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Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 3-16页

作者： Sara Mattana Silvia Caponi Francesco Tamagnini Daniele Fioretto francesca Palombo Department of Physics and Geology University of Perugia Perugia I-06123Italy Istituto Officina dei Materiali del CNR(CNR-IOM)-Unita di Perugia Department of Physics and Geology University of Perugia Perugia I-06123Italy Hatherly Laboratories Medical School University of ExeterExeter EX44PSUK School of Physics and Astronomy University of Exeter Exeter EX44QLUK

A myloidopathy is one of the most prominent hallmarks of Alkheimer's disease(AD),the leading cause of dementia worldwide,and is characterized by the accumulation of amyloid plaques in the brain *** plaques consist of abnornal deposits mainly composed of an aggregation-prone protein fragment,B-amyloid 140/1-42,into the extracellular *** micro-spectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal acoustic waves or phonons,giving access to the viscoelasticity of a sample on a subcellular ***,we describe the first application of micromechanical mapping based on Brillouin scattering spectroscopy to probe the stifness of individual amyloid plaques in the hippocampal part of the brain of a B-amyloid overexpressi ng transgenic *** analysis based on Brillouin and Raman microspectroscopy showed that amyloid plaques have a complex structure with a rigid core of B-pleated shoet conformation(B-aryloid)protein sur-rounded by a softer ring-shaped region richer in lipids and other protein *** preliminary results give a new insight into the plaque biophysics and biomechanics,and a valuable contrast mechanism for the study and diagnosis of amnyloidopathy.

关键词： Alzheimer's imaging vibrational spectrosecopy protein misfolding light scattering

Laparoscopic liver resections at the gates of 2020: a stand-alone field of hepatobiliary surgery

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 371-373页

作者： Federica Cipriani francesca Ratti Luca Aldrighetti Hepatobiliary Surgery Division IRCCS San Raffaele HospitalVia Olgettina 6020132 MilanItaly

We read with interest the review entitled"Laparoscopic liver resection:the current status and the future"written by *** Cai and published in Hepatobiliary Surgery and Nutrition(1).

关键词： Laparoscopic Surgery liver

Modeling shoreline sand waves on the coasts of Namibia and Angola

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International Journal of Sediment Research 2013年第3期28卷 338-348页

作者： francesca RIBAS Albert FALQUES Niels VAN DEN BERG Miquel CABALLERIA Department of Applied Physics Universitat Politecnica de CatalunyaSpain

The southwestern（SW） coast of Africa（Namibia and Angola） features long sandy beaches and a wave climate dominated by energetic swells from the Southsouthwest（SSW）,therefore approaching the coast with a very high *** images reveal that along that coast there are many shoreline sand waves with wavelengths ranging from 2 to 8 km.A more detailed study,including a Fourier analysis of the shoreline position,yields the wavelengths（among this range） with the highest spectral density ***,it becomes apparent that at least some of the sand waves are dynamically active rather than being controlled by the geological setting.A morphodynamic model is used to test the hypothesis that these sand waves could emerge as free morphodynamic instabilities of the coastline due to the obliquity in wave *** is found that the period of the incident water waves,T;,is crucial to establish the tendency to stability or instability,instability increasing for decreasing period,whilst there is some discrepancy in the observed *** results for T;= 7-8 s clearly show the tendency for the coast to develop free sand waves at about 4 km wavelength within a few years,which migrate to the north at rates of 0.2-0.6 km yr;.For larger T;or steeper profiles,the coast is stable but sand waves originated by other mechanisms can propagate downdrift with little decay.

关键词： Shoreline evolution Shoreline sand waves High angle wave instability Longshore sediment transport

Improving performance of robotic liver resections with high technical complexity by Robo-Lap approach

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 981-986页

作者： francesca Ratti Rebecca Marino Luca Aldrighetti Hepatobiliary Surgery Division IRCCS Ospedale San RaffaeleMilanItaly Vita-Salute San Raffaele University MilanItaly

Introduction The hybrid robotic-laparoscopic technique has been described-in the field of hepatic surgery-in order to overcome procedural challenges related to the lack of the robotic ultrasonic dissector(1-4):Robo-Lap approach hence combines the use of the robotic platform(specifically robotic bipolar forceps for coagulation and scissors)with the laparoscopic dissector handled by the surgeon at the table.

