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水文地质工程地质译丛 1989年第1期 81-85页

作者： filip.,S 庄琦华

高产植酸酶乳酸菌及其黑豆酸面团发酵低植酸营养面包研究

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食品与机械 2021年第2期37卷 186-193页

作者：曹伟超罗昆程新陈诚郑建仙黄卫宁李宁 filip Arnaut 周黎源江南大学食品科学与技术国家重点实验室江苏无锡214122 华南理工大学轻工与食品学院广东广州510641 广州焙乐道食品有限公司广东广州511400 焙乐道食品集团比利时布鲁塞尔1201 山东稻香村食品工业有限公司山东菏泽274000

从自然发酵的黑豆中筛选出一株具有高植酸酶活性的乳酸菌L-19并将其作为发酵剂制作黑豆酸面团。通过响应面分析法对黑豆酸面团的发酵工艺进行优化,探究最佳发酵条件下目标菌株的生长及产酸特性,并分析体系中多肽的分子量分布及抗营养因... 详细信息

从自然发酵的黑豆中筛选出一株具有高植酸酶活性的乳酸菌L-19并将其作为发酵剂制作黑豆酸面团。通过响应面分析法对黑豆酸面团的发酵工艺进行优化,探究最佳发酵条件下目标菌株的生长及产酸特性,并分析体系中多肽的分子量分布及抗营养因子含量变化,同时以感官品评的方式对黑豆酸面团面包的烘焙特性进行评价。结果表明:乳酸菌L-19经鉴定为乳酸片球菌(Pediococcus acidilactici),其胞外酶与胞内酶活性分别为1.36,0.30 U/mL。通过响应面设计确定的最优发酵条件为面团得率(DY)300、发酵温度37℃、接种量8%,黑豆基质中,目标菌株生长良好、酸化能力适中。黑豆酸面团经发酵后,体系中的多种抗营养因子得到有效降解,其中植酸降解率高达62.70%。此外,黑豆蛋白水解后释放出多种肽,其中小分子肽占比达51.47%。与对照组相比,L-19黑豆酸面团面包表现出更高的整体可接受度。因此,乳酸片球菌L-19能够有效改善黑豆酸面团面包的营养及感官品质,具有较佳的应用潜力。

关键词：植酸酶黑豆酸面团抗营养因子多肽

Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study

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Journal of Geriatric Cardiology 2021年第11期18卷 897-907页

作者： Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen filip Lyng Lindgren Sam Riahi Department of Cardiology Aalborg University HospitalDenmark Department of Cardiology Gentofte HospitalCopenhagen University HospitalDenmark Department of Clinical Research and Cardiology Nordsjaellands HospitalHillerødDenmark Department of Cardiology Skejby University HospitalDenmark Department of Cardiology RigshospitaletCopenhagen University HospitalDenmark Mølholm Clinic VejleDenmark Department of Cardiology Odense University hospitalDenmark Department of Cardiology Roskilde University HospitalDenmark Department of Thoracic Surgery Odense University HospitalDenmark AF-Study group Aalborg University Hospital Denmark Clinical Institute Aalborg UniversityDenmark

OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 *** addition,one-year all-cause mortality and AF relapse were ***&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide *** aged 65−74 years served as the reference group for patients≥75 *** of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within *** composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age.

关键词： patients fibrillation atrial

Correlation of Ceruloplasmin with Biomarkers of Cardiac Remodelling and Myofibrosis in Patients with Acute Decompensated Heart Failure Referred to a Tertiary Nurse Lead Heart Failure Clinic

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Open Journal of Nursing 2015年第11期5卷 971-975页

作者： filip Malek Dagmar Vondrakova Oxana Komendova Dana Ríhova Jana Vranova Lenka Sedlackova Tana Andreasova Petr Neuzil Department of Cardiology Na Homolce HospitalPragueCzech Republic Third School of Medicine Charles UniversityPragueCzech Republic Department of Clinical Biochemistry Haematology and ImmunologyNa Homolce HospitalPragueCzech Republic

