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SOX2 in cancer stemness: tumor malignancy and therapeutic potentials

Journal of Molecular Cell Biology 2020年第2期12卷 85-98页

作者： Mahfuz Al Mamun Kaiissar Mannoor Jun Cao firdausi qadri Xiaoyuan Song Hefei National Laboratory for Physical Sciences at the Microscale School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Oncology Laboratory Institute for Developing Science&Health Initiatives(ideSHi)Dhaka 1212Bangladesh CAS Key Laboratory of Brain Function and Disease CAS Center for Excellence in Molecular Cell ScienceSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China

Cancer stem cells(CSCs),a minor subpopulation of tumor bulks with self-renewal and seeding capacity to generate new tumors,posit a significant challenge to develop effective and long-lasting anti-cancer *** emergence of drug resistance appears upon failure of chemo-/radiation therapy to eradicate the CSCs,thereby leading to CSC-mediated clinical *** evidence suggests that transcription factor SOX2,a master regulator of embryonic and induced pluripotent stem cells,drives cancer stemness,fuels tumor initiation,and contributes to tumor aggressiveness through major drug resistance mechanisms like epithelial-to-mesenchymal transition,ATP-binding cassette drug transporters,anti-apoptotic and/or pro-survival signaling,lineage plasticity,and evasion of immune *** a better insight and comprehensive interrogation into the mechanistic basis of SOX2-mediated generation of CSCs and treatment failure might therefore lead to new therapeutic targets involving CSC-specific anti-cancer strategies.

关键词： S0X2 cancer stem cells(CSCs) drug resistance therapeutic potentials

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5-year vaccine protection following a single dose of Vi-tetanus toxoid conjugate vaccine in Bangladeshi children(TyVOID):a cluster randomised trial

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四川生理科学杂志 2024年第10期46卷 2360-2360页

作者： firdausi qadri International Centre for Diarrhoeal Disease Research Bangladesh Dhaka Bangladesh Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK NIHR Oxford Biomedical Research Centre and Oxford University Hospitals NHS Foundation Trust Oxford UK Department of Epidemiology of Microbial Diseases and Public Health Modelling Unit Yale School of Public Health New Haven CT USA International Vaccine Institute Seoul South Korea UCLA Fielding School of Public Health Los Angeles CA USA Vaccine Innovation Centre Korea University School of Medicine Seoul South Korea

Background:WHO currently recommends a single dose of typhoid conjugate vaccine(TCV)in high-burden countries based on 2-year vaccine efficacy data from large randomised controlled *** the decay of immunogenicity,the protection beyond 2 years is *** therefore extended the follow-up of the TyVAC trial in Bangladesh to assess waning of vaccine protection to 5 years after vaccination.

关键词： conjugate random cluster

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