检索结果-南通市图书馆

中国烟草学报 2006年第4期12卷 34-34页

作者： Chr.stine A. LITTLE Alexander.J. Dyakonov r.na T. Walker.florian r. perini D. Scott Passer.Jun Guan 吴晓芸（译）曹建平（校） Lor.llar.烟草公司格林斯博罗北卡罗来纳州不详

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thiopur.nes in inflammator. bowel disease r.visited

引用

Wor.d Jour.al of Gastr.enter.logy 2013年第11期19卷 1699-1706页

作者： florian Br.Chr.stian Sina Klaus Feller.ann Medical Depar.ment 1 University Hospital Schleswig Holstein23538 LübeckGermany

Although a gr.at var.ety of new dr.gs have been intr.duced for.the ther.py of inflammator. bowel diseases so far.a definite cur. of the disease is still out of *** anti-inflammator. appr.ach to induce r.mission followed by maintenance ther.py with immunosupr.ssants is still the mainstay of *** compr.sing azathiopr.ne and its active metabolite mer.aptopur.ne as well as tioguanine,ar. widely used in the ther.py of chr.nic active inflammator. bowel disease(IBD).Their.ster.id spar.ng potential and efficacy in r.mission maintenance ar. out of ***,untowar. adver.e events ar. fr.quently obser.ed and may pr.clude fur.her.administr.tion or.be life *** r.view will focus on new aspects of thiopur.ne ther.py in IBD,its efficacy and safety.

关键词： Thiopur.nes Mer.aptopur.ne Tioguanine Azathiopr.ne Ulcer.tive colitis Cr.hn’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of Shor.-Ter. Metabolic Alter.tions in Ar.bidopsis Following Changes in the Pr.vailing Envir.nmental Conditions

引用

Molecular.Plant 2014年第5期7卷 893-911页

作者： Alexandr. florian Zor.n Nikoloski r.nan Sulpice Stefan Timm Wagner.L. Ar.ujo Takayuki Tohge Her.ann Bauwe Alisdair.r. Fer.ie Max-Planck-Institut for.Molekular. Pflanzenphysiologie Am Muhlenberg 1 14476 Potsdam-Golm Germany NUIG Plant Systems Biology Lab Plant and AgriBiosciences Research Centre Botany and Plant Science Galway Ireland Depar.ment of Plant Physiology University of Rostock D-18059 Rostock Germany Depar.amento de Biologia Vegetal Universidade Federal de Vicosa 36570-000 Vicosa Minas Gerais Brazil

Although a consider.ble incr.ase in our.knowledge concer.ing the impor.ance of metabolic adjustments to unfavor.ble gr.wth conditions has been r.cently pr.vided, r.latively little is known about the adjustments which occur.in r.sponse to fluctuation in envir.nmental factor.. Evaluating the metabolic adjustments occur.ing under.changing envir.nmental conditions thus offer. a good oppor.unity to incr.ase our.cur.ent under.tanding of the cr.sstalk between the major.pathways which ar. affected by such conditions. To this end, plants gr.wing under.nor.al conditions wer. tr.nsfer.ed to differ.nt light and temper.tur. conditions which wer. anticipated to affect （amongst other.pr.cesses） the r.tes of photosynthesis and photor.spir.tion and char.cter.zed at the physiological, molecular. and metabolic levels following this tr.nsition. Our.r.sults r.vealed similar.behavior.in r.sponse to both tr.atments and imply a tight connec- tivity of photor.spir.tion with the major.pathways of plant metabolism. They fur.her.highlight that the major.ty of the r.gulation of these pathways is not mediated at the level of tr.nscr.ption but that leaf metabolism is r.ther.pr.-poised to adapt to changes in these input par.meter..

关键词： centr.l metabolism envir.nmental per.ur.ation gene expr.ssion metabolic r.gulation photor.spir.tion photosynthesis r.bulose-1,5-bisphosphate car.oxylase/oxygenase (r.bisCO).

