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Helicobacter pylori infection: Beyond gastric manifestations

World Journal of Gastroenterology 2020年第28期26卷 4076-4093页

作者： Maria Luisa Cordeiro Santos Breno Bittencourt de Brito filipe antonio frança da silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo Instituto Multidisciplinar em Saude Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual da Bahia Vitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

Helicobacter pylori(***)is a bacterium that infects more than a half of world’s *** it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric *** to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological *** that context,when considered the gastrointestinal tract,*** positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and ***,lower serum levels of iron and vitamin B12 have been found in patients with *** infection,leading to the emergence of anemias in a portion of *** regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barré***,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the *** that,the ***-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected ***,the occurrence of dermatological and ophthalmic disorders have also been related to that *** this sense,this minireview aims to gather the main studies associating *** infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of *** in those diseases.

关键词： Helicobacter pylori Extragastric Neurological Cardiovascular Autoimmune Ophthalmic Diabetes Timeline Treatment

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Nephrotoxicity in cancer treatment:An overview

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World Journal of Clinical Oncology 2020年第4期11卷 190-204页

作者： Maria Luísa Cordeiro Santos Breno Bittencourt de Brito filipe antonio frança da silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil

Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer *** kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular *** agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney *** clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal *** of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse ***,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity.

关键词： Acute kidney injury Cancer Chemotherapy Conventional cytotoxic agents Molecularly targeted agents Nephrotoxicity

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A Bidimensional Finite Element Study of Crack Propagation in Austempered Ductile Iron

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Computers, Materials & Continua 2023年第11期77卷 1411-1424页

作者： Gustavo von Zeska de frança Roberto Luís de Assumpção Marco antonio Luersen Carlos Henrique da silva Department of Mechanical Engineering Federal University of Technology–ParanáCuritiba81280-340Brazil

Austempered ductile iron(ADI)is composed of an ausferritic matrix with graphite nodules and has a wide range of applications because of its high mechanical strength,fatigue resistance,and wear resistance compared to other cast *** amount and size of the nodules can be controlled by the chemical composition and austenitizing *** the nodules have lower stiffness than the matrix and can act as stress concentrators,they influence crack ***,the crack propagation mechanism in ADI is not yet fully *** this study,we describe a numerical investigation of crack propagation in ADIs subjected to cyclic *** numerical model used to calculate the stress intensity factors in the material under the given conditions is built with the aid of Abaqus commercial finite element *** crack propagation routine,which is based on the Paris law,is implemented in *** results of the simulation show that the presence of a nodule generates a shear load on the crack ***,even under uniaxial tensile loading,the presence of the nodule yields a non-zero stress intensity factor in mode II,resulting in a deviation in the crack propagation *** is the primary factor responsible for changing the crack propagation direction towards the *** the parameters,for example,increasing the nodule size or decreasing the distance between the nodule and crack tip,can intensify this *** simulations comparing two different ADIs with the same graphite fraction area,the crack in the material with more nodules reaches another nodule in a shorter propagation time(or shorter number of cycles).This suggests that the high fatigue resistance observed in ADIs may be correlated with the number of nodules intercepted by a crack and the additional energy required to nucleate new *** summary,these findings contribute to a better understanding of crack propagation in ADIs,provide insights into the relationship between the presence

关键词： Austempered ductile iron(ADI) fatigue crack propagation graphite nodule

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Miscibility of Poly(hydroxybutyrate)/Poly(vinyl alcohol)Melt Blends Plasticized With Glycerol

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Journal of Renewable Materials 2019年第4期7卷 325-333页

作者： Deliane da silva Cabral antonio JoséFelix Carvalho Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloAv.João Dagnone110013563-120São Carlos-SP-Brazil

Poly(hydroxybutyrate)/poly(vinyl alcohol)(PHB/PVA)blends plasticized with glycerol were prepared by melt blending of PHB and glycerol plasticized *** PHB/PVA-glycerol compositions were 90:10,75:25 and 50:50 w/w,being the concentration of glycerol in the PVA mixture of 10 wt%.The blends were characterized by infrared spectroscopy,dynamic-mechanical thermal analysis,and scanning electron microscope of the fragile fractured *** results showed one single phase blend,indicating miscibility corroborated by the presence of a single glass transition *** blending method proved to be an efficient way to tune PHB properties keeping its biodegradable nature since both PVA and glycerol are fully biodegradable materials.

