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GOECP/SEOR radiotherapy guidelines for thymic epithelial tumours

World Journal of Clinical Oncology 2021年第4期12卷 195-216页

作者： Mikel Rico Sonia Flamarique Cristina Casares Tamara garcía Miriam López Maribel Martínez javier Serrano Manuel Blanco Raúl Hernanz Lourdes de Ingunza-Barón francisco JoséMarcos Felipe Couñago Department of Radiation Oncology Complejo Hospitalario de NavarraPamplona 31008NavarraSpain Health Research Institute of Navarre(IdiSNA) Navarra BiomedPamplona 31008NavarraSpain Department of Radiation Oncology University Hospital Miguel ServetZaragoza 50009AragónSpain Department of Radiation Oncology University Hospital of CaceresCáceres 10004ExtremaduraSpain Department of Radiation Oncology Hospital Universitario de FuenlabradaFuenlabrada 28942MadridSpain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009AragónSpain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain Department of Radiation Oncology Hospital Universitario TorrecárdenasAlmería 04009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009AndalucíaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

Thymic epithelial tumours(TET)are rare,heterogeneous neoplasms that range from resectable indolent tumours to aggressive thymic carcinomas with a strong tendency to *** pathological diagnosis is complex,in part due to the management of TETs is scant and mainly based on non-randomised studies and retrospective ***,the clinical management of TETs tends to be highly heterogenous,which makes it difficult to improve the evidence *** role of technological advances in the field of radiotherapy and new systemic therapies in the treatment of TETs has received little attention to *** the present clinical guidelines,developed by the GOECP/SEOR,we review recent developments in the diagnosis and classification of *** also present a consensus-based therapeutic strategy for each disease stage that takes into consideration the best available *** guidelines focus primarily on the role of radiotherapy,including recent advances,in the management of *** main aim of this document is to promote the standardisation of clinical practice and lay the foundations for future studies to clarify the main unresolved questions related to the optimal management of TET.

关键词： Targeted therapies Thymic epithelial tumors Radiotherapy Reirradiation Guidelines Chemotherapy

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Mathematical model for the ubiquitin activating enzyme E1

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Journal of Biomedical Science and Engineering 2010年第3期3卷 274-284页

作者： francisco javier López-Cánovas Francisca Cánovas María Antonia Günther Sillero Antonio Sillero 不详

The ubiquitin-activating enzyme E1 (EC 6.***.2.19) represents the first step in the degradation of proteins by the ubiquitin proteasome pathway. E1 transfers ubiquitin from the ubiquitinated E1 to the ubiquitin carrier proteins (E2), ubiquitin-protein ligases (E3) and proteins. This process is rather complex, and known from the work of Haas, Ciechanover, Hershko, Rose and others. The occurrence of 19 hypothetical intermediate enzyme forms (EFs) and 22 different reactions were considered in the presence of ubiquitin (Ub), ATP, adenosine 5’-tetraphosphate (p4A), pyrophosphate (P2), and tripolyphosphate (P3) as substrates, and iodoacetamide (IAA) and dithioth- reitol (DTT) as inhibitors. Inspired by the work of Cha (Cha (1968) J. Biol. Chem., 243, 820-825) we have treated these reactions in two complementary ways: in rapid equilibrium and in steady state. The kinetics of both types of reactions were simulated and solved with a system of ordinary differential equations using the Mathematica Program. The ubiquitination of E1 has been also theoretically coupled to the ubiquitination of E2, E3 and proteins. This makes the model useful to predict the theoretical influence of inhibitors (or of changes in some parameters of the reaction) on the ubiquitination of proteins. The Program responds to changes in the concentration of ATP or ubiquitin and has predictive properties as shown by the influence of AMP on the synthesis of p4A, calculated theoretically and confirmed experimentally.

关键词： Dinucleoside Polyphosphates Adenosine Tetraphosphate Tripolyphosphate Proteasome Mathematical Model

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Tubal pregnancy with molar degeneration in concurrent eutopic pregnancy. A case report

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 53-54页

作者： Jesus Joaquin Hijona Elosegui Antonio Carballo garcia francisco javier Frutos Arenas Juan Manuel Torres Marti 不详

This research paper presents the infrequent case of a heterotopic pregnancy based on a tubal ectopic pregnancy with molar degeneration in concurrent eutopic pregnancy. Treatment with evacuation/suction curettage and perlaparoscopic salpingectomy was required. This case report confirms what is biologically valid in the statistically unlikely.