关键词： robotic handle approach

Toward the use of smartphones for mobile mapping

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Geo-Spatial Information Science 2016年第3期19卷 210-221页

作者： Andrea Masiero francesca Fissore Francesco Pirotti Alberto Guarnieri Antonio Vettore Interdepartmental Research Center of Geomatics(CIRGEO) University of PadovaPadovaItaly

This paper considers the use of a low cost mobile device in order to develop a mobile mapping system(MMS),which exploits only sensors embedded in the *** goal is to make this MMS usable and reliable even in difficult environments(*** conditions,when also WiFi connection might not work).For this aim,a navigation system able to deal with the unavailability of the GNSS(***)is proposed *** is achieved by a pedestrian dead reckoning approach,i.e.a specific particle filter has been designed to enable good position estimations by a small number of particles(e.g.100).This specific characteristic enables its real time use on the standard mobile ***,3D reconstruction of the scene can be achieved by processing multiple images acquired with the standard camera embedded in the *** most of the vision-based 3D reconstruction systems are recently proposed in the literature,this work considers the use of structure from motion to estimate the geometrical structure of the *** detail level of the reconstructed scene is clearly related to the number of images processed by the reconstruction ***,the execution of a 3D reconstruction algorithm on a mobile device imposes several restrictions due to the limited amount of available energy and computing *** consideration motivates the search for new methods to obtain similar results with less computational *** paper proposes a novel method for feature matching,which allows increasing the number of correctly matched features between two images according to our simulations and can make the matching process more robust.

关键词： Mobile mapping positioning feature matching smartphone

Water Market: How to Exploit Opportunities at the Bottom of Pyramid

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Water Market: How to Exploit Opportunities at the Bottom of ...

作者： francesca CALO 复旦大学

学位级别：硕士

在过去的几十年中,一种新生的企业家精神,混合着显赫的社会背景和目标、并带着创新和强烈的风险发展模式,正在全球蔓延开来。这一用来解决社会失衡的新业务方法是社会企业家精神。这项工作的重点是针对特殊类型的创业型企业,旨在适应其... 详细信息

在过去的几十年中,一种新生的企业家精神,混合着显赫的社会背景和目标、并带着创新和强烈的风险发展模式,正在全球蔓延开来。这一用来解决社会失衡的新业务方法是社会企业家精神。这项工作的重点是针对特殊类型的创业型企业,旨在适应其典型的业务流程、服务和产品到市场金字塔的底部。相关文献确定了两个主要有待克服的挑战,以满足穷人中最贫困的那一部分的需要。一方面,有必要重新评估其产品和服务的价格性能关系,同时涉及资本效率的新水平和财务成绩的新测量模型。另一方面,在金字塔底部的投资意味着使数十亿人民摆脱贫穷和绝望,从而避免了社会腐败、政治混乱、恐怖主义和环境退化。尽管有学者的兴趣聚焦于分析金字塔底部市场举措的可行性,但大部分努力仍是主要处于理论层面上的。本研究的目的是提供一个深入的实证过程,其中私人行为者实施的经营战略目标是在水市场中产生社会和经济价值。在这样做时,定性分析是必然手段,建立在配对方法的基础上,以比较和对比六起案件,涉及两个跨国公司,两个社会企业和两家非盈利组织。相关分析对发展理论框架,描述项目实施,并在其中结合社会和经济价值的创造,具有功能性的解释作用。具体妨碍或协助执行过程的驱动力,也强调了为那些对进入新兴市场采取多元化战略感兴趣的人提供有用的指引。

关键词：企业家精神经营战略目标多元化战略创业型企业 Bottom venture sustainable informal sustainability 资本效率

Bottom of the Pyramid and Reverse Innovation: an Exploration in the Food Indutry

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Bottom of the Pyramid and Reverse Innovation: an Exploration...

