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Primary liver transplantation vs transplant after Kasai portoenterostomy in children with biliary atresia: A retrospective Brazilian single-center cohort

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World Journal of Transplantation 2024年第1期14卷 112-119页

作者： Melina Utz Melere Valberto Sanha Marco Farina Carolina Soares da silva Luiza Nader Cristine Trein Angelica Maria Lucchese Cristina Ferreira antonio Nocchi Kalil Flavia Heinz Feier Department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Brazil Department of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Department of Surgical Oncology Santa Rita Hospital/Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil

BACKGROUND Biliary atresia(BA)is the most common indication for pediatric liver transplantation,although portoenterostomy is usually performed ***,due to the high failure rate of portoenterostomy,liver transplantation has been advocated as the primary procedure for patients with *** is still unclear if a previous portoenterostomy has a negative impact on liver transplantation *** To investigate the effect of prior portoenterostomy in infants un-dergoing liver transplantation for *** This was a retrospective cohort study of 42 pediatric patients with BA who underwent primary liver transplantation from 2013 to 2023 at a single tertiary center in *** with BA were divided into two groups:Those undergoing primary liver transplantation without portoenterostomy and those undergoing liver transplantation with prior *** variables were compared using the Student’s t-test or the Kruskal-Wallis test,and categorical variables were compared using theχ2 or Fisher’s exact test,as *** Cox regression analysis was performed to determine risk factors for portal vein *** and graft survival analyses were conducted with the Kaplan–Meier product-limit estimator,and patient subgroups were compared using the two-sided log-rank *** Forty-two patients were included in the study(25[60%]girls),23 undergoing liver transplantation without prior portoenterostomy,and 19 undergoing liver transplantation with prior *** with prior portoenterostomy were older(12 vs 8 months;P=0.02)at the time of liver transplantation and had lower Pediatric End-Stage Liver Disease scores(13.2 vs 21.4;P=0.01).The majority of the patients(35/42,83%)underwent livingdonor liver *** group of patients without prior portoenterostomy appeared to have a higher incidence of portal vein thrombosis(39 vs 11%),but this result did not reach statistical *** portoenterostomy

关键词： Hepatic portoenterostomy Biliary atresia Liver transplantation Patient outcome assessment Portal vein Survival

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Increased basal plasma brain-derived neurotrophic factor levels in sprint runners

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Neuroscience Bulletin 2011年第5期27卷 325-329页

作者： Paulo Roberto Correia Fulvio Alexandre Scorza Sérgio Gomes da silva Aline Pansani Michelle Toscano-silva antonio Carlos de Almeida Ricardo Mario Arida 圣保罗联邦大学生理学系圣保罗联邦大学神经内外科系 So Joo del-Rei联邦大学实验与计算神经生物学实验室

Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters （100 m） at either the international （Olympics and Outdoor World Championships）（n = 14） or the domestic level （n = 8）, and sedentary subjects （n = 15）, were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.

关键词： brain-derived neurotrophic factor physical exercise sprint plasma brain human

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Cell Viability of Byrsonima intermedia A Juss Calli

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Journal of Agricultural Science and Technology(B) 2012年第6期2卷 713-720页

作者： Luciano Coutinho silva Renato Paiva daiane Peixoto Vargas Diogo Pedrosa Correa da silva Rairys Cravo Herrera Sandro Barbosa antonio Paulino da Costa Netto Biology Department Plant Physiology Sector Federal University of Lavras (UFLA) Caixa Postal 3037 CEP 37200-000 LavrasMinas Gerais Brasil Embrapa Clima Temperado Rodovia BR 392 km 78 CP 403 Pelotas Rio Grande do Sul CEP: 96010-971 Brasil Universidade Federal do Pare (UFPA) Campus Universitfrio de Altamira Rua Coronel Jose Porfirio 2515 Sao Sebastiao CEP68372-040 Altamira Pard Brasil Departamento de Ciencias Biologicas e da Terra Universidade Federal de Alfenas (UNIFAL) MG Rua Gabriel Monteiro da Silva 700 Centro CEP 37130-000 Alfenas Minas Gerais Brasil Laboratorio de Fisiologia Vegetal Universidade Federal de Goifs (UFG) Rua Riaehuelo S/N Unidade Jatoba Setor SamuelGraham 75804-020 Jatai GO Brasil

