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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in colorectal Cancer Cells

Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang JIN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(Pcolorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(Pconclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

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A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice

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Virologica Sinica 2024年第4期39卷 675-684页

作者： Yihua Jiang Lingjin Sun Nan Qiao Xiang Wang Caihong Zhu man Xing Hui Liu Ping Zhou Dongming Zhou Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508China R&D Centre Chengdu Kanghua Biological Products Co.LtdChengdu610000China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai200031China

Norovirus(NoV)infection is a major cause of gastroenteritis *** virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic *** date,there are no approved NoV vaccines for clinical ***,we aimed to develop a broad-acting quadrivalent NoV vaccine based on a chimpanzee adenovirus vector,AdC68,carrying the major capsid protein(VP1)of noroviral GI and GII *** to intramuscular(i.m.),intranasal(i.n.),or other prime-boost immunization regimens(i.m.t i.m.,i.m.t i.n.,i.n.t i.m.),AdC68-GI.1-GII.3(E1)-GII.4-GII.17(E3),administered via i.n.t *** higher titers of serum IgG antibodies and higher IgA antibodies in bronchoalveolar lavage fluid(BALF)and saliva against the four homologous VP1s in *** also significantly stimulated the production of blocking antibodies against the four *** response to re-stimulation with virus-like particles(VLP)-GI.1,VLP-GII.3,VLP-GII.4,and VLP-GII.17,the quadrivalent vaccine administered according to the i.n.t *** effectively triggered specific cell-mediated immune responses,primarily characterized by IFN-γ***,the preparation of this novel quadrivalent NoV vaccine requires only a single recombinant adenovirus to provide broad preventive immunity against the major GI/GII epidemic strains,making it a promising vaccine candidate for further development.

关键词： Norovirus(NoV) Quadrivalent vaccine Adenovirus vector

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Errata regarding missing Ethical Statements in previously published articles:Part 5

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Journal of Integrative Agriculture 2024年第2期23卷 739-739页

作者： Zhao, man

Ethical statements were not included in the published version of the following articles that appeared in previous issues of Journal of Integrative *** appropriate statements provided by the Authors are included below.

关键词： statements Ethical missing

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High-performance sodium storage for cobalt phosphide composite array electrodes

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Rare Metals 2024年第8期43卷 3724-3734页

作者： man Zhang Xiao-Xu Liu Tian-Yi Ji Yang Li Da-Wei Sheng Shao-Dong Li Pei-Pei Ren Ze-Xiang Shen School of Material Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore

Transition metal phosphides hold great potential as sodium-ion batteries anode materials owing to their high theoretical capacity and modest ***,volume changes and low intrinsic conductivity seriously largely hinder the further development of metal phosphide *** design of phosphide anode materials with reasonable structure is conducive to solving the problems of volume expansion and slow reaction kinetics during the *** this work,a composite material integrating zeolite imidazolate backbone(ZIF) and carbon materials was synthesized by the original growth ***,by the oxidation-phosphating process,coP nanoarray composites riveted to carbon fiber(coP@CF) were *** the coP@CF,coP nanoparticles are uniformly distributed on ZIF-derived carbon,reducing agglomeration and volume change during *** also provides a highly conductive network for the active material,improving the electrode ***,when evaluated as an anode for sodium-ion batteries,coP@CF electrode displays enhanced reversible capacity(262 mAh·g^(-1) at 0.1 A·g^(-1)after 100 cycles),which is much better than that of pure CF electrode(57 mAh·g^(-1) at 0.1 A·g^(-1) after 100 cycles)prepared without the addition of *** rate performance of coP@CF electrode is also superior to that of pure CF electrode at various current densities from 0.05 to1 A·g^(-1).The sodium storage behavior of coP@CF was revealed by ex-situ X-ray photoelectron spectroscopy,X-ray diffraction,and synchrotron radiation absorption *** method provides a reference for the design and synthesis of anode materials in sodium-ion batteries.

