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Latest developments in early diagnosis and specific treatment of severe influenza infection

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Journal of Intensive Medicine 2024年第2期4卷 160-174页

作者： francisco Valenzuela-Sánchez Blanca Valenzuela-Méndez Juan francisco rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandemics are unpredictable recurrent events with global health,economic,and social *** objective of this review is to provide an update on the latest developments in early diagnosis and specific treatment of the disease and its complications,particularly with regard to respiratory organ *** advances in treatment,the rate of mortality in the intensive care unit remains approximately 30%.Therefore,early identification of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in some patients,it is associated with an excessive systemic response mediated by an authentic cytokine *** process leads to severe primary pneumonia and acute respiratory distress *** prognostication in the emergency department based on comorbidities,vital signs,and biomarkers(e.g.,procalcitonin,ferritin,human leukocyte antigen-DR,mid-regional proadrenomedullin,and lactate)is *** of these biomarkers on admission may facilitate clinical decision-making to determine early admission to the hospital or the intensive care *** decisions are reached considering pathophysiological circumstances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunction,and septic shock).Moreover,early implementation is important to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility of drug resistance should also be *** options include other antiviral drugs and combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Acute respiratory distress syndrome Intensive care unit admission

Arrhythmic syncope: From diagnosis to management

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World Journal of Cardiology 2023年第4期15卷 119-141页

作者： Jaume francisco Pascual Pablo Jordan Marchite Jesús rodríguez Silva Nuria Rivas Gándara Unitat d’Arritmies Servei de Cardiologia VHIR Hospital Universitari Vall d’HebronBarcelona 08035Spain Grup de Recerca Cardiovascular Vall d’Hebron Institut de RecercaBarcelona 08035Spain CIBER de Enfermedades Cardiovasculares Instituto de Salud Carlos ⅢMadrid 28029Spain Departament de Medicina Universitat Autònoma de BarcelonaBellaterra 08193Spain

Syncope is a concerning symptom that affects a large proportion of *** can be related to a heterogeneous group of pathologies ranging from trivial causes to diseases with a high risk of sudden ***,benign causes are the most frequent,and identifying high-risk patients with potentially severe etiologies is crucial to establish an accurate diagnosis,initiate effective therapy,and alter the *** term cardiac syncope refers to those episodes where the cause of the cerebral hypoperfusion is directly related to a cardiac disorder,while arrhythmic syncope is cardiac syncope specifically due to rhythm ***,arrhythmias are the most common cause of cardiac *** bradyarrhythmia and tachyarrhythmia can cause a sudden decrease in cardiac output and produce *** this review,we summarized the main guidelines in the management of patients with syncope of presumed arrhythmic ***,we presented a thorough approach to syncope work-up through different tests depending on the clinical characteristics of the patients,risk stratification,and the management of syncope in different scenarios such as structural heart disease and channelopathies.

关键词： Syncope Arrhythmia Electrophysiological study Loop recorder Myocardiopathy Atrioventricular conduction block

In Vitro Propagation of Agave guiengola Gentry Using Semisolid Medium and Temporary Immersion Bioreactors

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 1003-1013页

作者： Lucía Isabel Chávez-Ortiz Joséfrancisco Morales-Domínguez Araceli rodríguez-Sahagún Eugenio Pérez-Molphe-Balch Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Laboratorio de Biología Molecular Vegetal Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán47820México

Agave guiengola Gentry is an endemic plant from a very small locality in Oaxaca,*** conservation status is fragile and can rapidly *** of its scarcity,this agave has been used solely for ornamental purposes,but it could have other uses if more plants were *** vitro propagation by enhanced axillary sprouting from stem segments was attained using Murashige and Skoog Basal Medium(MS)as well as basal medium supplemented with cytokinins 6-Benzylaminopurine(BA)or 6-(γ,γ-Dimethylallylamino)purine(2iP).The best treatment for shoot induction in semisolid medium consisted in MS supplemented with 2 mg l^(–1) BA,obtaining a mean of 3.7 shoots per *** interesting responses were observed,such as nodular callus induction using combinations of BA and 2,4-Dichlorophenoxyacetic acid(2,4-D);root induction without Plant Growth Regulators(PGR);and generation of shoot *** clusters constituted an excellent explant for micropropagation in temporary immersion bioreactors,obtaining a propagation rate of 43 shoots per explant with 1 min immersion and 6 h immersion *** new plants rooted and survived the transfer to *** study developed an in vitro propagation scheme to produce individuals that can be used either for reforestation,economical purposes,or to carry out studies in this species to assess its full potential,avoiding exploitation from wild plants.