关键词： Blend miscibility melt processing poly(hydroxybutyrate) poly(vinyl alcohol)

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Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis

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World Journal of Clinical Oncology 2018年第5期9卷 83-89页

作者： Breno Bittencourt de Brito filipe Ant?nio fran?a da silva Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da Bahia

The Helicobacter pylori(H. pylori) infection is a determinant factor in gastric cancer(GC) development. However, the infection outcomes are variable and depend on both host and bacterial characteristics. Some host cytokines such as interleukin(IL)-1β, IL-1 Ra, IL-8, IL-10 and tumor necrosis factor-α play important roles in the host immune system response to the pathogen, in the development of gastric mucosal lesions and in cell malignant transformation. Therefore, these host factors are crucial in neoplastic processes. Certain polymorphisms in genes that encode these cytokines have been associated with an increased risk of GC. On the other hand, various virulence factors found in distinct H. pylori bacterial strains, including cytotoxinassociated antigen A, vacuolating cytotoxin, duodenal ulcer promoting gene A protein, outer inflammatory protein and blood group antigen binding adhesin, have been associated with the pathogenesis of different gastric diseases. The virulent factors mentioned above allow the successful infection by the bacterium and play crucial roles in gastric mucosa lesions, including malignant transformation. Moreover, the role of host polymorphisms and bacterial virulence factors in gastric carcinogenesis seems to vary among different countries and populations. The identification of host and bacterium factors that are associated with an increased risk of GC development may be useful in determining the prognosis of infection in patients, what could help in clinical decision-making and in providing of an optimized clinical approach.

关键词： Helicobacter pylori Virulence factors Cytokines Gene polymorphisms Gastric cancer

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A Finite Element Study of the Influence of Graphite Nodule Characteristics on a Subsurface Crack in a Ductile Cast Iron Matrix under a Contact Load

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 59-71页

作者： Guilherme Suguinoshita Carlos Henrique da silva Marco antonio Luersen Department of Mechanical Engineering Federal University of Technology-Parana(UTFPR)Rua Deputado Heitor Alencar Furtado5000CEP 81280-340CuritibaBrazil

This paper describes a study of the effects of graphite nodule characteristics on a subsurface crack in austempered ductile iron(ADI).A representative specimen of ADI,subjected to sliding contact load,is modeled using finite elements aiming to obtain the shear stress intensity factor(KII).The parameters varied were(i)the nodule diameter(two different values were considered),(ii)the distance between the nodule and the tip of the crack and(iii)the position of the load relative to the tip of the *** results of the numerical simulations show that the smaller diameter nodule has a larger influence on KII,suggesting a higher contact fatigue crack propagation rate in the material with the smaller *** results are the opposite of those observed in experimental studies and would appear to indicate that other factors should be also considered to ensure realistic estimates of the contact fatigue strength of ADI.

关键词： Austempered ductile iron subsurface crack stress intensity factor finite element analysis graphite nodule

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Equity issues and the PeCUS index:an indirect analysis of community severance

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Geo-Spatial Information Science 2020年第4期23卷 293-304页

作者： daniela Vanessa Rodriguez Lara antonio Nelson Rodrigues da silva Department of Transportation Engineering São Carlos School of EngineeringUniversity of São PauloSão PauloBrazil

Urban barriers are often a consequence of the unplanned expansion of transport infrastructures,housing growth nearby existing transport infrastructures,and the vehicular traffic *** process,also known as“community severance”,is a problem that affects the travel patterns of the population and causes negative impacts to adjacent communities,but it is not easy to *** an alternative to the costly technologies and restricted-access data sometimes used to analyze urban barriers,we propose an analytical approach that assesses community severance levels by classifying the quality of Pedestrian Crossings on Urban Streets(the PeCUS index).Additionally,the approach is used to identify possible inequities nearby the different classification groups regarding demographic *** used the chi-square(χ^(2))test of independence and the standardized Pearson residuals to indicate deficits and excesses of residents regarding the demographic characteristics studied surrounding the urban *** found the following evidences of associations:residents with low-income or those aged up to 19 tend to live close to the worst crossings,whereas residents with permanent mobility constraints or the elderly tend to live near the crossings with the best ***,the study shows that the assessment of community severance by the analysis of the PeCUS index is ***,it reveals that the distribution of residents surrounding the distinct classes of quality of crossings is equitable for vulnerable social groups,except for low-income or young residents.

