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COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner

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World Journal of Pediatrics 2022年第6期18卷 373-382页

作者： Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio francisca sandoval Department of Neurology Hospital Dr.Exequiel González CortésGran Avenida JoséMiguel Carrera 33008900085SantiagoRegión MetropolitanaChile

Background Since December 2019,the SARS-CoV-2 virus has been a global health *** main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been *** this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic *** sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA *** studies cited were published between 2004 and 2022,and represent the most relevant articles in the *** World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological *** The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle *** can be present during COVID-19 or weeks after recovering from *** who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and *** neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated *** the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and *** Various neurologic manifestations have been associated with children’s SARS-CoV-2 *** is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting se

关键词： Coronavirus COVID-19 Neurologic Pediatric SARS-CoV-2 MIS-C

Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus)

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Burns & Trauma 2016年第4期4卷 264-272页

作者： Carolina Schencke Adriana Vasconcellos Cristian sandoval Paulina Torres francisca Acevedo Mariano del Sol Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CONICYT-PCHA/National Doctorate Programme/2014-21141130 SantiagoChile Facultad de Medicina Universidad de La FronteraTemucoChile Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CIMA Research Group Facultad de OdontologíaUniversidad de La FronteraTemucoChile CONICYT-PCHA/Doctorado Nacional/2015-21150991 SantiagoChile Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemucoChile Facultad de Medicina Universidad de La FronteraTemucoChile Centro de Excelencia en Estudios Morfológicos y Quirúrgicos(CEMyQ) Universidad de La FronteraTemucoChile Centro de Investigación en Ciencias Biomédicas Universidad Autónoma de ChileTemucoChile

Background:In the context of the search for cost-efficient treatments,Ulmo(Eurcyphia cordifolia)honey is an excellent alternative for treating burn wounds and could have a profound medical,social,and economic *** acid is an enzymatic co-factor necessary for the synthesis of collagen and the proliferation of fibroblasts and has been proposed as a coadjuvant to strengthen the healing effects of *** aim of this work was to evaluate by morphometric studies the healing wounds caused by burns treated with Ulmo honey alone and supplemented with ascorbic acid in guinea pig(Cavia porcellus).Methods:Fifteen guinea pigs were used and divided randomly into three groups:positive control(C+),experimental with unsupplemented honey(H),and experimental with supplemented honey(SH).A uniform deep burn covering 1 cm2of the back skin was *** following indices were calculated for the morphometric study:superficial contraction index of the wound,deep contraction index of the wound,wound severity index,global healing index,global contraction index,and dermal proliferation ***:The superficial contraction index of the wound,global healing index,global contraction,and dermal proliferation area values of the experimental with supplemented honey group were higher than the other groups(P<0.05).Conclusions:According to these results,the combination of honey with an antioxidant(ascorbic acid)promotes an appropriate action to support the healing *** study showed that by supplementing the Ulmo honey with ascorbic acid,the healing and contraction effects can be strengthened in burn wounds compared to unsupplemented *** results were proof of the synergy between honey and ascorbic acid in healing burn wounds.

关键词： Honey Ascorbic acid Burn Morphometry Wound healing

Increased DNA binding activity of NF-κB,STAT-3,SMAD3 and AP-1 in acutely damaged liver

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World Journal of Gastroenterology 2006年第37期12卷 5995-6001页

作者： Adriana Salazar-Montes Luis Ruiz-Corro Ana sandoval-Rodriguez Alberto Lopez-reyes Juan Armendariz-Borunda Institute of Molecular Biology in Medicine and Gene Therapy CUCS University of Guadalajara Apdo. Postal 2-123 Guadalajara 44281 Jal Mexico Institute of Molecular Biology in Medicine and Gene Therapy CUCS University of Guadalajara Apdo.Postal 2-123 Guadalajara 44281 Jal Mexico OPD Hospital Civil de Guadalajara Guadalajara Jal Mexico

AIM: To investigate the role of genes and kinetics of specific transcription factors in liver regeneration, and to analyze the gene expression and the activity of some molecules crucially involved in hepatic regeneration. METHODS: USING gel-shift assay and RT-PCR, transcription factors, such as NF-κB, STAT-3, SMAD3 and AP-1, and gene expression of inducible nitric oxide synthase (iNOS), hepatocyte growth factor (HGF) and c-met were analyzed in an animal model of chemically induced hepatectomy. RESULTS: Gene expression of HGF and its receptor c-met peaked at 3 h and 24 h after acute CCl4 intoxi- cation. iNOS expression was only observed from 6 to 48 h. Transcriptional factor NF-κB had an early activation at 30 min after acute liver damage. STAT-3 peaked 3 h post- intoxication, while AP-1 displayed a peak of activation at 48 h. SMAD3 showed a high activity at all analyzed times. CONCLUSION: TNF-α and IL-6 play a central role in hepatic regeneration. These two molecules are responsible for triggering the cascade of events and switch-on of genes involved in cell proliferation, such as growth factors, kinases and cyclins which are direct participants of cell proliferation.