关键词： Heterotopic Pregnancy Hydatiform Mole Molar Pregnancy Pregnancy Complications Tubal Pregnancy

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Management of recurrent hepatitis C virus after liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16409-16417页

作者： Miguel Jiménez-Pérez Rocío González-Grande francisco javier Rando-Mu?oz Liver transplantation and hepatology unit UGC de Aparato Digestivo Hospital Regional Universitario Department of Abdominal Diseases Hospital Nij Smellinghe Ziekenhuis

Chronic hepatitis C virus(HCV) infection is the leading cause of death from liver disease and the leading indication for liver transplantation(LT) in the United States and western Europe. LT represents the best therapeutic alternative for patients with advanced chronic liver disease caused by HCV or those who develop hepatocarcinoma. Reinfection by HCV of the graft is universal and occurs in 95% of transplant patients. This reinfection can compromise graft function and patient survival. In a few cases, the histological recurrence is minimal and non-progressive; however, in most patients it follows a more rapid course than in immunocompetent persons, and frequently evolves into cirrhosis with graft loss. In fact, the five-year and ten-year survival of patients transplanted because of HCV are 75% and 68%, respectively, compared with 85% and 78% in patients transplanted for other reasons. There is also a pattern of recurrence that is very severe, but rare(< 10%), called fibrosing cholestatic hepatitis, which often involves rapid graft loss. Patients who present a negative HCV viremia after antiviral treatment have better survival. Many studies published over recent years have shown that antiviral treatment of post-transplant HCV hepatitis carried out during the late phase is the best option for improving the prognosis of these patients. Until 2011, PEGylated interferon plus ribavirin was the standard of care, resulting in a sustained virological response in around 30% of recipients. The addition of protease inhibitors, such as boceprevir or telaprevir, to the standard of care, or the use of other direct-acting antiviral drugs may involve therapeutic changes in the context of HCV recurrence. This may result a better prognosis for these patients, particularly those with severe recurrence or factors predicting rapid progression of fibrosis. However, the use of these agents in LT still requires clarification in terms of safety and efficacy.

关键词： Hepatitis C virus Liver transplantation Re-currenc

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Antiprotozoal Activity of a <i>Thymus vulgaris</i>Methanol Extract and Its Fractions

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Health 2017年第7期9卷 1081-1094页

作者： Jesús Norberto Garza-González javier Vargas-Villarreal Ma Julia Verde-Star Catalina Rivas-Morales Azucena Oranday-Cárdenas Magda E. Hernandez-garcía Laura De La Garza-Salinas francisco González-Salazar Department of Chemistry Phytochemistry and Analytical Chemistry Lab Faculty of Biological Sciences University Autonomous of Nuevo Leon San Nicolas de los Garza Mexico Department of Basic Sciences Division of Health Sciences University of Monterrey San Pedro Garza Garcia Mexico Laboratory of Biochemistry and Cell Physiology Division of Cellular and Molecular Biology Center for Biomedical Research of the Northeast Mexican Social Security Institute Monterrey Mexico Mexican Social Security Institute Nuevo Leon Delegation Monterrey Mexico

Introduction: Thymus vulgaris is used in traditional medicine to treat gastrointestinal diseases because of its antifungal, antibacterial, and antispasmodic activity. Objective: To verify whether Thymus vulgaris also has antiprotozoal activity against Trichomonas vaginalis, Giardia lamblia and Entamoeba histolytica trophozoites. Materials and methods: Conventional cultures of parasites were measured on the third day during the logarithmic growth phase. The antiprotozoal activity of the methanol extract and its fractions were evaluated comparing growth in cultures with and without extracts. Next, the extract was fractionated by polarity-based partitioning. Then, the purity of each fraction was determined by thin layer chromatography (TLC). The percentage of growth inhibition was calculated with respect to untreated controls. The 50% inhibitory concentration (IC50) of each extract was calculated by PROBIT analysis. Results: We found that a methanol extract of the aerial parts of Thymus vulgaris, at 300 μg/mL, inhibited the in vitro growth of G. lamblia and T. vaginalis, while E. histolytica growth was poorly inhibited. The methanol extract was further separated into mixtures of ursolic, oleanolic, and betulinic acids. The IC50 values of ursolic acid against G. lamblia and T. vaginalis were 8.12 μg/mL and 5.51 μg/mL, respectively. Conclusions: The methanol extract fraction containing ursolic acid obtained from Thymus vulgaris has antiprotozoal activity against G. lamblia and T. vaginalis trophozoites.