关键词： Agavaceae temporary immersion systems callus induction micropropagation

Computer-Aided Diagnosis for Tuberculosis Classification with Water Strider Optimization Algorithm

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Computer Systems Science & Engineering 2023年第8期46卷 1337-1353页

作者： José Escorcia-Gutierrez Roosvel Soto-Diaz Natasha Madera Carlos Soto francisco Burgos-Florez Alexander rodríguez Romany F.Mansour Department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla080002Colombia Biomedical Engineering Program Universidad Simón BolívarBarranquilla080002Colombia Mechatronics Engineering Program Universidad Simón BolívarBarranquilla080002Colombia Department of Medicine Universidad del NorteBarranquilla081007Colombia Department of Mathematics Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt

Computer-aided diagnosis(CAD)models exploit artificial intelligence(AI)for chest X-ray(CXR)examination to identify the presence of tuberculosis(TB)and can improve the feasibility and performance of CXR for TB screening and *** the same time,CXR interpretation is a time-consuming and subjective ***,high resemblance among the radiological patterns of TB and other lung diseases can result in ***,computer-aided diagnosis(CAD)models using machine learning(ML)and deep learning(DL)can be designed for screening TB *** this motivation,this article develops a Water Strider Optimization with Deep Transfer Learning Enabled Tuberculosis Classification(WSODTL-TBC)model on Chest X-rays(CXR).The presented WSODTL-TBC model aims to detect and classify TB on CXR ***,the WSODTL-TBC model undergoes image filtering techniques to discard the noise content and U-Net-based image ***,a pre-trained residual network with a two-dimensional convolutional neural network(2D-CNN)model is applied to extract feature *** addition,the WSO algorithm with long short-term memory(LSTM)model was employed for identifying and classifying TB,where the WSO algorithm is applied as a hyperparameter optimizer of the LSTM methodology,showing the novelty of the *** performance validation of the presented WSODTL-TBC model is carried out on the benchmark dataset,and the outcomes were investigated in many *** experimental development pointed out the betterment of the WSODTL-TBC model over existing algorithms.

关键词： Computer-aided diagnosis water strider optimization deep learning chest x-rays transfer learning

Fixed Dose Combination of Magaldrate Plus Domperidone Is More Effective than Domperidone Alone in the Treatment of Patients with Gastroesophageal Reflux Symptoms: A Randomized Double-Blind Study

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Pharmacology & Pharmacy 2014年第2期5卷 216-223页

作者： Shendel Nyx rodríguez-Sánchez Héctor Isaac Rocha-González Cecilia fernández del Valle-Laisequilla Juan rodríguez-Silverio francisco Javier Flores-Murrieta Juan Gerardo Reyes-García Productos Medix S.A. de C.V. México City Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina del Instituto Politécnico Nacional Mexico City Mexico Instituto Nacional de Enfermedades Respiratorias Secretaría de Salud Mexico City Mexico

Gastroeophageal reflux is a condition in which the acidified liquid content of the stomach backs up into the esophagus. The antiacid magaldrate and prokinetic domperidone are two drugs clinically used for the treatment of gastroesophageal reflux symptoms. However, the evidence of a superior effectiveness of this combination in comparison with individual drugs is lacking. A double-blind, randomized and comparative clinical trial study was designed to characterize the efficacy and safety of a fixed dose combination of magaldrate (800 mg)/domperidone (10 mg) against domperidone alone (10 mg), in patients with gastroesophageal reflux symptoms. One hundred patients with gastroesophageal reflux diagnosed by Carlsson scale were randomized to receive a chewable tablet of a fixed dose of magaldrate/domperidone combination or domperidone alone four times each day during a month. Magaldrate/domperidone combination showed a superior efficacy to decrease global esophageal (pyrosis, regurgitation, dysphagia, hiccup, gastroparesis, sialorrhea, globus pharyngeus and nausea) and extraesophageal (chronic cough, hoarseness, asthmatiform syndrome, laryngitis, pharyngitis, halitosis and chest pain) reflux symptoms than domperidone alone. In addition, magaldrate/domperidone combination improved in a statistically manner the quality of life of patients with gastroesophageal reflux respect to monotherapy, and more patients perceived the combination as a better treatment. Both treatments were well tolerated. Data suggest that oral magaldrate/domperidone mixture could be a better option in the treatment of gastroesophageal reflux symptoms than only domperidone.

