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Neural Regeneration Research 2020年第4期15卷 759-768页

作者： Valentina Onesto Angelo Accardo Christophe Vieu francesco gentile Center for Advanced Biomaterials for Healthcare Italian Institute of TechnologyNaplesItaly Laboratoire d’Analyse et d’Architecture des Systemes(LAAS) Centre National de la Recherche ScientifiqueUniversite de ToulouseCNRSToulouseFrance Institut National des Sciences Appliquees–INSA ToulouseFrance Department of Electric Engineering and Information Technology University Federico IINaplesItaly Department of Precision and Microsystems Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

Understanding the mechanisms underlying cell-surface interaction is of fundamental importance for the rational design of scaffolds aiming at tissue engineering,tissue repair and neural regeneration ***,we examined patterns of neuroblastoma cells cultured in three-dimensional polymeric scaffolds obtained by two-photon *** of the intrinsic resolution of the technique,the micrometric cylinders composing the scaffold have a lateral step size of^200 nm,a surface roughness of around 20 nm,and large values of fractal dimension approaching *** found that cells in the scaffold assemble into separate groups with many elements per *** cell wiring,we found that resulting networks exhibit high clustering,small path lengths,and small-world *** values of the topological characteristics of the network can potentially enhance the quality,quantity and density of information transported in the network compared to equivalent random graphs of the same *** is one of the first direct observations of cells developing into 3D small-world networks in an artificial matrix.

关键词： 3D networks biomaterials nano-topography network topology neuro-regeneration small-world networks tissue engineering two-photon lithography

Environmental factors determining growth of salamander larvae： A field study

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Current Zoology 2015年第3期61卷 421-427页

作者： Laura LIMONGI gentile francesco FICETOLA Giuseppe ROMEO Raoul MANENTI Dipartimento di Bioscienze Universita degli Studi di Milano Via Celoria 26 20133 Milano Italy Dipartimento di Scienze dell'Ambiente e del Territorio e di Scienze della Terra UniversitA degli Studi di Milano-Bicocca. Piaz- za della Scienza 1 20126 Milano Italy Laboratoire d'Ecologie Alpine (LECA) Universit6 Grenoble Alpes F-38000 Grenoble France CNRS LECA F-38000 Grenoble France

Larval growth and survival of organisms are strongly influenced by abiotic and biotic factors, as demonstrated by ex- perimental studies performed under controlled laboratory or semi-natural conditions. Even if they have many advantages, ex- periments cannot cover the full complexity of natural conditions and field studies are needed for a better understanding of how environmental variation determines growth and development rate. Fire salamander Salamandra salamandra females give birth to larvae in a variety of habitats, both epigean and subterranean. In caves, salamander larvae successfully grow and metamorphose, but their growth is more than three times longer than in epigean streams and factors determining these differences require inves- tigation. We performed a field study to understand the factors related to the growth of fire salamander larvae in different envi- ronmental conditions, evaluating the relationship between environmental features and larval growth and differences between caves and epigean spring habitats. Both caves and epigean larvae successfully grew. Capture-mark-recapture allowed to individu- ally track individuals along their whole development, and measure their performance. Growth rate was significantly affected by environmental variables： larvae grew faster in environments with abundant invertebrates and few conspeciflcs. Taking into ac- count the effect of environmental variables, larval growth was significantly lower in caves. Food availability plays a different ef- fect in the two environments. Larval growth was positively related to the availability of invertebrates in epigean sites only. The development rate of hypogeous populations of salamanders is slower because of multiple parameters, but biotic factors play a much stronger role than the abiotic ones

关键词： Spring Freshwater Cave Amphibians Salamandra Cannibalism

Suspended sediment transport analysis in two Italian instrumented catchments

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Journal of Mountain Science 2016年第6期13卷 957-970页

作者： Adriana GARCIA-RAMA Stefano Giorgio PAGANO francesco gentile Mario Aristide LENZI Department of Land EnvironmentAgriculture and Forestry(TeSAF)University of PadovaAgripolis-Vialedell'Universita 16-35o20 Legnaro(PD)Italy Department of Agricultural and Environmental Science(DiSAAT) University of BariviaAmendola 165/A70126 BariItaly ApuliaBasin Authority SPper Casamassima km 370010 ValenzanoBariItaly

Suspended sediment transport in streams is an effective indicator of soil erosion at the watershed scale. This process was studied using the data obtained from two continuous monitoring stations installed in Italian watersheds, the Rio Cordon and Torrente CarapeUe. The catchments have substantially different climatic, morphological and land use characteristics. The Rio Cordon, a small Alpine watershed, has been monitored since 1986, while in the Torrente Carapelle, a medium-size Mediterranean watershed, the monitoring station has provided data since 2007. Several flood events with suspended sediment transport were isolated in the two catchments, excluding those determined by snowmelt in the Rio Cordon as this process does not affect the Carapelle watershed. Analysis of the events showed different behavior in terms of hysteresis loop trends between water discharge （m3 S-1） and suspended sediment concentration （g 1-1） values, as the Rio Cordon confirms clockwise relationships most frequently, while counter-clockwise trends represent the majority of cases for the Carapelle Torrent. The different behavior of the two watersheds was further analyzed by evaluating relationships between the main hydrological parameters related to suspended sediment transport. Runoff controls the total sediment budget in both catchments. In contrast, it was noted that the runoff process does not interfere in the magnitude of the suspended sediment transport in the Rio Cordon catchment, while variations due to the larger size of the catchment area characterize the events in the Carapelle watershed. Lastly, a flow peak threshold that determines the advance or delay of the hydrograph peak with respect to the sedigraph peak was established for the Carapelle Torrent, while it was not reported in the Rio Cordon.

关键词： Suspended sediment transport Continuous monitoring Hysteresis analysis Flowpeak threshold: Soil erosion

Predicting wild boar damages to croplands in a mosaic of agricultural and natural areas

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Current Zoology 2014年第2期60卷 170-179页

作者： gentile francesco FICETOLA Anna BONARDI Paola MAIROTA Vincenzo LERONNI Emilio PADOA-SCHIOPPA Dipartimento di Scienze dell'Ambiente e del Territorio e di Scienze delia Terra Universith degli Studi di Milano-Bicocca. Piazza della Scienza 1 20126 Milano Italy Dipartimento di Scienze Agro-Ambientali e Territoriali University of Bari Bari.

Crop damages by wildlife is a frequent form of human-wildlife conflict. Identifying areas where the risk of crop damages is highest is pivotal to set up preventive measures and reduce conflict. Species distribution models are routinely used to predict species distribution in response of environmental changes. The aim of this paper was assessing whether species distribution models can allow to identify the areas most at risk of crop damages, helping to set up management strategies aimed at the mitigation of human-wildlife conflicts. We obtained data on wild boar Sus scrofa damages to crops in the Alta Murgia National Park, Southern Italy, and related them to landscape features, to identify areas where the risk of wild boar damages is highest. We used MaxEnt to build species distribution models. We identified the spatial scale at which landscape mostly affects the distribution damages, and optimized the regularization parameter of models, through an information-theoretic approach based on AIC. Wild boar damages quickly increased in the period 2007-2011; cereals and legtmaes were the crops more affected. Large areas of the park have a high risk of wild boar damages. The risk of damages was related to low cover of urban areas or olive grows, intermediate values of forest cover, and high values of shrubland cover within a 2-km radius. Temporally independent validation data demonstrated that models can successfully predict damages in the future. Species distribution models can accurately identify the areas most at risk of wildlife damages, as models calibrated on data collected during only a subset of years correctly predicted damages in the subsequent year [Current Zoology 60 （2）： 170-179, 2014].