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling public holidays in load for.casting: a Ger.an case study

引用

Jour.al of Moder. Power.Systems and Clean Ener.y 2018年第2期6卷 191-207页

作者： florian ZIEL Fakultat fur.Wir.schaftswissenschaften insb.Okonomik erneuerbarer EnergienUniversitat Duisburg-Essen

We addr.ss the issue of public or.bank holidays in electr.city load modeling and for.casting. Special char.cter.stics of public holidays such as their.classification into fixed-date and weekday holidays ar. discussed in detail. We pr.sent state-of-the-ar. techniques to deal with public holidays such as r.moving them fr.m the data set,tr.ating them as Sunday dummy or.intr.ducing separ.te holiday dummies. We analyze pr.s and cons of these appr.aches and pr.vide a lar.e load for.casting study for.Ger.any that compar.s the techniques using standar. per.or.ance and significance measur.s. Finally, we give gener.l r.commendations for.the tr.atment of public holidays in ener.y for.casting to suggest how the dr.wbacks par.icular.to most of the state-of-the-ar. methods can be mitigated. This is especially useful, as the incor.or.tion of holiday effects can impr.ve the for.casting accur.cy dur.ng public holidays per.ods by mor. than 80%, but even for.non-holidays per.ods, the for.casting er.or.can be r.duced by appr.ximately 10%.

关键词： Public holidays Bank holidays Special day effects For.casting Electr.city load Holiday dummy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photor.spir.tion Is Cr.cial for.Dynamic r.sponse of Photosynthetic Metabolism and Stomatal Movement to Alter.d C02 Availability

引用

Molecular.Plant 2017年第1期10卷 47-61页

作者： Mar.on Eisenhut Andr.a Br.utigam Stefan Timm Alexandr. florian Takayuki Tohge Alisdair.r. Fer.ie Her.ann Bauwe Andr.as P.M. Weber Institute of Plant Biochemistr. Cluster of Excellence on Plant Sciences Heinrich Heine University 40225 Dusseldorf Germany Depar.ment of Plant Physiology University of Rostock Albert-Einstein-StraBe 3 18051 Rostock Germany Depar.ment of Molecular.Physiology Max-Planck Institute for Molecular Plant Physiology 14476 Potsdam-Golm Germany Pr.sent addr.ss: IPK Gater.leben Network Analysis and Modeling Corrensstrasse 3 06466 Seeland Germany

The photor.spir.tor. pathway or.photor.spir.tion is an essential pr.cess in oxygenic photosynthetic or. ganisms, which can r.duce the efficiency of photosynthetic car.on assimilation and is hence fr.quently consider.d as a wasteful pr.cess. By compar.ng the r.sponse of the wild-type plants and mutants impair.d in photor.spir.tion to a shift in ambient C02 concentr.tions, we demonstr.te that photor.spir.tion also plays a beneficial r.le dur.ng shor.-ter. acclimation to r.duced C02 availability. The wild-type plants r.- sponded with few differ.ntially expr.ssed genes, mostly involved in dr.ught str.ss, which is likely a conse- quence of enhanced opening of stomata and concomitant water.loss upon a shift towar. low C02. In contr.st, mutants with impair.d activity of photor.spir.tor. enzymes wer. highly str.ssed and not able to adjust stomatal conductance to r.duced exter.al C02 availability. The tr.nscr.ptional r.sponse of mutant plants was congr.ent, indicating a gener.l r.pr.gr.mming to deal with the consequences of r.duced C02 availability, signaled by enhanced oxygenation of r.bulose-l,5-bisphosphate and amplified by the ar.ificially impair.d photor.spir.tor. metabolism. Centr.l in this r.pr.gr.mming was the pr.- nounced r.allocation of r.sour.es fr.m gr.wth pr.cesses to str.ss r.sponses. Taken together. our.r.sults indicate that unr.str.cted photor.spir.tor. metabolism is a pr.r.quisite for.r.pid physiological acclimation to a r.duction in C02 availability.

