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Multiple Major Thrombo-Embolic Events, including Stroke, in a Patient with Combined Congenital Anti-Thrombin III Deficiency and MTHFR Homozygous Mutation

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World Journal of Cardiovascular Diseases 2017年第3期7卷 71-78页

作者： Islam I. Zaid Nora I. Abbas Ehab Shaker foad abd-allah Departement of Neurology Faculty of Medicine Cairo University Cairo Egypt Departement of Critical Care Medicine Faculty of Medicine Cairo University Cairo Egypt

We report a case of a young male patient suffering from congenital Anti-Thrombin III (AT III) deficiency, presented with four major thrombotic events. These events were acute coronary syndrome (Non-ST elevation myocardial infarction), cerebral infarction, peripheral acute upper limb (UL) ischemia and bilateral extensive deep venous thrombosis. The latter two developed despite that the patient was receiving full anticoagulation therapy. His International normalized ratio (INR) was 2.5. Eventually, the patient developed pulmonary embolism and died. He had a prominent family history of thrombotic events. Screening for AT III deficiency in young patients with thrombotic event (thrombophilia) is essential especially those having family history of the latter. This is justified as thrombotic events may occur in up to 80% of these patients. Our patient with 4 major thrombotic events ending in fatality in less than 1 month deserves the nomenclature.

关键词： Thrombophilia Thrombosis Congenital AT III Deficiency Stroke Acute Coronary Syndrome Deep Venous Thrombosis Acute Limb Ischemia

Low Ankle Brachial Index in Acute Ischemic Stroke: Does ApoE Gene Polymorphism Have a Role?

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World Journal of Cardiovascular Diseases 2015年第2期5卷 42-47页

作者： Shaimaa El-Jaafary Mohamed El-Tamawy Hassan Hosny Mona Fathy Ehab Shaker foad abd-allah Faculty of Medicine Cairo University Cairo Egypt

Background: The existence of asymptomatic peripheral arterial disease among patients with acute ischemic stroke has been studied and proved. Low ankle brachial index (ABI) is considered as a marker of atherosclerosis, and its relation to stroke severity was documented in some studies. The effect of different alleles of ApoE gene on acute ischemic stroke presentation in patients with low ABI is not known. Objective: To study the effect of ApoE gene polymorphism on stroke severity, outcome and recurrence in patients with asymptomatic peripheral arterial disease identified by low ABI. Methods: Patients with acute ischemic stroke were screened for the presence of asymp-tomatic peripheral arterial disease by estimating the ABI using a pocket Doppler ultrasound device. Assay of ApoE gene was done using the real-time PCR technique. Results: Low ABI was present in 31% of patients with acute ischemic stroke. There was no significant difference among patients with different ApoE alleles regarding the severity of their symptoms. Also, there was no significant difference among patients with normal ABI and those with abnormal ABI regarding the ApoE gene polymorphism. Conclusion: The current study showed that there was no significant relation between ApoE gene polymorphism and low ABI in ischemic stroke patients who had asymptomatic peripheral arterial disease.

关键词： Peripheral Arterial Disease ABI Acute Ischemic Stroke ApoE Gene Polymorphism

The impact of vascular risk factors multiplicity on severity of carotid atherosclerosis—A retrospective analysis of 1969 Egyptian subjects

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World Journal of Cardiovascular Diseases 2013年第6期3卷 414-418页

作者： Essam Baligh foad abd-allah Reham Mohammed Shamloul Ehab Shaker Hani Shebly Mohamed abdel-Ghany Department of Cardiovascular Medicine Cairo University Cairo Egypt Department of Neurology Cairo University Cairo Egypt

Background and Purpose: Carotid atherosclerosis has been recognized as a major cause of stroke. The cur-rent study aimed to describe the effect of multiplicity rather than the type of vascular risk factors on severity of carotid atherosclerosis among a large sample of Egyptian population. Methods: We analyzed the data of 1969 Egyptian subjects, who proved to have extra cranial carotid atherosclerotic disease by duplex scanning at the vascular laboratories of Cairo Uni-versity Hospitals. Demographic, clinical data and causes of referral were recorded and correlated with ultrasound findings. Atherosclerotic indices, namely IMT, plaque number and percentage of stenosis were used for evaluation of severity of carotid atherosclerosis. Furthermore, subjects were classified according to multiplicity of major atherosclerotic risk factors and multivariate regression analysis was performed to detect independent predictors of significant carotid disease. Results: Out of 1969 subjects with proved signs of extracranial carotid atherosclerosis by duplex ultrasonographic scan, 225 (11.4%) showed hemody-namic significant stenosis (≥50%). Multiplicity of risk factors beyond the age of 50 years was the strongest predictor of significant stenosis. Conclusion: Age more than 50 years and multiplicity rather than the type of risk factors were the strongest predictors of significant carotid atherosclerotic disease (CAD).