关键词： Hepatic regeneration Transcription factor Gene regulation

Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis *** absolute stereochemistry of the gargantulide family

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Organic Chemistry Frontiers 2022年第2期9卷 462-470页

作者： Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz Caridad Díaz francisca Vicente Kai Blin Fernando reyes Tilmann Weber Olga Genilloud Fundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaAvda.del Conocimiento 3418016 ArmillaGranadaSpain The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKemitorvetbuilding 2202800 Kgs.LyngbyDenmark

Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis *** CA-230715 during an antibacterial screening *** structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their *** sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides *** absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ *** addition,the absolute stereochemistry of gargantulide A has now been revised and *** B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.

关键词： absolute membered backbone

A Reliable Method to Quantify Trimethoprim and Sulfamethoxazole in Plasma of Children by HPLC with Application in Pharmacokinetic Studies

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American Journal of Analytical Chemistry 2019年第7期10卷 247-253页

作者： Alejandra Toledo Ló pez Hugo Juá rez Olguí n Ismael Lares-Asseff Fernanda reyes Gonzá lez Radames Alemon Medina Gabriela Pé rez Guillé francisca Trujillo Jimenez Laboratory of Pharmacology Instituto Nacional de Pediatr&#237 a Mexico City Mexico Centro de Investigació n Interdisciplinario para el Desarrollo Integral Regional Durango Mexico

Aim: To develop a simple and sensitive high-performance liquid chromatography method to determine plasmatic levels of trimethoprim/sulfamethoxazole in paediatric population. Method: Chromatographic separation was carried out using a reverse phase column with detection ultraviolet at a wavelength of 225 nm. The mobile phase consists of phosphate buffer 0.1 M, acetonitrile and methanol, (65:20:15) with a flow of 1.0 ml/min. Results: Calibration curve was linear over the concentration range for trimethoprim of 0.25 to 5 μg/ml and 5 to 100 μg/ml for sulfamethoxazole. Precision were found to be within 15% for both compounds. The detection limits and quantifications for trimethoprim/sulfamethoxazole were 0.2 - 0.25 μg/ml and 3 - 5 μg/ml respectively. Conclusions: The developed method was applied for the quantification of both compounds in plasma samples of two patients resulting concentrations within the therapeutic ranges. The method is convenient for pharmacokinetic studies.

关键词： Children Liquid Chromatography Phase Reverse Pharmacokinetics

Evaluation Regarding the Efficacy and Safety of a Probiotic Mixture in Healthy Volunteers with Evacuation Disorders

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Food and Nutrition Sciences 2012年第1期3卷 117-122页

作者： Lourdes Rodríguez-Fragoso Adriana sandoval-Ocampo Martha Corbalá-Nava Carlos A. Arjona-Canul Diana Lizbeth Gomez-Galicia Guillermo Tellez Billy Hargis Jorge reyes-Esparza 不详

Probiotics have been used in humans for almost a century and are widely recommended because they play an important role in gastrointestinal physiological and pathophysiological processes. The aim of this study was to evaluate the effi- cacy and safety of a probiotic mixture in healthy volunteers with evacuation disorders. We undertook a prospective study with historical control. We used the number of evacuations, effort and stool consistency 10 days before, 10 days during and 10 days after treatment with the probiotic as primary outcome measures. Eligible par-ticipants comprised 25 patients with an average age of 25.12 years (range: 18 - 55) who suffered from evacuation disorders. BIO L6 is a func- tional food consisting of a probiotic preparation that contains 1 mg (108 CFUs) of lyophilized strains of Lactic Acid Bacteria resuspended in 250 mL of drinking water. The probiotic preparation was prescribed daily for two weeks, five days a week. A significant increase in the number of evacuations was observed in 23 patients during BIO L6 consump- tion and continued in 20 after consumption. The degree of effort spent defecating decreased in 17 patients during treat- ment and in 7 after treatment. A significant improvement (P < 0.001) in stool consistency was also observed in all pa- tients receiving BIO L6. Fourteen patients had at least one adverse event (AE) for one or two days during treatment;most treatment-related AEs were considered minor or mild in terms of severity and were consistent with AEs reported for probiotic consumption. The results of this study suggest that the use of probiotic mixture BIO L6 is effective, safe and tolerable and provides beneficial effects for subjects with evacuations disorders.

关键词： Chronic Constipation Probiotic Lactic Acid Bacteria

Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A_(1) and A_(2) Adenosine-Receptor Antagonists in Rats

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Pharmacology & Pharmacy 2013年第3期4卷 303-311页

作者： Ilhuicamina Daniel Limon-Perez de Leon Maria del Carmen Parra-Cid Alejandro Munoz-Zurita Saul Alejandro Merino-Contreras Sara Montiel-Smith Socorro Meza-reyes Gerardo Ramirez-Meja Jesus sandoval-Ramirez Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de PueblaPueblaMexico Instituto Nacional de Rehabili-tacion Unidad de Ingenieria de TejidosTerapia Celular y Medicina RegenerativaMexico DFMexico.