作者： francesca Arosio 复旦大学

学位级别：硕士

创新一直是企业的经济增长的基础，它被公认为是跨国公司的成功的主要支撑之一。在今天，随着新兴经济体打崛起和创新方向改变，从而改变过去的管理经验。在更广泛的意义上说，全球化的结果是一个平坦的世界经济中新兴市场不再是一个可... 详细信息

创新一直是企业的经济增长的基础，它被公认为是跨国公司的成功的主要支撑之一。在今天，随着新兴经济体打崛起和创新方向改变，从而改变过去的管理经验。在更广泛的意义上说，全球化的结果是一个平坦的世界经济中新兴市场不再是一个可以被忽略打购买力，但是与此相反的是，他们可以成为的下一个创新的源泉和新机会的贡献者。这项研究开始处假设了属于新兴经济体的消费者不应该被视为社会的负担，相反的是，必须让他们成为潜在市场中创新的来源．此外，为了更好地了解这些市场的潜力，我们将分析新兴国家的消费者和他们消费的过程，并且能使他们能够转化为真正的消费者的特点。这将提供一个框架，以更好地理解的焦点的大小和属于它的底部的世界人口的潜力的经济发展和经济金字塔的功能的需求。此外，在本研究中，我們將探討創新的新動力，重點對食品行業。事實上，同時牢記反向創新是一個現象，涉及許多行業，我們希望更好地了解創新流動有關的食品工業和涉案司機。在這種模式中，將重點分析兩個主要的集群創新：涓滴和扭轉。第一，包括創新產品，從發達國家向新興經濟體流動，而第二個將調查從發展中國家向發達國家流動相反。这一篇沦文的目的是在于分析在当今打创新年革新的潮流在全球化当中扮演打角色和位置，分析现在当今打发展以及描述一副未来创新和革新打潮流在世界经济中所扮演打角色。这篇论文背后的众多原因之一是由于全球一体化现象以及越发占有重要地位的新兴经济体在当今快速发展并且不断发展变化的经济环境。作为创新经济，而不是只利用市场瞬息万变的经济环境。首先，我们在这篇沦文中指出了金字塔底部(BOP)的作用以及金字塔底部在新兴市场和经济休是一个具有极高利润空间的市场;然后，我们将论文打方向放在创新流动涉及发展中国家作为创新打领导者，而不是仅作为创新打受惠人。在事实上，我们强调了增加相关的反向创新流量，以及这方面的发展背后的原因。此外，我们专注于在过程和组织一个跨国企业的需求，和在一个新兴发达郭嘉成功地推出新产品。其次，我们指出，关于两类食品行业：烘培食物和婴幼儿食品产品的创新传统和反向扩散类型的经验证据。在这个框架内，我们的目标是调查反向创新的特点比较涓滴流量的扩散速度和价格定位的变化。更特别的是，我们会依靠经验验证反向创新普及的速度比创新的传统路径和下游的产品具有较高的价格定位比那些上游的产品。最后，通过推测比较的事实，在新兴经济体需要适应的营销策略的主要需求，我们将提供证据，一个简单方法的反向创新流动比传统的创新要来的更加容易扩散．此外，在本研究中，我們將探討創新的新動力，重點對食品行業。事實上，同時牢記反向創新是一個現象，涉及許多行業，我們希望更好地了解創新流動有關的食品工業和涉案司機。在這種模式中，將重點分析兩個主要的集群創新;涓滴和扭轉。第一，包括創新產品，從發達國家向新興經濟體流動，而第二個將調查從發展巾國家向發達國家流動相反．研究的口的是提供一個問题的答案，但與此相反，以減輕涓滴和反向創新以及缺乏有關食品行業的研究，其最新的流量差距最近的貢獻研究創新。在這個框架内，我們將確定四個集群創新的特點：首先，創新是發展富裕的經濟體，而且不流外人這個邊界，我們將定義集群“只開發了”創新流動。其次，創新，在新興經濟體開始，沒有達到西方世界的， “新興”創新,第三“涓滴”創新傳統路徑，從發達國家到新興國家，最後，那些出生於發展中經濟體和應用，後來在發達國家，這個被稱為“反向”创新流量。

关键词：反向创新金字塔的底部扩散类型的创新价格定位扩散速度全球化

Rationality in Support to Creativity: Management and Control in the Creative Process

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Rationality in Support to Creativity: Management and Control...

