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LDH conversion films for active protection of AZ31 Mg alloy

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Journal of Magnesium and Alloys 2023年第1期11卷 201-216页

作者： B.Pillado B.Mingo R.del Olmo E.Matykina A.M.Kooijman Y.gonzalez−garcia R.Arrabal M.Mohedano Departamento de Ingeniería Química y de Materiales Facultad de Ciencias QuímicasUniversidad ComplutenseMadrid 28040Spain Department of Materials University of ManchesterOxford RoadManchester M139PLUK Institute of Optoelectronics Military University of Technology2 Kaliskiego Str.Warsaw 00-908Poland Materials Science and Engineering Department Delft University of TechnologyMekelweg 2Delft 2628 CDthe Netherlands

Zinc aluminium(Zn-Al)and lithium aluminium(Li-Al)–layered double hydroxides(LDH)coatings with incorporated inhibitors(Li-,Mo-and W-based)were successfully synthesized on AZ31 Mg ***-Al LDH W and Li-Al LDH Li showed the highest corrosion resistance and were selected for further *** cross-section examination revealed a bi-layer structure composed of an outer part with loose flakes and a denser inner ***,FTIR,and XPS analysis confirmed the incorporation of the ***-treatments with corrosion inhibitors containing solutions resulted in the selective dissolution of the most external layer of the LDH coating,reducing the surface roughness,hydrophilicity and paint adhesion of the *** corrosion properties were confirmed by SVET evaluation for the Zn-Al LDH W *** proposed active corrosion mechanism involves the ion-exchange of aggressive Cl-ions,deposition of hydroxides and competitive adsorption of W-rich corrosion inhibitors.

关键词： AZ31 Magnesium Layered double hydroxides Corrosion inhibitors Active corrosion protection

＂Takeaway＂ drug delivery： A new nanomedical paradigm

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Nano Research 2017年第7期10卷 2234-2243页

作者： Elena gonzalez-Domfnguez Benito Rodriguez-gonzalez Moises Perez-Lorenzo Miguel A. Correa-Duarte Department of Physical Chemistry Biomedical Research Center (CINBIO) and Southern Galicia Institute of Health Research (IISGS)Universidade de Vigo 36310 Vigo Spain

An alternative model to the well-established paradigm of the externally switchable drug delivery systems is herein proposed. In contrast to the on--off archetype, here the amount of released drug is pre-set by the application of an external stimulus, and is gradually released after the withdrawal of the exogenous signal. These attributes are achieved through an innovative approach featuring the integration of plasmonic nanovehicles in a polymer-based film. Such a platform is provided with optically responsive capabilities together with multiple diffusional barriers, allowing for an ＂on-demand＂ time-limited release where light acts as a therapeutic ＂starting shot＂. These nanoarchitectured depots have great potential as implantable drug delivery systems in clinical scenarios where a recurrent, sustained, and yet, on--off administration of medication is required. The application of these hybrid materials may extend the implementation of nanomedicine strategies beyond the point-of-care setting.

关键词： release plasmonic nanocapsule hydrogel near infrared (NIR)

Laparoscopic staging in hilar cholangiocarcinoma:Is it still justified?

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 127-131页

作者： fernando Rotellar fernando Pardo HPB and Liver Transplant Unit Department of General and Abdominal SurgeryUniversity Clinic of NavarreUniversity of Navarre31008 PamplonaSpain

Radical resection remains the only potential curative therapy for hilar cholangiocarcinoma(HCCA).The aim of staging laparoscopic(SL) is to identify patients with previously undetected advanced disease who will not benefit from surgical palliation and therefore avoid unnecessary *** accuracy of non-invasive imaging techniques has significantly improved during the last *** a consequence,the diagnostic yield of SL of biliary tract malignancy should have decreased *** the same time,some authors have recently questioned the value of laparoscopic ultrasound(LUS) as a complement of *** this setting,the precise role of SL and LUS in the preoperative workup of HCCA remains *** it seems undoubtedly clear that its efficacy has decreased in the last decades,there is a general consensus that the universal use of SL shouldn't be recommended anymore;SL should be performed only in selected patients with higher risk of holding unresectable disease(T2/T3 or Bismuth type 3/4 and patients with suspicion of metastases).It would also be recommended in patients with potentially resectable disease who would need preoperative invasive ***,SL should be performed preceding laparotomy in one *** studies on the benefit of SL and LUS in this subset of HCCA patients are warranted.

关键词： Hilar cholangiocarcinoma Laparoscopy Staging laparoscopy Laparoscopic ultrasound

The Human Rightsin Galician Press （FaroDe Vigo and La Voz De Galicia）

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Journalism and Mass Communication 2013年第11期3卷 718-727页

作者： Aurora garcia gonzalez Beatriz Martinez Rodriguez University ofVigo Vigo Spain

Democratic society requires that press freedom is reflected through the preservation of human rights. The aim of this study was to analyse quantitatively the media discourse in the environment of Galicia to see how they deal with different aspects related to the subject. The papers used for the study were for the months from January to September Faro fie Vigo and La Voz de Galicia, in order to establish whether there is a constant in the treatment is done, especially in regard to topics, dedicated spaces, sources and so on.

