检索结果-南通市图书馆

Chronic cola drinking induces metabolic and cardiac alterations in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2011年第4期3卷 111-116页

作者： José Milei Matilde Otero Losada Hernán Gómez Llambí Daniel R Grana Daniel Suárez francisco Azzato Giuseppe Ambrosio Instituto de Investigaciones Cardiológicas University of Buenos Aires CONICET Division of Cardiology University of Perugia School of Medicine

AIM: To investigate the effects of chronic drinking of cola beverages on metabolic and echocardiographic parameters in rats. METHODS: Forty-eight male Wistar rats were divided in 3 groups and allowed to drink regular cola (C), diet cola (L), or tap water (W) ad libitum during 6 mo. After this period, 50% of the animals in each group were euthanized. The remaining rats drank tap water ad libitum for an additional 6 mo and were then sacrificed. Rat weight, food, and beverage consumption were measured regularly. Biochemical, echocardiographic and systolic blood pressure data were obtained at baseline, and at 6 mo (treatment) and 12 mo (washout). A complete histopathology study was performed after sacrifice. RESULTS: After 6 mo, C rats had increased body weight (+7%, P < 0.01), increased liquid consumption (+69%, P < 0.001), and decreased food intake (-31%, P < 0.001). C rats showed mild hyperglycemia and hypertriglyceridemia. Normoglycemia (+69%, P < 0.01) and sustained hypertriglyceridemia (+69%, P < 0.01) were observed in C after washout. Both cola beverages induced an increase in left ventricular diastolic diameter (C: +9%, L: +7%, P < 0.05 vs W) and volumes (diastolic C: +26%, L: +22%, P < 0.01 vs W; systolic C: +24%, L: +24%, P < 0.05 vs W) and reduction of relative posterior wall thickness (C: -8%, L: -10%, P < 0.05 vs W). Cardiac output tended to increase (C: +25%, P < 0.05 vs W; L: +17%, not significant vs W). Heart rate was not affected. Pathology findings were scarce, related to aging rather than treatment. CONCLUSION: This experimental model may prove useful to investigate the consequences of high consumption of soft drinks.

关键词： Cola beverages Echocardiography Metabolic syndrome Soft drinks

A Neuro-Fuzzy Approach for Automatic Detection of Breast Cancer Based on Raman Spectroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2014年第2期11卷 158-167页

作者： francisco Javier Luna Rosas Julio Cesar Martinez Romo Ricardo Mendoza Gonzalez Valentin Lopez Rivas Miguel Mora Gonzalez Gricelda Medina Veloz Computer Science Department Instituto Tecnologico de Aguascalientes Aguascalientes 20256 Mexico Centro Universitario de los Lagos Universidad de Guadalajara Jalisco 44100 Mexico Universidad Tecnologica del Norte de Aguascalientes Aguascalientes 20256 Mexico

The harmful presence of cancerous cells in the feminine breast brings as a result, breast cancer, illness that has spread widely lately, not only in Mexico, but in other parts of the planet. In this paper, we present a method of automatic breast cancer classification, in which a Raman signal is classified as coming from a biopsy of healthy tissue (class ? 1 ) or biopsy of diseased tissue (class ? 2 ); to do so, we created patterns from Raman spectra accurately measuring each Raman peak to provide naturally reduced data to a classifier; we used ANFIS (adaptative neuro-fuzzy inference system) classifier and high rates of correct classification were obtained. This provides the specialists with important clinical tools for a rapid and efficient automatic detection of breast cancer. We consider that our approach can be applicable to other kinds of cancer, e. g., lung, prostate, and stomach.

