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Phytochemical Studies, Antimicrobial and Anti-Inflammatory Properties of the Hydroethanolic Extract of Kalanchoe pinnata (Lam.) Pers. from Togolese Flora

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Journal of Biosciences and Medicines 2024年第10期12卷 349-360页

作者： Luckman Gbati Yao Hoinsou fo-doh clefasse koula Ablam Alognon Minyo Ega Sossa Montant Sossawè Poli Tibanguebé Doumongue Gérard Akouétévi Toudji Efui Holaly Gbekley Bouraïma Djeri Aboudoulatif Diallo Damintoti Simplice Karou Microbiology and food Quality Control Laboratory (LAMICODA) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Laboratory of Biomedical Sciences Food and Environmental Health-Research Unit in Biomedical Sciences and Bioactive Substances (LaSBASE-UR-2SB) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Department of Biochemistry/Nutrition Laboratory of Biochemistry Applied to Nutrition Faculty of Sciences University of Lom Lom Togo Toxicology Laboratory Faculty of Health Sciences University of Lom Lom Togo

Kalanchoe pinnata (Lam.) Pers. is known as a plant that has many special benefits such as anti-inflammatory and antibacterial. The present study was carried out to perform a phytochemicals study and evaluate the antimicrobial and anti-inflammatory activity of the hydroethanolic extract of Kalanchoe pinnata (Lam.) Pers. leaves. After phytochemicals screening, the content of phenolic compounds, proanthocyanidol and flavonoids in the extract of this plant was determined spectrophotometrically. Antimicrobial activity was assessed using the micro-dilution technique on 96-well plates in liquid medium, combined with agar spreading. Anti-inflammatory activity was assessed using the 1% carrageenan induced rat paw oedema model. Phytochemical screening revealed the presence of alkaloids, saponins, triterpenes and sterols, phenols and flavonoids in the plant extract in varying proportions. The extract contained (0.049 ± 0.03 µg EAG/mg extract) total polyphenols, (0.215 ± 0.025 µg CE/mg extract) proanthocyanidins and (385.435 ± 0.0328 µg ER/mg ES) flavonoids. The hydroethanolic extract of the leaves of this plant inhibited the in vitro growth of the microbial strains studied to varying degrees. The MIC of the extract varied from 12.5 to 25 mg/mL and the BMC from 12.5 to 50 mg/mL. The plant did not show any activity on 1% carrageenan-induced rat paw edema.

关键词： Kalanchoe pinnata Hydroethanolic Extract Phytochemistry Pharmacological Activities Togo

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Toxicological Study of the Hydroalcoholic Extract of a Recipe of Three Plants Used in Traditional Togolese Medicine

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Journal of Biosciences and Medicines 2024年第8期12卷 270-280页

作者： Yao Hoinsou Sossawè Poli fodoh clefasse koula Luckman Gbati Ablam Alognon Tibanguebé Doumongue Minyo Ega Sossa Montant Gérard Akouétévi Toudji Efui Holaly Gbekley Bouraïma Djeri Microbiology and food Quality Control Laboratory (LAMICODA) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Laboratory of Biomedical Sciences Food and Environmental Health-Research Unit in Biomedical Sciences and Bioactive Substances (LaSBASE-UR-2SB) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Department of Biochemistry/Nutrition Laboratory of Biochemistry Applied to Nutrition Faculty of Sciences University of Lom Lom Togo Laboratory of Biology Phytochemistry Toxicology Pharmacology and Agrifood Institute African Biomedical Agrifood Societal and Environmental Sciences (IASBASE) Lom Togo

This work consisted of assessing the toxicity of a recipe of three plants used in traditional Togolese medicine. Acute and sub-acute toxicity was assessed according to OECD chemical test guidelines n˚423 dated December 17, 2001 and n˚407 dated October 3, 2008 respectively. Cytotoxicity was assessed using the 3-(4,5-dimethylthiazolyl-2-yl-2,5-diphenyltetrazolium bromide (MTT) test. No significant toxicity was observed after 14 and 28 days, although a dose-dependent decrease in creatinemia was observed in male rats (the recipe to be used to moderate creatinine levels). Cytotoxicity was without effect on NCM 365 cells. The results obtained justify the use of the recipe in traditional medicine.

关键词： Carica papaya Cocos nucifera Persea americana Toxicity Togo

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