关键词： Carotid Atherosclerosis Risk Factors Duplex Carotid Stenosis

Prevalence of Cerebral Atherosclerosis among Patients with Metabolic Syndrome: A Case Control Study on Egyptian Subjects

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World Journal of Cardiovascular Diseases 2016年第1期6卷 8-13页

作者： Sherif Elwan Tarek Zoheir Tawfik Heba Sayed Assal Shaimaa El-Jaafary Montasser Mohamed Hegazy Salwa Tawfik Alshaimaa Mahmoud Aboulfotooh foad abd-allah Department of Internal Medicine National Research Institute Cairo Egypt Department of Neurology Cairo University Cairo Egypt

Background: The metabolic syndrome (MetS) is a clustering of vascular risk factors that tend to increase the risk of occurrence of diabetes mellitus type 2 (DMT2), cardiovascular and cerebro-vascular ischemic events. The aim of the present study is to investigate the association of extra-cranial and intracranial arterial atherosclerosis as well as silent brain infarction (SBI) with MetS, thereby determining the potential cerebrovascular atherosclerotic risk of MetS in the Egyptian population. Methods: A case control study was conducted on 50 Egyptian subjects with MetS and 30 without with age range from 40 - 60 years old. All participants were free from cerebrovascular ischemic events [stroke or transient ischemic attack (TIA)]. All participants underwent complete neurological examination, assessment of the diagnostic criteria for MetS, carotid and transcranial duplex ultrasonography (U/S) and brain MRI. Results: Preclinical carotid atherosclerosis (athero-sclerotic plaques with <50% stenosis) was associated with MetS (P value = 0.02) that persisted after adjustment for age and other confounders. There was no significant association between increased intima media thickness (IMT) and MetS. There was non-significant association between MetS and intracranial atherosclerotic disease (ICAD) or the degree of intracranial stenosis (ICS). Conversely, there was a highly significant association between MetS and SBI even after adjustment for age and other confounders (P value = 0.001). Conclusion: Metabolic syndrome is an important factor associated with mild to moderate atherosclerosis (<50% stenosis) and silent brain infarcts among asymptomatic individuals. Interventions to reduce MetS are important for prevention of subclinical and clinical cerebral atherosclerotic disease.

关键词： Metabolic Syndrome Preclinical Atherosclerosis Silent Brain Infarction Neurovascular Ultrasound Brain MRI Egyptian Population

Performance assessment of a spiral methanol to hydrogen fuel processor for fuel cell applications

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Journal of Natural Gas Chemistry 2012年第5期21卷 526-533页

作者： foad Mehri Majid Taghizadeh Chemical Engineering Department Babol University of TechnologyP.O.Box 484*** BabolIran

A novel design of plate-type microchannel reactor has been developed for fuel cell-grade hydrogen *** Cu/Zn/Al2O3 was used as catalyst for the reforming reaction,and its effectiveness was evaluated on the mole fraction of products,methanol conversion,hydrogen yield and the amount of carbon monoxide under various operating ***,0.5 wt% Ru/Al2O3 as methanation catalyst was prepared by impregnation method and coupled with MSR step to evaluate the capability of methanol processor for CO *** on the experimental results,the optimum conditions were obtained as feed flow rate of 5mL/h and temperature of 250℃,leading to a low CO selectivity and high H2 *** designed reformer with catalyst coated layer was compared with the conventional packed bed reformer at the same operating *** constructed fuel processor had a good performance and excellent capability for on-board hydrogen production.

