Toxicological Study of the Hydroalcoholic Extract of a Recipe of Three Plants Used in Traditional Togolese Medicine
Toxicological Study of the Hydroalcoholic Extract of a Recipe of Three Plants Used in Traditional Togolese Medicine作者机构：Microbiology and Food Quality Control Laboratory (LAMICODA) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Laboratory of Biomedical Sciences Food and Environmental Health-Research Unit in Biomedical Sciences and Bioactive Substances (LaSBASE-UR-2SB) Higher School of Biological and Food Techniques (ESTBA) University of Lom Lom Togo Department of Biochemistry/Nutrition Laboratory of Biochemistry Applied to Nutrition Faculty of Sciences University of Lom Lom Togo Laboratory of Biology Phytochemistry Toxicology Pharmacology and Agrifood Institute African Biomedical Agrifood Societal and Environmental Sciences (IASBASE) Lom Togo
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2024年第12卷第8期
页 面：270-280页
学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学]
主 题：Carica papaya Cocos nucifera Persea americana Toxicity Togo
摘 要：This work consisted of assessing the toxicity of a recipe of three plants used in traditional Togolese medicine. Acute and sub-acute toxicity was assessed according to OECD chemical test guidelines n˚423 dated December 17, 2001 and n˚407 dated October 3, 2008 respectively. Cytotoxicity was assessed using the 3-(4,5-dimethylthiazolyl-2-yl-2,5-diphenyltetrazolium bromide (MTT) test. No significant toxicity was observed after 14 and 28 days, although a dose-dependent decrease in creatinemia was observed in male rats (the recipe to be used to moderate creatinine levels). Cytotoxicity was without effect on NCM 365 cells. The results obtained justify the use of the recipe in traditional medicine.
维普期刊数据库