关键词：自适应神经模糊推理系统拉曼光谱自动检测乳腺癌模糊方法分类模式 ANFIS 前列腺癌

无阿片类药物应用时手术中输注艾司洛尔可以减少门诊腹腔镜胆囊切除术后芬太尼的用量

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2008年第6期4卷 52-59页

作者： Vincent Collard,MD Giovanni Mistraletti, MD Ali Taqi, MD Juan francisco Asenjo,MD Liane S. Feldman, MD Gerald M. Fried, MD Franco Carli, MD, Mphil 颜学滔宋学敏(译) 王焱林(校) Department of Anesthesia and Surgery Steinberg-Bernstein Centre for Minimally Invasive Surgery McGill University Health Centre Montreal Quebec Canada 不详

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼... 详细信息

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼的手术后阿片类药物的用量、副作用及患者的出院时间。方法90例患者分3组，进行前瞻性、随机双盲研究。对照组（n=30），手术中间断输注芬太尼；艾司洛尔组（聍=30），手术中持续输注艾司洛尔（5～15μg·kg～min^-1），不补充阿片类药物；瑞芬太尼组（n=30），持续输注瑞芬太尼（0．1-0．5μg·kg^-1·min^-1）。标准化全身麻醉，辅助药物包括：对乙酰氨基酚、酮洛酸、切皮时使用局麻药、地塞米松和氟哌利多。手术后使用芬太尼镇痛。结果手术后在麻醉恢复室，艾司洛尔组与其他2组相比，芬太尼的用量明显减少，为91．5±42．7μg；瑞芬太尼组为237．8±54．7μg，对照组为168．1±96．8μg（P〈0．0001）。与艾司洛尔组（30％）相比，瑞芬太尼组（67．9％）和对照组（66．7％）手术后恶心的发生率更高（P〈0．01）。手术后White-Song评分，艾司洛尔组到达12～14的速度比瑞芬太尼组更快（P〈0．01），出院时间早45-60分钟（P〈0．004）。结论手术中持续输注艾司洛尔能显著减少手术后芬太尼和昂丹司琼的用量，有利于患者及早出院。

关键词：阿片类药物门诊手术患者瑞芬太尼艾司洛尔腹腔镜胆囊切除术后术中输注用量药物应用

脂质体包裹罗哌卡因在人口腔粘膜表面麻醉中的应用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2008年第4期4卷 80-84页

作者： Michelle Franz-Montan André L. R. Silva Karina Cogo Cristiane de C. Bergamaschi Maria C.Volpato José Ranali Eneida de Paula francisco C. Groppo 胥亮(译) 岳云(校) Department of Physiological Sciences Dentistry School of Piracicaba Piracicaba SP Brazil Department of Biochemistry Institute of Biology State University of Campinas-UNICAMP Campinas SP Brazil 不详

背景如果能够消除局部麻醉时针刺所导致的疼痛，将是牙科学的一个重大进步。方法在本交叉双盲研究中，我们评估了脂质体包裹罗哌卡因用于表面麻醉的效果。30例健康志愿者接受了各60mg的表面麻醉药：1％脂质体包裹罗哌卡因，1％普通罗哌... 详细信息

背景如果能够消除局部麻醉时针刺所导致的疼痛，将是牙科学的一个重大进步。方法在本交叉双盲研究中，我们评估了脂质体包裹罗哌卡因用于表面麻醉的效果。30例健康志愿者接受了各60mg的表面麻醉药：1％脂质体包裹罗哌卡因，1％普通罗哌卡因，2．5％利多卡因和2．5％丙胺卡因混合物（EMLA），以及20％苯佐卡因凝胶。麻醉位置在右上犬齿处的颊皱褶，各种药物于不同时间应用，每种使用2分钟。当30G针头刺入后，以视觉模拟评分法（VAS）评估疼痛。用针刺试验测定表面麻醉的维持时间，用电子牙髓刺激器评估牙髓反应。结果在脂质体包裹罗哌卡因组、罗哌卡因组、EMLA组及苯佐卡因组中，VAS中位数和四分位数间距（以cm计）分别为0．8（0．4～1．5），1．6（0．8～2．6），1．1（0．3～2．7），2．2（0．9～2．9）。脂质体包裹罗哌卡因组较苯佐卡因组的VAS评分均数更低（P=0．0205）。在脂质体包裹罗哌卡因组、罗哌卡因组、EMLA组及苯佐卡因组中，软组织麻醉持续时间的中位数和四分位数间距分别为11（7～14），6．5（4～11），14（11～16），7（6～9）分钟。EMLA和脂质体包裹罗哌卡因的镇痛效能相当，与其他麻醉药相比，软组织麻醉持续时间更长（P=0．0001）。结论1％脂质体包裹罗哌卡因凝胶在减轻针刺疼痛和软组织麻醉维持时间上与EMLA相当。以上所有表面麻醉药均不能产生牙髓麻醉作用。

