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Prognosis value of heat-shock proteins in esophageal and esophagogastric cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1578-1595页

作者： Eric Toshiyuki Nakamura Amanda Park Marina Alessandra Pereira Daniel Kikawa francisco Tustumi Department of Gastroenterology Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Scientific Initiation Universidade Mogi das CruzesSão Paulo 08780911Brazil Department of Evidence-Based Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Department of Surgery Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

BACKGROUND Heat shock proteins(HSPs)are molecular chaperones that play an important role in cellular protection against stress events and have been reported to be overex-pressed in many *** prognostic significance of HSPs and their regulatory factors,such as heat shock factor 1(HSF1)and CHIP,are poorly *** To investigate the relationship between HSP expression and prognosis in esophageal and esophagogastric *** A systematic review was conducted in accordance with PRISMA recommend-ations(PROSPERO:CRD42022370653),on Embase,PubMed,Cochrane,and ***,case-control,and cross-sectional studies of patients with eso-phagus or esophagogastric cancer were ***-positive patients were compared with HSP-negative,and the endpoints analyzed were lymph node metastasis,tumor depth,distant metastasis,and overall survival(OS).HSPs were stratified according to the HSP family,and the summary risk difference(RD)was calculated using a random-effect *** The final selection comprised 27 studies,including esophageal squamous cell carcinoma(21),esophagogastric adenocarcinoma(5),and mixed neoplasms(1).The pooled sample size was 3465 ***40 and 60 were associated with a higher 3-year OS[HSP40:RD=0.22;95%confidence interval(CI):0.09-0.35;HSP60:RD=0.33;95%CI:0.17-0.50],while HSF1 was associated with a poor 3-year OS(RD=-0.22;95%CI:-0.32 to-0.12).The other HSP families were not associated with long-term ***1 was associated with a higher probability of lymph node metastasis(RD=-0.16;95%CI:-0.29 to-0.04).HSP40 was associated with a lower probability of lymph node dissemination(RD=0.18;95%CI:0.03-0.33).The expression of other HSP families was not significantly related to tumor depth and lymph node or distant *** The expression levels of certain families of HSP,such as HSP40 and 60 and HSF1,are associated with long-term survival and lymph node dissemination in patients with esophageal and esophagogastric cancer.

关键词： Heat-shock proteins Heat-shock response Prognosis Esophageal neoplasms Meta-analysis

Back to the future:Some similarities and many differences between autism spectrum disorder and early onset *** to pathophysiology?

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Science Bulletin 2024年第16期69卷 2476-2477页

作者： francisco Xavier Castellanos New York University Grossman School of Medicine New York NY 10016USA Nathan Kline Institute for Psychiatric Research Orangeburg NY 10962USA

In the first issue of the recently launched journal,Medicine Plus,Lu et al.[1]report on a remarkable effort encompassing nearly 600 young participants examined at five centers in *** focus was on the first episode early-onset schizophrenia(EOS;onset before age 18 years)and autism spectrum disorder(ASD),contrasted to each other and healthy controls(HC).Historically,autism was initially considered a form of infantile schizophrenia,although it was differentiated from early-onset schizophrenia as early as 1955 by Eisenberg and Kanner[2].

关键词： schizophrenia al. spectrum

Enhancement of the Antigenotoxic and Antioxidant Actions of Eugenol from Spice Clove and the Stabilizer Gum Arabic on Colorectal Carcinogenesis

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Food and Nutrition Sciences 2024年第1期15卷 71-100页

作者： Nayanna de Oliveira Ramos Melo Lucas Gabriel da Costa Marques Humberto Maia Costa Neto Matheus De sousa Silva francisco Vagnaldo Fechine Jamacaru Bruno Coêlho Cavalcanti Antônio Adailson De sousa Silva Conceição Aparecida Dornelas Postgraduate Program in Medical-Surgical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus of Research and Development of Medicines (NPDM) Laboratory of Pharmacology and Preclinical Research School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus for Research and Development of Medicines (NPDM) National Laboratory of Experimental Oncology Federal University of Ceará Fortaleza Brazil Postgraduate Program in Pathology and Medical-Surgical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil

Spices are defined as any aromatic condiment of plant origin used to alter the flavor and aroma of foods. Besides flavor and aroma, many spices have antioxidant activity, mainly related to the presence in cloves of phenolic compounds, such as flavonoids, terpenoids and eugenol. In turn, the most common uses of gum arabic are in the form of powder for addition to soft drink syrups, cuisine and baked goods, specifically to stabilize the texture of products, increase the viscosity of liquids and promote the leavening of baked products (e.g., cakes). Both eugenol, extracted from cloves, and gum arabic, extracted from the hardened sap of two species of the Acacia tree, are dietary constituents routinely consumed virtually throughout the world. Both of them are also widely used medicinally to inhibit oxidative stress and genotoxicity. The prevention arm of the study included groups: Ia, IIa, IIIa, Iva, V, VI, VII, VIII. Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the same period and for an additional 9 weeks, the animals received either water, 10% GA, EUG, or 10% GA + EUG by gavage. The treatment arm of the study included groups Ib, IIb, IIIb e IVb, IX, X, XI, XII). Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the subsequent 9 weeks, the animals received either water, 10% GA, EUG or 10% GA + EUG by gavage. The novelty of this study is the investigation of their use alone and together for the prevention and treatment of experimental colorectal carcinogenesis induced by dimethylhydrazine. Our results show that the combined use of 10% gum arabic and eugenol was effective, with antioxidant action in the colon, as well as reducing oxidative stress in all colon segments and preventing and treating genotoxicity in all colon segments. Furthermore, their joint administration reduced the number of aberrant crypts and th

关键词： Eugenol Gum Arabic Carcinogenesis Oxidative Stress Genotoxicity

A decomposition of light’s spin angular momentum density

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Light(Science & Applications) 2024年第8期13卷 1578-1589页

作者： Alex J.Vernon Sebastian Golat Claire Rigouzzo Eugene A.Lim francisco J.Rodríguez-Fortuño Department of Physics King’s College LondonStrandLondon WC2R 2LSUK London Centre for Nanotechnology LondonUK

Light carries intrinsic spin angular momentum(SAM)when the electric or magnetic field vector rotates over time.A familiar vector equation calculates the direction of light’s SAM density using the right-hand rule with reference to the electric and magnetic polarisation *** Maxwell’s equations,this vector equation can be decomposed into a sum of two distinct terms,akin to the well-known Poynting vector decomposition into orbital and spin *** present the first general study of this spin decomposition,showing that the two terms,which we call canonical and Poynting spin,are chiral analogies to the canonical and spin momenta of light in its interaction with *** canonical momentum,canonical spin is directly *** canonical and Poynting spin incorporate spatial variation of the electric and magnetic fields and are influenced by optical *** decomposition allows us to show that a linearly polarised vortex beam,which has no total SAM,can nevertheless exert longitudinal chiral pressure due to equal and opposite canonical and Poynting spins.

关键词： canonical momentum angular

Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado francisco J.Llorente-Cantarero Juan francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

Hydrochar and synthetic natural gas co-production for a full circular economy implementation via hydrothermal carbonization and methanation:An economic approach

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Journal of Environmental Sciences 2024年第6期140卷 69-78页

作者： Judith González-Arias Guillermo Torres-Sempere Miriam González-Castaño francisco MBaena-Moreno Tomás RReina Inorganic Chemistry Department and Materials Sciences Institute University of Seville-CSICSevilleSpain Materials Sciences Institute(ICMSE) CSIC-University of SevilleSevilleSpain Department of Chemistry and Chemical Engineering Chalmers University of TechnologyGothenburgSE 41296Sweden

Herein we study the economic performance of hydrochar and synthetic natural gas coproduction from olive tree *** process entails a combination of hydrothermal carbonization and *** a previous work,we evidenced that standalone hydrochar production via HTC results ***,we propose a step forward on the process design by implementing a methanation,adding value to the gas effluent in an attempt to boost the overall process techno-economic *** different plant capacities were analyzed(312.5,625 and 1250 kg/hr).The baseline scenarios showed that,under the current circumstances,our circular economy strategy in *** analysis of the revenues shows that hydrochar selling price have a high impact on NPV and subsidies for renewable coal production could help to boost the profitability of the *** the contrary,the analysis for natural gas prices reveals that prices 8 times higher than the current ones in Spain must be achieved to reach *** seems unlikely even under the presence of a strong subsidy *** costs analysis suggests that a remarkable electricity cost reduction or electricity consumption of the HTC stage could be a potential strategy to reach profitability ***,significant reduction of green hydrogen production costs is deemed instrumental to improve the economic performance of the *** results show the formidable techno-economic challenge that our society faces in the path towards circular economy societies.

