy

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Frontiers of physics 2023年第5期18卷 161-171页

作者： Xingjia Cheng Wen Xu Hua Wen Jing Zhang Heng Zhang Haowen Li francois M.Peeters Qingqing Chen Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Micro Optical Instruments Inc. Shenzhen 518118China School of Physics and Astronomy and Yunnan Key Laboratory of Quantum Information of Yunnan Province Yunnan UniversityKunming 650091China Department of Physics University of AntwerpGroenenborgerlaan 171B-2020 AntwerpenBelgium

Bilayer (BL) molybdenum disulfide (MoS_(2)) is one of the most important electronic structures not only in valleytronics but also in realizing twistronic systems on the basis of the topological mosaics in moiré superlattices. In this work, BL MoS_(2) on sapphire substrate with 2H-stacking structure is fabricated. We apply the terahertz (THz) time-domain spectroscopy (TDS) for examining the basic optoelectronic properties of this kind of BL MoS_(2). The optical conductivity of BL MoS_(2) is obtained in temperature regime from 80 K to 280 K. Through fitting the experimental data with the theoretical formula, the key sample parameters of BL MoS_(2) can be determined, such as the electron density, the electronic relaxation time and the electronic localization factor. The temperature dependence of these parameters is examined and analyzed. We find that, similar to monolayer (ML) MoS_(2), BL MoS_(2) with 2H-stacking can respond strongly to THz radiation field and show semiconductor-like optoelectronic features. The theoretical calculations using density functional theory (DFT) can help us to further understand why the THz optoelectronic properties of BL MoS_(2) differ from those observed for ML MoS_(2). The results obtained from this study indicate that the THz TDS can be applied suitably to study the optoelectronic properties of BL MoS_(2) based twistronic systems for novel applications as optical and optoelectronic materials and devices.

关键词： terahertz time-domain spectroscopy bilayer MoS_(2) optoelectronics

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Three-and two-dimensional calculations for the interface anisotropy dependence of magnetic properties of exchange-spring Nd2Fe(14)B/α-Fe multilayers with out-of-plane easy axes

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Chinese Physics B 2020年第3期29卷 389-395页

作者： Qian Zhao Xin-Xin He francois-Jacques Morvan Guo-Ping Zhao Zhu-Bai Li Inner Mongolia Key Laboratory for Utilization of Bayan Obo Multi-Metallic Resources Elected State Key LaboratoryDepartment of Applied PhysicsCollege of ScienceInner Mongolia University of Science and TechnologyBaotou 014010China Ningbo Institute of Industrial Technology Chinese Academy of SciencesNingbo 315201China College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610066China

Hysteresis loops,energy products and magnetic moment distributions of perpendicularly oriented Nd2Fe(14)B/α-Fe exchange-spring multilayers are studied systematically based on both three-dimensional(3D)and one-dimensional(1D)micromagnetic methods,focused on the influence of the interface *** calculated results are carefully compared with each *** interface anisotropy effect is very palpable on the nucleation,pinning and coercive fields when the soft layer is very ***,as the soft layer thickness increases,the pinning and coercive fields are almost unchanged with the increment of interface anisotropy though the nucleation field still monotonically *** interface anisotropy decreases the maximum energy products and increases slightly the angles between the magnetization and applied *** magnetic moment distributions in the thickness direction at various applied fields demonstrate a progress of three-step magnetic reversal,i.e.,nucleation,evolution and irreversible motion of the domain *** above results calculated by two models are in good agreement with each ***,the in-plane magnetic moment orientations based on two models are *** 3D calculation shows a progress of generation and disappearance of vortex state,however,the magnetization orientations within the film plane calculated by the 1D model are *** results suggest that negative interface anisotropy is necessarily avoided experimentally.

关键词： micromagnetics interface anisotropy Nd2Fe(14)B/α-Fe multilayers magnetic properties

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Homological Solution of the Lanczos Problems in Arbitrary Dimension

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Journal of Modern Physics 2021年第6期12卷 829-858页

作者： Jean-francois Pommaret CERMICS Ecole des Ponts ParisTech France

When D is a linear partial differential operator of any order, a direct problem is to look for an operator D1 generating the compatibility conditions (CC) D1η = 0 of Dξ = η. Conversely, when D1 is given, an inverse problem is to look for an operator D such that its CC are generated by D1 and we shall say that D1 is parametrized by D = D0. We may thus construct a differential sequence with successive operators D, D1, D2, ..., each operator parametrizing the next one. Introducing the formal adjoint ad() of an operator, we have but ad (Di-1) may not generate all the CC of ad (Di). When D = K [d1, ..., dn] = K [d] is the (non-c

关键词： Differential Sequence Variational Calculus Lanczos Potential Lanczos Operator Vessiot Structure Equations

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Onto Orthogonal Projections in the Space of Polynomials P_n[x]

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Journal of Applied Mathematics and Physics 2023年第1期11卷 22-45页

作者： Jean-francois Niglio Department of Mathematics Kingston University London UK

In this article, I consider projection groups on function spaces, more specifically the space of polynomials Pn[x]. I will show that a very similar construct of projection operators allows us to project into the subspaces of Pn[x] where the function h ∈Pn[x] represents the closets function to f ∈Pn[x] in the least square sense. I also demonstrate that we can generalise projections by constructing operators i.e. in Rn+1 using the metric tensor on Pn[x]. This allows one to project a polynomial function onto another by mapping it to its coefficient vector in Rn+1. This can be also achieved with the Kronecker Product as detailed in this paper.

关键词： Polynomials and Projections Projections The Kronecker Product Idempotent Operators

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Vapor and Pressure Sensors Based on Cellulose Nanofibers and Carbon Nanotubes Aerogel with Thermoelectric Properties

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Journal of Renewable Materials 2018年第3期6卷 277-287页

作者： Rajendran Muthuraj Abhishek Sachan Mickael Castro Jean-francois Feller Bastien Seantier Yves Grohens Dupuy de Lôme Research Institute(IRDL) FRE CNRS 3744University of Southern BrittanyRue de Saint Maudé56321 Lorient CedexFrance

In this work,thermally insulating and electrically conductive aerogels were prepared from cellulose nanofibers(CNF)and carbon nanotubes(CNTs)by environmentally friendly freeze-drying *** thermal conductivity of neat CNF aerogel is 24 mW/(m・K)with a density of 0.025 g/*** the addition of CNTs into CNF aerogel,the electrical conductivity was significantly increased while the thermal conductivity was increased to 38 mW/(m・K).Due to these interesting properties,the Seebeck coefficient and the figure of merit(ZT)of the CNF/CNTs aerogels were measured and showed that CNF/CNTs aerogel thermoelectric properties can be *** compressibility and electrical resistance of the CNF/CNTs aerogel highlighted its pressure-responsive property.A set of volatile organic compounds(VOCs)were exposed to aerogels to monitor the resistance *** CNF/CNTs aerogel showed high sensitivity and good response to both nonpolar and polar vapors due to the absorption by both CNF and CNTs *** prepared CNF/CNTs aerogel is therefore a good candidate for thermal insulation,thermoelectric material,VOCs sensing,and pressure-sensing applications.

关键词： CNF/CNTs aerogel thermal conductivity pressure sensing thermoelectric materials VOCs sensing

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