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*** nanoparticles as a new drug vector for glaucoma therapy

Annals of Eye Science 2018年第1期 488-488页

作者： florence masse Mathieu Ouellette Elodie Boisselier Department of Medicine UniversitéLavalQuebecQCCanada Département d'ophtalmologie Facultéde MédecineCUO-RechercheCentre de recherche du CHU de QuébecHôpital du St-SacrementQuebecQCCanada

Background:Glaucoma is an optical neuropathy affecting over 67 million people in the *** of current active molecules,as travoprost(hydrophobic)is limited when administered by ophthalmic ***,more than 99.9%is discarded due to multiple factors including lacrimal *** retention time of drugs at the cornea leads to their poor *** aim of the project is to develop a drug delivery system allowing the drug penetration through biological *** hypothesis is that a drug delivery system based on gold nanoparticles should enhance the efficiency of the *** main objective is to study the encapsulation ability of gold nanoparticles towards *** specific objectives are(I)the synthesis and characterizations of gold nanoparticles;(II)the establishment of the encapsulation protocol;(III)the method development of the separation of free and encapsulated drugs and;(IV)the quantification of the encapsulated ***:Gold nanoparticles were synthesized by a new method developed in our *** encapsulation protocol was settled using aqueous conditions at 37℃.The separation of free and encapsulated drugs was performed with magnetic *** quantification of the encapsulated drugs was then performed by high performance liquid chromatography and confirmed by UV-visible ***:Gold nanoparticles of 28±1 nm were synthesized and purified according to our new experimental *** encapsulation protocol lasts 5 days in the optimised *** separation method involving magnetic beads was optimized to get rid of non-specific *** travoprost was incubated with the nanoparticles until the reach of equilibrium in ***:We showed that active molecules used for glaucoma therapy,as travoprost,can be encapsulated in gold *** analysis will allow identifying the encapsulation properties of various gold nanoparticles,differing by their size,shape and chemical s

关键词： Gold nanoparticles drug vector glaucoma travoprost

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*** gold nanoparticles as a drug delivery system for ocular therapy

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Annals of Eye Science 2019年第1期 198-198页

作者： florence masse Pascale Desjardins Mathieu Ouellette Camille Couture Mahmoud Mohamed Omar Vincent Pernet Sylvain Guérin Élodie Boisselier Department of Ophthalmology Laval UniversityQuebecQCCanada CUO-Recherche Hôpital du St-SacrementCentre de recherche du CHU de QuébecQuebecQCCanada Centre de Recherche en Organogénèse expérimentale de l’UniversitéLaval/LOEX QuébecQCCanada

Background:Ocular therapy administrated by ophthalmic drops is advantageous thanks to its ***,efficiency of active molecules is limited when administered by this ***,more than 99.9%is discarded due to multiple factors including lacrimal *** retention time of drugs at the cornea leads to their poor *** hypothesis is that a drug delivery system based on gold nanoparticles should enhance the efficiency of the *** main objective is to develop new methods to improve active molecules biodisponibility in ocular therapy thanks to a new drug delivery system implying gold *** specific objectives are:(I)to synthesize and characterize ultrastable gold nanoparticles,(II)to establish the drug encapsulation protocol,(III)to develop a separation method of free and encapsulated drugs to allow their quantification,(IV)to study the cytotoxicity of our gold ***:Ultrastable gold nanoparticles were synthesized by a new method and their ultrastability toward several harsh conditions was *** encapsulation protocol was settled for several *** separation of free and encapsulated drugs was performed with magnetic *** quantification of the encapsulated drugs was performed by HPLC.A MTS assay was performed on 3 corneal epithelial cell populations,exposed or unexposed to gold *** corneas were prepared using the self-assembly method.A wound healing experience was performed on those corneas with or without ***:Gold nanoparticles were synthesized and purified according to our new experimental *** support harsh conditions as several cycles of freeze-drying,heating,salt exposition and *** the first time in literature,gold nanoparticle support autoclave *** separation method involving magnetic beads was optimized to get rid of non-specific *** encapsulation efficiency varies according to the act

关键词： Gold nanoparticles ultrastability drug delivery MTS assay wound healing assay

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Myth and geology

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Episodes 2008年第3期31卷 366-368页

作者： L. Piccardi W.B.masse

I dare say many geologists may wonder why the Geological Society would be publishing a book on such a topic. Surely geology has advanced well beyond the stage of myth! But the field is now quite ＇respectable＇ and the papers in this volume grow from a session held at the International Geological Congress in florence in 2004. The field of geology and myth was founded virtually single handed by Dorothy Vitaliano in her Legends of the Earth （1973） and she gave the keynote address at the florence meeting.

关键词：地质学地理岩石出版工作

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