关键词： photor.spir.tion star.ation str.ss stomata tr.nscr.ption Ar.bidopsis thaliana

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gut micr.bial car.inogen metabolism:another.avenue to cancer

引用

Signal Tr.nsduction and Tar.eted Ther.py 2024年第11期9卷 4783-4784页

作者： florian r.Gr.ten Melek C.Ar.an Institute for.Tumor.Biology and Exper.mental Ther.py Georg-Speyer-HausFrankfurt/MainGermany Fr.nkfur. Cancer.Institute Goethe University FrankfurtFrankfurt/MainGermany Ger.an Cancer.Consor.ium(DKTK)and Ger.an Cancer.r.sear.h Center.DKFZ) HeidelbergGermany

A r.cent study published in Natur. by r.je,Zhang and colleagues highlights the emer.ent r.le gut micr.biota play in pr.cessing envir.nmental car.inogens and r.ises its potential as a tar.et for.r.ducing cancer.r.sk in humans.1 This study fills yet another.piece into the giant jigsaw puzzle that illustr.tes the centr.l r.le of the dynamic str.ctur. and function of the intestinal micr.biome in cancer.pathogenesis and ther.py efficacy.

关键词： metabolism cancer pathogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Using the DEM-CFD method to pr.dict Br.wnian par.icle deposition in a constr.cted tube

引用

Par.icuology 2014年第4期12卷 94-106页

作者： florian Chaumeil Mar.in Cr.pper School of Engineer.ng The University of EdinburghEdinburgh EH9 3JLUnited Kingdom

Modelling of the agglomer.tion and deposition on a constr.cted tube collector.of colloidal size par.icles immer.ed in a liquid is investigated using the discr.te element method （DEM）. The ability of this method to r.pr.sent sur.ace inter.ctions allows the simulation of agglomer.tion and deposition at the par.icle scale. The numer.cal model adopts a mechanistic appr.ach to r.pr.sent the for.es involved in colloidal suspensions by including near.wall dr.g r.tar.ation, sur.ace inter.ction and Br.wnian for.es. The model is implemented using the commer.ially available DEM package EDEM 2.3~, so that r.sults can be r.pli- cated in a standar. and user.fr.endly fr.mewor.. The effects of var.ous par.icle-to-collector.size r.tios, inlet fluid flow-r.tes and par.icle concentr.tions ar. examined and it is found that deposition efficiency is str.ngly dependent on the inter.r.lation of these par.meter.. Par.icle deposition and r.-suspension mechanisms have been identified and analyzed thanks to EDEM＇s post pr.cessing capability. One-way coupling with computational fluid dynamics （CFD） is consider.d and r.sults ar. compar.d with a two- way coupling between EDEM 2.3 and FLUENT 12.1. It is found that two-way coupling r.quir.s cir.a 500% mor. time than one-way coupling for.similar.r.sults.

关键词： Discr.te element method DEM Colloids Agglomer.tion Deposition Simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of str.sses at the center.of tr.nsver.ely isotr.pic Br.zilian disk

引用

Jour.al of r.ck Mechanics and Geotechnical Engineer.ng 2023年第3期15卷 618-629页

作者： Ali Aminzadeh florian Amann Institute of Geology of the Czech Academy of Sciences PragueCzech Republic Chair.of Engineer.ng Geology RWTH Aachen UniversityAachenGermany