关键词： human rights press Galician

Complexity of adaptive testing in scenarios defined extensionally

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Frontiers of Computer Science 2023年第3期17卷 11-28页

作者： Ismael RODRÍGUEZ David RUBIO fernando RUBIO Dpto.Sistemas Informáticos y Computación Facultad de InformáticaUniversidad Complutense de MadridMadrid 28040Spain Instituto de Tecnologías del Conocimiento Universidad Complutense de MadridMadrid 28040Spain Instituto de Biomecánica de Valencia.Universitat Politècnica de València València 46022Spain

In this paper,we consider a testing setting where the set of possible definitions of the Implementation Under Test(IUT),as well as the behavior of each of these definitions in all possible interactions,are extensionally defined,i.e.,on an element-by-element and case-by-case *** this setting,the problem of finding the minimum testing strategy such that collected observations will necessarily let us decide whether the IUT is correct or not(i.e.,whether it necessarily belongs to the set of possible correct definitions or not)is studied in four possible problem variants:with or without non-determinism;and with or without more than one possible definition in the sets of possible correct and incorrect *** computational complexity of these variants is studied,and properties such as PSPACE-completeness and Log-APX-hardness are identified.

关键词： formal testing adaptive testing computational complexity PSPACE-completeness approximation hardness

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz gonzalez Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Impact of emulated inertia from wind power on under-frequency protection schemes of future power systems

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Journal of Modern Power Systems and Clean Energy 2016年第2期4卷 211-218页

作者： Francisco Manuel gonzalez-LONGATT Loughborough University Loughborough LE652JGUK

Future power systems face several *** of them is the use of high power converters that decouple new energy sources from the AC power *** situation decreases the total system inertia affecting its ability to overcome system frequency *** wind power industry has created several controllers to enable inertial response on wind turbines generators:artificial,emulated,simulated,or synthetic *** paper deals with the issues related to the emulated inertia of wind turbines based on full-converters and their effect on the under-frequency protection schemes during the recovery period after system frequency disturbances *** main contribution of this paper is to demonstrate the recovery period of under-frequency transients in future power systems which integrate wind turbines with emulated inertia capability does not completely avoid the worse scenarios in terms of under-frequency load *** extra power delivered from a wind turbine during frequency disturbances can substantially reduce the rate of frequency *** it provides time for the active governors to respond.

关键词： Frequency controller Frequency stability Power system Protection scheme Wind turbine generator

Nonalcoholic fatty liver disease in type 2 diabetes: awareness is the first step toward change

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 493-496页

作者： fernando Bril Division of Endocrinology University of FloridaGainesvilleFLUSA Diabetes and Metabolism 2Internal MedicineDepartment of MedicineUniversity of FloridaGainesvilleFLUSA

In a recent article published in J Hepatol,Younossi et *** a comprehensive systematic review and meta-analysis on the prevalence of NAFLD,NASH and advanced fibrosis in patients with type 2 diabetes mellitus(T2DM)across the globe(1).Among the 80 studies included in the final analysis(for a total of 49,419 patients)the prevalence of NAFLD was between 50–70%in all continents,except for Africa,where a prevalence of 30.4%was *** lower prevalence of NAFLD in Africa is consistent with prior reports showing a lower prevalence of NAFLD among African-American individuals(2,3).Of note,once African-American patients develop NAFLD,their progression to NASH and advanced fibrosis is similar to other ethnic groups,and still a significant cause of cirrhosis in this population(4).

关键词： NAFLD prevalence al.

Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 486-495页

作者： Nelia Hernandez fernando Bessone Hospital de Clinicas Universidad de la RepublicaMontevideoUruguay Hospital Provincial del Centenario University of Rosario School of MedicineRosarioArgentina

Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer,rheumatologic,autoimmune,and inflammatory diseases,and are currently being evaluated in hepatocellular carcinoma(HCC).They are classified by their mechanism of action and include tumor necrosis factor-alpha(TNF-α)antagonists,T cell mediated antitumor inhibitors,interleukin receptor antagonists,and immune checkpoint inhibitors(ICIs).Some ICIs cause frequent hepatotoxicity with a variable clinical,biochemical,and serological presentation,especially in patients receiving another immunomodulatory *** of the cases of liver damage induced by biological agents spontaneously regress after drug withdrawal,but the others require steroid ***,there are no widely accepted recommendation for the use of corticosteroids in these patients,even though international cancer societies have their own *** drug-induced autoimmune hepatitis(DIAIH)from classic AIH is challenging for pathologists,but liver biopsy is valuable,particularly in cases with unclear clinical ***,novel histological patterns have been described in liver damage induced by these agents(i.e.,endothelitis,ring granuloma and secundary sclerosing cholangitis associated with lymphocytic infiltration of cytotoxic CD8+T cells).Here,we describe the clinical and biochemical characteristics of patients with hepatotoxicity induced by TNF-αantagonists and *** issues involved in the administration of corticosteroid therapy,and hepatitis B virus(HBV)reactivation induced by immunosuppressive therapy are also discussed.

关键词： Hepatotoxicity Checkpoint inhibitors Biologics Autoimmune hepatitis Drug-induced liver injury