作者： francesca RIVA 复旦大学

学位级别：硕士

今天的经济是有风险的、动态的,企业需要创新才能生存和竞争。创新定义为能够把已经存在的元素融入到新观念和有用的观念中去的能力,它具有相互作用的多面性,具有对比元素。当创新为一个经济系统服务时,它成为实现预期利润的投入,它必... 详细信息

今天的经济是有风险的、动态的,企业需要创新才能生存和竞争。创新定义为能够把已经存在的元素融入到新观念和有用的观念中去的能力,它具有相互作用的多面性,具有对比元素。当创新为一个经济系统服务时,它成为实现预期利润的投入,它必须合理化以满足其经济职责。创新与控制之间的对比是不可避免的,创新过程中的这种辩证的本质是本研究的核心。本项研究的目的是要阐明在新组织规则下创新合理成为培养创造力和促进公司业绩的决定性力量。创新的秘密发现于管理人员与有创造性的个体之间存在的个人创造性和协作关系中。当团队具有一体化,合作和沟通的特点时,可以减少不确定性和促进正面的积极的情感,这些情感可以增强认知从已知到新启示之间的多样性。创新型管理者担当着保障这些使创新自由滋长的适当条件的重要角色。这可能只是玩心理和了解创造者的思路的方式。本文的理论框架是被实际案例所证明的,这些案例来自于对时尚、音乐以及广告行业的一些采访和调查。本文的第一部分介绍了有关创新的文献综述;第二部分介绍了进行调查的真实案例;最后一部分讨论调查结果。

关键词： manager creative Florida 新启示决定性力量 creativity 预期利润 something 文献综述 motivation

Cystic echinococcosis of the liver: A primer for hepatologists

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World Journal of Hepatology 2014年第5期6卷 293-305页

作者： francesca Rinaldi Enrico Brunetti Andreas Neumayr Marcello Maestri Samuel Goblirsch francesca Tamarozzi Division of Infectious and Tropical Diseases San Matteo Hospital Foundation 27100 Pavia Italy Department of Clinical Surgical Diagnostic and Paediatric Sciences University of Pavia WHO Collaborating Centre for the Clinical Management of Cystic Echinococcosis 27100 Pavia Italy Swiss Tropical and Public Health Institute 4002 Basel Switzerland University of Basel 4003 Basel Switzerland Division of General Surgery University of Pavia San Matteo Hospital Foundation 27100 Pavia Italy Emergency Medicine Winona Health Services Winona MN 55987 United States

Cystic echinococcosis(CE) is a complex, chronic and neglected disease with a worldwide distribution. The liver is the most frequent location of parasitic cysts. In humans, its clinical spectrum ranges from asymptom-atic infection to severe, potentially fatal disease. Four approaches exist in the clinical management of CE: surgery, percutaneous techniques and drug treatment for active cysts, and the "watch and wait" approach for inactive cysts. Allocation of patients to these treat-ments should be based on cyst stage, size and location, available clinical expertise, and comorbidities. However, clinical decision algorithms, efficacy, relapse rates, and costs have never been properly evaluated. This paper reviews recent advances in classification and diagnosisand the currently available evidence for clinical deci-sion-making in cystic echinococcosis of the liver.

关键词： Cystic echinococcosis Hydatidosis Clinical management Diagnosis Treatment Surgery Albenda-zole Watch-and-wait Follow-up Percutaneous treatment