关键词： Community severance transport barriers pedestrian crossings equity open data geographic information systems(GIS)

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Special Issue on 15th Brazilian Polymer Conference:Biopolymers,Eco-Friendly and Biodegradable Polymers and Other Topics Related to Polymeric Materials Derived from Renewable Materials

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Journal of Renewable Materials 2021年第4期9卷 599-600页

作者： antonio Aprigio da silva Curvelo antonio José Felix Carvalho daniel Pasquini São Carlos Institute of Chemistry University of São PauloSão Carlos13566-590-SPBrazil São Carlos School of Engineering University of São PauloSão Carlos13563-120-SPBrazil Institute of Chemistry Federal University of UberlândiaUberlândia38400-902MGBrazil

This issue of Journal of Renewable Materials is a special issue dedicated to the 15th Brazilian Polymer Conference(15th CBPol)which was held in Bento Gonçalves,Rio Grande do Sul State,Brazil,from 27 to 31 October,2019[1].CBPol is the main scientific forum in the field of polymer science and technology in *** conference has been held biannually since 1991 and in this event had almost 900 participants mainly from Brazil,but also from Argentina,Chile,Peru,USA,Canada,Belgium,france,Great Britain,Portugal and Spain,with 60%students and 40%professionals.A total of 1,100 papers from 2725 authors were presented,from which 25%(280 papers)was in the field of Biomaterials showing the importance of these materials which are in general based on renewable *** 280 works were developed mainly by researchers from Brazilian institutions(universities and research institutes),mainly from the south and southeast regions of the *** subject of more than 70%of the works was dedicated on vegetal raw materials,medicinal applications,packaging and composite materials.

关键词： materials showing annually

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Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release

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Journal of Integrative Medicine 2022年第2期20卷 153-162页

作者： Célia Cristina Malaguti Figueiredo Amanda da Costa Gomes filipe Oliveira Granero Joao Luiz Bronzel Junior Luciana Pereira silva Valdecir Farias Ximenes Regildo Márcio Goncalves da silva Institute of Chemistry São Paulo State UniversityAraraquaraSão Paulo 14800-060Brazil Educational Foundation of the City of Assis AssisSão Paulo 19807-130Brazil Department of Chemistry School of SciencesSão Paulo State UniversityBauruSão Paulo 17033-360Brazil Department of Biotechnology School of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão Paulo 19806-900Brazil

Objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus *** also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule ***:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)*** activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(NO)and thiobarbituric acid reactive species(TBARS)*** were prepared using maltodextrin as wall material and freeze-drying as encapsulation *** characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins *** and antioxidant assays were performed using crude dry extract and saponin fraction of *** before and after ***:Saponin fraction showed an increase of 32.8%total ***-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained *** evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with ***,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the *** dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARS(32.49%)*** fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and NO test(15.13μmol nitrite formed per gram of extract)presented the highest ***:This study presen

关键词： Glycation Microencapsulation Oxidative stress Saponins Tribulus terrestris

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Laser texturing of piston ring for tribological performance improvement

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Friction 2023年第10期11卷 1895-1905页

作者： Rita FERREIRA Óscar CARVALHO Luís SOBRAL Sandra CARVALHO filipe silva CMEMS-UMinho University of MinhoGuimarães 4800058Portugal LABBELS-Associate Laboratory Guimarães 4800058Portugal CEMMPRE-Center for Mechanical Engineering Materials and ProcessesUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal MAHLE Componentes de MotoresS.A.Núcleo Industrial de MurtedeCantanhede 3060-372Portugal

The radial surface coating layer of compression piston rings is used to improve their wear resistance during the internal combustion engine ***,at top dead centers,the friction coefficient of the piston ring–cylinder liner pair is detrimental to the engine’s tribological *** this work,dimples with different texture dimensions and densities were tested in a home-developed *** friction coefficient was measured for all samples,and for those with the best results,their wear resistance was *** texture with an aspect ratio of 0.25 and a density area of 15%reported the best tribological results.

关键词： piston ring surface texture friction wear

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