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Immunological aspects of liver cell transplantation

World Journal of Transplantation 2016年第1期6卷 42-53页

作者： Felix Oldhafer Michael Bock Christine S Falk florian wr vondran Regenerative Medicine and Experimental Surgery (Re Medi ES) Department of General Visceral and Transplant Surgery Hannover Medical School Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School German Center for Infection Research (DZIF) Partner Site Hannover-Braunschweig Institute of Transplant Immunology Integrated Research and Treatment Centre Transplantation (IFB-Tx) Hannover Medical School

Within the field of regenerative medicine, the liver is of major interest for adoption of regenerative strategies due to its well-known and unique regenerative capacity. Whereas therapeutic strategies such as liver resection and orthotopic liver transplantation(OLT) can be considered standards of care for the treatment of a variety of liver diseases, the concept of liver cell transplantation(LCTx) still awaits clinical breakthrough. Success of LCTx is hampered by insufficient engraftment/long-term acceptance of cellular allografts mainly due to rejection of transplanted cells. This is in contrast to the results achieved for OLT where longterm graft survival is observed on a regular basis and, hence, the liver has been deemed an immuneprivileged organ. Immune responses induced by isolated hepatocytes apparently differ considerably from those observed following transplantation of solid organs and, thus, LCTx requires refined immunological strategies to improve its clinical outcome. In addition, clinical usage of LCTx but also related basic research efforts are hindered by the limited availability of high quality liver cells, strongly emphasizing the need for alternative cell sources. This review focuses on the various immunological aspects of LCTx summarizing data available not only for hepatocyte transplantation but also for transplantation of non-parenchymal liver cells and liver stem cells.

关键词： Liver cell transplantation Cell-based therapy Hepatocyte transplantation Transplant immunology Regenerative medicine

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Nerve compression and pain in human volunteers with narrow vs wide tourniquets

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World Journal of Orthopedics 2015年第4期6卷 394-399页

作者： florian M Kovar Manuela Jaindl Gerhard Oberleitner Georg Endler Julia Breitenseher Daniela Prayer Gregor Kasprian florian Kutscha-Lissberg Department of Trauma Surgery Medical University of Vienna1090 ViennaAustria Labors.at 1190 ViennaAustria Department of Radiology Medical University Vienna1090 ViennaAustria Department of Orthopedics Landesklinikum Wr.Neustadt2700 Wr.NeustadtAustria

AIM: To assess the clinical effects and the morphological grade of nerve ***: In a prospective single-center randomized, open study we assessed the clinical effects and the morphological grade of nerve compression during 20 min of either a silicon ring(group A) or pneumatic tourniquet(group B) placement variantly on the upper non-dominant limb in 14 healthy human volunteers. Before and during compression, the median and radial nerves were visualized in both groups by 3 Tesla MR imaging, using high resolutional(2.5 mm slice thickness) axial T2-weighted sequences. RESULTS: In group A, Visual analog pain scale was 5.4 ± 2.2 compared to results of group B, 2.9 ± 2.5, showing a significant difference(P = 0.028). FPS levels in group A were 2.6 ± 0.9 compared to levels in group B 1.6 ± 1, showing a significant difference(P = 0.039). Results related to measureable effect on median and radial nerve function were equal in both groups. No undue pressure signs on the skin, redness or nerve damage occurred in either group. There was no significant difference in the diameters of the nerves without and under compression in either group on T2 weighted ***: Based on our results, no differences between narrow and wide tourniquets were identified. Silicon ring tourniquets can be regarded as safe for short time application.

关键词： Nerve compression Magnetic resnane iamge Wide tourniquet Narrow tourniquet Human volunteers

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Incidence and analysis of radial head and neck fractures

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World Journal of Orthopedics 2013年第2期4卷 80-84页

作者： florian M Kovar Manuela Jaindl Gerhild Thalhammer Schuster Rupert Patrick Platzer Georg Endler Ines Vielgut florian Kutscha-Lissberg Department of Trauma Surgery Medical University of Vienna 1090 Vienna Austria Institute of Central Laboratory Wilheminenspital 1160 Vienna Austria Department of Orthopedic Surgery Medical University Graz 8010 Graz Austria Department of Orthopedics Country-hospital Wr. Neustadt 2700 Wr. Neustadt Austria

AIM: To investigate several complications like persistent radial head dislocation, forearm deformity, elbow stiffness and nerve palsies, associated with radial head fractures. METHODS: This study reviewed the clinical records and trauma database of this level Ⅰ Trauma Center and identified all patients with fractures of the radial head and neck who where admitted between 2000 and 2010. An analysis of clinical records revealed 1047 patients suffering from fractures of the radial head or neck classified according to Mason. For clinical examination, range of motion, local pain and overall outcome were assessed. RESULTS: The incidence of one-sided fractures was 99.2% and for simultaneous bilateral fractures 0.8%. Non-operative treatment was performed in 90.4%(n = 947) of the cases, surgery in 9.6%(n = 100). Bony union was achieved in 99.8%(n = 1045) patients. Full satisfaction was achieved in 59%(n = 615) of the patients. A gender related significant difference(P = 0.035) in Mason type distribution-type Ⅲ fractures were more prominent in male patients vs type Ⅳ fractures in female patients-was observed in our study population. CONCLUSION: Mason typeⅠfractures can be treated safe conservatively with good results. In type Ⅱ to Ⅳ surgical intervention is usually considered to be indicated.

关键词： Elbow Radial head Radial neck Fracture Children Adult

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