Byrsonima intermedia A Juss. is a species with pharmacological properties from the Brazilian Cerrado that shows difficulties related to sexual propagation. Research on cell viability may provide useful information for the selection of cells with embryogenic potential during the callus culture, Within this context, our research is aimed at establishing the cell viability of calli from Byrsonima intermedia leaf segments. The calli went through three subculture phases, of 60 days each, in MS medium with 0.09 M sucrose, 0.6% agar, pH 5.8 and 4.52 laM 2,4-D. The calli were stored in dark conditions and samples were collected every 10 days from each subculture for viability tests with fluorescein 3,6-diacetate （Fda） and 2,3,5-triphenyltetrazolium chloride （TTC）. The staining methods allowed quantifying cell viability in each subculture. The best results from the Fda tests were obtained at 21, 25 and 29 days for the first, second and third subcultures respectively, with 53,86%, 61.88% and 53.73% viable cells. Regarding the TTC test, the largest absorbance values were obtained at 21, 27 and 28 days for the first, second and third subcultures respectively. Fluorescence and spectrophotometry analyses were efficient for determination of cell viability during callus cultivation period.

关键词： Cell viability fluorescein 3 6-diacetate 2 3 5-tripheniltetrazolium chloride subculture tissue culture native plant.

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Effect of Different Sources and Doses of Nitrogen on Vegetative and Productive Performance of Sugarcane under a Dystrophic Red Latosol Condition

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Journal of Agricultural Science and Technology(B) 2018年第1期8卷 50-59页

作者： Flávio Henrique Ferreira Gomes Frederico antonio Loureiro Soares Marconi Batista Teixeira Edson Cabral da silva Nelmicio Furtado da silva Fernando Nobre Cunha Cicero Teixeira silva Costa Federal Institute of Education Science and Technology of GoiásRio Verde CampusRio Verde 75901-970GOBrazil Federal Institute of Education Science and Technology of Mato Grosso do SulCampus NaviraíNaviraí79950-000MSBrazil

The aim of this work was to evaluate the effects of the application of different sources and doses of nitrogen(N)in the growth and productivity of sugarcane in cane *** experiments were conducted in the area of Rio Paraiso II farm,belonging to the Raízen factory,in the city of Jataí,*** soil was classified as dystrophic red *** experimental design used was in randomized block,analysed in factorial scheme of 2×4×4,with three *** factors analysed were two sources of N(urea and ammonium nitrate),four doses of N(0,60,120 and 180 kg/ha)and four evaluation times(210,250,290 and 330 d after planting(daP)).The parameters analysed were plant height(PH),diameter of stalks(DS),length of internodes(LI)and productivity of stalks(PS).Results observed significant difference in the sources and doses of N for the evaluated parameters in sugarcane *** in the average doses of 110 kg/ha and 100.87 kg/ha provided the greatest PH and LI of sugarcane,*** nitrate at a dose of 180 kg/ha presented the largest DS of sugarcane(cane plant)at 330 *** PS of sugarcane SP80-1816 at 60 kg/ha and 120 kg/ha ammonium nitrate has higher *** the PS,it is recommended the application of doses between 60 kg/ha and 120 kg/ha of N of the source ammonium nitrate in sugar cane(cane plant).

关键词： Saccharum spp. urea ammonium nitrate yield biometry

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Alternative Control of Alternaria Brown Spot in Tangerine

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Agricultural Sciences 2020年第12期11卷 1217-1231页

作者： antonio Manoel da silva Filho Élida Barbosa Corrêa Alisson Queiroz Moura Juan Manuel Anda Rocabado Phytopathology Laboratory of the State University from Paraiba (UEPB) Lagoa Seca Brazil Department of Agricultural Engineering Federal University of Campina Grande (DEAG/UFCG) Campina Grande Brazil Center University Araras Dr. Edmundo Ulson Araras Brazil Laboratory of Electronic Microscopy Federal University of the Rec&#244 ncavo of Bahia (UFRB) Cruz das Almas Brazil

