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The role of exclusive enteral nutrition in the management of orofacial granulomatosis in children

世界儿科杂志:英文版 2016年第4期12卷 421-424页

作者： Mohamed Mutalib Khaled Bezanti Mamoun Elawad fevronia kiparissi Department of Pediatric Gastroenterology Great Ormond Street Hospital NHS Foundation Trust

Background:Orofacial granulomatosis(OFG)is a term used to describe a persistent,painless swelling of lips and orofacial *** can be associated with ulceration,gingival hypertrophy and cobble stone appearance of the buccal *** is commonly associated with Crohn’s disease and can precede the intestinal manifestation of the *** enteral nutrition(EEN)is a recognized treatment for induction of remission for Crohn’s *** aim of this study was to review the use of EEN in the management of OFG in ***:Retrospective review of medical records of all children diagnosed with OFG between 2007 and 2012 was *** of comorbidities,progression to inflammatory bowel disease(IBD)and response to EEN was ***:Twenty-nine children were included,mean age at diagnosis was 9 years(standard deviation 3.9)*** children had isolated OFG and 19 had OFG and IBD,of which 12 presented with OFG and IBD and 7 developed IBD *** time to progression to IBD was 33 months(inter quartile range:9.8-85.5).Twenty-two children completed 6 weeks of EEN,and 19 showed clinical improvement in the OFG ***:EEN appears to be an effective treatment option for children with isolated OFG or OFG and IBD.

关键词： gastroenterology inflammatory bowel disease inflammation orofacial granulomatosis

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Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration

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Neural Regeneration Research 2024年第6期19卷 1318-1324页

作者： Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas Georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas fevronia Angelatou Georgia Kouroupi Ilias Kazanis Laboratory of Developmental Biology Department of Biology University of Patras Laboratory of Cellular and Molecular Neurobiology-Stem Cells Hellenic Pasteur Institute 3. Department of Physiology School of Medicine University of Patras

We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the “weaver” mouse, a model of progressive nigrostriatal degeneration. Here, we extended our investigation in two clinically-relevant ways. First, we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian donors. Second, we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice, at late stages of degeneration. We found that BNN-20 has limited direct effects on cultured human induced pluripotent stem cell-derived neural progenitor cells, marginally enhancing their differentiation towards neurons and partially reversing the pathological phenotype of dopaminergic neurons generated from parkinsonian donors. In agreement, we found no effects of BNN-20 on the mouse neural progenitor cells grafted in the substantia nigra of weaver mice. However, the graft strongly induced an endogenous neurogenic response throughout the midbrain, which was significantly enhanced by the administration of microneurotrophin BNN-20. Our results provide straightforward evidence of the existence of an endogenous midbrain neurogenic system that can be specifically strengthened by BNN-20. Interestingly, the lack of major similar activity on cultured human induced pluripotent stem cell-derived neural progenitors and their progeny reveals the in vivo specificity of the aforementioned pro-neurogenic effect.

关键词： adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells (iPSCs) neurotrophic factors Parkinson's disease substantia

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Spontaneous cerebral abscess due to Bacillus subtilis in an immunocompetent male patient: A case report and review of literature

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World Journal of Clinical Cases 2018年第16期6卷 1169-1174页

作者： Ioannis Tsonis Lydia Karamani Panagiota Xaplanteri fevronia Kolonitsiou Petros Zampakis Georgios Gatzounis Markos Marangos Stelios F Assimakopoulos Department of Neurosurgery University of Patras Medical School Department of Microbiology University of Patras Medical School Department of Radiology University of Patras Medical School Department of Internal Medicine Division of Infectious Diseases University of Patras Medical School

BACKGROUND Bacillus subtilis(B. subtilis) is considered a nonpathogenic microorganism of the genus Bacillus and a common laboratory contaminant. Only scarce reports of B. subtilis central nervous system infection have been reported, mainly in the form of pyogenic meningitis,usually in cases of direct inoculation by trauma or *** SUMMARY A 51-year-old man, with a free previous medical history, presented to the Emergency Department of our hospital complaining of recurrent episodes of left upper limb weakness, during the last month, which had been worsened the last 48 h. During his presentation in Emergency Department he experienced a generalized tonic-clonic grand mal seizure. Brain magnetic resonance imaging(MRI) scan with intravenous Gadolinium revealed a 3.3 cm × 2.7 cm lesion at the right parietal lobe surrounded by mild vasogenic edema, which included the posterior central gyrus. The core of the lesion showed relatively homogenous restricted diffusion. Post Gadolinium T1 W1 image, revealed a ring-shaped enhancement. Due to the imaging findings, brain abscess was our primary consideration. Detailed examination for clinical signs of infectious foci revealed only poor oral hygiene with severe tooth decay and periodontal disease, but without detection of dental abscess. The patient underwent surgical treatment with right parietal craniotomy and total excision of the lesion. Pus and capsule tissue grew B. subtilis and according to antibiogram intravenous ceftriaxone 2 g bids was administered for 4 wk. The patient remained asymptomatic and follow-up MRI scan two months after operation showed complete removal of the *** This case highlights the ultimate importance of appropriate oral hygiene and dental care to avoid potentially serious infectious complications and second, B. subtilis should not be considered merely as laboratory contaminant especially when cultivated by appropriate central nervous system specimen.

关键词： Bacillus subtilis Brain abscess Central nervous system infection Craniotomy Meningitis Case report

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