关键词： Environmental heterogeneity Human-wildlife conflict Landscape composition Predictive distribution model Protected areas Spatial scale Sus scrofa

Length–mass allometries in amphibians

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Integrative Zoology 2018年第1期13卷 36-45页

作者： Luca SANTINI Ana BENÍTEZ-LÓPEZ gentile francesco FICETOLA Mark A.J.HUIJBREGTS Department of Environmental Science Institute for Wetland and Water ResearchFaculty of ScienceRadboud UniversityNijmegenthe Netherlands Department of Bioscience University of MilanMilanItaly Alpine Ecology Laboratory Grenoble Alpes UniversityGrenobleFrance PBL Netherlands Environmental Assessment Agency The Haguethe Netherlands

Body mass is rarely recorded in amphibians,and other body measurements(*** to vent length,SVL)are generally collected ***,length measurements,when used as proxies of body mass in comparative analyses,are problematic if different taxa and morphotypes are *** developed allometric relationships to derive body mass from SVL *** fitted phylogenetic generalized least square models for frogs(Anura)and salamanders(Caudata)and for several families *** tested whether allometric relationships differed between species with different habitat preferences and between morphs in *** were fitted with SVL-mass measurements for 88 frog and 42 salamander *** assessed the predictive performance of the models by ***,the models showed high explained variance and low forecasting *** differed among semi-aquatic,terrestrial and arboreal frogs,and between paedomorphic and non-paedomorphic *** mass estimates derived from our models allow for comparability of studies on multiple taxa and can be used for testing theories built upon evolutionary and ecological processes which are directly related to body mass.

关键词： Anura body size body weight Caudata SVL

Time dependent dispersion of nanoparticles in blood vessels

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Journal of Biomedical Science and Engineering 2010年第5期3卷 517-524页

作者： francesco gentile Paolo Decuzzi 不详

The dispersion of intravasculary injected nanoparticles can be efficiently described by introducing an effective diffusion coefficient Deff which quantifies the longitudinal mass transport in blood vessels. Here, the original work of Gill and Sankarasubramanian was modified and extended to include 1) the variati- on over time of Deff;2) the permeability of the blood vessels and 3) non-Newtonian rheology of blood. A general solution was provided for Deff depending on space (?), time (?), plug radius (?c) and a subset of permeability parameters. It was shown that increasing the vessel plug radius (thus hematocrit) or permeability leads to a reduction in Deff, limiting the transport of nanoparticles across those vessels. It was also shown that the asymptotic time beyond which the solution attains the steady state behaviour is always independent of the plug radius and wall permeability. The analysis presented can more accurately predict the transport of nanoparticles in blood vessels, compared to previously developed models.

关键词： Nanoparticle Transport Casson Fluid Permeable Blood Vessels Drug Delivery

Environmental Suitability and Distribution of the Caucasian Rock Agama,Paralaudakia caucasia (Sauria:Agamidae) in Western and Central Asia

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Asian Herpetological Research 2013年第3期4卷 207-213页

作者： Seyyed Saeed HOSSEINIAN YOUSEFKHANI gentile francesco FICETOLA Nasrullah RASTEGAR-POUYANI Natalia B ANANJEVA Eskandar RASTEGAR-POUYANI Rafaqat MASROOR Iranian Plateau Herpetology Research Group(IPHRG) Faculty of ScienceRazi University Dipartimento di Scienze dell’Ambiente e del Territorio e di Scienze della Terra Università degli Studi di Milano Bicocca Department of Biology Faculty of ScienceRazi University Department of Herpetology Zoological InstituteRussian Academy of Sciences Department of Biology Faculty of ScienceHakim Sabzevari University Pakistan Museum of Natural History Garden AvenueShakarparian

Predictive potential distribution modeling is crucial in outlining habitat usage and establishing conservation management priorities. In this paper we provide detailed data on the distribution of the Caucasian rock agama Para- laudakia caucasia, and use species distribution models （MAXENT） to evaluate environmental suitability and potential distribution at a broad spatial scale. Locality data on the distribution of P. caucasia have been gathered over nearly its entire range by various authors from field surveys. The distribution model ofP caucasia showed good performance （AUC = 0.887）, and predicted high suitability in regions mainly located in Tajikistan, north Pakistan, Afghanistan, southeast Turkmenistan, northeast Iran along the Elburz mountains, Transcaueasus （Azerbajan, Armenia, Georgia）, northeastern Turkey and northward along the Caspian Sea coast in Daghestan, Russia. The identification of suitable areas for this species will help to assess conservation status of the species, and to set up management programs.

