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Osteoblasts are inherently programmed to repel sensory innervation

Bone Research 2020年第3期8卷 343-355页

作者： Luis Leitao Estrela Neto francisco conceicao Ana Monteiro Marina Couto Cecilia JAlves Daniela MSousa Meriem Lamghari Instituto de Investigacao e Inovacao em Saude(i3S) Universidade do Porto4200-135 PortoPortugal Instituto de Engenharia Biomedica(INEB) Universidade do Porto4200-135 PortoPortugal Instituto de Ciencias Biomedicas Abel Salazar(ICBAS) Universidade do Porto4050-313 PortoPortugal

Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of *** innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone ***,the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still ***,we demonstrated that differentiation of human mesenchymal stem cells to osteoblasts leads to a marked impairment of their ability to promote axonal growth,evidenced under sensory neurons and osteoblastic-lineage cells *** mechanisms by which osteoblast lineage cells provide this nonpermissive environment for axons include paracrine-induced repulsion and loss of neurotrophic factors *** identified a drastic reduction of NGF and BDNF production and stimulation of Sema3A,Wnt4;and Shh expression culminating at late stage of OB *** noted a correlation between Shh expression profile,OB differentiation stages,and OB-mediated axonal *** of Shh activity and signaling reversed the repulsive action of osteoblasts on sensory ***,to strengthen our model,we localized the expression of Shh by osteoblasts in bone ***,our findings provide evidence that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation,and highlight osteoblast-derived Shh as an essential player in this cue-induced regulation.

关键词： stimulation innervation reversed

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Pressure- and Urea-Induced Denaturation of Bovine Serum Albumin: Considerations about Protein Heterogeneity

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Open Journal of Biophysics 2012年第1期2卷 4-14页

作者： Douglas Ricardo Norberto Joelma Mauricio Vieira Ancelmo Rabelo de Souza Jose Ailton conceicao Bispo Carlos francisco Sampaio Bonafe 不详

Urea denatures proteins at different concentrations, depending on the experimental conditions and the protein. We in-vestigated the pressure-induced denaturation of bovine serum albumin (BSA) in the presence of subdenaturing concen-trations of urea based on a two-state equilibrium. Pressure-induced denaturation was enhanced at urea concentrations ([U]) of 3.5 M to 8.0 M, with the free energy of denaturation at atmospheric pressure ranging from +5.0 to –2.5 kJ/mol of BSA. The m values appeared to be biphasic, with m1 and m2 of 0.92 and 2.35 kJ mol–1?M–1, respectively. Plots of versus ln[U] yielded values of u, the apparent stoichiometric coefficient, of 1.68 and 6.67 mol of urea/mol of BSA for m1 and m2, respectively. These values were compared with the m and u values of other monomeric proteins reported in or calculated from the literature. The very low values of u systematically observed for proteins were suggestive of heterogeneity in the free energy of denaturation. Thus, a u value of 140 mol of urea/mol of BSA may indicate the existence of a heterogeneous molecular population with respect to the free energy of dena-turation.

关键词： Apparent Stoichiometric Coefficient Bovine Serum Albumin High Pressure-Induced Denaturation Protein Heterogeneity Urea-Induced Denaturation

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Mango Tree Response to Lime Applied during the Production Phase

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Open Journal of Soil Science 2012年第2期2卷 155-161页

作者： Eliozeas Vicente de Almeida francisco Maximino Fernandes Renato de Mello Prado Aparecida conceicao Boliani Luiz de Souza Correa Sao Paulo State University Campus JaboticabalBrazil Sao Paulo State University Campus Ilha SolteiraBrazil

Tropical soils are usually highly acidic and this may hamper mango trees nutrition and production. The objective of this work was to evaluate the effects of lime doses applied to the soil surface on the plant nutritional status, the production, and the technological quality of mango fruits. The study was carried out at Selviria, in the state of Mato Grosso, Brazil, in a Typic Haplustox. Thirteen year old producing mango plants of the “Heden” variety, grafted on rootstock of the “Coquinho” variety, were used in this experiment. Lime doses of 0, 1.55, 3.10, 4.655, and 6.20 t ha–1 were applied to the soil. Each treatment was replicated 4 times and the experimental units distributed according to a randomized complete block design. Lime (CaO: 390 g kg–1;MgO: 130 g kg–1) was superficially applied to the soil and then incorporated at depths between 0 and 5 cm in the total area of the orchard. The soil chemical characteristics pH, Ca, Mg, K, sum of bases, and bases saturation, in the 0 - 20 cm layer, were evaluated 16 and 28 months after soil liming. Plant nutritional status was evaluated 12 months after soil liming. Fruit production and technological quality were evaluated during the cropping years of 2006 and 2007. Soil liming had a positive effect on the evaluated soil chemical characteristics and this improved plant nutritional status and fruit technological quality as well as increased fruit production. These beneficial effects though were observed only in the second year after soil liming. The highest fruit production was verified when soil bases saturation was of 72% and the contents of Ca and Mg were of 32 and 8 g kg–1, respectively.

