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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 17-18页

作者： Daniel E. ffytche t.j. Sundar Rao P.S.S. 王海燕 Division of Ocular Immunology Department of OphthalmologyJohns Hopkins University School of Medicine1620 McElderry StreetBaltimoreMD 21205United States Dr.

Aim:to evaluate the incidence of and risk factors for ocular complications in multibacillary(MB)leprosy patients during their 2 year,fixed duration,multidrug therapy(MDt).Methods:Periodic eye examinations were conducted prospectively on a cohort of 301 consecutive newly diagnosed MB patients every 6 months during their 2 year course of *** of ocular pathology was calculated as the number of events per person year of event free follow up of patients who did not have the specific finding at ***:292(97%)patients had one or more follow up *** incidence of lagophthalmos was 1.2% /patient year(95% CI 0.5% to 2.8%);corneal opacity was 7.4% /patient year(95% CI 5.1% to 10.6%);uveal involvement was 5.1% /patient year(95% CI 3.3% to 7.8%),and cataract that reduced vision to 6/18 or less was seen in 4.3% /patient year(95% CI 2.7% to 6.9%)of ***,23 individuals(5.8% /patient year,95% CI 3.9 to 8.8)developed leprosy related potentially blinding pathology during the 2 years of ***:Approximately 20% of patients with MB leprosy can be expected to develop ocular complications of leprosy during a 2 year course of MDt,many(11%)of which are potentially vision *** monitoring to detect and treat ocular complications at defined intervals during MDt is indicated.

关键词：麻风患者联合药物治疗眼部并发症眼科检查葡萄膜角膜混浊眼部病变

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多杆菌麻风病患者多种药物联合治疗2年后眼部并发症的发病率

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 36-36页

作者： Daniel E. ffytche t.j. Kempen j.H. 闫丽 Division of Ocular Immunology Department of Ophthalmology Johns Hopkins University School of Medicine 1620 McElderry Street Baltimore MD 21205 United StatesDr.

Aim: to evaluate the incidence of and risk factors for ocular complications in multibacillary (MB) leprosy patients following completion of 2 year, fixed duration, multidrug therapy (MDt). Methods: Biannual eye examinations were conducted prospectively on a cohort of MB patients who had completed MDt and followed up for 5 years. the incidence of ocular pathology was calculated as the number of events per person year of event free follow up of patients who did not have the specific finding before completion of MDt. Results: 278 patients had one or more follow up visits after completion of MDt. the incidence of lagophthalmos was 0.24%/patient year (95%CI 0.10%to 0.37%); corneal opacity, 5.35%/patient year (95%CI 4.27%to 6.70%); uveal involvement, 3.78%/patient year (95%CI 2.96%to 4.83%); and cataract that reduced vision to 6/18 or less, 2.4%/patient year (95%CI 1.77%to 3.26%). Overall, 5.65%/patient year (95%CI 4.51 %to 7.09%) developed leprosy related ocular disease and 3.86%/patient year (95%CI 3.00%to 4.95%) developed leprosy related, potentially blinding ocular pathology during the period following *** and otfier disability also predicted incident eye disease. Conclusions: Every year, approximately 5.6%of patients with MB who have completed MDt can be expected to develop new ocular complications of leprosy, which often (3.9%) are potentially vision threatening. Because many of these complications cannot be detected without slit lamp examination, periodic monitoring, particularly of older patients and those with other disability, is recommended, in order to detect and treat ocular complications satisfactorily.

关键词：麻风病麻风眼部并发症并发病疾病药物联合患者发病率杆菌

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