关键词： Thymus vulgaris Trichomonas vaginalis Giardia lamblia Entamoeba histolytica Antiprotozoal Agents

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What the Hell Am I Doing Here？ A Look at a Series of Geriatric Centers, Profile of the Institutionalized Persons and Reasons for Admission

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Journal of Life Sciences 2017年第1期11卷 47-52页

作者： Pascual Lopez, Jose A. Rodriguez Lavado, Paula garcia Jimenez, Catalina Martinez Valero, francisco J. Aracil Femeindez, javier Family Physician Primary Care Health Center Calasparra 30420 Murcia Spain Family Medicine Resident Primary Care Health Center Calasparra 30420 Murcia Spain

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Kfz.385油罐车

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模型世界 2018年第2期 79-81页

作者： francisco javier Martínez Rodríguez

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK15... 详细信息

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK159金属锈蚀液,从而可以让蚀刻片表面变暗,并且让质感更像是真实的暗色钢制表面。我非常建议在使用任何蚀刻片时候都配合这款溶媒液,因为他同时还可以让漆在蚀刻片表面上有更好的附着力,同时粘贴起来也更方便。

关键词：油罐车油画颜料 Kfz.385 库尔斯克 AK

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The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez Elena garcia-Martin Carmen Martinez Julian Benito-Leon Julian Benito-Leon Jorge Millan-PascualMaria Diaz-Sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores Torrecillas Esteban garcla-Albea Jose francisco Plaza-Nieto Felix javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词： associated increased sclerosis

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Translational pancreatic cancer research:a comparative study on patient-derived xenograft models

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World Journal of Gastroenterology 2018年第7期24卷 794-809页

作者： Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat javier Padillo Ruiz Department of Hepatobiliary and Pancreatic Surgery Virgen del Rocio University Hospital Oncology Surgery Cell Therapy and Organ Transplantation Group Institute of Biomedicine of Seville (IBiS) Virgen del Rocio University Hospital University of Seville Statistics Methodology and Evaluation of Research Unit Virgen del Rocio University Hospital Pathology Department Virgen del Rocio University Hospital

AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude *** This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical *** In our experie

关键词： Immunohistological analysis Pancreatic cancer Patient-derived xenograft Animal model Nude mice

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Implementation of the Hough Transform for Iris Detection and Segmentation

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Advances in Molecular Imaging 2019年第1期9卷 6-18页

作者： francisco javier Paulín-Martínez Alberto Lara-Guevara Rosa María Romero-González Hugo Jiménez-Hernández Facultad de Informática Universidad Autónoma de Querétaro Querétaro México

The iris is used as a reference for the study of unique biometric marks in people. The analysis of how to extract the iris characteristic information represents a fundamental challenge in image analysis, due to the implications it presents: detection of relevant information, data coding schemes, etc. For this reason, in the search for extraction of useful and characteristic information, approximations have been proposed for its analysis. In this article, it is presented a scheme to extract the relevant information based on the Hough transform. This transform helps to find primitive geometries in the irises, which are used to characterize each one of these. The results of the implementation of the algorithm of the Hough transform applied to the location and segmentation of the iris by means of its circumference are presented in the paper. Two public databases of iris images were used: UBIRIS V2 and CASIA-IrisV4, which were acquired under the same conditions and controlled environments. In the pre-processing stage the edges are found from the noise elimination in the image through the Canny detector. Subsequently, to the images of the detected edges, the Hough transform is applied to the disposition of the geometries detected.

关键词： Image Processing Iris Segmentation Hough Transform

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