关键词： Antiacid Domperidone Gastroesophageal Reflux Magaldrate Prokinetic

Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis

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World Journal of Hepatology 2016年第1期8卷 74-82页

作者： emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández Servicio de Medicina Interna Hospital Universitario de CanariasUniversidad de La Laguna38320 Canary IslandsSpain

AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) ***: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and ***: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines.

关键词： Resistin Adiponectin Insulin resistance Proinflammatory cytokines Leptin Hepatitis C virus Liver steatosis

Study of Functionalized Gold Nanoparticles with Anti-gp63 IgG Antibody for the Detection of Glycoprotein gp63 in Membrane Surface of <i>Leishmania</i>Genus Parasites

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American Journal of Analytical Chemistry 2013年第7期4卷 100-108页

作者： Pedro rodríguez Humberto Rojas Miguel Medina Jazzmin Arrivillaga Yosue francisco Fracehuli Dager Vincent Piscitelli Manuel Caetano Alberto fernández Jimmy Castillo Centro de Microscopia Electrónica Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Departamento de Biología Universidad Simón Bolívar Caracas Venezuela Escuela de Biología Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Laboratorio de Espectroscopia Laser Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela

In this work we present the preparation and functionalization of gold nanoparticles (AuNPs) for the detection of presence of gp63 glycoprotein in the surface of Leishmania genus parasites. AuNPs were prepared by induced laser ablation in a clean and biologically suitable media. The nanoparticles were functionalized with anti-gp63 lgG antibody in order to study the interaction with the glycoprotein component gp63 (63 kDa) present on the membrane surface of Leishmania genus parasites. The functionalized AuNPs showed potential as a spectrometric indicator of the parasite existence, both by the detection of the presence of the gp63 in solution and through the specific interaction with the parasites in vitro. The specificity of the study opens a new line of research on the use of modified nanoparticles in the development of a fast and easy assay for Leishmaniosis diagnostics.

关键词： Leishmania Nanoparticles Surface Plasmon Resonance gp63 Protein

Different strategies of treatment for uterine cervical carcinoma stage ⅠB2-ⅡB

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World Journal of Clinical Oncology 2014年第2期5卷 86-92页

作者： Lucas Minig María Guadalupe Patrono Nuria Romero Juan francisco rodríguez Moreno Jesús Garcia-Donas Gynecologic Oncology Program Clara Campal Comprehensive Cancer CenterHM Hospitales28050 Madrid Spain Gynecologic Oncology Program Medical Oncology Department Clara Campal Comprehensive Cancer Center HM Hospitales28050 Madrid Spain

Uterine cervical cancer is the second most common gynecological malignancy. It is estimated that over 35% of tumors are diagnosed at locally advanced disease, stage ⅠB2-ⅡB with an estimated 5-year overall survival of 60%. During the last decades, the initial treatment for these women has been debated and largely varies through different countries. Thus, radical concurrent chemoradiation is the standard of care in United Sated and Canada, and neoadjuvant chemotherapy followed by radical surgery is the first line of treatment in some institutions of Europe, Asia and Latin America. Until today, there is no evidence of which strategy is better over the other. This article describe the evidence as well as the advantages and disadvantages of the main strategies of treatment for women affected by uterine cervical cancer stage ⅠB2-ⅡB.

关键词： Locally advanced cervical cancer Federation of Gynecology and Obstetrics stage ⅠB2-ⅡB Radiotherapy Neoajuvant chemotherapy Radical hysterectomy

A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria rodríguez-Barroso Alberto Argente-Garrido Daniel Jiménez-López Jose M.Moyano Javier Del Ser Weiping Ding francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks