SOX2 in cancer stemness: tumor malignancy and therapeutic potentials
SOX2 in cancer sternness: tumor malignancy and therapeutic potentials作者机构：Hefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Oncology LaboratoryInstitute for Developing Science&Health Initiatives(ideSHi)Dhaka 1212Bangladesh CAS Key Laboratory of Brain Function and DiseaseCAS Center for Excellence in Molecular Cell ScienceSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2020年第12卷第2期
页 面：85-98页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work is supported by the National Key Scientific Program of China(2016YFA0100502) M.A.M.is a recipient of the CASTWAS President’s Fellowship.X.S.is a recipient of the 1000 Talents Plan Professorship for Young Talents(KJ2070000026)
主 题：S0X2 cancer stem cells(CSCs) drug resistance therapeutic potentials
摘 要：Cancer stem cells(CSCs),a minor subpopulation of tumor bulks with self-renewal and seeding capacity to generate new tumors,posit a significant challenge to develop effective and long-lasting anti-cancer *** emergence of drug resistance appears upon failure of chemo-/radiation therapy to eradicate the CSCs,thereby leading to CSC-mediated clinical *** evidence suggests that transcription factor SOX2,a master regulator of embryonic and induced pluripotent stem cells,drives cancer stemness,fuels tumor initiation,and contributes to tumor aggressiveness through major drug resistance mechanisms like epithelial-to-mesenchymal transition,ATP-binding cassette drug transporters,anti-apoptotic and/or pro-survival signaling,lineage plasticity,and evasion of immune *** a better insight and comprehensive interrogation into the mechanistic basis of SOX2-mediated generation of CSCs and treatment failure might therefore lead to new therapeutic targets involving CSC-specific anti-cancer strategies.
维普期刊数据库