检索结果-南通市图书馆

Prevalence, Risk Factors, and Awareness of Chronic Kidney disease among diabetes Mellitus and Hypertensive Individuals at the Buea Regional Hospital, Cameroon

引用

Journal of Biosciences and Medicines 2023年第4期11卷 260-277页

作者： Patience Nformi Ndapkwi Elisabeth Zeuko’o Menkem Oteh Njockawoh Mpey Eleonore Ngounou Woquan Sama Luma Watching djakissam Erastus Nembo Nembu Jackson Seukep Armel francis désiré bomba taksinkou denis Teuwafeu Fabrice Fekam Boyom department of Biomedical Sciences Faculty of Health Sciences University of Buea Buea Cameroon Antimicrobial and Biocontrol Agent Unit Laboratory for Phytobiochemistry and Medicinal Plants Studies Department of Biochemistry Faculty of Sciences University of Yaoundé 1 Yaoundé Cameroon department of Medical Laboratory Sciences Faculty of Health Sciences University of Buea Buea Cameroon department of Internal Medicine and Pediatrics Faculty of Health Sciences University of Buea Buea Cameroon

Background: Kidney failure, cardiovascular disease, and early mortality are just a few of the major negative effects of chronic renal disease, a serious global health issue. The considerable financial and public health burden associated with chronic kidney disease can be lessened by raising awareness and adopting better practices for its impact, prevention, and early identification. Objective: In this study, individuals with hypertension and diabetes were evaluated for their knowledge of chronic kidney disease, its prevalence, and its risk factors. Method: It was a hospital-based cross-sectional study conducted on adult (>18 years) patients with diabetes mellitus and hypertension. Each participant provided written informed consent before having their data collected through interviews, medical information, and blood samples for CKd screening. The CKd epidemiology collaboration (CKd-EPI) equation was used to calculate the glomerular filtration rate (GFR) from serum creatinine, and CKd was determined using the estimated GFR (e-GFR). To find independent CKd factors, multivariate logistic regression was employed, with a p-value of 0.05 being regarded as statistically significant. This was accomplished using SPSS (Statistical Program for Social Sciences) version 22.0, IBM Corp., Armonk, NY. Result: A total of 156 participants took part in the study among which 95 (60.9%) were male, most of the participants 82 (52.6%) were aged between 51 - 70 years (mean 59.42 ± 11.007), 76 (48.7%) were unemployed and 97 (62.2%) were single. Overall, the knowledge score of participants on CKd was 65.4% for good knowledge and 34.6% for poor or inadequate knowledge of CKd. More than half of the participants (60%) had chronic kidney disease. Among these, the greatest proportion of CKd patients were those who were hypertensive (88.2%) followed by those who were both hypertensive and diabetic (70.7%). Conclusion: There is poor management of CKd in the South West Region of Cameroon which has co

关键词： Chronic Kidney disease Prevalence Risk Factors Hypertension diabetes Mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum(Mimosaceae) on rats

引用

Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 150-159页

作者： Mbiantcha Marius Almas Jabeen Ateufack Gilbert Shabana U.Simjee bomba Tatsinkou francis desire Nida dastagir Laboratory of Animal Physiology and Phytopharmacology Faculty of Science University of Dschang dr.Panjwani Center for Molecular Medicine and drug Research International Center for Chemical and Biological Sciences University of Karachi H.E.J.Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi

Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum africanum stem bark(PAME) and it possible action mechanism. Methods: PAME was tested on carrageenan ?induced hyperalgesia using plantar test(thermal) and analgesymeter(mechanical) in rats, on prostaglandin E_2(PGE_2) induced mechanical hyperalgesia and vincristine induced neuropathic pain in rat, both with analgesymeter. Modulators of NO/cG MP/K^+ channel pathway and endogenous opioids receptor antagonists and/or agonists were used to determine the possible action mechanism of PAME. Results: PAME significantly decreased carrageenan induced thermal and mechanical hyperalgesia, as well as PGE_2 induced mechanical hyperalgesia. PAME significantly protected the animals against the installation of neuropathic pain. Anti-nociception activity produced by PAME was significantly blocked in animals pre?treated with all the antagonists(naloxone, NW-nitro-L-arginine methyl ester(L-NAME), methylene blue and glibenclamide). Conclusions: Results of this study reveal that, PAME administrate orally, can induce anti-hyperalgesic action against installation of inflammatory pain as well as neuropathic pain. The mechanism underlying PAME antihyperalgesic effect could probably be associated with an activation of opioid receptors and NO/cG MP/K^+ channel pathway.

关键词： Piptadeniastrum africanum Neuropathic pain Inflammatory pain cGMP Nitric oxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：