关键词： Western Asia Paralaudakia caucasia distribution Maxent modeling Agamidae

A doublet mechanics model for the ultrasound characterization of malignant tissues

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Journal of Biomedical Science and Engineering 2011年第5期4卷 362-374页

作者： francesco gentile Jason Sakamoto Raffaella Righetti Paolo Decuzzi Mauro Ferrari 不详

Non invasive ultrasound-based imaging systems are being more commonly used in clinical bio-microscopy applications for both ex vivo and in vivo analysis of tissue pathological and physiological states. These modalities usually employ high-frequency ultrasound systems to overcome spatial resolution limits of conventional clinical diagnostic approaches. Biological tissues are non continuous, non homogeneous and exhibit a multiscale organization from the sub-cellular level (￡1 mm) to the organ level (31 cm). When the ultrasonic wavelength used to probe the tissues becomes comparable with the tissue's microstructure scale, the propagation and reflection of ultrasound waves cannot be fully interpreted employing classical models developed within the continuum assumption. In this study, we present a multiscale model for analyzing the mechanical response of a non-continuum double-layer system exposed to an ultrasound source. The model is developed within the framework of the Doublet Mechanics theory and can be applied to the non-invasive analysis of complex biological tissues.

关键词： Nanomechanics Doublet Mechanics Ultrasound Spectroscopy Biopsy Microscopic Elastography Ultrasound Biomicroscopy

SARS-CoV-2 and liver damage:a possible pathogenetic link

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 322-324页

作者： Ludovico Abenavoli Ivan gentile Alberto Enrico Maraolo francesco Negro Department of Health Sciences University Magna GraeciaCatanzaroItaly Department of Clinical Medicine and Surgery Section of Infectious Diseases Member of UNESCO Chair on Health Education and Sustainable Development University of Naples"Federico II"NaplesItaly First Division of Infectious Diseases Cotugno HospitalAORN dei ColliNaplesItaly Divisions of Gastroenterology and Hepatology and of Clinical Pathology Geneva University HospitalsGenevaSwitzerland

On December 31,2019,the World Health Organization(WHO)China Country Office,was informed of pneumonia cases of unknown etiology detected in Wuhan,a city of Hubei Province in China.

关键词： China. Wuhan damage

Role of interleukin polymorphisms in gastric cancer: “Pros and cons”

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World Journal of Gastrointestinal Oncology 2010年第6期2卷 265-271页

作者： francesco Perri Fulvia Terracciano Marco gentile Antonio Merla Daniela Scimeca Angelo Zullo Department of Gastroenterology and Digestive Endoscopy "Casa Sollievo della Sofferenza" Hospital Department of Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital

Helicobacter pylori (H. pylori ) infection is the leading cause of gastric cancer worldwide. Infection with this bacterium causes a chronic active immune response that persists for the life of the host. The combination of bacterial factors, environmental insults, and the host immune response drives the initiation and progression of mucosal atrophy, metaplasia, and dysplasia toward GC. Among the host factors, IL-1 gene cluster polymorphisms (IL-1B encoding IL-1β and IL-1RN encoding IL-1ra, its naturally occurring receptor antagonist) play a decisive role in modulating the risk of developing hypochlorhydria, gastric atrophy and GC in the presence of H. pylori infection. In particular, one single nucleotide polymorphism in the IL-1B promoter (IL-1B-511C T), and the short allele of a 86-bp variable number of tandem repeats polymorphism in the IL-1RN second intron (IL-1RN*2) are associated with an increased risk for GC. However this hypothesis is still to be fully confirmed. This review focuses on the divergent results obtained by several epidemiological and functional in vitro and in vivo studies and show that IL-1 genotyping has still no role in the clinical management of patients with H. pylori infection.

关键词： Cytokine Gastric cancer Gene Interleukin Helicobacter pylori Polymorphism