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Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives

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World Journal of Gastroenterology 2008年第22期14卷 3464-3470页

作者： Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois franoise smets Etienne M Sokal Université Catholique de Louvain Cliniques Universitaires Saint Luc HPED Department PEDI Unit Laboratory of Pediatric Hepatology and Cell Therapy Brussels B-1200 Belgium

Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives.

关键词： Hepatocyte transplantation Cell therapy Inborn error of metabolism Crigler-Najjar Liver regeneration Animal models

Past Successes and New Challenges:China's Foreign Trade at a Turning Point

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China & World Economy 2010年第3期18卷 1-23页

作者： franoise Lemoine the CEPII Paris

Since 1979, China has recorded a remarkable trade performance, which has been driven by international processing and the offshoring strategies of foreign firms. The diversification of Chinese exports and their technological upgrading have been phenomenal However, there is also inertia, illustrated by the persistent dualism of the trade sector, the unrelenting specialization in downmarket products and the deteriorating terms of trade. These weaknesses have helped its partners to adjust to the rise of this new trade power. In the past decade, China＇s economy has faced the adverse effects o fan export-led growth and the global crisis has revealed its vulnerability. China is now forced to rebalance its economy. This will imply major changes in foreign trade, in favor of ordinary trade and away from processing. In the foreseeable future, China is unlikely to become the driver of international demand but will remain the engine of Asian economic integration.

关键词： China foreign trade technology terms of trade

Microwave irradiation: Novel and facile methods for the synthesis of new pyrimidinones

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Chinese Chemical Letters 2014年第8期25卷 1207-1210页

作者： Aida Chaker Fathi Zribi franoise Nepveu Fakher Chabchoub Department of Chemistry University of Sfax Road Soukra km 4-3000 SfaxTunisia UPS UMR 152 PHARMA-DEV University of Toulouse III 118 road of Narbonne F-31062 Cedex 9 Toulouse France Department of Chemistry University of Sfax Road Soukra km 4-3000 Sfax Tunisia IRD UMR 152 F-31062 Cedex 9 Toulouse France

We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields（72%–80%） and high purity of the title compounds.

关键词： Microwave-irradiation Aminonitriles naphtopyraniques Chloroacetylchloride Pyrimidinones

Simulation of coupled THM process in surrounding rock mass of nuclear waste repository in argillaceous formation

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Journal of Central South University 2015年第2期22卷 631-637页

作者：蒋中明 HOXHA Dashnor HOMAND fran?oise 陈永贵 School of Hydraulic Engineering Changsha University of Science & Technology Laboratory of Environment Geotechnical Engineering National Superior School of Geology Department of Geotechnical Engineering School of Civil Engineering Tongji University

To investigate and analyze the thermo-hydro-mechanical(THM) coupling phenomena of a surrounding rock mass in an argillaceous formation, a nuclear waste disposal concept in drifts was represented physically in an in-situ test way. A transversely isotropic model was employed to reproduce the whole test process numerically. Parameters of the rock mass were determined by laboratory and in-situ experiments. Based on the numerical simulation results and in-situ test data, the variation processes of pore water pressure, temperature and deformation of surrounding rock were analyzed. Both the measured data and numerical results reveal that the thermal perturbation is the principal driving force which leads to the variation of pore water pressure and deformations in the surrounding rock. The temperature, pore pressure and deformation of rock mass change rapidly at each initial heating stage with a constant heating power. The temperature field near the heater borehole is relatively steady in the subsequent stages of the heating phase. However, the pore pressure and deformation fields decrease gradually with temperature remaining unchanged condition. It also shows that a transversely isotropic model can reproduce the THM coupling effects generating in the near-field of a nuclear waste repository in an argillaceous formation.

关键词： argillaceous formation thermo-hydro-mechanical(THM) process in-situ test

New insights into the effects of molecular weight and end group on the temperature-induced phase transition of poly(N-isopropylacrylamide) in water

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Science China Chemistry 2013年第1期56卷 56-64页

作者： QIU XingPing KOGA Tsuyoshi TANAKA Fumihiko WINNIK fran oiseM. Department of Chemistry and Faculty of Pharmacy University of MontrealCP 6128 Succursale Centre VilleMontrealQC H3C 3J7Canada Department of Polymer Chemistry Graduate School of EngineeringKyoto UniversityKatsuraKyoto 615-8510Japan Institute of Theoretical Polymer Science (ITPS) 5-19-2 Ozenji Asao-kuKawasaki 615-8510Japan World Premier International (WPI) Research Center Initiative International Center for Materials Nanoarchitectonics (MANA) and National Institute for Materials Science (NIMS)1-1 NamikiTsukuba 305-0044Japan