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

关键词： Xantines Adenosine Receptors Antagonists Turning Behavior Anti-Parkinsonian Drugs

Comprehensive Left Ventricular Mechanics Analysis by Speckle Tracking Echocardiography in COVID-19

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World Journal of Cardiovascular Diseases 2021年第2期11卷 113-125页

作者： Francisco J. González-Ruiz Emmanuel A. Lazcano-Díaz Zuilma Y. Vásquez-Ortiz Fernanda Bernal-Ceballos Rodrigo Gopar-Nieto Consuelo Orihuela-sandoval José P. Hernández-reyes Edgar García-Cruz Eduardo Bucio-Reta Ángel Ramos-Enríquez Luis A. Cota-Apodaca Luis Efren-Santos Blanca Estela Broca-García Daniel Manzur-sandoval Efrén Melano-Carranza Fernandez de la Reguera Guillermo Gustavo Rojas-Velasco Francisco Baranda-Tovar Department of Cardiovascular Critical Care National Institute of Cardiology “Dr. Ignacio Chávez” México City México Department of Echocardiography National Institute of Medical Science and Nutrition “Dr. Salvador Zubirán” México City México PhD Program National University of Mexico (UNAM) México City México Cardiovascular Diseases Department National Institute of Cardiology “Dr. Ignacio Chávez” México City México

Background: Cardiac involvement and the consequences of inflammation induced by SARS-CoV2 infection could have catastrophic long-term consequences. Left ventricular mechanics could identify a specific pattern of myocardial fiber damage in patients infected with COVID-19. To our knowledge there are no publications referring to the global description of ventricular mechanics in patients with COVID-19. Objective: To describe left ventricular mechanics in hospitalized patients with COVID-19. Methods: In this cross-sectional study, we included 40 hospitalized patients with confirmed diagnostic of COVID-19, from April 11, 2020, to September 6, 2020. Demographic and laboratory data, clinical and echocardiographic characteristics were collected, as well as events during hospitalization. Left ventricular deformation was analyzed and reported. Results: Subclinical dysfunction was observed in 82.5% (left ventricular longitudinal strain [LVGLS] -17.05% and global circumferential strain [GCS] -18.6%) of the patients, likewise, the mean twist and apical rotation were preserved, and even increased as part of the compensating mechanism to maintain the ejection fraction. Conclusion: In patients hospitalized with COVID-19, despite having a normal left ventricular ejection fraction, subclinical myocardial damage was found, manifested by a decrease in Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS). This behavior is similar to that of cardiomyopathies in the early stage of the disease, and given the pathophysiological mechanisms involved in the disease, its long-term consequences should be monitored and evaluated.

关键词： COVID-19 Speckle Tracking Echocardiography Myocarditis Cardiomyopa-thy Cardiac Mechanics Strain Myocardial Damage Deformation Imaging Myocardial Strain

Gastrointestinal tumors and infectious agents:A wide field to explore

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World Journal of Meta-Analysis 2021年第6期9卷 505-521页

作者： Miriam López-Gómez Belén García de Santiago Pedro-David Delgado-López Eduardo Malmierca Jesús González-Olmedo César Gómez-Raposo Carmen sandoval Pilar Ruiz-Seco Nora Escribano Jorge Francisco Gómez-Cerezo Enrique Casado Medical Oncology Department.Precision Oncology Laboratory Infanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Pharmacy Department Infanta Sofia University HospitalSan Sebastián de los Reyes 28703MadridSpain Neurosurgery Department Burgos University HospitalBurgos 09006Spain Internal Medicine Department Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Medical Oncology Department Infanta Sofia University HospitalSan Sebastián de los Reyes 28703MadridSpain Intensive Care Unit Jiménez Díaz FoundationMadrid 28040MadridSpain

Infection is currently one of the main contributors to *** fact,the International Agency for Research on Cancer has categorized eleven biological agents as group I *** is estimated that around 16%of the 12.7 million new cancers diagnosed in 2008 were attributable to infectious *** underdeveloped regions carry the highest incidence rates,about 7.4%of infectionrelated cancer cases occur in developed *** are increasingly aware of the potential carcinogenic role of common virus like the Human Papilloma virus in cervical cancer,or the hepatitis B and C viruses in ***,the carcinogenic role of several other infectious agents is less *** that gastrointestinal malignancies carry an overall poor prognosis,a better understanding of the carcinogenic mechanisms triggered by infectious agents is key to decrease the rate of cancer related *** measures directed to such infections would ideally impact *** this paper we review the main pathogenic mechanisms related to the development of gastrointestinal malignancies induced by infectious microorganisms and other pathogens which are currently under investigation.

关键词： Gastrointestinal tumors Infectious agents Bacteria Virus Prevention