Microwave irradiation: Novel and facile methods for the synthesis of new pyrimidinones

作     者：Aida Chaker Fathi Zribi Franoise Nepveu Fakher Chabchoub 

作者机构：Department of Chemistry University of Sfax Road Soukra km 4-3000 SfaxTunisia UPS UMR 152 PHARMA-DEV University of Toulouse III 118 road of Narbonne F-31062 Cedex 9 Toulouse France Department of Chemistry University of Sfax Road Soukra km 4-3000 Sfax Tunisia IRD UMR 152 F-31062 Cedex 9 Toulouse France 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第8期

页      面：1207-1210页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Ministry of Higher Education  Scientific Research and Technology of Tunisia and the University of Toulouse III for financial support 

主　　题：Microwave-irradiation Aminonitriles naphtopyraniques Chloroacetylchloride Pyrimidinones 

摘      要：We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields（72%–80%） and high purity of the title compounds.