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B cells in pancreatic cancer stroma

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World Journal of Gastroenterology 2022年第11期28卷 1088-1101页

作者： francesca romana delvecchio Michelle r Goulart rachel Elizabeth Ann Fincham Michele Bombadieri Hemant M Kocher William Harvey research Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts Cancer Institute Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Barts and the London HPB Centre Barts Health NHS TrustLondon E11BBUnited Kingdom

Pancreatic cancer is a disease with high unmet clinical *** cancer is also characterised by an intense fibrotic stroma,which harbours many immune *** in both human and animal models have demonstrated that the immune system plays a crucial role in modulating tumour onset and *** human pancreatic ductal adenocarcinoma,high B-cell infiltration correlates with better patient ***,B cells have received recent interest in pancreatic cancer as potential therapeutic ***,the data on the role of B cells in murine models is unclear as it is dependent on the pancreatic cancer model used to ***,it appears that B cells do organise along with other immune cells such as a network of follicular dendritic cells(DCs),surrounded by T cells and DCs to form tertiary lymphoid structures(TLS).TLS are increasingly recognised as sites for antigen presentation,T-cell activation,Bcell maturation and differentiation in plasma *** this review we dissect the role of B cells and provide directions for future studies to harness the role of B cells in treatment of human pancreatic cancer.

关键词： B cells Pancreatic cancer Cancer immunology Tertiary lymphoid structures Anti-tumour immunoglobulins Plasma cells

Natural killer cells in pancreatic cancer stroma

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World Journal of Gastroenterology 2021年第24期27卷 3483-3501页

作者： rachel Elizabeth Ann Fincham francesca romana delvecchio Michelle r Goulart Joe Poe Sheng Yeong Hemant M Kocher Barts Cancer Institute-CrUK Centre of Excellence Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Institute of Molecular and Cellular Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Centre for Tumour Biology Barts Cancer Institute-CRUK Centre of ExcellenceQueen Mary University of LondonLondon EC1M 6BQUnited Kingdom

Pancreatic cancer remains one of medicine’s largest areas of unmet *** five-year survival rates of<8%,little improvement has been made in the last 50 *** presenting with advance stage disease,treatment options are **... 详细信息

Pancreatic cancer remains one of medicine’s largest areas of unmet *** five-year survival rates ofrovement has been made in the last 50 *** presenting with advance stage disease,treatment options are *** date,surgery remains the only potentially curative option,however,with such late disease presentation,the majority of patients are ***,new therapeutic options and a greater understanding of the complex stromal interactions within the tumour microenvironment are sorely needed to revise the dismal outlook for pancreatic cancer *** killer(NK)cells are crucial effector units in cancer *** used as a prognostic biomarker in a range of malignancies,NK cells have received much attention as an attractive target for immunotherapies,both as cell therapy and as a pharmaceutical *** this interest,the role of NK cells in pancreatic cancer remains poorly ***,increasing evidence of the importance of NK cells in this dismal prognosis disease is beginning to come to ***,we review the role of NK cells in pancreatic cancer,examine the complex interactions of these crucial effector units within pancreatic cancer stroma and shed light on the increasingly attractive use of NK cells as therapy.

关键词： Pancreatic cancer Natural killer cells Tumour microenvironment Pancreatic cancer stroma Stromal cells

radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria

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World Journal of Gastroenterology 2021年第18期27卷 2205-2218页

作者： Maria Conticchio riccardo Inchingolo Antonella delvecchio Letizia Laera francesca ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antoniorampoldi renèAdam Daniel Cherqui Luca Antonio Aldrighetti riccardo Memeo Departement of Emergency and Trasplantation of Organs General Surgery Unit“M.Rubino”Policlinico di BariBari 70124Italy Interventional radiology Unit "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy Department of Emergency and Organ Transplantation General Surgery Unit“M.Rubino”University of BariCeglie Messapica 70124Italy Department of Oncology "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy Department of Surgery Univ Vita Salute San RaffaeleMilan 20132Italy Department of Visceral and Oncological Surgery Gustave Roussy Cancer Campus Grand ParisVillejuif 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Department of Digestive and Hepatobiliary Surgery Henri Mondor University HospitalCreteil 94000France Department of Surgery University of Geneva HospitalsGeneva 44041Switzerland Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41124Italy Institut de recherche Contre les Cancers de l'Appareil Digestif Strasbourg 67000France Department of Surgery Keio University School of MedicineShinjuku-ku 160-8582Japan Hepato-Biliary and Pancreatic Surgical Unit Nouvel Hôpital CivilStrasbourg cedex 67091France Department of Hepatobiliary Pancreatic and Digestive SurgeryUniversity Hospital Robert Debréof ReimsReims 51100France Hepatobiliary and Pancreatic Surgery Unit General Surgery DepartementTroyes HospitalTroyes Zip or Postal CodeFrance University of Champagne-Ardenne Reims 51100France Unit of Minimally Invasive and robotic Digestive Surgery "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Reina Sofia University HospitalCordoba 14004Spain Interventional radiology Unit Niguarda HospitalMilan 20132Italy 20132 Italy RenèAdam Hepatobiliary Center Hopital Paul BrousseVillejuif 94800France Unit of Hepato-Pancreatic-Biliary Surgery Univ Vita Salute San RaffaeleMilan 20132Italy Uni

