检索结果-南通市图书馆

尼美舒利及其他非甾体类抗炎药物肝毒性的队列研究

在线全文

学校读者我要写书评

暂无评论

英国医学杂志中文版 2004年第3期7卷 190-190页

作者： Giuseppe Traversa Clara Bianchi Roberto Da Cas Iosief Abraha francesca menniti-ippolito Mauro Venegoni 李伟

目的:与其他非甾体类抗炎药物相比较,评价尼美舒利(nimesulide)急性肝毒性的危险性。设计:回顾性队列研究和巢式病例对照研究。地点:意大利翁布里亚地区(Umbria region)。参与者:1997年1月～2001年12月31日间400000例当前、近期或者... 详细信息

目的:与其他非甾体类抗炎药物相比较,评价尼美舒利(nimesulide)急性肝毒性的危险性。设计:回顾性队列研究和巢式病例对照研究。地点:意大利翁布里亚地区(Umbria region)。参与者:1997年1月～2001年12月31日间400000例当前、近期或者过去应用过非甾体类抗炎药物者(近2百万个处方)。

关键词：尼美舒利非甾体类抗炎药药物毒性肝损伤

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

On the Regularity of Shear Thickening Viscous Fluids

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2009年第3期30卷 273-280页

作者： francesca CRISPO Dipartimento di Matematica Applicata "U.Dini" Università di PisaVia Buonarroti 1/c56127 PisaItaly.

The aim of this note is to improve the regularity results obtained by H. Beirao da Veiga in 2008 for a class of p-fluid flows in a cubic domain. The key idea is exploiting the better regularity of solutions in the tan... 详细信息

关键词： Non-Newtonian fluids Shear dependent viscosity Boundary regularity

Investigation of the porous drag and permeability at the porous-fluid interface: Influence of the filtering parameters on Darcy closure

在线全文

学校读者我要写书评

暂无评论

Particuology 2023年第7期78卷 122-135页

作者： Wojciech Sadowski francesca di Mare Chair of Thermal Turbomachines and Aeroengines Department of Mechanical EngineeringRuhr University BochumUniversitatsstr.15044801Germany

The porous-fluid interface encompasses a region bridging the flow inside a porous medium and a free-flowing *** the context of volume-averaged simulations,it can be described by a set of gradually changing parameters defining the porous medium,mainly porosity and *** this paper,both the permeability and the porous-induced drag force are evaluated a-priori,by explicitly filtering a set of Particle-Resolved Simulations(PRS)of the flow in the channel partially occupied by the porous *** porous matrices are considered and the influence of the geometry and filtering parameters on the macroscopic quantities is ***,the focus is placed on the requirements for the kernel type and size to perform filtering accurately,and their impact on the distribution of permeability at the *** performance of the typically used models for the permeability is compared to the explicitly filtered ***,a new model for permeability and the drag force is introduced,taking into account the information about the fltering size and non-uniformity of the velocity *** model greatly improves the prediction of velocity at the porous-fluid interface and serves as a proof of concept that a successful porous drag model should strive to include information about both parameters.

关键词： Porous-fluid interface Explicit filtering Permeability Porous drag

Simulation of unconventional well tests with the finite volume method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2012年第3期9卷 317-329页

作者： CANCELLIERE Michel VERGA francesca Politecnico di Torino DITAGTorino (TO) 10129 Italy

The finite volume method has been successfully applied in several engineering fields and has shown outstanding performance in fluid dynamics simulation. In this paper, the general framework for the simulation ofnear-wellbore systems using the finite volume method is described. The mathematical model and the numerical model developed by the authors are presented and discussed. A radial geometry in the vertical plane was implemented so as to thoroughly describe near-wellbore phenomena. The model was then used to simulate injection tests in an oil reservoir through a horizontal well and proved very powerful to correctly reproduce the transient pressure behavior. The reason for this is the robustness of the method, which is independent of the gridding options because the discretization is performed in the physical space. The model is able to describe the phenomena taking place in the reservoir even in complex situations, i.e. in the presence of heterogeneities and permeability barriers, demonstrating the flexibility of the finite volume method when simulating non-conventional tests. The results are presented in comparison with those obtained with the finite difference numerical approach and with analytical methods, if possible.

关键词： Finite volume method numerical methods horizontal well modeling injection testing gridding

Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： Paola Ruffo francesca De Amicis Emiliano Giardina francesca Luisa Conforti Medical Genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly Genomic Medicine Laboratory UILDM IRCCS Fondazione Santa LuciaRomeItaly Department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

Is it possible to develop a cerebellar reserve?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第5期17卷 994-996页

作者： francesca Gelfo Laura Petrosini Department of Human Sciences Guglielmo Marconi UniversityRomeItaly IRCCS Fondazione Santa Lucia RomeItaly

The concept of neural plasticity accounts for the now well clarified brain ability to react to internal and external stimuli by transforming its structure and *** translation of whatever experience in specific electrical signals that run through our neural networks induces a number of plastic changes at both functional and structural levels.

关键词： function. translation clarified

SPL transcription factors prevent inflorescence reversion in rice

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第7期14卷 1041-1043页

作者： francesca Giaume Fabio Fornara Department of Biosciences University of MilanVia Celoria 2620133 MilanItaly

Plants show an incredible diversity of forms,dimensions,archi-tectures,structures,and reproductive ***,they can be geometrically described as composed of simple building units called phytomers,which are produced by the shoot apical meri-stem(SAM).A phytomer is made up of a node bearing a leaf and an axillary meristem,and of an internode connecting the node to the following *** of phytomers creates the plant body,similarly to a LEGO construction made of simple *** of the phytomeric unit creates *** leaf can change in size and shape;the axillary meristem can be dormant or active,determinate or indeterminate;the internode can elongate considerably,or be compressed to the extent it might look invisible.

关键词： connecting dimensions visible

Pluripotent stem cell derived inhibitory interneurons–principles and applications in health and disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第2期15卷 251-252页

作者： francesca Keefe Meng Li Neuroscience and Mental Health Research Institute School of Medicine and School of Bioscience Cardiff University

Inhibitory interneurons are gamma-aminobutyric acid-ergic (GABAergic) nerve cells that act to maintain the appropriate excitation-inhibition balance, and synchronise the output of principle cells to generate rhythmic patterns of firing (Kessaris et al., 2014). This critical role, along with their brain-wide distribution, has led to the implication of interneurons in many neuropathologies, including schizophrenia, autism, dystonia and epilepsies (Marín, 2012).

关键词： cells act has led