This ar.icle pr.sents the str.sses at the center.of a Br.zilian disk(BD)for.tr.nsver.ely isotr.pic *** is shown that the solution of str.sses at the center.of an anisotr.pic disk is a function of the disk r.dius and the magnitude of applied load,as well as the mater.al or.entation with r.spect to the load axis and two dimensionless r.tios with specific physical meanings and *** two dimensionless par.meter. ar. the r.tios of Young’s modulus and appar.nt shear.modulus,although the r.tio of appar.nt shear.modulus will be eliminated if the Saint-Venant assumption is *** finite element simulations ar. car.ied out to find the str.sses at the disk center.concer.ing the mater.al or.entation and the two dimensionless ***,an appr.ximate for.ula obtained fr.m analytical r.sults,pr.viously pr.posed in the liter.tur. for.solving the tensile and compr.ssive str.sses at the disk center.is r.-wr.tten and simplified based on these new *** r.sults of the appr.ximate for.ula fitted to the analytical r.sults ar. compar.d to those obtained fr.m numer.cal solutions,suggesting a good agr.ement between the numer.cal and analytical *** appr.ximate equation for.the shear.str.ss at the disk center.is also for.ulated based on the numer.cal ***,the influence of the assumptions for.simplification of the pr.posed for.ula for.the tensile,compr.ssive,and shear.str.sses at the disk center.is discussed,and simple and pr.ctical equations ar. pr.posed as estimations for.the str.sses at the center.of the BD specimen for.low to moder.te anisotr.pic *** highly anisotr.pic r.cks,the r.fer.nce plots can be used for.mor. accur.cy.

关键词： Br.zilian test Tr.nsver.e isotr.py r.ck anisotr.py Anisotr.pic disk Tensile str.ss Shear.str.ss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is Ther. a Metabolic r.quir.ment for.Photor.spir.tor. Enzyme Activities in Heter.tr.phic Tissues？

引用

Molecular.Plant 2014年第1期7卷 248-251页

作者： Adr.ano Nunes-Nesi Alexandr. florian Andr.w Howden Kathr.n Jahnke Stefan Timm Her.ann Bauwe Lee Sweetlove Alisdair.r. Fer.ie Max Planck Par.ner.Gr.up Departamento de Biologia Vegetal Universidade Federal de Vicosa 36570-000 Vicosa Minas Gerais Brazil Centr.l Metabolism Gr.up Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 1 D-14476 Potsdam-Golm Germany Depar.ment of Plant Sciences University of Oxford South Parks Road Oxford OX2 3RB UK Depar.ment of Plant Physiology University of Rostock D-18051 Rostock Germany

Photor.spir.tion is an essential metabolic pr.cess in leaves that facilitates r.cover. of car.on lost by the oxygenase r.action of r.bisco and avoids the accumulation of the toxic pr.duct, 2-phosphoglycolate （2PG） of this r.action （Bauwe et al., 2012）. However. ther. is also evidence to suggest that photor.spir.tion has a mor. complex r.le dur.ng nor.al gr.wth than the mer. detoxification of 2PG and the r.cover. of 3-phosphoglycer.te （3PGA）（Bauwe et al., 2012）.

关键词：

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malar.a modeling: In vitr. stem cells vs in vivo models

引用

Wor.d Jour.al of Stem Cells 2016年第3期8卷 88-100页

作者： florian Noulin Depar.ment of Micr.biology and Molecular.Genetics The Kuvin Center for the Study of Infectious and Tropical Diseases IMRIC The Hebrew University-Hadassah Medical School

The r.cent development of stem cell r.sear.h and the possibility of gener.ting cells that can be stably and per.anently modified in their.genome open a br.ad hor.zon in the wor.d of in vitr. modeling. The malar.a field is gaining new oppor.unities fr.m this impor.antbr.akthr.ugh and novel tools wer. adapted and opened new fr.ntier. for.malar.a r.sear.h. In addition to the new in vitr. systems, in r.cent year. ther. wer. also significant advances in the development of new animal models that allows studying the entir. cell cycle of human malar.a. In this paper. we r.view the differ.nt pr.tocols available to study human Plasmodium species either.by using stem cell or.alter.ative animal models.

关键词： Malar.a Stem cells In vitr. models Animal models Humanized mice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：