BACKGrOUND Surgical resection and radiofrequency ablation(rFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan *** To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(Lr)or *** The study included 594 patients with HCC in Milan criteria(429 in Lr group and 165 in rFA group)managed in 10 European *** analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox *** After PSM,we compared 136 patients in the Lr group with 136 patients in the rFA *** survival at 1,3,and 5 years was 91%,80%,and 76%in the Lr group and 97%,67%,and 41%in the rFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the Lr group,and 63%,36%,and 25%for the rFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the rFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(Or)=1.89],increased value of international normalized ratio(>1.3)(Or=1.60),treatment with radiofrequency(Or=1.46),and multiple nodules(Or=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(Or=1.51)and radiofrequency(Or=1.37)were independent factors associated with a higher recurrence *** Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria.

关键词： Hepatocellular carcinoma Milan criteria radiofrequency ablation Surgical resection Elderly patients Propensity score matching

Liver resection vs radiofrequency ablation in single hepatocellular carcinoma of posterosuperior segments in elderly patients

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1696-1707页

作者： Antonella delvecchio riccardo Inchingolo rita Laforgia francesca ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antonio rampoldi renèAdam Daniel Cherqui Luca Antonio Aldrighetti riccardo Memeo Unit of General Surgery "A.Perrino"HospitalCeglie Messapica 70124BariItaly Interventional radiology Unit "F.Miulli"General Regional HospitalAcquaviva delle Fonti 75100Italy Unit of Laparoscopic Surgery University of BariBary 70124Italy Unit of Hepato-Pancreatic-Biliary Surgery University Vita Salute San RaffaeleMilan 20132Italy Department of Surgical Oncology Gustave Roussy Cancer Campus Grand ParisVillejuif 94800France of General Surgery Reina Sofia University HospitalCordoba 14004Spain Department of Digestive and Hepatobiliary Surgery Henry Mondor University HospitalCreteil 94000France Division of Transplantation Geneva University HospitalGeneva 44041Switzerland Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 42121Italy Department of Digestive Surgery Strasbourg University HospitalStrasbourg 67000France Department of Digestive and Hepatobiliary Surgery Robert DebrèUniversity HospitalReims 51100France Unit of Minimally Invasive and robotic Digestive Surgery "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70124Italy Interventional radiology Unit Niguarda HospitalMilan 20162Italy Department of Hepatobiliary Surgery Paul Brousse University HospitalVillejuif 94800France Department of Hepatobiliary Surgery University Vita Salute San RaffaeleMilan 20132Italy Unit of Hepato-Pancreatic-Biliary Surgery "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70124Italy

BACKGrOUND Liver resection and radiofrequency ablation are considered curative options for hepatocellular *** choice between these techniques is still controversial especially in cases of hepatocellular carcinoma affecting posterosuperior segments in elderly *** To compare post-operative outcomes between liver resection and radiofrequency ablation in elderly with single hepatocellular carcinoma located in posterosuperior *** A retrospective multicentric study was performed enrolling 77 patients age≥70-years-old with single hepatocellular carcinoma(≤30 mm),located in posterosuperior segments(4a,7,8).Patients were divided into liver resection and radiofrequency ablation groups and preoperative,peri-operative and long-term outcomes were retrospectively analyzed and compared using a 1:1 propensity score *** After propensity score matching,twenty-six patients were included in each *** time and overall postoperative complications were higher in the resection group compared to the ablation group(165 min vs 20 min,Prespectively).A median hospital stay was significantly longer in the resection group than in the ablation group(7.5 d vs 3 d,Prtality was comparable between the two *** were no significant differences between resection and ablation group in terms of overall survival and disease free survival at 1,3,and 5 *** radiofrequency ablation in posterosuperior segments in elderly is safe and feasible and ensures a short hospital stay,better quality of life and does not modify the overall and disease-free survival.

