多杆菌性麻风患者接受联合药物治疗2年后的眼病发生率

作     者：Daniel E. Ffytche T.J. Sundar Rao P.S.S. 王海燕 

作者机构：Division of Ocular ImmunologyDepartment of OphthalmologyJohns Hopkins University School of Medicine1620 McElderry StreetBaltimoreMD 21205United States Dr. 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第10期

页      面：17-18页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：麻风患者 联合药物治疗 眼部并发症 眼科检查 葡萄膜 角膜混浊 眼部病变 

摘      要：Aim:To evaluate the incidence of and risk factors for ocular complications in multibacillary(MB)leprosy patients during their 2 year,fixed duration,multidrug therapy(MDT).Methods:Periodic eye examinations were conducted prospectively on a cohort of 301 consecutive newly diagnosed MB patients every 6 months during their 2 year course of *** of ocular pathology was calculated as the number of events per person year of event free follow up of patients who did not have the specific finding at ***:292(97%)patients had one or more follow up *** incidence of lagophthalmos was 1.2% /patient year(95% CI 0.5% to 2.8%);corneal opacity was 7.4% /patient year(95% CI 5.1% to 10.6%);uveal involvement was 5.1% /patient year(95% CI 3.3% to 7.8%),and cataract that reduced vision to 6/18 or less was seen in 4.3% /patient year(95% CI 2.7% to 6.9%)of ***,23 individuals(5.8% /patient year,95% CI 3.9 to 8.8)developed leprosy related potentially blinding pathology during the 2 years of ***:Approximately 20% of patients with MB leprosy can be expected to develop ocular complications of leprosy during a 2 year course of MDT,many(11%)of which are potentially vision *** monitoring to detect and treat ocular complications at defined intervals during MDT is indicated.