Background: Ceruloplasmin is an acute phase protein with plasma copper binding properties, and is a potent extracellular antioxidative enzyme. Inflammation and oxidative stress might explain the role of ceruloplasmin in the pathophysiology of heart failure. Study objective: The objective is to assess the correlation of ceruloplasmin levels with biomarkers of cardiac remodelling and myofibrosis in patients with acute decompensated heart failure. Patients and methods: Blood samples were taken and serum levels of soluble ST2, galectin-3, NT-proBNP and ceruloplasmin were analysed in 31 consecutive patients with systolic HF referred to tertiary care nurse lead heart failure clinic with acute decompensated CHF requiring i.v. diuretics. The mean patients’ age was 68 years, mean left ventricular ejection fraction (LV EF) was 29%, 66% patients had ischemic aetilogy of CHF and 33% had atrial fibrillation. Results: The mean ceruloplasmin level was 0.243 g/l, mean galectin-3 level was 1.26 ng/ml, mean sST2 level was 38.15 ng/ml, and mean NT-proBNP was 1927 pg/ml. The ceruloplasmin level correlated with NT-proBNP (r = 0.58, p < 0.05) and with sST2 (r = 0.77, p < 0.001), sST2 levels correlated significantly with NT-proBNP (r = 0.66, p < 0.01). The ceruloplasmin level did not correlate with galectin-3 concentration. Conclusion: The ceruloplasmin level correlates with the biomarkers of cardiac remodelling (NT-proBNP, sST2), but not with the biomarker of myofibrosis (galectin-3). This finding supports the hypothesis of inflammatory response in acute decompensated heart failure.

关键词： Acute Decompensated Heart Failure Ceruloplasmin NT-proBNP sST2 Galectin-3

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沙门氏菌——多重药物耐药性和活疫苗使用

国外畜牧学（猪与禽） 2017年第12期37卷 19-21页

作者：唐彩琰 filip van Immerseel

沙门氏菌依然是一种重要的食源性病原菌,人感染沙门氏菌是由非宿主特异性或宿主范围广的沙门氏菌血清型引发的。这些不同血清型的沙门氏菌在多种食品生产用动物的肠道中定植且不表现出任何症状,但会引发人类暴发肠道疾病。

关键词：沙门氏菌药物耐药性食源性病原菌活疫苗宿主特异性血清型鸡盲肠疫苗接种细菌宿主范围

Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity

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Cancer Drug Resistance 2023年第4期6卷 709-728页

作者： Hannah Zaryouh Ines De Pauw Hasan Baysal Joran Melis Valentin Van den Bossche Christophe Hermans Ho Wa Lau Hide Lambrechts Celine Merlin Cyril Corbet Marc Peeters Jan Baptist Vermorken Jorrit De Waele filip Lardon An Wouters Center for Oncological Research(CORE) Integrated Personalized&Precision Oncology Network(IPPON)University of AntwerpCampus Drie EikenAntwerp 2610Belgium Pole of Pharmacology and Therapeutics(FATH) Institut de Recherche Experimentale et Clinique(IREC)UCLouvainBrussels B-1200Belgium institut Roi Albert Il Department of Medical OncologyCliniques Universitaires Saint-LucBrussels B-1200Belgium Department of Medical Oncology Antwerp University HospitalEdegem 2650Belgium

Aim:Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma(HNSCC).To accurately study novel combination treatments,suitable preclinical mouse models for cetuximab resistance are key yet currently *** study aimed to optimize an acquired cetuximab-resistant mouse model,with preservation of the innate immunity,ensuring intact antibody-dependent cellular cytotoxicity(ADCC)***:Cetuximab-sensitive and acquired-resistant HNSCC cell lines,generated in vitro,were subcutaneously engrafted in Rag2 knock-out(KO),BALB/c Nude and CB17 Scid mice with/without Matrigel or *** tumor growth was established,mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 *** addition,immunohistochemistry was used to evaluate the tumor and its ***:Despite several adjustments in cell number,cell lines and the addition of Matrigel,Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell *** tumor growth of resistant SC263-R cells could be induced in CB17 Scid ***,these cells had lost their resistance phenotype in *** revealed a high infiltration of macrophages in cetuximab-treated SC263-R ***-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to ***:We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines,*** models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.

关键词： HNSCC cetuximab resistance xenograft mouse model immunodeficient mice

国际法协会2004年柏林大会国际商事仲裁委员会关于既判力原则与仲裁的中期报告

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武汉仲裁 2015年第1期 85-113页

作者：张戈 filip De Ly Audley Shep Audley Sheppard 南航广州飞机维修工程有限公司

目录第一部分:引言;第二部分:英国普通法系;第三部分:美国普通法系;第四部分:欧洲民法法系;第五部分:国际法;第六部分:国际仲裁;第七部分:关键问题。第一部分:引言商事仲裁委员会受委任研究仲裁中的平行程序与既判力原则问题,并做出研... 详细信息

目录第一部分:引言;第二部分:英国普通法系;第三部分:美国普通法系;第四部分:欧洲民法法系;第五部分:国际法;第六部分:国际仲裁;第七部分:关键问题。第一部分:引言商事仲裁委员会受委任研究仲裁中的平行程序与既判力原则问题,并做出研究该问题的学术报告。本报告是商事仲裁委员会受委任后作出的首次报告,该报告是关于既判力原则的中期报告。