关键词： spiral fuel processor hydrogen fuel cell methanol steam reforming

Market-based coordination of price-responsive demand using Dantzig-Wolfe decomposition method

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Energy and AI 2023年第4期14卷 329-340页

作者： foad Najafi Matthias Fripp Department of Electrical Engineering University of Hawaii at Manoa2540 Dole StreetHonoluluHawaiiUnited States

The increasing penetration of Distributed Generation(DG)and Demand Responsive(DR)loads in power systems has necessitated the development of novel approaches to address the coordination problem of Price Responsive Devices(PRD).These PRDs are treated as self-interested players aiming to optimize their consumption patterns based on prevailing *** this paper,we propose a new algorithm based on the Dantzig-Wolfe(DW)Decomposition method,which tackles the coordination problem of self-interested PRDs in a distributed *** the distributed nature of the DW approach,we model the self-interested algorithms of PRDs as sub-problems within the DW *** coordinator,or grid operator,responsible for collecting the energy consumption information(energy bids)of PRDs,solves the master problem of the DW and determines the price signal *** proposed algorithm exhibits fast convergence as the sub-problems within DW,which could involve a large number of PRDs(potentially millions),can be solved ***,based on the DW theory,if the PRDs’subproblems are convex,reaching the optimal point(equivalent to Nash Equilibrium)is guaranteed within a limited number of *** evaluate the proposed model,we conducted a simulation involving 200 participant households,each equipped with two types of loads:Electric Vehicles(EVs)as examples of inter-ruptible loads,and Electric Water Heaters(EWHs)as examples of Thermostatically Controlled Loads(TCLs).The results demonstrate that when the algorithm converges to the optimal point,both the generation cost and user payment(based on the marginal cost of generation)***,there is a significant reduction in the Peak to Average Ratio(PAR)of the aggregate load.

关键词： Demand-side management(DSM) Distributed optimization Dantzig-Wolfe algorithm Price responsive devices(PRD) Appliance coordination

A dicationic,podand-like,ionic liquid water system accelerated copper-catalyzed azide-alkyne click reaction

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Chinese Chemical Letters 2014年第12期25卷 1643-1647页

作者： Mohammad Javaherian foad Kazemi Masoumeh Ghaemi Department of Chemistry College of ScienceShahid Chamran University Department of Chemistry University for Advanced Studies in Basic Sciences

In this work,an effective,task specific,dicationic,podand-like ionic liquid was synthesized and applied to improve the capability features of click ***,to broaden the scope and decreasing the serious limitations of preparation methods of organic azides,a simple green procedure for the preparation of alkyl azides,the fundamental starting materials in click reactions,from alcohols under solvent-free conditions and microwave irradiation has been reported,for the first time.

关键词： Dicationic ionic liquid Click chemistry 1 2 3-Triazoles Alkyl azides Alkynes Microwave irradiation

Strength properties of soft clay treated with mixture of nano-SiO_2 and recycled polyester fiber

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第4期7卷 367-378页

作者： foad Changizi abdolhosein Haddad Department of Civil Engineering Semnan University

This paper investigates the effect of recycled polyester fiber, produced from polyethylene （PET） bottles, in combination with nano-SiO2 as a new stabilizer to improve the mechanical properties of soils. We intend to study the effect of adding nano-SiO2 and recycled polyester fiber on soil engineering properties, especially the shear strength and unconfined compressive strength （UCS）, using clayey soil with low liquid limit. Three different combinations of fiber-soil ratios ranging between 0.1% and 0.5% as well as three different combinations of nano-soil ratios ranging between 0.5% and 1% are used. The shear strength and UCS of treated specimens are obtained from direct shear test and unconfined compression test, respectively. Results of this study show that the addition of recycled polyester fiber and nano-SiO2 increases the strength of soil specimens. Both the shear strength and UCS are improved by increasing the contents of recycled polyester fiber and nano-SiO2 in the soil mixture. The increase in the nano-SiO2 content leads to a reduction in failure strain, but the increase in the content of recycled polyester fiber leads to an increase in failure strain. The increase in the contents of recycled polyester fiber and nano-SiO2 leads to an increase in elastic modulus of soils. Based on the test results, the addition of recycled polyester fiber improves the mechanical properties of soils stabilized with nano-SiO2 as well as the recycled polyester fiber has a positive effect on soil behaviors.

关键词： Recycled polyester fiberNano-SiO2 Strength propertiesElastic modulus

Practical reduction of imines by NaBH_4/alumina under solvent-free conditions:An efficient route to secondary amine

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Chinese Chemical Letters 2008年第10期19卷 1167-1170页

作者： foad Kazemi Ali Reza Kiasat Ebrahim Sarvestani Institute for Advanced Studies in Basic Sciences(IASBS) Zanjan 45195Iran Chemistry Department College of ScienceShahid Chamran UniversityAhvaz 61357-4-3169Iran

Sodium borohydride supported on alumina reduces imines to the corresponding secondary amines in high to excellent isolated yields under solvent-free conditions. Noteworthy is that highly chemoselective reactions were ... 详细信息

关键词： Imine Secondary amine Solvent free Reduction Sodium borohydride