Alternaria brown spot is considered the main disease of tangerines in the State of Paraiba. The objective of work was to evaluate vegetal tinctures from bitter melon (Momordica charantia) and guava (Psidium guajava) leaves, as an alternative control for Alternaria brown spot in tangerine. The effects of vegetal tinctures were tested in leaves and fruits (detached) of tangerine “dancy” inoculated with tangerine pathotype of Alternaria alternata. The effect of tinctures on mycelium growth and spore germination of the pathogen was tested. Tinctures at 20% concentration promoted reduction of disease severity. A reduction of 80% in the diameter of leaf lesions was observed for bitter melon tinctures and 75.3% for guava tinctures. In fruits, the reduction was 48.4% (bitter melon tinctures) and 43.3% (guava tinctures). Guava tinctures, starting at a concentration of 5%, inhibited 100% of mycelium growth of tangerine pathotype of A. alternata, while the use of bitter melon tinctures inhibited 100% of mycelium growth starting at a concentration of 10%. The greater sensitivity to tinctures observed when these were added to the culture medium when compared to inoculation in leaves and fruits may be explained due to the higher exposition of the pathogen to the active principle when the vegetal tinctures were added to the culture medium, than when tinctures were sprayed over the vegetal surface in fruits and leaves. The number of germinated spores decreases 76.7% and 82% when using tinctures from guava and bitter melon (20%). Tinctures from bitter melon and guava are potential tools for alternative management of the Alternaria brown spot in tangerine “dancy”.

关键词： Alternaria alternata f. sp. citri Momordica charantia Psidium guajava Vegetal Extracts Vegetal Tinctures

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Adipose tissue,systematic inflammation,and neurodegenerative diseases

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Neural Regeneration Research 2023年第1期18卷 38-46页

作者： Ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel F.Frihling Patrícia Souza e silva Luiz filipe R.Nde Moraes Ludovico Migliolo S-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the *** nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory *** presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory *** this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive *** addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease neuroinflammation

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Application of NMR Relaxometry to Study Nanostructured Poly(vinyl alcohol)/MMT/Cephalexin Materials for Use in Drug Delivery Systems

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Materials Sciences and Applications 2016年第7期7卷 380-387页

作者： antonio de Pádua Castelo Branco Cunha Maria Inês Bruno Tavares Emerson Oliveira da silva Instituto de Macromoléculas Professora Eloisa Mano da Universidade Federal do Rio de Janeiro CT Bloco J Cidade Universitária Ilha do Fundao Rio de Janeiro Brazil

Polymers containing nanoparticles dispersed and distributed in the matrix can be used for control of drug release. In this work, hydrophilic matrix systems were prepared using poly(vinyl alcohol) and unmodified clay containing the same amount of cephalexin. The materials were obtained through in situ polymerization and were characterized by the conventional technique of FTIR and NMR relaxometry, through determination of proton spin-lattice relaxation time, in order to understand the molecular behavior of the new materials. The NMR relaxometry data showed that the new materials containing low quantities of clay (0.25% and 0.75%) and the same amount of cephalexin (0.5 g) had very good dispersion and distribution of the clay and drug in the polymer matrix. The combination of clay and cephalexin formed a more homogenous material with a narrow domain curve and low relaxation values. The material containing 0.25% clay presented a mixed morphology, with part exfoliated and part intercalated, as could be seen from the relaxation domain distribution, which was larger than that for material with 0.75% clay.

