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A new iron free treatment with oral fish cartilage polysaccharide for iron deficiency chronic anemia in inflammatory bowel diseases:A pilot study

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World Journal of Gastroenterology 2007年第10期13卷 1575-1578页

作者： Andrea Belluzzi Giulia Roda francesca tonon Antonio Soleti Alessandra Caponi Anna Tuci Aldo Roda Enrico Roda Enrico Roda Gastroenterology UnitUniversity of BolognaS.Orsola HospitalVia Massarenti

AIM:To investigate the effect of a new oral preparation,highly concentrated in fish cartilage,in a group of inflammatory bowel diseases(IBD)patients with chronic iron deficient ***:In an open label pilot study,we supple-mented a group of 25 patients(11 with Crohn's disease and 14 with ulcerative colitis)in stable clinical conditions and chronic anemia with a food supplement which does not contain iron but contains a standardized fraction of fish cartilage glycosaminoglycans and a mixture of antioxidants(Captafer Medestea,Turin,Italy).Patients received 500 mg,twice a day during meals,for at least 4 *** were suggested to maintain their alimentary *** time 0 and after 2 and 4 mo,emocrome,sideremia and ferritin were *** data were analyzed with Student's t ***:Three patients relapsed during the study(2 in the 3rd mo,1 in the 4th mo),two patients were lost to follow up and two patients dropped out(1 for orticaria,1 for gastric burning).Of the remaining 18 patients,levels of serum iron started to rapidly increase within the 2nd mo of treatment,P < 0.05),whereas serum ferritin and hemoglobin needed a longer period to significantly improve their serum levels(mo 4)P < *** product was safe,easy to administer and well tolerated by ***:These data suggest a potential new treatment for IBD patients with iron deficiency chronic anemia and warrant further larger controlled studies.

关键词：炎症性肠病缺铁性慢性贫血鱼类软骨多糖口服无铁制剂治疗

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Message in a bottle from the tumor microenvironment:tumor-educated DCs instruct B cells to participate in immunosuppression

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Cellular & Molecular Immunology 2017年第9期14卷 730-732页

作者： francesca Mion Silvia tonon Viviana Valeri Carlo E Pucillo Department of Medicine University of UdineUdineItaly

Once tumour cells have overcome the molecular mechanisms that prevent their uncontrolled proliferation,the only enemy they need to deal with is the immune system,which is able to recognize and destroy transformed ***,one of the evasion mechanisms put in place by the tumour is made by the suppressive arm of the immune system itself.

关键词： tumour instru overcome

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