关键词：粘膜表面麻醉脂质体包裹罗哌卡因视觉模拟评分法 VAS评分苯佐卡因 EMLA 口腔

Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第7期7卷 1001-1006页

作者： Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres francisco Salas-Gordillo Xaira Rivera-Gutierrez Fatima Higuera-de la Tijera Gastroenterology Department Hospital General de México "Dr. Eduardo Liceaga" Internal Medicine Department Hospital General de México "Dr. Eduardo Liceaga" Faculty of Medicine "Universidad Veracruzana"

AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial ***: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of "Hospital General de México Dr. Eduardo Liceaga", we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid ***: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.

关键词： Mean platelet volume Cirrhosis Ascites fluid infection Culture negative neutrocytic ascites Systemic inflammatory response

Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2011年第3期3卷 93-97页

作者： Luiz César Guarita-Souza Júlio César francisco Rossana Simeoni Jose Rocha Faria-Neto Katherine Athayde Teixeira de Carvalho Department of Post Graduation Surgery Pontifical Catholic University of Parana The PeléPequeno Príncipe Institute Child and Adolescent Health Research and Pequeno Príncipe Faculty

Although some authors suggest that there is mitotic division in the heart,most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function,and if the area of infarction is extensive ventricular remodeling may occur,leading to the development of heart *** transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac *** myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits,however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts,for treating the underlying cause of disease,the loss of cell contractility.

关键词： Cell transplantation Cardiomyopathy Skeletal myoblasts Stem cells

Limitations of multimodality imaging in the diagnosis of pannus formation in prosthetic aortic valve and review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2015年第4期7卷 224-229页

作者： Juan Bautista Soumoulou Tomás francisco Cianciulli Andrea Zappi Alberto Cozzarin María Cristina Saccheri Jorge Alberto Lax Robert Guidoin Ze Zhang Department of Cardiology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155 AHDArgentina Researcher of the Ministry of Health Government of the City of Buenos Aires Department of Pathology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155AHDArgentina Department of Surgery and Radiology Laval University and Québec Biomaterials InstituteCHUQQuebec G1K 7P4Canada

Pannus formation is a rare complication and occurs almost exclusively in mechanical prosthetic *** consists of fibrous tissue that covers the surface of the prosthesis either concentrically or eccentrically,resulting in valve *** pathophysiology seems to be associated to a chronic inflammatory process that explains the late and insidious clinical *** diagnosis should be considered in patients with high transvalvular gradients on transthoracic echo,and workup should be completed with fluoroscopy and transesophageal *** is always surgical and recurrence is *** present a case of pannus formation in a prosthetic aortic valve and a review of the literature regarding this disorder.

关键词： Pannus formation Prosthetic aortic valve Fluoroscopy Transthoracic echocardiography Transesophageal echocardiography

PRDM1在弥漫性大B细胞淋巴瘤中的表达及临床意义

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PRDM1在弥漫性大B细胞淋巴瘤中的表达及临床意义

“智慧能源系统信息支撑技术”专题特约主编寄语

第十次全国淋巴瘤学术会议

作者：刘艳艳 Christophe LEBOEUF 施静艺李军民王黎沈扬 José—francisco GARCIA 沈志祥陈竺陈赛娟 Anne JANIN 赵维莅上海交通大学医学院附属瑞金医院上海血液病研究所