关键词： Mangifera indica L. Productivity Soil Acidity Savannah

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Harmonia axyridis Pallas(Coleoptera:Coccinellidae):Biological aspects and thermal requirements

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Advances in Entomology 2014年第1期2卷 42-46页

作者： Tatiana de Oliveira Ramos Terezinha Monteiro dos Santos-Cividanes francisco Jorge Cividanes Lais da conceicao dos Santos Department of Plant Health Faculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual PaulistaJaboticabalBrazil Agencia Paulista de Tecnologia dos Agronegocios(APTA) Regional Centro LesteRibeirao PretoBrazil

The aim of this study was to determine the biological aspects and thermal requirements of Harmonia axyridis Pallas (Coleoptera: Coccinellidae) fed daily with Anagasta kuehniella (Zeller) (Lep-idoptera: Pyralidae) eggs. Under laboratory conditions, the experiment was carried out in acclimatized chambers set to 18°C, 21°C, 24°C, 27°C, and 30°C. Larvae of H. axyridis were separated, kept in a glass tube, and fed with A. kuehniella eggs. The Asiatic lady beetle adults were separated into 20 couples and kept in plastic cups receiving the same food as the larvae. The length of the larval, pupal, and total biological cycle (from egg to adult) stages declined significantly from 18°C to 27°C, but was stable between 27°C and 30°C. Survival was similar for larvae from the first to the fourth stadium when kept at 18°C, 21°C, and 24°C with a higher total biological cycle survival at 27°C. H. axyridis males presented higher longevity at 18°C and 21°C in comparison to females that had a longer life and a higher fecundity at 24°C and 27°C, respectively. The lower thermal limit for biological cycle development was 12.4°C, and the thermal constant was 243.9 degree-days.

关键词： Anagasta kuehniella Biological Control Degree-Days

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Child Oncology and Hospital Recreation

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Journal of Cancer Therapy 2019年第2期10卷 157-165页

作者： conceicao de Maria Lima Nascimento Erenice conceicao de Almeida Barbosa Brunna Rafaella Do Carmo Silva Karoline Queiroz Martins Almeida de Araújo Gilzandra Lira Dantas Florencio Ana Carla Gomes Canário Paulo francisco de Almeida Neto FCU Sao PauloBrazil UFRN NatalBrazil UNINASSAU NatalBrazil FAK FortalezaBrazil UFPB Joao PessoaBrazil UFSC FlorianópolisBrazil SBOC Sao PauloBrazil

Introduction: Hospital Recreation (HR) aims to reduce disasters caused by hospital admission. Objectives: To expose the behavior of children in cancer treatment (CA) during HR, and to verify which recreational activities generate the most adherence. Methods: The research is an experimental clinical trial of a non-probabilistic and intentional sample, with a quantitative and qualitative approach. Participants were 43 children (both sexes), with CA, admitted to the Pediatric Hospital Oncology Center—PHOC. The mean age of the children in fact was 7.5 years, and the data of mean and standard deviation between parenthood confer with the data of the results found during the research. The study lasted 12 weeks, with 38 sessions lasting 3 hours. Using games of activity: cognitive, manipulative, perceptive, creative and cooperative. Inclusion criteria: 1) being hospitalized in the PHOC, of the city of Natal;2) being released by the medical team to participate in the activities. Children who were on special care in the ICU were excluded from the study. The behavior of the children was evaluated by the observation matrix proposed by Urie Bonfenbrenner, approached by Krebs and Koller. At the end of the research, an interview was made with patients about the HR experience. Results: In the subjects the molecular behavior showed relevance of ~50%, and the cooperative of ~80% in relation to HR, and the cognitive activities showed an adhesion index of ~90%. Conclusion: The participants showed greater adherence in the cognitive activities, and the predominance of the molecular behavior in relation to hospital recreation, highlighting the cooperative behavior among the individuals. In this way, the activities of HR can complement conventional medical treatment.

关键词： Ludic Activity Hospital Children Recreation Playful Cancer

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Intense Exercise in the Quality of Life of Breast Cancer Survivors:A Meta-Analysis

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Journal of Cancer Therapy 2019年第12期10卷 895-907页

作者： Paulo francisco de Almeida Neto Erenice conceicao de Almeida Barbosa Karoline Queiroz Martins Almeida de Araujo Tatianny de Macedo Cesario Brunna Rafaella do Carmo Silva Thiago Gil Vieira de Figueiredo Lima Nelson Carvas Junior Ana Carla Gomes Canario Federal University of Rio Grande do Norte UFRNNatalRNBrazil Brazilian Society of Clinical Oncology SBOCSao PauloSPBrazil Mauricio of Nassau University Center UNINASSANatalRNBrazil Institute of Medical Assistance to the state public servant IAMSPESao PauloSPBrazil Federal University of Paraíba UFPBJoao PessoaPBBrazil

The treatment of breast cancer (BC) leaves emotional and functional sequels affecting the quality of life (QOL) of the survivors. We aim to investigate, intense exercises in the rehabilitation of BC survivors. Using the systematic search model in the PubMed databases;Lilacs Bireme and Scielo. Meta-Analysis used the Meta package implemented in software R (version 3.3.2) p < 0.05. We selected 29 articles, and after reading in the Integra, we excluded 27 texts being included in the meta-analysis only 2. In the QOL, the heterogeneity in the emotional function showed a difference of 75%, in the social function 36% and in the physics 32%. Using intense exercises in BC survivors during rehabilitation improves overall QOL, muscle structure, and preserves functional capacity.

关键词： Breast Cancer High-Intensity Exercises High-Intensity Intermittent Exercise Women’s Health

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Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue

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Journal of Biomedical Science and Engineering 2013年第12期6卷 1178-1185页

作者： Julio Cesar francisco Ricardo Correa Cunha Rossana Baggio Simeoni Luiz Cesar Guarita-Souza Reginaldo Justino Ferreira Ana Carolina Irioda Carolina Maria C.Oliveira Souza Garikipati Venkata Naga Srikanth Soniya Nityanand Juan Carlos Chachques Katherine Athayde Teixeira de Carvalho Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health Sciences Pontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of Technology CuritibaBrazil Department of Hematology Stem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical Research Pompidou HospitalUniversity of Paris DescartesParisFrance

Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.

关键词： Amniotic Membrane Heart Tissue Engineering Stem Cells

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