In an attempt to clarify issues related to the molecular weight dependence of the phase transition of poly(N-isopropylacrylamide) (PNIPAM) in water,we prepared a library of PNIPAM samples of well-controlled molecular weight (7000 to 45000 g/mol) bearing identical groups on each chain *** polymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of N-isopropylacrylamide (NIPAM) with a bifunctional chain tranfer agent and further end group *** effects of the end group chemical structure,hydroxyethyl (HE),propargyl (Pr),chloroethyl (CE),n-butyl (nBu),n-hexyl (nHe),and isobutylsulfanylthiosulfanyl (IBS) on the phase transition temperature of aqueous PNIPAM solutions were investigated by high-sensitivity differential scanning calorimetry (HS-DSC),yielding the enthalpy ΔH and the endotherm maximum temperature (T M),and turbidimetry,providing the cloud point (T CP) of each *** T CP and T M of the PNIPAM sample of lowest molar mass (M n 7,000 g/mol,0.5 g/L) ranged,respectively,from 38.8 to 22.5 °C and 42.2 to 26.0 °C,depending on the structure of the end-group,whereas H showed no strong end-group *** phase transition of all polymers,except,-di(n-butyl-PNIPAM),exhibited a marked dependence on the polymer molar mass.

关键词： poly(N-isopropylacrylamide) phase transition temperature high-sensitivity differential scanning calorimetry turbidimetry end group effect

Rise of China and India in International Trade:From Textiles to New Technology

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China & World Economy 2008年第5期16卷 16-34页

作者： franoise Lemoine Deniz nal-Kesenci Senior Economist Center d'Etudes Prospectives et d'Informations Internationales (CEPⅡ)ParisFrance Economist CEPⅡ ParisFrance

China and India are two demographic giants that have become big developing economic powers. They have maintained their specialization in textiles and developed outward-oriented sectors linked to new technologies, taking advantage of offshoring and outsourcing. Their increasing contribution to international trade is changing the world supply and demand of manufactured goods, primary goods and services. They are new leaders in the international division of labor, but beyond technological catch-up, their challenge is quality upgrading. Both countries are increasingly contributing to global economic growth, but they cannot yet trigger the growth of the rest of the world by themselves.

关键词： China foreign trade India technology

On the Motion Law of Fronts for Scalar Reaction-Diffusion Equations with Equal Depth Multiple-Well Potentials

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 83-148页

作者： Fabrice BETHUEL Didier smets UPMC-Paris6 UMR 7598 LJLLParisF-75005France

Slow motion for scalar Allen-Cahn type equation is a well-known phenomenon,precise motion law for the dynamics of fronts having been established first using the socalled geometric approach inspired from central manifold theory(see the results of Carr and Pego in 1989). In this paper, the authors present an alternate approach to recover the motion law, and extend it to the case of multiple wells. This method is based on the localized energy identity, and is therefore, at least conceptually, simpler to implement. It also allows to handle collisions and rough initial data.

关键词： Reaction-diffusion systems Parabolic equations Singular limits

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CONTE DE GRCE

法语学习 2008年第5期 4-9页

作者： franoise Pinot

Il était une fois un homme pauvre qui pour survivre1 vendait du bois et de la *** parvenait ainsi à obtenir un peu de pain et de fromage pour lui et sa fille *** jour,alors qu'il passait sur le port,il vit

关键词：法语教学方法翻译方法教材

Tourism and heritage in the enhancement of Tianjin

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Built Heritage 2020年第2期4卷 1-20页

作者： Bruno Chauffert-Yvart françoise Ged Yue Lu Christine Mengin Émilie Rousseau 不详 International Research Center for Architectural Heritage Conservation Shanghai Jiao Tong UniversityShanghaiChina Equipe Interdisciplinaire de Recherches sur le Tourisme UniversitéParis 1 Panthéon-Sorbonne21 rue Broca75005 ParisFrance Full list of author information is available at the end of the article

This article examines what is being promoted about Tianjin’s rich heritage through its tourism and heritage *** industrial city traditionally known for its crafts and gastronomy,Tianjin has gradually begun to promote its Chinese heritage and,since the 2000s,its city centre,which is noteworthy for its former foreign concessions and 19th-and 20th-century architectural *** long neglect,the city centre has become a major component in the promotion of the *** on the analysis of tourism materials and studies conducted since the mid-2000s,this article first discusses the development of tourism in Tianjin and the chronology and interweaving of the services involved in heritage ***,it focuses on the reception of the city’s tourism offerings and on urban development operations in two sectors,Wudadao(or‘Five avenues’),located in the former British Concession,and the‘I-Style Town’in the former Italian Concession.

关键词： Tianjin Foreign concessions Tourism Built heritage Heritage policies Wudadao I-style town