关键词： cobalt phosphide Array structure Freestanding anodes Sodium-ion batteries

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Genetic causal association between gut microbiota and sepsis: Evidence from a two-sample bidirectional Mendelian randomization analysis

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Journal of Intensive Medicine 2024年第3期4卷 362-367页

作者： Jungen Tang man Huang Department of General Intensive Care Unit The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina

Background Sepsis is a severe and potentially life-threatening condition characterized by a dysregulated host response and organ *** causal relationship between intestinal microbiota and sepsis is *** A two-sample Mendelian randomization(MR)study was performed to proxy the causal association between gut microbiota and *** genome-wide association study(GWAS)data of sepsis and gut microbiome were collected from the Integrative Epidemiology Unit(IEU)OpenGWAS,with summary-level data obtained from the UK *** traditional methods were used to estimate the potential causal relationships between gut microbiota and sepsis,including the inverse-variance weighted method,weighted median method,MR-Egger regression,simple mode,and weighted *** MR analysis was performed on the bacteria that were found to be causally associated with sepsis in forward MR ***'s Q statistic was used to quantify the heterogeneity of instrumental *** The inverse-variance weighted estimate suggested that class Lentisphaeria(odds ratio[OR]=0.86,95%confidence interval[CI]:0.78 to 0.94,P=0.0017,q=0.1596)and order Victivallales(OR=0.86,95%CI:0.78 to 0.94,P=0.0017,q=0.1596)have a protective effect on *** genus Eubacterium eligens group(OR=1.34,95%CI:1.11 to 1.63,P=0.0029,q=0.1881)was positively associated with the risk of *** may be a significant risk factor for genus Odoribacter(OR=1.18,95%CI:1.10 to 1.39,P=0.0415,q=0.9849)and Phascolarctobacterium(OR=1.21,95%CI:1.00 to 1.46,P=0.0471,q=0.9849),but this effect was not statistically significant after false discovery rate *** was a suggestive association between sepsis and Faecalibacterium(OR=0.85,95%CI:0.73 to 0.98,P=0.0278)and Ruminococcus 1(OR=0.85,95%CI:0.73 to 1.00,P=0.0439),which were not significant after false discovery rate correction(q>0.2).conclusions This study found that class Lentisphaeria,order Victivallales,and genus Eubacterium eligens group

关键词： Gut microbiota Sepsis Mendelian randomization

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A Multi-Channel CMOS Analog Front-End Interface IC with 157.8 d B Current Detection Dynamic Range

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Chinese Journal of Electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG man-Kay LAW Li ZHOU Jie CHEN Ming CHEN Institute of Microelectronics of the Chinese Academy of Science University of Chinese Academy of Sciences Zunyi Normal University Institute of Microelectronics and Dept.of ECE FST University of Macau

A high dynamic range and low-noise CMOS(complementary metal-oxide-semiconductor transistor)front-end interface integrated circuit(IC) with multi-channel detection is presented in this paper. Two different current detection channels, composed of a trans-impedance amplifier(TIA) and an integrator-differentiator TIA, are used to boost the current detection range. A capacitance-coupled instrument amplifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigma-delta modulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective number of bits above 16 bits. The presented interface IC is implemented in 0.18-μm CMOS process with supply voltage of 3.3 V, and a proto-type electrochemical sensor platform with miniaturized sensor array is developed to verify the functionality of the interface IC. Measurement results indicate that the designed interface IC achieves 157.8 d B current detection dynamic range, and the measured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigma-delta modulation Semiconductor device measurement Voltage measurement Current measurement Noise Bandwidth

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Intensive care unit-acquired weakness: Recent insights

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Journal of Intensive Medicine 2024年第1期4卷 73-80页

作者： Juan Chen man Huang Department of General Intensive Care Unit The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina

Intensive care unit-acquired weakness(ICU-AW)is a common complication in critically ill patients and is associated with a variety of adverse *** include the need for prolonged mechanical ventilation and ICU stay;higher ICU,in-hospital,and 1-year mortality;and increased in-hospital ***-AW is associated with multiple risk factors including age,underlying disease,severity of illness,organ failure,sepsis,immobilization,receipt of mechanical ventilation,and other factors related to critical *** pathological mechanism of ICUAW remains unclear and may be considerably *** review aimed to evaluate recent insights into ICU-AW from several aspects including risk factors,pathophysiology,diagnosis,and treatment strategies;this provides new perspectives for future research.

关键词： Intensive care unit-acquired weakness Muscle weakness Muscle atrophy Risk factor Mechanism Treatment

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An unusual etiology of subarachnoid hemorrhage,basilar artery perforator aneurysms,in Macao:Three case reports and review of literature

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World Journal of Clinical Cases 2024年第20期12卷 4337-4347页

作者： Ieong-Chon man Tam-man Pan Kuok-Cheong U Department of Radiology Hospital Conde S.JanuárioMacao SAR 999078China

BACKGROUND Subarachnoid hemorrhage is a severe neurological condition that requires prompt and appropriate treatment to prevent *** are the most common cause of spontaneous subarachnoid ***,basilar artery perforator aneurysms(BAPAs)are a rare *** is no consensus on the optimal management of ruptured BAPAs in the acute *** SUMMARY We present a case series of 3 patients with ruptured BAPAs who were treated at our *** patients had a modified Fisher grade of I,and one had a grade of IV on initial *** aneurysms were detected by computed tomography angiography in two cases and conventional angiography in one *** 3 patients underwent endovascular treatment with Guglielmi detachable ***-treatment,the patients had good clinical outcomes,and follow-up brain computed tomography scans showed reduced subarachnoid hemorrhage without any new ***,one patient experienced a cerebral infarction 2 months later and eventually succumbed to the *** other 2 patients showed progressive recovery,and no aneurysm recurrence was observed at the 2-year *** Endovascular treatment may be a preferable approach for managing ruptured BAPAs compared with surgical intervention or conservative *** detection and prompt treatment is important to achieve favorable patient outcomes.

关键词： Basilar artery Intracranial aneurysm Endovascular treatment Subarachnoid hemorrhage Case report

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Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu Wei Qiu-man Xu Wei Shang Qing Li Jing-Sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin co-culture Paenibacillus polymyxa corynebacterium glutamicum Medium optimization Metabolic precursors

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Prognostic significance of grade of malignancy based on histopathological differentiation and Ki-67 in pancreatic ductal adenocarcinoma

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Cancer Biology & Medicine 2024年第5期21卷 416-432页

作者： Yuexiang Liang Guannan Sheng Yu Guo Yiping Zou Hanhan Guo Zhifei Li Shaofei Chang Quan man Song Gao Jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Gastrointestinal Oncology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Department of Gastrointestinal Pancreatic Surgery Shanxi Provincial People’s HospitalTaiyuan 030012China

Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell ***-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer and neuroendocrine ***,its prognostic significance in pancreatic ductal adenocarcinoma(PDAC)remains ***:Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled,and relevant prognostic factors were *** of malignancy(GOM),a novel index based on histopathological differentiation and Ki-67,is proposed,and its clinical significance was ***:The optimal threshold for Ki-67 was determined to be 30%.Patients with a Ki-67 expression level>30%rather than≤30%had significantly shorter 5-year overall survival(OS)and recurrence-free survival(RFS).In multivariate analysis,both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and *** GOM was used to independently stratify OS and RFS into 3 tiers,regardless of TNM stage and other established prognostic *** tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers,and surpassed the predictive performance of TNM stage for OS and ***:Ki-67 is a valuable prognostic indicator for *** of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.

关键词： Pancreatic ductal adenocarcinoma prognosis Ki-67 differentiation TNM stage

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