目的：探讨 PRDM1α和 PRDM1β在弥漫性大 B 细胞淋巴瘤中的表达以及分型与临床疗效的关系;探讨 PRDM1与高侵袭性弥漫性大 B 细胞淋巴瘤相关的内在机制及克服 PRDM1相关耐药的途径。方法：选择弥漫性大 B 细胞淋巴瘤患者82例,免疫组织... 详细信息

目的：探讨 PRDM1α和 PRDM1β在弥漫性大 B 细胞淋巴瘤中的表达以及分型与临床疗效的关系;探讨 PRDM1与高侵袭性弥漫性大 B 细胞淋巴瘤相关的内在机制及克服 PRDM1相关耐药的途径。方法：选择弥漫性大 B 细胞淋巴瘤患者82例,免疫组织化学方法检测 CD10、BCL6、IRF4将其分为生发中心和非生发中心两种亚型。显微切割联合 RT— PCR 以及免疫组织化学方法检测患者中 PRDM1α和β基因及 PRDM1蛋白表达;体外实验选择 Namalwa 细胞株,RT—PCR 和 Western Blotting 方法观察阿霉素和美罗华单独或联合给药对 PRDM1影响,ELISA 方法检测对 NFκB 活性的影响,同时观察 NFκB 抑制剂 PDTC 对 PRDM1的作用。统计学分析应用 Kaplan—Meier 生存分析、log 回归,多因素生存分析用 Cox 回归模型。统计分析软件 SAS8．2。结果：PRDM1α和 PRDM1β转录本仅表达于弥漫性大 B 细胞淋巴瘤非生发中心亚型的肿瘤细胞,而 PRDM1β在 CHOP 方案治疗的非生发中心型患者中与短生存期相关,但在 R—CHOP 方案治疗组中未显示相关性;尽管 PRDM1蛋白表达在生发中心型(13/33,39．4%)和非生发中心型(24/49,49．0%)之间无统计学意义,但表达 PRDM1β转录本的非生发中心型病人均检测出 PRDM1蛋白表达,且淋巴瘤细胞中 PRDM1与 IRF4表达显著相关。体外实验中,耐药的 Namalwa 细胞也表达 PRDM1β, 美罗华能够抑制 PRDM1β表达,同时伴随 NF—κB 活性的降低。NFκB 抑制剂 PDTC 在抑制细胞株生长同时也抑制 PRDM1β。结论：PRDM1β在弥漫性大 B 细胞淋巴瘤非生发中心亚型中可能成为一个新的预后标志;与肿瘤发生有关的 PRDM1β与 IRF4共同表达可能是弥漫性大 B 细胞淋巴瘤高侵袭性的一种原因;降解 PRDM1β可能是美罗华对弥漫性大 B 细胞淋巴瘤增效的生物学机制之一;通过检测 NF—κB 活性可能预测对美罗华治疗有效的 B 细胞淋巴瘤患者。

关键词：美罗华 PRDM1 弥漫性大 B 细胞淋巴瘤激光显微切割

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国电机工程学报 2021年第3期41卷 789-789页

作者：黄琦宋永华 francisco de Leon Yilu Liu 成都理工大学电子科技大学澳门大学纽约大学田纳西大学诺克思维尔分校

当前,世界各国电力能源系统发展的两大驱动力主要来自新能源的高效开发利用和用户侧互动参与。信息理论和信息通信技术,作为一种革命性变革驱动技术,在推动电力能源系统演化革新方面发挥了重要作用,以新能源和信息技术深度融合为特征的... 详细信息

当前,世界各国电力能源系统发展的两大驱动力主要来自新能源的高效开发利用和用户侧互动参与。信息理论和信息通信技术,作为一种革命性变革驱动技术,在推动电力能源系统演化革新方面发挥了重要作用,以新能源和信息技术深度融合为特征的能源革命正推动传统能源系统向智慧能源系统发展。

关键词：信息通信技术电力能源能源革命信息技术新能源革命性变革深度融合智慧能源