关键词： Elderly Hepatocellular carcinoma Posterosuperior segments Liver resection radiofrequency ablation Multicentric study

Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 72-81页

作者： Maria Conticchio riccardo Inchingolo Antonella delvecchio francesca ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de’Angelis Javier Briceño Antonio rampoldi renèAdam Daniel Cherqui Luca Antonio Aldrighetti riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy Interventional radiology Unit “F.Miulli”Regional General HospitalBari 70021Italy Unit of Hepatobiliary Surgery San Raffaele HospitalMilano 20132Italy Departement de Chirurgie Viscérale Gustave Roussy Cancer Campus Grand ParisParis 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Assistance Publique-Hôpitaux de Paris Department of Digestive and Hepatobiliary SurgeryCentre Hospitalier Universitaire Henri MondorCréteilParis 94000France Service of Abdominal Surgery Poliambulanza FoundationBrescia 25124Italy Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41121Italy Institut de recherche Contre les Cancers de l’Appareil Digestif(IrCAD) Strasbourg 67000France Service de Chirurgie Viscérale et Digestive Nouvel Hôpital CivilStrasbourg 67000France Department of Surgery Hôpital Robert DebréReims 51092France Interventional radiology Unit Niguarda HospitalMilan 20162Italy Department of Surgery Centre HepatobiliaireHopital Paul BrousseParis 94000France

BACKGrOUND The impact of obesity on surgical outcomes in elderly patients candidate for liver surgery is still *** To evaluate the impact of high body mass index(BMI)on perioperative and oncological outcome in elderly patients(>70 years old)treated with laparoscopic liver resection for hepatocellular carcinoma(HCC).METHODS retrospective multicenter study including 224 elderly patients(>70 years old)operated by laparoscopy for HCC(196 with a BMIrved from January 2009 to January *** After propensity score matching,patients in two groups presented comparable results,in terms of operative time(median range:200 min vs 205 min,P=0.7 respectively in non-obese and obese patients),complications rate(22%vs 26%,P=1.0),length of hospital stay(median range:4.5 d vs 6.0 d,P=0.1).There are no significant differences in terms of short-and long-term postoperative *** The present study showed that BMI did not impact perioperative and oncologic outcomes in elderly patients treated by laparoscopic resection for HCC.

关键词： Hepatocellular carcinoma Body mass index Laparoscopy Surgical resection Elderly patients Propensity score matching

Peri-operative score for elderly patients with resectable hepatocellular carcinoma

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World Journal of Hepatology 2023年第12期15卷 1307-1314页

作者： Maria Conticchio riccardo Inchingolo Antonella delvecchio francesca ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antonio rampoldi renèAdam Daniel Cherqui Luca Antonio Aldrighetti riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalAcquaviva Delle Fonti 70021Italy Interventional radiology Unit Department of Radiology“F.Miulli”Regional General HospitalAcquaviva Delle Fonti 75100Italy Hepatobiliary Surgery Division IRCSS San Raffaele Scientific InstituteMilan 20132Italy Hepatobiliary Surgery Division Vita-Salute San Raffaele UniversityMilan 20132Italy Département de Chirurgie Viscérale Gustave Roussy Cancer Campus Grand ParisParis 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Department of Digestive and Hepatobiliary Surgery Assistance Publique-Hôpitaux de ParisCréteil 94000France Service of Abdominal Surgery Poliambulanza FoundationBrescia 25124Italy Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41121Italy Department of Surgery Institut de Recherche Contre les Cancers de l'Appareil Digestif(IRCAD)Strasbourg 67000France Service de Chirurgie Viscérale et Digestive Nouvel Hôpital CivilUnitéINSERM U1110Strasbourg 67000France Department of Surgery Hôpital Robert DebréReims 51092France Assistance Publique-Hôpitaux de Paris Centre Hospitalier Universitaire Henri MondorParis 94000France Unit of Hepatobiliary Surgery and Liver Transplantation Hospital University Reina SofíaCordoba 14004Spain Interventional radiology Unit Niguarda HospitalMilan 20162Italy Department of Surgery Centre HepatobiliaireHopital Paul BrousseParis 94000France

BACKGrOUND Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma(HCC),also in elderly *** this,the evaluation of patient condition,liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and *** To identify new perioperative risk factors that could be associated with higher 90-and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk *** A multicentric,retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC;several independent variables correlated with death from all causes at 90 and 180 d were *** coefficients of Cox regression proportional-hazards model for sixmonth mortality were rounded to the nearest integer to assign risk factors'weights and derive the scoring *** Multivariate analysis found variables(American Society of Anesthesiology score,high rate of comorbidities,Mayo end stage liver disease score and size of biggest lesion)that had independent correlations with increased 90-and 180-d mortality.A clinical risk score was developed with survival *** This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality.

关键词： Hepatocellular carcinoma Score Laparoscopy Surgical resection Elderly patients Multivariate analysis