关键词： Polymer Relaxometry NMR Nanotechnology

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Evaluation of Porous Structure of Cement Pastes Made with Residual Rice Husk Ash

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Journal of Civil Engineering and Architecture 2014年第11期8卷 1396-1402页

作者： Joao Henrique da silva Rego antonio Alberto Nepomucenol Enio Pazini Figueiredo Nicole Pagan Hasparyk Department of Environmental and Civil Engineering University of Brasilia Brasilia/DF 70910-900 Brazil School of Civil Engeneering Federal University of Goi6s Goidnia/GO 74605-22 Brazil Department of Technical Support and Control Furnas Centrals Eldtricas Aparecida de Goidnia/GO 74001-970 Brazil

In several countries, the residual RHA （rice husk ash） has been produced in rice processing industries or in thermoelectric plants that use rice husk to generate heat and/or electrical energy, usually without burning process control. This causes a reduction in the amorphous silica content of residual RHA, which distinguishes them from the RHA produced according to controlled burning process, which is totally amorphous and considered a highly reactive pozzolan. In this paper, the hydration products and the porous structure of binders paste were studied by replacing, in weight of 5%, 10% and 20% of Portland cement OPC （ordinary Portland cement）, by residual RHAs named A and B, which have high and low content of amorphous silica, respectively, using microstructure evaluation techniques as XRD （X-ray diffraction）, TG （thermogravimetric） tests and MIP （mercury intrusion porosimetry）. A reducing the size of the pores of the pastes was observed according to the increase of content replacement of RHA A and RHA B.

关键词： Mineral addition residual rice husk ash pozzolanic activity porous structure microstructure.

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Good Practices in Strategic Environmental Assessment Processes under the Brazilian Practitioners’ Vision

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Journal of Environmental Protection 2018年第6期9卷 720-735页

作者： antonio W. L. da silva Marinilse Netto Paulo Selig Alexandre Lerípio Santa Catarina State University-UDESC Chapecó Brazil Community University of the Region of Chapecó-Unochapecó Chapecó Brazil Federal University of Santa Catarina-UFSC Florianópolis Santa Catarina Brazil University of Vale do Itajaí-Univali Univali Brazil

The use of good practices (GP) can improve the technical quality and, as a consequence, the outcome of the Strategic Environmental Assessment (SEA) process, increasing its effectiveness. This study aimed to present GP pointed out by Brazilian practitioners (members of the SEA development teams) from the perspective afforded by their participation in processes of this tool. The data were collected through personal interviews with 11 professionals responsible for preparing a total of 17 SEAs, who were asked about what measures adopted in the SEA could be considered BP. The responses were audio-recorded, transcribed, and had their content assessed by Content Analysis technique. Nine GP were highlighted by practitioners. The GP indicated represent a valuable contribution to the improvement of future use of SEA, either in Brazil or in other countries, because they are the result of consolidated experience in real cases of application of the tool.

关键词： Best Practices Environmental Management Environmental Policy Knowledge Management Sustainability

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Influence of the COVID-19 pandemic in the gastrointestinal oncology setting:An overview

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World Journal of Gastrointestinal Pathophysiology 2022年第5期13卷 157-169页

作者： Breno Bittencourt de Brito Hanna Santos Marques filipe Antônio frança da silva Maria Luísa Cordeiro Santos Glauber Rocha Lima Araújo Lara de Araujo Valente Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45055-380BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been impacting healthcare in various ways worldwide and cancer patients are greatly affected by the coronavirus disease 2019(COVID-19)*** reorganization of the health facilities in order to supply the high demand resulting from the aforementioned infection as well as the social isolation measures led to impairments for the diagnosis and follow-up of patients with gastrointestinal cancers,which has had an impact on the prognosis of the oncologic *** that context,health authorities and organizations have elaborated new guidelines with specific recommendations for the management of individuals with gastrointestinal neoplasms during the *** note,oncologic populations seem to be more susceptible to unfavorable outcomes when exposed to SARS-CoV-2 infection and some interactions involving virus,tumor,host immune system and anticancer therapies are probably related to the poorer prognosis observed in those COVID-19 ***,vaccination stands out as the main prevention method against severe SARS-CoV-2 infection and some particularities have been observed regarding the seroconversion of vaccinated oncologic patients including those with gastrointestinal *** this minireview,we gather updated information regarding the influence of the pandemic in the diagnosis of gastrointestinal neoplasms,new recommendations for the management of gastrointestinal cancer patients,the occurrence of SARSCoV-2 infection in those individuals and the scenario of the vaccination against the virus in that population.

关键词： Gastrointestinal cancer COVID-19 Treatment Diagnosis Vaccination Pandemic

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