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Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats

Asian Pacific Journal of Tropical Medicine 2015年第9期8卷 673-681页

作者： Théophile Dimo fidèle ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet Department of Animal Biology and Physiology Faculty of Science University of Yaoundé 1 Department of Biological Sciences Faculty of Science University of Ngaoundéré Department of Basic Health Sciences College of Applied Medical Sciences Qassim University

Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension.

关键词： Cassia occidentalis Diuretic Antioxidant Urine kidney function Electrolytes

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Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii(Rutaceae) in Wistar rats

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Journal of Integrative Medicine 2015年第5期13卷 326-335页

作者： fidèle ntchapda Maguirgue Kakesse Michel Archange Tagne Fokam Olivier Mbouemboue Pancha Djedouboum Abakar Théophile Dimo Department of Biological Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Biomedical Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaoundé I

OBJECTIVE： Zanthoxylum heitzii is a medicinal plant widely used in central Africa for the treatment of many diseases, especially cardiovascular diseases and hypertension. The diuretic effects of crude stern bark extraction were determined and its safety in rats was evaluated. METHODS： The diuretic effects of crude stem bark extraction of Z. heitzii were investigated in Wistar rats （250 g ＋ 10 g） of both sexes. The crude stem bark extraction of Z. heitzii at the doses of 225, 300 and 375 mg/kg was administered to rats at 5 mL/kg body weight. Urine volume was determined 1, 2, 3, 4, 5, 6 and 24 h after administration of the extract. Kinetics of electrolyte elimination in response to a single oral administration dose of acute treatment was measured. The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as reference （furosemide and hydrochlorothiazide）. Urinary and plasma concentrations of sodium and potassium ions were determined using flame photometry. Concentrations of creatinine, urea, glucose, albumin and electrolytes in the plasma and urine samples were evaluated using a two-way digital bidirectional spectrophotometer. The osmolarity of plasma and urine samples was measured by cytometry using an osmometer. Aldosterone was measured by radioimmunoassay. RESULTS： The plant extract accelerated the elimination of overloaded fluid and increased urine volume and the excretion of Na＋, K＋ and CI 24 h after administration （P〈0.05）. The increase in elimination of Na＋, K＋, and Cl- induced by the extract caused alkalinization of the urine, and showed a strong inhibitory effect on carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375 mg/kg. At the maximum diuretic response, urinary osmolarity decreased significantly （P 〈 0.05） when compared to controls. The stability of aldosterone level, the absence of correlation with the plasma levels of Na＋, and increased clearance of free water in t

关键词： Zanthoxylum heitzii diuretic urine volume urine pH electrolytes temperature rectal

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Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats

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Asian Pacific Journal of Tropical Medicine 2015年第5期8卷 359-365页

作者： fidele ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet Théophile Dimo Department of Biological Sciences Faculty of ScienceUniversity of Ngaoundéré Department of neuroscience Faculty of Medicine.University of Montreal Department of Basic Health Sciences College of Applied Medical SciencesQassim University Department of Animal Biology and Physiology Faculty of ScienceUniversity of Yaoundé

Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular ***:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four *** of general toxicity,body temperature and weight,and water and food intake were monitored in live *** sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was ***:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total *** peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation ***:These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects.

关键词： Zanthoxylum heitzii Plant extract Antioxidant Anti-atherosclerogenic Hypocholesterolemic Hypolipidemic

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Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats

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Journal of Integrative Medicine 2021年第3期19卷 243-250页

作者： fidele ntchapda Fernand C.Tchatchouang David Miaffo Barthelemy Maidadi Lorella Vecchio Rodrigue E.Talla Christian Bonabe Paul F.Seke Etet Theophile Dimo Department of Biological Sciences University of NgaoundereNgaoundereAdamawa RegionCameroon Department of Life and Earth Sciences Higher Teachers’Training CollegeUniversity of MarouaExtreme North RegionCameroon Center for Sustainable Health and Development GarouaNorth RegionCameroon Department of Physiological Sciences and Biochemistry Faculty of Medicine and Biomedical SciencesUniversity of NgaoundereGarouaNorth RegionCameroon Department of Animal Biology and Physiology University of Yaoundé1YaoundeCentre RegionCameroon

Objective:Ipomoea batatas(L.)*** a food plant used in African traditional medicine to treat cardiovascular diseases and related *** assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of *** leaves in a rat model of diet-induced ***:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four ***,rats were treated once daily(per os)with *** extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four *** treatment,animals were observed for another four weeks and then *** were excised and processed for histopathological studies,and blood glucose level and lipid profile were ***:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard *** of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic ***:Our findings suggest that *** leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine.

关键词： Hypercholesterolemic rat Ipomoea batatas Atherosclerotic plaques High-density lipoprotein cholesterol Low-density lipoprotein cholesterol Very low-density lipoprotein cholesterol

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