关键词：商事判力部分仲裁报告委员会

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处理小麦中多糖的工具——NIRS

国外畜牧学（猪与禽） 2013年第3期33卷 27-28页

作者：王晶晶 Natasja Smeets filip Nuyens 比利时Kemin Europa NV公司

在欧洲,小麦因其淀粉和蛋白含量高而成为家禽日粮中一种主要的饲料成分。然而,众所周知,小麦中的非淀粉多糖(Non-Starch Polysaccharides,NSP)对家禽有抗营养作用,此外,其浓度非常不定,而目前的饲料配方没有考虑该变异性。本文将讨论NS... 详细信息

在欧洲,小麦因其淀粉和蛋白含量高而成为家禽日粮中一种主要的饲料成分。然而,众所周知,小麦中的非淀粉多糖(Non-Starch Polysaccharides,NSP)对家禽有抗营养作用,此外,其浓度非常不定,而目前的饲料配方没有考虑该变异性。本文将讨论NSP在肉鸡营养中的重要性,以及近红外光谱法(Near Infrared Reflectance Spectroscopy,NIRS)监测其浓度的可能性。

关键词：非淀粉多糖 NIRS 小麦抗营养作用工具近红外光谱法家禽日粮饲料成分

Fixation methods for electron microscopy of human and other liver

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World Journal of Gastroenterology 2010年第23期16卷 2851-2866页

作者： Eddie Wisse filip Braet Hans Duimel Celien Vreuls Ger Koek Steven WM Olde Damink Maartje AJ van den Broek Bart De Geest Cees HC Dejong Chise Tateno Peter Frederik Electron Microscope Unit University of Maastricht Australian Key Center for Microscopy and Microanalysis Sydney University Department of Internal Medicine University of Maastricht Department of Surgery University of Maastricht Center for Molecular and Vascular Biology University of Leuven PhoenixBio Co.

For an electron microscopic study of the liver,expertise and complicated,time-consuming processing of hepatic tissues and cells is *** interpretation of electron microscopy(EM) images requires knowledge of the liver fine structure and experience with the numerous artifacts in fixation,embedding,sectioning,contrast staining and microscopic ***,the aim of this paper is to present a detailed summary of different methods for the preparation of hepatic cells and tissue,for the purpose of preserving long-standing expertise and to encourage new investigators and clinicians to include EM studies of liver cells and tissue in their projects.

关键词： Liver Tissue fixation Perfusion Electron microscopy Biopsy

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乳杆菌发酵对荞麦面包抗氧化及烘焙特性影响

食品工业科技 2015年第19期36卷 49-53页

作者：张思佳张薇苏晓琴 OJOBI Omedi-jacob 徐岩黄卫宁李宁 ARNAUT filip 江南大学食品科学与技术国家重点实验室江苏无锡214122 江南大学生物工程学院工业生物技术教育部重点实验室江苏无锡214122 广州焙乐道食品有限公司广东广州511400 焙乐道食品集团

利用植物乳杆菌和发酵乳杆菌发酵荞麦面团制作酸面团面包,研究乳酸菌发酵使面包面团抗氧化和烘焙特性的影响。结果表明:乳酸菌发酵降低了荞麦面团的p H,令其总酸度值增加。乳酸菌发酵使荞麦酸面团抗氧化能力有所提高,其中植物乳杆菌发... 详细信息

利用植物乳杆菌和发酵乳杆菌发酵荞麦面团制作酸面团面包,研究乳酸菌发酵使面包面团抗氧化和烘焙特性的影响。结果表明:乳酸菌发酵降低了荞麦面团的p H,令其总酸度值增加。乳酸菌发酵使荞麦酸面团抗氧化能力有所提高,其中植物乳杆菌发酵的荞麦面团总酚含量提高21.3%、DPPH和ABTS自由基清除能力分别为未发酵荞麦面团的3倍和1.2倍。乳酸菌的引入还能够改善热加工对抗氧化活性物质的影响,烘焙后植物乳杆菌和发酵乳杆菌面包的总酚含量仅减少48.5%和51.6%,而DPPH和ABTS自由基清除能力分别仅降低了41.2%、54.8%和69.0%、68.4%。乳酸菌发酵能够显著改善面包的质构,添加发酵乳杆菌后荞麦面包硬度减少了25.5%,其感官评分高于未发酵荞麦面包。

关键词：传统酸面团乳杆菌荞麦面包烘焙特性抗氧化特性