关键词： Hydrothermal carbonization CO_(2)waste valorization Methanation Profitability analysis

Diplopoda in the world fossil record

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Zoological Systematics 2024年第3期49卷 185-245页

作者： Michelle Álvarez-Rodríguez francisco Riquelme Miguel Hernández-Patricio Fabio Cupul-Magaña Laboratorio de Sistemática Molecular Escuela de Estudios Superiores del JicareroUniversidad Autónoma del Estado de MorelosC.P.62909JojutlaMorelosMexico MMRN Centro de Investigaciones BiológicasUniversidad Autónoma del Estado de MorelosC.P.62209CuernavacaMorelosMexico Unafíliate Centro Universitario de la Costa Universidad de GuadalajaraC.P.48280Puerto VallartaJaliscoMexico

We present a comprehensive catalog with an updated database of the fossil record of Diplopoda in the *** data was collected from descriptions and reports published from 1854 to the *** also include new records from Mexican amber(Upper Oligocene-Lower Miocene),counting 83 unknown fossil inclusions,with the first records of the orders Polyxenida,Platydesmida,and Julida,as well as the families Sphaeriodesmidae and Trichopolydesmidae within *** to our results,Diplopoda counts 413 records featuring 299 distinct taxa ranging from the Middle Silurian to the Upper Pleistocene,representing three subclasses,two subterclasses,six superorders,25 orders,15 superfamilies,55 families,93 genera,and 161 fossil *** date,no fossils of the order Siphonocryptida have been *** fossil record extends over three geological eras:the Paleozoic,with 161 taxa,including 97 species;the Mesozoic,with 53 taxa and 22 species;and the Cenozoic,with 85 taxa and 42 *** referred material shows different forms of fossil *** comprises 123 impressions,99 compressions,26 ichnites,predominantly from Paleozoic and Mesozoic sediments,and 165 amber inclusions from late Mesozoic and Cenozoic ***,this catalog allows us to estimate the size and taxonomic composition of Diplopoda in the fossil record worldwide.

关键词： Millipedes Paleozoic Mesozoic Cenozoic new records catalog

Stress tensors and quantification of fracture patterns to analyze connectivity and potential fluid flow in a mesa landform of the Northern Andes

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Journal of Mountain Science 2024年第1期21卷 271-291页

作者： GARCÍA-ARIAS Sergio VELANDIA francisco ALVAREZ Angélica SANABRIA-GÓMEZ JoséD TARAZONA Yessenia VARGAS María Camila Escuela de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern Cordillera of Colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and a conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and a random distribution in the southwestern block. WinTensor treatment of slickensides yielded a maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used Frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos Colombia Win-Tensor FracPaQ Strike-slip faults Fractured aquifers

Morphometric Attributes of Two Native Forage Species According to Water Source Distance in Semiarid Central Grasslands of Argentina

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2063-2074页

作者： Carla Etel Suárez María Sol Rossini Ernesto francisco Atilio Morici Héctor Daniel Esterlich Laboratorio de Ecología en Ambientes Semiáridos Ecología VegetalFacultad de AgronomíaUNLPamSanta Rosa6300Argentina Facultad de Ciencias Veterinarias UNLPamGeneral Pico6360Argentina Becaria Doctoral CONICET APNFacultad de AgronomíaUNLPamSanta Rosa6300Argentina

The semiarid grasslands of Argentina’s central region have been modified by domestic livestock grazing,both in their composition and *** increase in the proportion of woody and non-forage species and the decrease in forage species are some of the most evident results of this *** is limited available information about the effect of differential grazing pressures on morphometric attributes of native species,and it also depends on the life histories of the species in this *** objective of this work was to evaluate some morphometric aspects in the grasses Poa ligularis Nees ex Steud and Piptochaetium napostaense(Speg.).Hack according to distance from the water source in communities in the central semiarid region of *** study area included areas of low grassland,golden forests,and secondary forests in grasslands(6 fields with 9 paddocks).Grazing pressure was established based on the distance to the water source,so sampling areas were designated near the water source(grazing pressure is greater)and far from the water source(grazing pressure light)in each of the *** both species,specimens were selected at random,and the following attributes were measured:crown diameter at ground level(cm),burial depth(cm),average tiller weight per plant(***^(−1)),and the density of tillers per unit of crown surface(***^(−2)crown).The morphometric attributes evaluated showed differences according to the distance to the watering hole and in the different *** species presented similar behaviors for the *** were significant differences in the depth of burial and the average weight of tillers per plant,being greater in the areas close to the water *** the distance to the watering hole,there were no significant differences in crown diameter and tiller density,but the highest values were recorded for the former near the watering hole and for the second far from the watering *** pastures with low

关键词： Grazing pressure tiller density tiller weight crown burial depth Poa ligularis Piptochaetium napostaense